Epigenetic Target Information

General Information of the Epigenetic Target (ID: EPITAR00527)

Target Name	Urokinase-type plasminogen activator (PLAU)
Synonyms	U-plasminogen activator; uPA Click to Show/Hide
Gene Name	PLAU
Sequence	MRALLARLLLCVLVVSDSKGSNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQHCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHNYCRNPDNRRRPWCYVQVGLKLLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTKEENGLAL Click to Show/Hide
Family	Peptidase S1 family
Function	Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin. Click to Show/Hide
Gene ID	5328
HGNC ID	HGNC:9052
Ensembl Gene ID	ENSG00000122861
KEGG ID	hsa:5328
Chromosomal Location	10q22.2

RNA Modification Sequencing Data Associated with the Target (ID: EPITAR00527)

Urokinase-type plasminogen activator (PLAU)

N6-methyladenosine (m6A)

In total 31 m6A sequence/site(s) in this target gene
mod ID: M6ASITE000844		Click to Show/Hide the Full List
mod site	chr10:73910700-73910701:+		[1]
Sequence	CATTTGTCGCGTTGATGAAGACTTCACAGCTCCATCAGCTG
Motif Score	3.319380952
Cell/Tissue List	U2OS; A549; MSC; TIME
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000481390.5; ENST00000496926.1
External Link	RMBase: m6A_site_106684
mod ID: M6ASITE000845		Click to Show/Hide the Full List
mod site	chr10:73911142-73911143:+		[2]
Sequence	GGTCGCAGCACAGTGCGGAGACCGCAGCCCCGGAGCCCGGG
Motif Score	2.876744048
Cell/Tissue List	A549; H1299; Jurkat; GSC-11; HEK293T; HEK293A-TOA; iSLK; MSC; TIME; HEC-1-A
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000446342.5; ENST00000496926.1; ENST00000372764.4; ENST00000481390.5
External Link	RMBase: m6A_site_106688
mod ID: M6ASITE000846		Click to Show/Hide the Full List
mod site	chr10:73911649-73911650:+		[2]
Sequence	TTGACTGATGCTGCCCAAGGACCTCTGATCAGCACCAGGGG
Motif Score	3.622404762
Cell/Tissue List	A549; Jurkat; peripheral-blood; iSLK; MSC; TIME; endometrial; HEC-1-A; GSCs; NB4; MM6
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000446342.5; ENST00000481390.5; ENST00000494287.1; ENST00000372764.4
External Link	RMBase: m6A_site_106693
mod ID: M6ASITE000847		Click to Show/Hide the Full List
mod site	chr10:73911728-73911729:+		[3]
Sequence	TCCATCCACAGCAGGGCCAGACTCTCCCCAGGAAATGGGAC
Motif Score	3.319380952
Cell/Tissue List	H1B; Jurkat; peripheral-blood; endometrial; HEC-1-A; MM6
Seq Type List	m6A-seq
Transcript ID List	ENST00000494287.1; ENST00000372764.4; ENST00000446342.5; ENST00000481390.5
External Link	RMBase: m6A_site_106695
mod ID: M6ASITE000848		Click to Show/Hide the Full List
mod site	chr10:73911747-73911748:+		[3]
Sequence	GACTCTCCCCAGGAAATGGGACAGGGTGGCAGCGGAGGCTT
Motif Score	3.643047619
Cell/Tissue List	H1B; Jurkat; peripheral-blood; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000494287.1; ENST00000446342.5; ENST00000372764.4; ENST00000481390.5
External Link	RMBase: m6A_site_106696
mod ID: M6ASITE000849		Click to Show/Hide the Full List
mod site	chr10:73911772-73911773:+		[3]
Sequence	GTGGCAGCGGAGGCTTGAGAACCACGGGGGTTGGCACTGGC
Motif Score	2.930744048
Cell/Tissue List	H1B; Jurkat; peripheral-blood; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000372764.4; ENST00000494287.1; ENST00000481390.5; ENST00000446342.5
External Link	RMBase: m6A_site_106697
mod ID: M6ASITE000850		Click to Show/Hide the Full List
mod site	chr10:73911819-73911820:+		[4]
Sequence	GGGAGGAAGAGGCCGCCGGGACTGCCCCAGCCTGCGGGCAT
Motif Score	4.065041667
Cell/Tissue List	Jurkat; peripheral-blood; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000481390.5; ENST00000494287.1; ENST00000372764.4; ENST00000446342.5
External Link	RMBase: m6A_site_106698
mod ID: M6ASITE000851		Click to Show/Hide the Full List
mod site	chr10:73911887-73911888:+		[5]
Sequence	TCCATTTCTCCTGGCTGGAAACCCATGGTCTTCCATTTGAG
Motif Score	2.185083333
Cell/Tissue List	peripheral-blood; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000372764.4; ENST00000494287.1; ENST00000481390.5; ENST00000446342.5
External Link	RMBase: m6A_site_106699
mod ID: M6ASITE000852		Click to Show/Hide the Full List
mod site	chr10:73911909-73911910:+		[5]
Sequence	CCATGGTCTTCCATTTGAGAACTAGATACGAACAGGGTGAG
Motif Score	3.373380952
Cell/Tissue List	peripheral-blood; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000446342.5; ENST00000372764.4; ENST00000494287.1; ENST00000481390.5
External Link	RMBase: m6A_site_106701
mod ID: M6ASITE000853		Click to Show/Hide the Full List
mod site	chr10:73911920-73911921:+		[5]
Sequence	CATTTGAGAACTAGATACGAACAGGGTGAGGCGAGAGGGAG
Motif Score	2.951386905
Cell/Tissue List	peripheral-blood; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000494287.1; ENST00000446342.5; ENST00000481390.5; ENST00000372764.4
External Link	RMBase: m6A_site_106702
mod ID: M6ASITE000854		Click to Show/Hide the Full List
mod site	chr10:73912051-73912052:+		[5]
Sequence	CTCTTCCAGGGCAGCAATGAACTTCATCAAGTTCCATGTGA
Motif Score	3.373380952
Cell/Tissue List	peripheral-blood; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000372764.4; ENST00000446342.5; ENST00000481390.5; ENST00000494287.1
External Link	RMBase: m6A_site_106703
mod ID: M6ASITE000855		Click to Show/Hide the Full List
mod site	chr10:73912217-73912218:+		[6]
Sequence	ACCTTTGTTCTCTCCAGCGAACTGTGACTGTCTAAATGGAG
Motif Score	3.373380952
Cell/Tissue List	HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000372764.4; ENST00000494287.1; ENST00000446342.5; ENST00000481390.5
External Link	RMBase: m6A_site_106704
mod ID: M6ASITE000856		Click to Show/Hide the Full List
mod site	chr10:73912240-73912241:+		[6]
Sequence	GTGACTGTCTAAATGGAGGAACATGTGTGTCCAACAAGTAC
Motif Score	2.951386905
Cell/Tissue List	HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000481390.5; ENST00000494287.1; ENST00000446342.5; ENST00000372764.4
External Link	RMBase: m6A_site_106705
mod ID: M6ASITE000857		Click to Show/Hide the Full List
mod site	chr10:73912983-73912984:+		[7]
Sequence	CCGAGGAAAGGCCAGCACTGACACCATGGGCCGGCCCTGCC
Motif Score	2.859755952
Cell/Tissue List	kidney
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000481390.5; ENST00000446342.5; ENST00000372764.4; ENST00000494287.1
External Link	RMBase: m6A_site_106706
mod ID: M6ASITE000858		Click to Show/Hide the Full List
mod site	chr10:73914002-73914003:+		[7]
Sequence	TTACCCAAAGAAGGAGGACTACATCGTCTACCTGGGTCGCT
Motif Score	2.078666667
Cell/Tissue List	kidney
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000372764.4; ENST00000446342.5
External Link	RMBase: m6A_site_106707
mod ID: M6ASITE000859		Click to Show/Hide the Full List
mod site	chr10:73914071-73914072:+		[8]
Sequence	GATGAAGTTTGAGGTGGAAAACCTCATCCTACACAAGGACT
Motif Score	2.185083333
Cell/Tissue List	MT4; HEC-1-A
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000446342.5; ENST00000372764.4
External Link	RMBase: m6A_site_106708
mod ID: M6ASITE000860		Click to Show/Hide the Full List
mod site	chr10:73914089-73914090:+		[8]
Sequence	AAACCTCATCCTACACAAGGACTACAGCGCTGACACGCTTG
Motif Score	4.065041667
Cell/Tissue List	MT4; HEC-1-A
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000372764.4; ENST00000446342.5
External Link	RMBase: m6A_site_106709
mod ID: M6ASITE000861		Click to Show/Hide the Full List
mod site	chr10:73914101-73914102:+		[7]
Sequence	ACACAAGGACTACAGCGCTGACACGCTTGCTCACCACAACG
Motif Score	2.859755952
Cell/Tissue List	kidney
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000446342.5; ENST00000372764.4
External Link	RMBase: m6A_site_106710
mod ID: M6ASITE000862		Click to Show/Hide the Full List
mod site	chr10:73914825-73914826:+		[6]
Sequence	GGTGTGCGCAGCCATCCCGGACTATACAGACCATCTGCCTG
Motif Score	4.065041667
Cell/Tissue List	HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000372764.4; ENST00000446342.5
External Link	RMBase: m6A_site_106711
mod ID: M6ASITE000863		Click to Show/Hide the Full List
mod site	chr10:73914834-73914835:+		[6]
Sequence	AGCCATCCCGGACTATACAGACCATCTGCCTGCCCTCGATG
Motif Score	2.876744048
Cell/Tissue List	HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000446342.5; ENST00000372764.4
External Link	RMBase: m6A_site_106712
mod ID: M6ASITE000864		Click to Show/Hide the Full List
mod site	chr10:73914876-73914877:+		[7]
Sequence	ATAACGATCCCCAGTTTGGCACAAGCTGTGAGATCACTGGC
Motif Score	2.830589286
Cell/Tissue List	kidney
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000372764.4; ENST00000446342.5
External Link	RMBase: m6A_site_106713
mod ID: M6ASITE000865		Click to Show/Hide the Full List
mod site	chr10:73915384-73915385:+		[6]
Sequence	CTGCTGACCCACAGTGGAAAACAGATTCCTGCCAGGTGAGT
Motif Score	2.20572619
Cell/Tissue List	HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000372764.4; ENST00000446342.5
External Link	RMBase: m6A_site_106714
mod ID: M6ASITE000866		Click to Show/Hide the Full List
mod site	chr10:73916392-73916393:+		[6]
Sequence	ATCTTTGGCGTCACAGGGAGACTCAGGGGGACCCCTCGTCT
Motif Score	3.319380952
Cell/Tissue List	HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000372764.4; ENST00000446342.5
External Link	RMBase: m6A_site_106715
mod ID: M6ASITE000867		Click to Show/Hide the Full List
mod site	chr10:73916402-73916403:+		[9]
Sequence	TCACAGGGAGACTCAGGGGGACCCCTCGTCTGTTCCCTCCA
Motif Score	3.622404762
Cell/Tissue List	MM6; Jurkat; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000372764.4; ENST00000446342.5
External Link	RMBase: m6A_site_106716
mod ID: M6ASITE000868		Click to Show/Hide the Full List
mod site	chr10:73916479-73916480:+		[10]
Sequence	CCGTGGATGTGCCCTGAAGGACAAGCCAGGCGTCTACACGA
Motif Score	3.643047619
Cell/Tissue List	hESC-HEK293T; U2OS; A549; MM6; Jurkat; peripheral-blood; endometrial; HEC-1-A; AML
Seq Type List	MAZTER-seq; MeRIP-seq; m6A-seq; miCLIP
Transcript ID List	ENST00000446342.5; ENST00000372764.4
External Link	RMBase: m6A_site_106717
mod ID: M6ASITE000869		Click to Show/Hide the Full List
mod site	chr10:73916653-73916654:+		[11]
Sequence	TCCATCAGCTGTAAGAAGAGACTGGGAAGATAGGCTCTGCA
Motif Score	3.319380952
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; H1299; MM6; Jurkat; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000446342.5; ENST00000372764.4
External Link	RMBase: m6A_site_106719
mod ID: M6ASITE000870		Click to Show/Hide the Full List
mod site	chr10:73916711-73916712:+		[10]
Sequence	GCCACCCACCAGGGCGAACGACAATAGCTTTACCCTCAGGC
Motif Score	2.865571429
Cell/Tissue List	hESC-HEK293T; A549
Seq Type List	MAZTER-seq; m6A-CLIP/IP
Transcript ID List	ENST00000372764.4; ENST00000446342.5
External Link	RMBase: m6A_site_106720
mod ID: M6ASITE000871		Click to Show/Hide the Full List
mod site	chr10:73916757-73916758:+		[11]
Sequence	CCTGGGTGCTGGCTGCCCAGACCCCTCTGGCCAGGATGGAG
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; H1299; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000446342.5; ENST00000372764.4
External Link	RMBase: m6A_site_106721
mod ID: M6ASITE000872		Click to Show/Hide the Full List
mod site	chr10:73916828-73916829:+		[12]
Sequence	AGCAACTTGTCTTTTTCTGGACTGAAGCCTGCAGGAGTTAA
Motif Score	4.065041667
Cell/Tissue List	HepG2; A549; U2OS; H1A; H1B; fibroblasts; GM12878; H1299; MM6; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; endometrial; HEC-1-A; NB4; AML
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP; miCLIP
Transcript ID List	ENST00000372764.4; ENST00000446342.5
External Link	RMBase: m6A_site_106722
mod ID: M6ASITE000873		Click to Show/Hide the Full List
mod site	chr10:73917021-73917022:+		[13]
Sequence	CAGCGGTTTGGGGAGCAGAGACACTAACGACTTCAGGGCAG
Motif Score	2.897386905
Cell/Tissue List	A549; H1299; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000372764.4; ENST00000446342.5
External Link	RMBase: m6A_site_106723
mod ID: M6ASITE000874		Click to Show/Hide the Full List
mod site	chr10:73917256-73917257:+		[7]
Sequence	CCTCTTGGGTCCCCCACGTGACAGTGCCTGGGAATGTATTA
Motif Score	2.859755952
Cell/Tissue List	kidney
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000446342.5; ENST00000372764.4
External Link	RMBase: m6A_site_106724

Ref 1	RNA-methylation-dependent RNA processing controls the speed of the circadian clock. Cell. 2013 Nov 7;155(4):793-806. doi: 10.1016/j.cell.2013.10.026.
Ref 2	Viral N(6)-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus. Nat Commun. 2019 Oct 9;10(1):4595. doi: 10.1038/s41467-019-12504-y.
Ref 3	m(6)A RNA modification controls cell fate transition in mammalian embryonic stem cells. Cell Stem Cell. 2014 Dec 4;15(6):707-19. doi: 10.1016/j.stem.2014.09.019. Epub 2014 Oct 16.
Ref 4	N(6)-methyladenosine of HIV-1 RNA regulates viral infection and HIV-1 Gag protein expression. Elife. 2016 Jul 2;5:e15528. doi: 10.7554/eLife.15528.
Ref 5	R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m(6)A/MYC/CEBPA Signaling. Cell. 2018 Jan 11;172(1-2):90-105.e23. doi: 10.1016/j.cell.2017.11.031. Epub 2017 Dec 14.
Ref 6	m(6)A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer. Nat Cell Biol. 2018 Sep;20(9):1074-1083. doi: 10.1038/s41556-018-0174-4. Epub 2018 Aug 27.
Ref 7	Single-base mapping of m(6)A by an antibody-independent method. Sci Adv. 2019 Jul 3;5(7):eaax0250. doi: 10.1126/sciadv.aax0250. eCollection 2019 Jul.
Ref 8	Dynamics of the human and viral m(6)A RNA methylomes during HIV-1 infection of T cells. Nat Microbiol. 2016 Feb 22;1:16011. doi: 10.1038/nmicrobiol.2016.11.
Ref 9	FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N(6)-Methyladenosine RNA Demethylase. Cancer Cell. 2017 Jan 9;31(1):127-141. doi: 10.1016/j.ccell.2016.11.017. Epub 2016 Dec 22.
Ref 10	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 11	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 12	Histone H3 trimethylation at lysine 36 guides m(6)A RNA modification co-transcriptionally. Nature. 2019 Mar;567(7748):414-419. doi: 10.1038/s41586-019-1016-7. Epub 2019 Mar 13.
Ref 13	Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites. Cell Rep. 2014 Jul 10;8(1):284-96. doi: 10.1016/j.celrep.2014.05.048. Epub 2014 Jun 26.

Epigenetic Target Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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