Epigenetic Target Information

General Information of the Epigenetic Target (ID: EPITAR00548)
Target Name Heme oxygenase 1 (HMOX1)
Synonyms
HO; HO1: HO-1
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Gene Name HMOX1
Sequence
MERPQPDSMPQDLSEALKEATKEVHTQAENAEFMRNFQKGQVTRDGFKLVMASLYHIYVALEEEIERNKESPVFAPVYFPEELHRKAALEQDLAFWYGPRWQEVIPYTPAMQRYVKRLHEVGRTEPELLVAHAYTRYLGDLSGGQVLKKIAQKALDLPSSGEGLAFFTFPNIASATKFKQLYRSRMNSLEMTPAVRQRVIEEAKTAFLLNIQLFEELQELLTHDTKDQSPSRAPGLRQRASNKVQDSAPVETPRGKPPLNTRSQAPLLRWVLTLSFLVATVAVGLYAM
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Family Heme oxygenase family
Function
Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron (PubMed:11121422, PubMed:19556236, PubMed:7703255). Affords protection against programmed cell death and this cytoprotective effect relies on its ability to catabolize free heme and prevent it from sensitizing cells to undergo apoptosis (PubMed:20055707). {ECO:0000269|PubMed:11121422, ECO:0000269|PubMed:19556236, ECO:0000269|PubMed:7703255, ECO:0000303|PubMed:20055707}.; (Microbial infection) During SARS-COV-2 infection, promotes SARS-CoV-2 ORF3A-mediated autophagy but is unlikely to be required for ORF3A-mediated induction of reticulophagy. {ECO:0000269|PubMed:35239449}.; [Heme oxygenase 1 soluble form]: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron. {ECO:0000269|PubMed:7703255}.
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Gene ID 3162
HGNC ID HGNC:5013
Ensembl Gene ID ENSG00000100292
KEGG ID hsa:3162
Chromosomal Location 22q12.3
RNA Modification Sequencing Data Associated with the Target (ID: EPITAR00548)
Heme oxygenase 1 (HMOX1)
5-methylcytidine (m5C)
In total 18 m6A sequence/site(s) in this target gene
mod ID: M5CSITE002906 Click to Show/Hide the Full List
mod site chr22:35391963-35391964:+
Sequence GCCGGGCACGATGGCTCATGCCTGTAATCCCAGCACTTTGG
Cell/Tissue List T24
Seq Type List Bisulfite-seq
Transcript ID List ENST00000216117.9; rmsk_5283598
External Link RMBase: m5C_site_30700
mod ID: M5CSITE002907 Click to Show/Hide the Full List
mod site chr22:35391964-35391965:+
Sequence CCGGGCACGATGGCTCATGCCTGTAATCCCAGCACTTTGGG
Cell/Tissue List T24
Seq Type List Bisulfite-seq
Transcript ID List ENST00000216117.9; rmsk_5283598
External Link RMBase: m5C_site_30701
mod ID: M5CSITE002908 Click to Show/Hide the Full List
mod site chr22:35391971-35391972:+
Sequence CGATGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGA
Cell/Tissue List T24
Seq Type List Bisulfite-seq
Transcript ID List rmsk_5283598; ENST00000216117.9
External Link RMBase: m5C_site_30702
mod ID: M5CSITE002909 Click to Show/Hide the Full List
mod site chr22:35391972-35391973:+
Sequence GATGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAG
Cell/Tissue List T24
Seq Type List Bisulfite-seq
Transcript ID List ENST00000216117.9; rmsk_5283598
External Link RMBase: m5C_site_30703
mod ID: M5CSITE002910 Click to Show/Hide the Full List
mod site chr22:35391973-35391974:+
Sequence ATGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGG
Cell/Tissue List T24
Seq Type List Bisulfite-seq
Transcript ID List rmsk_5283598; ENST00000216117.9
External Link RMBase: m5C_site_30704
mod ID: M5CSITE002911 Click to Show/Hide the Full List
mod site chr22:35391976-35391977:+
Sequence GCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAC
Cell/Tissue List T24
Seq Type List Bisulfite-seq
Transcript ID List rmsk_5283598; ENST00000216117.9
External Link RMBase: m5C_site_30705
mod ID: M5CSITE002912 Click to Show/Hide the Full List
mod site chr22:35391978-35391979:+
Sequence TCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCACGG
Cell/Tissue List T24
Seq Type List Bisulfite-seq
Transcript ID List rmsk_5283598; ENST00000216117.9
External Link RMBase: m5C_site_30706
mod ID: M5CSITE002913 Click to Show/Hide the Full List
mod site chr22:35392113-35392114:+
Sequence CACACCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAG
Cell/Tissue List T24
Seq Type List Bisulfite-seq
Transcript ID List rmsk_5283598; ENST00000216117.9
External Link RMBase: m5C_site_30707
mod ID: M5CSITE002914 Click to Show/Hide the Full List
mod site chr22:35392115-35392116:+
Sequence CACCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAA
Cell/Tissue List T24
Seq Type List Bisulfite-seq
Transcript ID List rmsk_5283598; ENST00000216117.9
External Link RMBase: m5C_site_30708
mod ID: M5CSITE002915 Click to Show/Hide the Full List
mod site chr22:35392122-35392123:+
Sequence AATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCTCCTA
Cell/Tissue List T24
Seq Type List Bisulfite-seq
Transcript ID List ENST00000216117.9; rmsk_5283598
External Link RMBase: m5C_site_30709
mod ID: M5CSITE002916 Click to Show/Hide the Full List
mod site chr22:35392128-35392129:+
Sequence AGCTACTCGGGAGGCTGAGGCAGGAGAATCTCCTAAGTCCG
Cell/Tissue List T24
Seq Type List Bisulfite-seq
Transcript ID List rmsk_5283598; ENST00000216117.9
External Link RMBase: m5C_site_30710
mod ID: M5CSITE002917 Click to Show/Hide the Full List
mod site chr22:35392163-35392164:+
Sequence AGTCCGGGAGGCAGAGGTTGCAGTGAGCCGAGATTGCACCA
Cell/Tissue List T24
Seq Type List Bisulfite-seq
Transcript ID List rmsk_5283598; ENST00000216117.9
External Link RMBase: m5C_site_30711
mod ID: M5CSITE002918 Click to Show/Hide the Full List
mod site chr22:35392170-35392171:+
Sequence GAGGCAGAGGTTGCAGTGAGCCGAGATTGCACCACTGTACT
Cell/Tissue List T24
Seq Type List Bisulfite-seq
Transcript ID List rmsk_5283598; ENST00000216117.9
External Link RMBase: m5C_site_30712
mod ID: M5CSITE002919 Click to Show/Hide the Full List
mod site chr22:35392171-35392172:+
Sequence AGGCAGAGGTTGCAGTGAGCCGAGATTGCACCACTGTACTC
Cell/Tissue List T24
Seq Type List Bisulfite-seq
Transcript ID List rmsk_5283598; ENST00000216117.9
External Link RMBase: m5C_site_30713
mod ID: M5CSITE002920 Click to Show/Hide the Full List
mod site chr22:35392179-35392180:+
Sequence GTTGCAGTGAGCCGAGATTGCACCACTGTACTCCATCCTGG
Cell/Tissue List T24
Seq Type List Bisulfite-seq
Transcript ID List ENST00000216117.9; rmsk_5283598
External Link RMBase: m5C_site_30714
mod ID: M5CSITE002921 Click to Show/Hide the Full List
mod site chr22:35392181-35392182:+
Sequence TGCAGTGAGCCGAGATTGCACCACTGTACTCCATCCTGGGC
Cell/Tissue List T24
Seq Type List Bisulfite-seq
Transcript ID List rmsk_5283598; ENST00000216117.9
External Link RMBase: m5C_site_30715
mod ID: M5CSITE002922 Click to Show/Hide the Full List
mod site chr22:35392182-35392183:+
Sequence GCAGTGAGCCGAGATTGCACCACTGTACTCCATCCTGGGCG
Cell/Tissue List T24
Seq Type List Bisulfite-seq
Transcript ID List ENST00000216117.9; rmsk_5283598
External Link RMBase: m5C_site_30716
mod ID: M5CSITE002923 Click to Show/Hide the Full List
mod site chr22:35392184-35392185:+
Sequence AGTGAGCCGAGATTGCACCACTGTACTCCATCCTGGGCGAC
Cell/Tissue List T24
Seq Type List Bisulfite-seq
Transcript ID List rmsk_5283598; ENST00000216117.9
External Link RMBase: m5C_site_30717
N6-methyladenosine (m6A)
In total 28 m6A sequence/site(s) in this target gene
mod ID: M6ASITE057947 Click to Show/Hide the Full List
mod site chr22:35381271-35381272:+ [1]
Sequence CGTCCTAGCCCCACCCCGGGACACTGCCACACAGCGACAGA
Motif Score 3.643047619
Cell/Tissue List HeLa; HepG2; HEK293T; A549; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; GSCs; NB4
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000481190.1; ENST00000412893.5; ENST00000216117.9
External Link RMBase: m6A_site_563682
mod ID: M6ASITE057948 Click to Show/Hide the Full List
mod site chr22:35381307-35381308:+ [1]
Sequence ACAGAGCCCAGGAGCCAGAAACTTGGGCTCTGGAGTCAGGA
Motif Score 2.627720238
Cell/Tissue List HeLa; HepG2; A549; CD4T; peripheral-blood; GSC-11; HEK293T; iSLK; MSC; TIME; endometrial; GSCs; NB4
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000481190.1; rmsk_5283562; ENST00000412893.5; ENST00000216117.9
External Link RMBase: m6A_site_563683
mod ID: M6ASITE057949 Click to Show/Hide the Full List
mod site chr22:35383155-35383156:+ [2]
Sequence GGAGGCCACCAAGGAGGTGCACACCCAGGCAGAGAATGCTG
Motif Score 2.830589286
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000412893.5; ENST00000216117.9; ENST00000481190.1
External Link RMBase: m6A_site_563684
mod ID: M6ASITE057950 Click to Show/Hide the Full List
mod site chr22:35383188-35383189:+ [1]
Sequence GAATGCTGAGTTCATGAGGAACTTTCAGAAGGGCCAGGTGA
Motif Score 3.373380952
Cell/Tissue List HeLa; HepG2; A549; CD4T; peripheral-blood; GSC-11; HEK293T; iSLK; MSC; TIME; endometrial; GSCs
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000412893.5; ENST00000216117.9; ENST00000481190.1
External Link RMBase: m6A_site_563685
mod ID: M6ASITE057951 Click to Show/Hide the Full List
mod site chr22:35386706-35386707:+ [2]
Sequence GGTGATGGCCTCCCTGTACCACATCTATGTGGCCCTGGAGG
Motif Score 2.053113095
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000481190.1; ENST00000412893.5; ENST00000216117.9
External Link RMBase: m6A_site_563686
mod ID: M6ASITE057952 Click to Show/Hide the Full List
mod site chr22:35386742-35386743:+ [2]
Sequence GGAGGAGGAGATTGAGCGCAACAAGGAGAGCCCAGTCTTCG
Motif Score 2.173910714
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000481190.1; ENST00000216117.9; ENST00000412893.5
External Link RMBase: m6A_site_563687
mod ID: M6ASITE057953 Click to Show/Hide the Full List
mod site chr22:35386814-35386815:+ [1]
Sequence CAAGGCTGCCCTGGAGCAGGACCTGGCCTTCTGGTACGGGC
Motif Score 3.622404762
Cell/Tissue List HeLa; HepG2; A549; peripheral-blood
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000481190.1; ENST00000216117.9; ENST00000412893.5
External Link RMBase: m6A_site_563688
mod ID: M6ASITE057954 Click to Show/Hide the Full List
mod site chr22:35386859-35386860:+ [2]
Sequence CTGGCAGGAGGTCATCCCCTACACACCAGCCATGCAGCGCT
Motif Score 2.078666667
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000412893.5; ENST00000216117.9; ENST00000481190.1
External Link RMBase: m6A_site_563689
mod ID: M6ASITE057955 Click to Show/Hide the Full List
mod site chr22:35386940-35386941:+ [2]
Sequence GCTGCTGGTGGCCCACGCCTACACCCGCTACCTGGGTGACC
Motif Score 2.078666667
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000412893.5; ENST00000216117.9
External Link RMBase: m6A_site_563690
mod ID: M6ASITE057956 Click to Show/Hide the Full List
mod site chr22:35387006-35387007:+ [1]
Sequence GATTGCCCAGAAAGCCCTGGACCTGCCCAGCTCTGGCGAGG
Motif Score 3.622404762
Cell/Tissue List HeLa; HepG2; H1A; A549; peripheral-blood; HEK293T; endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000412893.5; ENST00000216117.9
External Link RMBase: m6A_site_563691
mod ID: M6ASITE057957 Click to Show/Hide the Full List
mod site chr22:35387051-35387052:+ [2]
Sequence GGCCTTCTTCACCTTCCCCAACATTGCCAGTGCCACCAAGT
Motif Score 2.173910714
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000412893.5; ENST00000494998.1; ENST00000216117.9
External Link RMBase: m6A_site_563692
mod ID: M6ASITE057958 Click to Show/Hide the Full List
mod site chr22:35387099-35387100:+ [1]
Sequence GCTCTACCGCTCCCGCATGAACTCCCTGGAGATGACTCCCG
Motif Score 3.373380952
Cell/Tissue List HeLa; HepG2; H1A; A549; Huh7; CD4T; peripheral-blood; HEK293T; endometrial; NB4
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000412893.5; ENST00000494998.1; ENST00000216117.9
External Link RMBase: m6A_site_563693
mod ID: M6ASITE057959 Click to Show/Hide the Full List
mod site chr22:35387152-35387153:+ [1]
Sequence GGGTGATAGAAGAGGCCAAGACTGCGTTCCTGCTCAACATC
Motif Score 3.319380952
Cell/Tissue List HeLa; HepG2; A549; Huh7; CD4T; peripheral-blood; endometrial
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000494998.1; ENST00000216117.9
External Link RMBase: m6A_site_563694
mod ID: M6ASITE057960 Click to Show/Hide the Full List
mod site chr22:35387168-35387169:+ [2]
Sequence CAAGACTGCGTTCCTGCTCAACATCCAGGTGAGGGTCGGGC
Motif Score 2.173910714
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000216117.9; ENST00000494998.1
External Link RMBase: m6A_site_563695
mod ID: M6ASITE057961 Click to Show/Hide the Full List
mod site chr22:35389897-35389898:+ [2]
Sequence GCAGGAGCTGCTGACCCATGACACCAAGGACCAGAGCCCCT
Motif Score 2.859755952
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000494998.1; ENST00000216117.9
External Link RMBase: m6A_site_563696
mod ID: M6ASITE057962 Click to Show/Hide the Full List
mod site chr22:35389906-35389907:+ [1]
Sequence GCTGACCCATGACACCAAGGACCAGAGCCCCTCACGGGCAC
Motif Score 3.622404762
Cell/Tissue List HeLa; HepG2; A549; Huh7; CD4T; peripheral-blood; endometrial
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000216117.9; ENST00000494998.1
External Link RMBase: m6A_site_563697
mod ID: M6ASITE057963 Click to Show/Hide the Full List
mod site chr22:35389951-35389952:+ [2]
Sequence GCTTCGCCAGCGGGCCAGCAACAAAGTGCAAGGTGAGAGCA
Motif Score 2.173910714
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000494998.1; ENST00000216117.9
External Link RMBase: m6A_site_563698
mod ID: M6ASITE057964 Click to Show/Hide the Full List
mod site chr22:35390011-35390012:+ [1]
Sequence TCTGGGCTACACATGGAGGGACTTGGCTGTCTGACTGTAGT
Motif Score 4.065041667
Cell/Tissue List HeLa; HepG2; A549; Huh7; peripheral-blood
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000494998.1; ENST00000216117.9
External Link RMBase: m6A_site_563699
mod ID: M6ASITE057965 Click to Show/Hide the Full List
mod site chr22:35393484-35393485:+ [1]
Sequence CAGATTCTGCCCCCGTGGAGACTCCCAGAGGGAAGCCCCCA
Motif Score 3.319380952
Cell/Tissue List HeLa; A549; peripheral-blood; HEK293T; MSC; TIME
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000216117.9
External Link RMBase: m6A_site_563700
mod ID: M6ASITE057966 Click to Show/Hide the Full List
mod site chr22:35393509-35393510:+ [2]
Sequence CAGAGGGAAGCCCCCACTCAACACCCGCTCCCAGGCTCCGC
Motif Score 2.173910714
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000216117.9
External Link RMBase: m6A_site_563701
mod ID: M6ASITE057967 Click to Show/Hide the Full List
mod site chr22:35393628-35393629:+ [1]
Sequence GCTGGCTCCCAGGGCCATGAACTTTGTCCGGTGGAAGGCCT
Motif Score 3.373380952
Cell/Tissue List HeLa; A549; peripheral-blood; iSLK; MSC; TIME
Seq Type List m6A-seq; m6A-CLIP/IP; MeRIP-seq
Transcript ID List ENST00000216117.9
External Link RMBase: m6A_site_563702
mod ID: M6ASITE057968 Click to Show/Hide the Full List
mod site chr22:35393786-35393787:+ [2]
Sequence CATCTTCCCCAACGAAAAGCACATCCAGGCAATGGCCTAAA
Motif Score 2.830589286
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000216117.9
External Link RMBase: m6A_site_563703
mod ID: M6ASITE057969 Click to Show/Hide the Full List
mod site chr22:35393806-35393807:+ [3]
Sequence ACATCCAGGCAATGGCCTAAACTTCAGAGGGGGCGAAGGGA
Motif Score 2.627720238
Cell/Tissue List Huh7
Seq Type List MeRIP-seq
Transcript ID List ENST00000216117.9
External Link RMBase: m6A_site_563704
mod ID: M6ASITE057970 Click to Show/Hide the Full List
mod site chr22:35393875-35393876:+ [4]
Sequence CCTGCAGCAGAGCCTGGAAGACACCCTAATGTGGCAGCTGT
Motif Score 2.897386905
Cell/Tissue List HEK293T; hESC-HEK293T
Seq Type List DART-seq; MAZTER-seq
Transcript ID List ENST00000216117.9
External Link RMBase: m6A_site_563705
mod ID: M6ASITE057971 Click to Show/Hide the Full List
mod site chr22:35393937-35393938:+ [2]
Sequence AGTTTCAAGTATCCTTGTTGACACGGCCATGACCACTTTCC
Motif Score 2.859755952
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000216117.9
External Link RMBase: m6A_site_563706
mod ID: M6ASITE057972 Click to Show/Hide the Full List
mod site chr22:35393939-35393940:+ [4]
Sequence TTTCAAGTATCCTTGTTGACACGGCCATGACCACTTTCCCC
Motif Score 2.058863095
Cell/Tissue List HEK293T
Seq Type List DART-seq
Transcript ID List ENST00000216117.9
External Link RMBase: m6A_site_563707
mod ID: M6ASITE057973 Click to Show/Hide the Full List
mod site chr22:35393979-35393980:+ [4]
Sequence CGTGGGCCATGGCAATTTTTACACAAACCTGAAAAGATGTT
Motif Score 2.07285119
Cell/Tissue List HEK293T
Seq Type List DART-seq
Transcript ID List ENST00000216117.9
External Link RMBase: m6A_site_563708
mod ID: M6ASITE057974 Click to Show/Hide the Full List
mod site chr22:35394188-35394189:+ [2]
Sequence ACTTTTGTGTGAAATAATAAACAACATTGTCTGATAGTAGC
Motif Score 2.20572619
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000216117.9
External Link RMBase: m6A_site_563709