Epigenetic Target Information

General Information of the Epigenetic Target (ID: EPITAR00534)

Target Name	Target of Myb1 membrane trafficking protein (TOM1)
Synonyms	Target of Myb protein 1 Click to Show/Hide
Gene Name	TOM1
Sequence	MDFLLGNPFSSPVGQRIEKATDGSLQSEDWALNMEICDIINETEEGPKDALRAVKKRIVGNKNFHEVMLALTVLETCVKNCGHRFHVLVASQDFVESVLVRTILPKNNPPTIVHDKVLNLIQSWADAFRSSPDLTGVVTIYEDLRRKGLEFPMTDLDMLSPIHTPQRTVFNSETQSGQDSVGTDSSQQEDSGQHAAPLPAPPILSGDTPIAPTPEQIGKLRSELEMVSGNVRVMSEMLTELVPTQAEPADLELLQELNRTCRAMQQRVLELIPQIANEQLTEELLIVNDNLNNVFLRHERFERFRTGQTTKAPSEAEPAADLIDMGPDPAATGNLSSQLAGMNLGSSSVRAGLQSLEASGRLEDEFDMFALTRGSSLADQRKEVKYEAPQATDGLAGALDARQQSTGAIPVTQACLMEDIEQWLSTDVGNDAEEPKGVTSEEFDKFLEERAKAADRLPNLSSPSAEGPPGPPSGPAPRKKTQEKDDDMLFAL Click to Show/Hide
Family	TOM1 family
Function	Adapter protein that plays a role in the intracellular membrane trafficking of ubiquitinated proteins, thereby participating in autophagy, ubiquitination-dependent signaling and receptor recycling pathways (PubMed:14563850, PubMed:15047686, PubMed:23023224, PubMed:25588840, PubMed:26320582, PubMed:31371777). Acts as a MYO6/Myosin VI adapter protein that targets MYO6 to endocytic structures (PubMed:23023224). Together with MYO6, required for autophagosomal delivery of endocytic cargo, the maturation of autophagosomes and their fusion with lysosomes (PubMed:23023224). MYO6 links TOM1 with autophagy receptors, such as TAX1BP1; CALCOCO2/NDP52 and OPTN (PubMed:31371777). Binds to polyubiquitinated proteins via its GAT domain (PubMed:14563850). In a complex with TOLLIP, recruits ubiquitin-conjugated proteins onto early endosomes (PubMed:15047686). The Tom1-Tollip complex may regulate endosomal trafficking by linking polyubiquitinated proteins to clathrin (PubMed:14563850, PubMed:15047686). Mediates clathrin recruitment to early endosomes by ZFYVE16 (PubMed:15657082). Modulates binding of TOLLIP to phosphatidylinositol 3-phosphate (PtdIns(3)P) via binding competition; the association with TOLLIP may favor the release of TOLLIP from endosomal membranes, allowing TOLLIP to commit to cargo trafficking (PubMed:26320582). Acts as a phosphatidylinositol 5-phosphate (PtdIns(5)P) effector by binding to PtdIns(5)P, thereby regulating endosomal maturation (PubMed:25588840). PtdIns(5)P-dependent recruitment to signaling endosomes may block endosomal maturation (PubMed:25588840). Also inhibits Toll-like receptor (TLR) signaling and participates in immune receptor recycling (PubMed:15047686, PubMed:26320582). {ECO:0000269\|PubMed:14563850, ECO:0000269\|PubMed:15047686, ECO:0000269\|PubMed:15657082, ECO:0000269\|PubMed:23023224, ECO:0000269\|PubMed:25588840, ECO:0000269\|PubMed:26320582, ECO:0000269\|PubMed:31371777}. Click to Show/Hide
Gene ID	10043
HGNC ID	HGNC:11982
Ensembl Gene ID	ENSG00000100284
KEGG ID	hsa:10043
Chromosomal Location	22q12.3

RNA Modification Sequencing Data Associated with the Target (ID: EPITAR00534)

Target of Myb1 membrane trafficking protein (TOM1)

Adenosine-to-Inosine editing (A-to-I)

In total 3 m6A sequence/site(s) in this target gene
mod ID: A2ISITE011282		Click to Show/Hide the Full List
mod site	chr22:35321067-35321068:+		[1]
Sequence	GGGCATCAGAACACTATGCTAGCTGGGCTCAGGGACTCATG
Transcript ID List	ENST00000411850.5; ENST00000382034.9; ENST00000608749.5; ENST00000395736.7; ENST00000443206.2; ENST00000608674.5; ENST00000425375.5; ENST00000449508.1; ENST00000439512.5; ENST00000424387.5; ENST00000449058.7; ENST00000456128.5; ENST00000447733.5; ENST00000404284.6; ENST00000487670.1
External Link	RMBase: RNA-editing_site_92389
mod ID: A2ISITE011283		Click to Show/Hide the Full List
mod site	chr22:35331808-35331809:+		[1]
Sequence	GAGGCAGGAGAATTGCTTGAACCCAGGAGGCAGAGGTTGCA
Transcript ID List	ENST00000447733.5; ENST00000382034.9; ENST00000424387.5; ENST00000449058.7; ENST00000456128.5; rmsk_5283425; ENST00000425375.5; ENST00000411850.5; ENST00000404284.6; ENST00000491987.1
External Link	RMBase: RNA-editing_site_92390
mod ID: A2ISITE011284		Click to Show/Hide the Full List
mod site	chr22:35341530-35341531:+		[1]
Sequence	GTCGGGATTCATCGGAACCAACACACCGCGAGCCTGCTGTA
Transcript ID List	ENST00000425375.5; ENST00000424387.5; ENST00000447733.5; ENST00000382034.9; ENST00000411850.5; ENST00000404284.6; ENST00000449058.7
External Link	RMBase: RNA-editing_site_92391

N6-methyladenosine (m6A)

In total 57 m6A sequence/site(s) in this target gene
mod ID: M6ASITE057890		Click to Show/Hide the Full List
mod site	chr22:35299932-35299933:+		[2]
Sequence	AGCGGCGGTAGCAGCAATGGACTTTCTCCTGGGGAACCCGT
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; U2OS; HEK293T; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000424387.5; ENST00000456128.5; ENST00000404284.6; ENST00000382034.9; ENST00000411850.5; ENST00000439512.5; ENST00000465529.1; ENST00000449058.7; ENST00000449508.1; ENST00000608674.5; ENST00000395736.7; ENST00000425375.5; ENST00000487670.1; ENST00000447733.5; ENST00000608749.5
External Link	RMBase: m6A_site_563625
mod ID: M6ASITE057891		Click to Show/Hide the Full List
mod site	chr22:35299947-35299948:+		[2]
Sequence	AATGGACTTTCTCCTGGGGAACCCGTTCAGCTCTCCAGTGG
Motif Score	2.930744048
Cell/Tissue List	HeLa; HepG2; U2OS; HEK293T; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000608674.5; ENST00000382034.9; ENST00000404284.6; ENST00000439512.5; ENST00000456128.5; ENST00000447733.5; ENST00000449058.7; ENST00000449508.1; ENST00000425375.5; ENST00000487670.1; ENST00000395736.7; ENST00000411850.5; ENST00000608749.5; ENST00000424387.5; ENST00000465529.1
External Link	RMBase: m6A_site_563626
mod ID: M6ASITE057892		Click to Show/Hide the Full List
mod site	chr22:35299969-35299970:+		[2]
Sequence	CCGTTCAGCTCTCCAGTGGGACAGCGCATCGGTGAGTCCCT
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; HEK293T; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000411850.5; ENST00000465529.1; ENST00000424387.5; ENST00000395736.7; ENST00000456128.5; ENST00000608674.5; ENST00000447733.5; ENST00000449508.1; ENST00000382034.9; ENST00000439512.5; ENST00000404284.6; ENST00000425375.5; ENST00000608749.5; ENST00000487670.1; ENST00000449058.7
External Link	RMBase: m6A_site_563627
mod ID: M6ASITE057893		Click to Show/Hide the Full List
mod site	chr22:35317909-35317910:+		[2]
Sequence	TGGCTCCCTGCAGAGCGAGGACTGGGCCCTCAACATGGAGA
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; Huh7; CD4T; peripheral-blood; HEK293T; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000443206.2; ENST00000487670.1; ENST00000395736.7; ENST00000608749.5; ENST00000382034.9; ENST00000425375.5; ENST00000411850.5; ENST00000447733.5; ENST00000449508.1; ENST00000439512.5; ENST00000456128.5; ENST00000608674.5; ENST00000449058.7; ENST00000404284.6; ENST00000465529.1; ENST00000424387.5
External Link	RMBase: m6A_site_563628
mod ID: M6ASITE057894		Click to Show/Hide the Full List
mod site	chr22:35317936-35317937:+		[3]
Sequence	CCTCAACATGGAGATCTGCGACATCATCAACGAGACGGAGG
Motif Score	2.865571429
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000404284.6; ENST00000382034.9; ENST00000449058.7; ENST00000608749.5; ENST00000395736.7; ENST00000465529.1; ENST00000443206.2; ENST00000487670.1; ENST00000447733.5; ENST00000449508.1; ENST00000425375.5; ENST00000424387.5; ENST00000411850.5; ENST00000608674.5; ENST00000456128.5; ENST00000439512.5
External Link	RMBase: m6A_site_563629
mod ID: M6ASITE057895		Click to Show/Hide the Full List
mod site	chr22:35322008-35322009:+		[2]
Sequence	GAGAATCGTGGGGAATAAGAACTTCCACGAGGTGATGCTGG
Motif Score	3.373380952
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000404284.6; ENST00000382034.9; ENST00000447733.5; ENST00000424387.5; ENST00000425375.5; ENST00000443206.2; ENST00000608749.5; ENST00000487670.1; ENST00000395736.7; ENST00000411850.5; ENST00000456128.5; ENST00000449508.1; ENST00000608674.5; ENST00000439512.5; ENST00000449058.7
External Link	RMBase: m6A_site_563630
mod ID: M6ASITE057896		Click to Show/Hide the Full List
mod site	chr22:35322069-35322070:+		[2]
Sequence	TCTGTCTGTCCTGTGGCAGGACTACGGTCCACTGAAAGTCA
Motif Score	4.065041667
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000404284.6; ENST00000411850.5; ENST00000608674.5; ENST00000425375.5; ENST00000395736.7; ENST00000443206.2; ENST00000424387.5; ENST00000449058.7; ENST00000456128.5; ENST00000447733.5; ENST00000439512.5; ENST00000449508.1; ENST00000608749.5; ENST00000382034.9; ENST00000487670.1
External Link	RMBase: m6A_site_563631
mod ID: M6ASITE057897		Click to Show/Hide the Full List
mod site	chr22:35322101-35322102:+		[2]
Sequence	TGAAAGTCACCTCCCCTCAGACCCAGCAGGACTCCCAGCCT
Motif Score	2.876744048
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000449058.7; ENST00000411850.5; ENST00000447733.5; ENST00000395736.7; ENST00000608674.5; ENST00000424387.5; ENST00000382034.9; ENST00000404284.6; ENST00000443206.2; ENST00000439512.5; ENST00000487670.1; ENST00000456128.5; ENST00000449508.1; ENST00000425375.5; ENST00000608749.5
External Link	RMBase: m6A_site_563632
mod ID: M6ASITE057898		Click to Show/Hide the Full List
mod site	chr22:35322111-35322112:+		[2]
Sequence	CTCCCCTCAGACCCAGCAGGACTCCCAGCCTCCTCTGAGCT
Motif Score	4.065041667
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000447733.5; ENST00000425375.5; ENST00000608674.5; ENST00000439512.5; ENST00000411850.5; ENST00000443206.2; ENST00000395736.7; ENST00000424387.5; ENST00000449058.7; ENST00000456128.5; ENST00000449508.1; ENST00000608749.5; ENST00000382034.9; ENST00000487670.1; ENST00000404284.6
External Link	RMBase: m6A_site_563633
mod ID: M6ASITE057899		Click to Show/Hide the Full List
mod site	chr22:35322249-35322250:+		[2]
Sequence	CCCAATCCCCCAGCATGGGAACAGACGCTTACATCACTCCA
Motif Score	2.951386905
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000439512.5; ENST00000456128.5; ENST00000425375.5; ENST00000382034.9; ENST00000424387.5; ENST00000404284.6; ENST00000447733.5; ENST00000449508.1; ENST00000411850.5; ENST00000395736.7; ENST00000608674.5; ENST00000487670.1; ENST00000443206.2; ENST00000449058.7; ENST00000608749.5
External Link	RMBase: m6A_site_563634
mod ID: M6ASITE057900		Click to Show/Hide the Full List
mod site	chr22:35322272-35322273:+		[2]
Sequence	GACGCTTACATCACTCCAGAACCACTGGCAGGGAGAGCCTG
Motif Score	2.930744048
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000395736.7; ENST00000608674.5; ENST00000404284.6; ENST00000439512.5; ENST00000447733.5; ENST00000382034.9; ENST00000443206.2; ENST00000449058.7; ENST00000425375.5; ENST00000424387.5; ENST00000456128.5; ENST00000449508.1; ENST00000487670.1; ENST00000608749.5; ENST00000411850.5
External Link	RMBase: m6A_site_563635
mod ID: M6ASITE057901		Click to Show/Hide the Full List
mod site	chr22:35323036-35323037:+		[4]
Sequence	CGGCCCTCCAGGTCTTAGAAACCTGTGTCAAGAACTGCGGG
Motif Score	2.185083333
Cell/Tissue List	MT4; Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000449058.7; ENST00000449508.1; ENST00000456128.5; ENST00000608674.5; ENST00000404284.6; ENST00000395736.7; ENST00000443206.2; ENST00000608749.5; ENST00000447733.5; ENST00000411850.5; ENST00000382034.9; ENST00000439512.5; ENST00000424387.5; ENST00000425375.5
External Link	RMBase: m6A_site_563636
mod ID: M6ASITE057902		Click to Show/Hide the Full List
mod site	chr22:35323049-35323050:+		[2]
Sequence	CTTAGAAACCTGTGTCAAGAACTGCGGGCACCGCTTCCACG
Motif Score	3.373380952
Cell/Tissue List	HeLa; MT4; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000411850.5; ENST00000439512.5; ENST00000424387.5; ENST00000443206.2; ENST00000608674.5; ENST00000449058.7; ENST00000449508.1; ENST00000425375.5; ENST00000456128.5; ENST00000382034.9; ENST00000447733.5; ENST00000395736.7; ENST00000404284.6; ENST00000608749.5
External Link	RMBase: m6A_site_563637
mod ID: M6ASITE057903		Click to Show/Hide the Full List
mod site	chr22:35323088-35323089:+		[2]
Sequence	CGTGCTGGTGGCCAGCCAGGACTTCGTGGAGAGTGTGCTGG
Motif Score	4.065041667
Cell/Tissue List	HeLa; MT4; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000439512.5; ENST00000456128.5; ENST00000443206.2; ENST00000449058.7; ENST00000411850.5; ENST00000382034.9; ENST00000395736.7; ENST00000425375.5; ENST00000404284.6; ENST00000449508.1; ENST00000424387.5; ENST00000608749.5; ENST00000447733.5; ENST00000608674.5
External Link	RMBase: m6A_site_563638
mod ID: M6ASITE057904		Click to Show/Hide the Full List
mod site	chr22:35323114-35323115:+		[2]
Sequence	TGGAGAGTGTGCTGGTGAGGACCATCCTGCCCAAGAACAAC
Motif Score	3.622404762
Cell/Tissue List	HeLa; MT4; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000608674.5; ENST00000456128.5; ENST00000449058.7; ENST00000424387.5; ENST00000447733.5; ENST00000411850.5; ENST00000395736.7; ENST00000449508.1; ENST00000382034.9; ENST00000439512.5; ENST00000608749.5; ENST00000404284.6; ENST00000443206.2; ENST00000425375.5
External Link	RMBase: m6A_site_563639
mod ID: M6ASITE057905		Click to Show/Hide the Full List
mod site	chr22:35323130-35323131:+		[2]
Sequence	GAGGACCATCCTGCCCAAGAACAACCCACCCACCATCGTGC
Motif Score	2.951386905
Cell/Tissue List	HeLa; hESC-HEK293T; MT4; Huh7
Seq Type List	m6A-seq; MAZTER-seq; MeRIP-seq
Transcript ID List	ENST00000449508.1; ENST00000608674.5; ENST00000395736.7; ENST00000404284.6; ENST00000608749.5; ENST00000425375.5; ENST00000411850.5; ENST00000443206.2; ENST00000382034.9; ENST00000424387.5; ENST00000449058.7; ENST00000447733.5; ENST00000456128.5; ENST00000439512.5
External Link	RMBase: m6A_site_563640
mod ID: M6ASITE057906		Click to Show/Hide the Full List
mod site	chr22:35323154-35323155:+		[3]
Sequence	CCCACCCACCATCGTGCATGACAAAGTGCTCAACCTCATCC
Motif Score	2.859755952
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000382034.9; ENST00000439512.5; ENST00000425375.5; ENST00000424387.5; ENST00000456128.5; ENST00000404284.6; ENST00000447733.5; ENST00000449508.1; ENST00000395736.7; ENST00000443206.2; ENST00000608749.5; ENST00000608674.5; ENST00000411850.5; ENST00000449058.7
External Link	RMBase: m6A_site_563641
mod ID: M6ASITE057907		Click to Show/Hide the Full List
mod site	chr22:35323531-35323532:+		[5]
Sequence	TCCGCAGCTCGCCCGATCTGACAGGTGTGGTCACCATCTAT
Motif Score	2.859755952
Cell/Tissue List	liver
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000449058.7; ENST00000608674.5; ENST00000411850.5; ENST00000447733.5; ENST00000395736.7; ENST00000404284.6; ENST00000439512.5; ENST00000425375.5; ENST00000382034.9; ENST00000608749.5; ENST00000449508.1; ENST00000497448.1; ENST00000443206.2; ENST00000456128.5; ENST00000424387.5
External Link	RMBase: m6A_site_563642
mod ID: M6ASITE057908		Click to Show/Hide the Full List
mod site	chr22:35323556-35323557:+		[2]
Sequence	TGTGGTCACCATCTATGAGGACCTGCGGAGGAAAGGCCTGG
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; MT4; Huh7; endometrial; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000449058.7; ENST00000608749.5; ENST00000447733.5; ENST00000497448.1; ENST00000443206.2; ENST00000382034.9; ENST00000439512.5; ENST00000456128.5; ENST00000425375.5; ENST00000395736.7; ENST00000424387.5; ENST00000411850.5; ENST00000404284.6; ENST00000449508.1; ENST00000608674.5
External Link	RMBase: m6A_site_563643
mod ID: M6ASITE057909		Click to Show/Hide the Full List
mod site	chr22:35323598-35323599:+		[2]
Sequence	GTTCCCCATGACTGACCTGGACATGCTGTCACCCATCCACA
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; liver; hESC-HEK293T; MT4; Huh7; CD4T; peripheral-blood; endometrial; NB4; MM6
Seq Type List	m6A-seq; m6A-REF-seq; MAZTER-seq; MeRIP-seq
Transcript ID List	ENST00000404284.6; ENST00000439512.5; ENST00000395736.7; ENST00000449058.7; ENST00000608674.5; ENST00000411850.5; ENST00000425375.5; ENST00000608749.5; ENST00000382034.9; ENST00000456128.5; ENST00000497448.1; ENST00000447733.5; ENST00000449508.1; ENST00000424387.5; ENST00000443206.2
External Link	RMBase: m6A_site_563644
mod ID: M6ASITE057910		Click to Show/Hide the Full List
mod site	chr22:35323785-35323786:+		[2]
Sequence	AGACCGTGTTCAACTCAGAGACACAATCAGGACAGGATTCT
Motif Score	2.897386905
Cell/Tissue List	HeLa; HepG2; MT4; Huh7; CD4T; peripheral-blood; HEK293T; endometrial; NB4; MM6
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000424387.5; ENST00000447733.5; ENST00000395736.7; ENST00000382034.9; ENST00000449508.1; ENST00000497448.1; ENST00000456128.5; ENST00000411850.5; ENST00000449058.7; ENST00000404284.6; ENST00000439512.5; ENST00000443206.2; ENST00000425375.5
External Link	RMBase: m6A_site_563645
mod ID: M6ASITE057911		Click to Show/Hide the Full List
mod site	chr22:35323796-35323797:+		[2]
Sequence	AACTCAGAGACACAATCAGGACAGGATTCTGTGGGCACTGA
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; MT4; Huh7; CD4T; peripheral-blood; HEK293T; endometrial; HEC-1-A; NB4; MM6
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000497448.1; ENST00000443206.2; ENST00000439512.5; ENST00000382034.9; ENST00000449058.7; ENST00000447733.5; ENST00000411850.5; ENST00000424387.5; ENST00000456128.5; ENST00000425375.5; ENST00000395736.7; ENST00000449508.1; ENST00000404284.6
External Link	RMBase: m6A_site_563646
mod ID: M6ASITE057912		Click to Show/Hide the Full List
mod site	chr22:35323834-35323835:+		[2]
Sequence	TGACTCCAGCCAGCAAGAGGACTCTGGCCAGCATGCTGCCC
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; Huh7; Jurkat; CD4T; peripheral-blood; HEK293T; endometrial; HEC-1-A; NB4; MM6
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000439512.5; ENST00000382034.9; ENST00000449058.7; ENST00000404284.6; ENST00000411850.5; ENST00000424387.5; ENST00000449508.1; ENST00000425375.5; ENST00000456128.5; ENST00000497448.1; ENST00000447733.5
External Link	RMBase: m6A_site_563647
mod ID: M6ASITE057913		Click to Show/Hide the Full List
mod site	chr22:35323885-35323886:+		[5]
Sequence	CCCGCCCATACTCTCCGGTGACACGCCCATAGCACCAACCC
Motif Score	2.859755952
Cell/Tissue List	brain; kidney; liver
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000424387.5; ENST00000456128.5; ENST00000425375.5; ENST00000447733.5; ENST00000491987.1; ENST00000439512.5; ENST00000497448.1; ENST00000411850.5; ENST00000404284.6; ENST00000449058.7; ENST00000382034.9
External Link	RMBase: m6A_site_563648
mod ID: M6ASITE057914		Click to Show/Hide the Full List
mod site	chr22:35323910-35323911:+		[2]
Sequence	CCCATAGCACCAACCCCGGAACAGGTAAACGAGCCTGGGGT
Motif Score	2.951386905
Cell/Tissue List	HeLa; HepG2; brain; MM6; Huh7; Jurkat; CD4T; peripheral-blood; HEK293T; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; m6A-REF-seq; MeRIP-seq
Transcript ID List	ENST00000497448.1; ENST00000382034.9; ENST00000404284.6; ENST00000449058.7; ENST00000411850.5; ENST00000425375.5; ENST00000439512.5; ENST00000456128.5; ENST00000491987.1; ENST00000424387.5; ENST00000447733.5
External Link	RMBase: m6A_site_563649
mod ID: M6ASITE057915		Click to Show/Hide the Full List
mod site	chr22:35327370-35327371:+		[2]
Sequence	CACCCAGGCCGAGCCCGCAGACCTGGAGCTGCTGCAGGTGA
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; MM6; Jurkat; CD4T; peripheral-blood; HEK293T; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq
Transcript ID List	ENST00000411850.5; ENST00000404284.6; ENST00000456128.5; ENST00000425375.5; ENST00000447733.5; ENST00000382034.9; ENST00000491987.1; ENST00000424387.5; ENST00000449058.7
External Link	RMBase: m6A_site_563650
mod ID: M6ASITE057916		Click to Show/Hide the Full List
mod site	chr22:35330455-35330456:+		[3]
Sequence	CATCGTCAATGACAATCTCAACAATGTGTTCCTGCGCCATG
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000447733.5; ENST00000404284.6; ENST00000382034.9; ENST00000449058.7; ENST00000424387.5; ENST00000491987.1; ENST00000425375.5; ENST00000456128.5; ENST00000411850.5
External Link	RMBase: m6A_site_563651
mod ID: M6ASITE057917		Click to Show/Hide the Full List
mod site	chr22:35331297-35331298:+		[6]
Sequence	TTTTTTTTCTTTTTGCAGAGACAGGGGTCTCACTGTGTTGC
Motif Score	2.897386905
Cell/Tissue List	Huh7; Jurkat; CD4T; endometrial; NB4; MM6
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000424387.5; ENST00000491987.1; ENST00000404284.6; ENST00000447733.5; ENST00000382034.9; ENST00000456128.5; ENST00000449058.7; ENST00000411850.5; ENST00000425375.5
External Link	RMBase: m6A_site_563652
mod ID: M6ASITE057918		Click to Show/Hide the Full List
mod site	chr22:35331333-35331334:+		[6]
Sequence	GTTGCCCAGGCTAGTCTCAAACTCTTGGCCTCAAGCAGTCC
Motif Score	2.627720238
Cell/Tissue List	Huh7; Jurkat; CD4T; endometrial
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000425375.5; ENST00000411850.5; ENST00000491987.1; ENST00000382034.9; ENST00000456128.5; ENST00000447733.5; ENST00000449058.7; ENST00000424387.5; ENST00000404284.6
External Link	RMBase: m6A_site_563653
mod ID: M6ASITE057919		Click to Show/Hide the Full List
mod site	chr22:35331456-35331457:+		[2]
Sequence	GAGTCACATCCCCAAGAGAGACTTGGATTGGCTGAGCTTCA
Motif Score	3.319380952
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000449058.7; ENST00000411850.5; ENST00000382034.9; ENST00000491987.1; ENST00000456128.5; ENST00000404284.6; ENST00000424387.5; ENST00000425375.5; ENST00000447733.5
External Link	RMBase: m6A_site_563654
mod ID: M6ASITE057920		Click to Show/Hide the Full List
mod site	chr22:35332996-35332997:+		[2]
Sequence	GTAGGTTTGAACGGTTCCGAACAGGCCAGACCACCAAGGTA
Motif Score	2.951386905
Cell/Tissue List	HeLa; hESC-HEK293T
Seq Type List	m6A-seq; MAZTER-seq
Transcript ID List	ENST00000382034.9; ENST00000491987.1; ENST00000424387.5; ENST00000456128.5; ENST00000404284.6; ENST00000447733.5; ENST00000449058.7; ENST00000425375.5; ENST00000411850.5
External Link	RMBase: m6A_site_563655
mod ID: M6ASITE057921		Click to Show/Hide the Full List
mod site	chr22:35333005-35333006:+		[2]
Sequence	AACGGTTCCGAACAGGCCAGACCACCAAGGTAAAAGTCTTC
Motif Score	2.876744048
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000456128.5; ENST00000424387.5; ENST00000447733.5; ENST00000425375.5; ENST00000382034.9; ENST00000449058.7; ENST00000411850.5; ENST00000491987.1; ENST00000404284.6
External Link	RMBase: m6A_site_563656
mod ID: M6ASITE057922		Click to Show/Hide the Full List
mod site	chr22:35333366-35333367:+		[2]
Sequence	AGAAAGGAACGAAGCTGCAGACAGCGGGGATGATCAGGGCA
Motif Score	2.897386905
Cell/Tissue List	HeLa; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000449058.7; ENST00000404284.6; ENST00000424387.5; ENST00000491987.1; ENST00000456128.5; ENST00000411850.5; ENST00000447733.5; ENST00000382034.9; ENST00000425375.5
External Link	RMBase: m6A_site_563657
mod ID: M6ASITE057923		Click to Show/Hide the Full List
mod site	chr22:35333440-35333441:+		[3]
Sequence	GCCGGCAGCTGACCTGATCGACATGGGCCCTGACCCAGCAG
Motif Score	2.865571429
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000425375.5; ENST00000411850.5; ENST00000424387.5; ENST00000382034.9; ENST00000404284.6; ENST00000447733.5; ENST00000491987.1; ENST00000456128.5; ENST00000449058.7
External Link	RMBase: m6A_site_563658
mod ID: M6ASITE057924		Click to Show/Hide the Full List
mod site	chr22:35334399-35334400:+		[3]
Sequence	TCGACTGGAAGATGAGTTTGACATGTTTGCGCTGACACGGG
Motif Score	2.859755952
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000425375.5; ENST00000491987.1; ENST00000449058.7; ENST00000382034.9; ENST00000411850.5; ENST00000447733.5; ENST00000424387.5; ENST00000404284.6
External Link	RMBase: m6A_site_563659
mod ID: M6ASITE057925		Click to Show/Hide the Full List
mod site	chr22:35334413-35334414:+		[3]
Sequence	AGTTTGACATGTTTGCGCTGACACGGGGCAGCTCACTGGCT
Motif Score	2.859755952
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000491987.1; ENST00000449058.7; ENST00000382034.9; ENST00000425375.5; ENST00000404284.6; ENST00000447733.5; ENST00000424387.5; ENST00000411850.5
External Link	RMBase: m6A_site_563660
mod ID: M6ASITE057926		Click to Show/Hide the Full List
mod site	chr22:35344244-35344245:+		[2]
Sequence	CTCAGTGACTGGATGGTGAGACAAGGCATGGTGAGCAGGGG
Motif Score	2.897386905
Cell/Tissue List	HeLa; CD34; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000404284.6; ENST00000447733.5; ENST00000382034.9; ENST00000492723.1; ENST00000424387.5; ENST00000425375.5; ENST00000411850.5; ENST00000449058.7
External Link	RMBase: m6A_site_563661
mod ID: M6ASITE057927		Click to Show/Hide the Full List
mod site	chr22:35344356-35344357:+		[2]
Sequence	CTGCTCTCCAAGGGAGTGGGACCCAGGAGAAGGCCCAGAGG
Motif Score	3.622404762
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000449058.7; ENST00000424387.5; ENST00000382034.9; ENST00000425375.5; ENST00000447733.5; ENST00000492723.1; ENST00000411850.5; ENST00000404284.6
External Link	RMBase: m6A_site_563662
mod ID: M6ASITE057928		Click to Show/Hide the Full List
mod site	chr22:35344408-35344409:+		[2]
Sequence	GCAGCTGAGGGTCTTGCGGGACCCCAGGGCTCAGGCTGTTT
Motif Score	3.622404762
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000382034.9; ENST00000447733.5; ENST00000404284.6; ENST00000492723.1; ENST00000449058.7; ENST00000411850.5; ENST00000425375.5; ENST00000424387.5
External Link	RMBase: m6A_site_563663
mod ID: M6ASITE057929		Click to Show/Hide the Full List
mod site	chr22:35344502-35344503:+		[2]
Sequence	CTCTTGAGTCTCGGGCAAGGACAAGGTAGCCCGTCTGGCAG
Motif Score	3.643047619
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000382034.9; ENST00000449058.7; ENST00000425375.5; ENST00000424387.5; ENST00000447733.5; ENST00000411850.5; ENST00000492723.1; ENST00000404284.6
External Link	RMBase: m6A_site_563664
mod ID: M6ASITE057930		Click to Show/Hide the Full List
mod site	chr22:35344680-35344681:+		[2]
Sequence	CTGGGTGACAGAGCTTGGAAACCAAACTGGCCTGGTTGGGG
Motif Score	2.185083333
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000424387.5; ENST00000492723.1; ENST00000449058.7; ENST00000404284.6; ENST00000447733.5; ENST00000382034.9; ENST00000411850.5; ENST00000425375.5
External Link	RMBase: m6A_site_563665
mod ID: M6ASITE057931		Click to Show/Hide the Full List
mod site	chr22:35344685-35344686:+		[2]
Sequence	TGACAGAGCTTGGAAACCAAACTGGCCTGGTTGGGGAAAGA
Motif Score	2.627720238
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000411850.5; ENST00000447733.5; ENST00000425375.5; ENST00000424387.5; ENST00000382034.9; ENST00000404284.6; ENST00000449058.7; ENST00000492723.1
External Link	RMBase: m6A_site_563666
mod ID: M6ASITE057932		Click to Show/Hide the Full List
mod site	chr22:35344705-35344706:+		[2]
Sequence	ACTGGCCTGGTTGGGGAAAGACTCTGTCTGTCTTTTCCAAA
Motif Score	3.319380952
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000425375.5; ENST00000404284.6; ENST00000411850.5; ENST00000449058.7; ENST00000382034.9; ENST00000424387.5; ENST00000492723.1; ENST00000447733.5
External Link	RMBase: m6A_site_563667
mod ID: M6ASITE057933		Click to Show/Hide the Full List
mod site	chr22:35344782-35344783:+		[2]
Sequence	CTGATTAATAGTAAATAGGAACTGGCCTATTGGTTTCTTGA
Motif Score	3.373380952
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000425375.5; ENST00000411850.5; ENST00000447733.5; ENST00000404284.6; ENST00000492723.1; ENST00000382034.9; ENST00000424387.5; ENST00000449058.7
External Link	RMBase: m6A_site_563668
mod ID: M6ASITE057934		Click to Show/Hide the Full List
mod site	chr22:35345755-35345756:+		[2]
Sequence	CCAGGCCTGCCTCATGGAGGACATCGAGCAGTGGCTGTCCA
Motif Score	3.643047619
Cell/Tissue List	HeLa; hESC-HEK293T; MT4; peripheral-blood; endometrial; NB4
Seq Type List	m6A-seq; MAZTER-seq; MeRIP-seq
Transcript ID List	ENST00000424387.5; ENST00000425375.5; ENST00000447733.5; ENST00000449058.7; ENST00000492723.1; ENST00000411850.5; ENST00000382034.9; ENST00000404284.6
External Link	RMBase: m6A_site_563669
mod ID: M6ASITE057935		Click to Show/Hide the Full List
mod site	chr22:35347060-35347061:+		[3]
Sequence	TCCCCTTCCTCTAGAATTTGACAAATTCCTGGAAGAACGGG
Motif Score	2.859755952
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000424387.5; ENST00000449058.7; ENST00000382034.9; ENST00000411850.5; ENST00000447733.5; ENST00000492723.1; ENST00000404284.6; ENST00000425375.5
External Link	RMBase: m6A_site_563670
mod ID: M6ASITE057936		Click to Show/Hide the Full List
mod site	chr22:35347093-35347094:+		[2]
Sequence	AGAACGGGCCAAAGCCGCGGACCGATTGCCCAACCTCTCCA
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; MT4; peripheral-blood; HEK293T; endometrial; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000411850.5; ENST00000424387.5; ENST00000449058.7; ENST00000447733.5; ENST00000425375.5; ENST00000404284.6; ENST00000492723.1; ENST00000382034.9
External Link	RMBase: m6A_site_563671
mod ID: M6ASITE057937		Click to Show/Hide the Full List
mod site	chr22:35347170-35347171:+		[7]
Sequence	GCCCAGCGCCCCGGAAGAAGACCCAGGAGAAAGATGATGAC
Motif Score	2.876744048
Cell/Tissue List	HepG2; MT4; peripheral-blood; HEK293T; endometrial; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000492723.1; ENST00000424387.5; ENST00000382034.9; ENST00000411850.5; ENST00000449058.7; ENST00000447733.5; ENST00000425375.5; ENST00000404284.6
External Link	RMBase: m6A_site_563672
mod ID: M6ASITE057938		Click to Show/Hide the Full List
mod site	chr22:35347189-35347190:+		[3]
Sequence	GACCCAGGAGAAAGATGATGACATGCTGTTTGCCTTATGAG
Motif Score	2.859755952
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000425375.5; ENST00000447733.5; ENST00000382034.9; ENST00000404284.6; ENST00000492723.1; ENST00000449058.7; ENST00000411850.5; ENST00000424387.5
External Link	RMBase: m6A_site_563673
mod ID: M6ASITE057939		Click to Show/Hide the Full List
mod site	chr22:35347252-35347253:+		[5]
Sequence	CCCAGGTCCCCACTGCTCTCACACCCTTAGGCTGGGACCTC
Motif Score	2.047297619
Cell/Tissue List	kidney; liver; hESC-HEK293T
Seq Type List	m6A-REF-seq; MAZTER-seq
Transcript ID List	ENST00000449058.7; ENST00000492723.1; ENST00000404284.6; ENST00000382034.9; ENST00000425375.5; ENST00000411850.5; ENST00000424387.5; ENST00000447733.5
External Link	RMBase: m6A_site_563674
mod ID: M6ASITE057940		Click to Show/Hide the Full List
mod site	chr22:35347268-35347269:+		[6]
Sequence	TCTCACACCCTTAGGCTGGGACCTCCCTCCCTCCTCTGGTG
Motif Score	3.622404762
Cell/Tissue List	HEK293T; Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000424387.5; ENST00000382034.9; ENST00000411850.5; ENST00000425375.5; ENST00000449058.7; ENST00000447733.5; ENST00000404284.6; ENST00000492723.1
External Link	RMBase: m6A_site_563675
mod ID: M6ASITE057941		Click to Show/Hide the Full List
mod site	chr22:35347387-35347388:+		[2]
Sequence	GTGTGGAGGCAGTGGGATGAACTGGGGGACAGGTCTGCGCT
Motif Score	3.373380952
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hESCs; GM12878; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000449058.7; ENST00000425375.5; ENST00000382034.9; ENST00000404284.6; ENST00000492723.1; ENST00000447733.5; ENST00000411850.5; ENST00000424387.5
External Link	RMBase: m6A_site_563676
mod ID: M6ASITE057942		Click to Show/Hide the Full List
mod site	chr22:35347395-35347396:+		[2]
Sequence	GCAGTGGGATGAACTGGGGGACAGGTCTGCGCTGCAGTGGG
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; HEK293T; liver; A549; U2OS; H1A; H1B; hESCs; GM12878; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq; m6A-REF-seq
Transcript ID List	ENST00000447733.5; ENST00000449058.7; ENST00000425375.5; ENST00000492723.1; ENST00000404284.6; ENST00000382034.9; ENST00000424387.5; ENST00000411850.5
External Link	RMBase: m6A_site_563677
mod ID: M6ASITE057943		Click to Show/Hide the Full List
mod site	chr22:35347441-35347442:+		[8]
Sequence	GCTGCTCTGCCTCCTTTCCCACCCCAGCTGACCATGAGACT
Motif Score	2.032470238
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000424387.5; ENST00000425375.5; ENST00000447733.5; ENST00000411850.5; ENST00000492723.1; ENST00000449058.7; ENST00000404284.6; ENST00000382034.9
External Link	RMBase: m6A_site_563678
mod ID: M6ASITE057944		Click to Show/Hide the Full List
mod site	chr22:35347459-35347460:+		[2]
Sequence	CCACCCCAGCTGACCATGAGACTTTGCTGAGAAGTGGAGGC
Motif Score	3.319380952
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hESCs; GM12878; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000404284.6; ENST00000425375.5; ENST00000411850.5; ENST00000382034.9; ENST00000447733.5; ENST00000492723.1; ENST00000424387.5; ENST00000449058.7
External Link	RMBase: m6A_site_563679
mod ID: M6ASITE057945		Click to Show/Hide the Full List
mod site	chr22:35347486-35347487:+		[2]
Sequence	TGAGAAGTGGAGGCCCCAGGACAGGCTGGCTGGCTGGCTGG
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; HEK293T; kidney; A549; U2OS; H1A; H1B; hESCs; GM12878; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq; m6A-REF-seq
Transcript ID List	ENST00000382034.9; ENST00000404284.6; ENST00000424387.5; ENST00000425375.5; ENST00000449058.7; ENST00000411850.5; ENST00000447733.5; ENST00000492723.1
External Link	RMBase: m6A_site_563680
mod ID: M6ASITE057946		Click to Show/Hide the Full List
mod site	chr22:35347969-35347970:+		[2]
Sequence	TCCCCAATTAAAGGTAGAAAACCACCCTGCTAGCAGCATTG
Motif Score	2.185083333
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000411850.5; ENST00000492723.1; ENST00000449058.7; ENST00000447733.5; ENST00000404284.6; ENST00000425375.5; ENST00000382034.9; ENST00000424387.5
External Link	RMBase: m6A_site_563681

Ref 1	RADAR: a rigorously annotated database of A-to-I RNA editing. Nucleic Acids Res. 2014 Jan;42(Database issue):D109-13. doi: 10.1093/nar/gkt996. Epub 2013 Oct 25.
Ref 2	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 3	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 4	Dynamics of the human and viral m(6)A RNA methylomes during HIV-1 infection of T cells. Nat Microbiol. 2016 Feb 22;1:16011. doi: 10.1038/nmicrobiol.2016.11.
Ref 5	Single-base mapping of m(6)A by an antibody-independent method. Sci Adv. 2019 Jul 3;5(7):eaax0250. doi: 10.1126/sciadv.aax0250. eCollection 2019 Jul.
Ref 6	N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection. Cell Host Microbe. 2016 Nov 9;20(5):654-665. doi: 10.1016/j.chom.2016.09.015. Epub 2016 Oct 20.
Ref 7	Efficacy of MEK inhibition in patients with histiocytic neoplasms. Nature. 2019 Mar;567(7749):521-524. doi: 10.1038/s41586-019-1012-y. Epub 2019 Mar 13.
Ref 8	DART-seq: an antibody-free method for global m(6)A detection. Nat Methods. 2019 Dec;16(12):1275-1280. doi: 10.1038/s41592-019-0570-0. Epub 2019 Sep 23.

Epigenetic Target Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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