Epigenetic Target Information

General Information of the Epigenetic Target (ID: EPITAR00512)

Target Name	Scaffold protein ILK (ILK)
Synonyms	ILK-1; ILK-2; Inactive integrin-linked kinase; p59ILK; ILK1; ILK2 Click to Show/Hide
Gene Name	ILK
Sequence	MDDIFTQCREGNAVAVRLWLDNTENDLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDTPLHLAASHGHRDIVQKLLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLVANGALVSICNKYGEMPVDKAKAPLRELLRERAEKMGQNLNRIPYKDTFWKGTTRTRPRNGTLNKHSGIDFKQLNFLTKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFSHPNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPLIPRHALNSRSVMIDEDMTARISMADVKFSFQCPGRMYAPAWVAPEALQKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIPPGISPHVCKLMKICMNEDPAKRPKFDMIVPILEKMQDK Click to Show/Hide
Family	Protein kinase superfamily. TKL Ser/Thr protein kinase family.
Function	Scaffold protein which mediates protein-protein interactions during a range of cellular events including focal adhesion assembly, cell adhesion and cell migration (PubMed:17420447, PubMed:20005845, PubMed:30367047, PubMed:32528174). Regulates integrin-mediated signal transduction by contributing to inside-out integrin activation (By similarity). Recruits PARVA and LIMS1/PITCH to form the heterotrimeric IPP (ILK-PINCH-PARVIN) complex which binds to F-actin via the C-terminal tail of LIMS1 and the N-terminal region of PARVA, promoting F-actin filament bundling, a process required to generate force for actin cytoskeleton reorganization and subsequent dynamic cell adhesion events such as cell spreading and migration (PubMed:30367047). Binding to PARVA promotes effective assembly of ILK into focal adhesions while PARVA-bound ILK can simultaneously engage integrin-beta cytoplasmic tails to mediate cell adhesion (PubMed:20005845). Plays a role with PARVG in promoting the cell adhesion and spreading of leukocytes (PubMed:16517730). Acts as an upstream effector of both AKT1/PKB and GSK3 (PubMed:9736715). Mediates trafficking of caveolae to the cell surface in an ITGB1-dependent manner by promoting the recruitment of IQGAP1 to the cell cortex which cooperates with its effector DIAPH1 to locally stabilize microtubules and allow stable insertion of caveolae into the plasma membrane (By similarity). Required for the maintenance of mitotic spindle integrity by promoting phosphorylation of TACC3 by AURKA (PubMed:18283114). Associates with chromatin and may act as a negative regulator of transcription when located in the nucleus (PubMed:17420447). {ECO:0000250\|UniProtKB:O55222, ECO:0000250\|UniProtKB:Q99J82, ECO:0000269\|PubMed:16517730, ECO:0000269\|PubMed:17420447, ECO:0000269\|PubMed:18283114, ECO:0000269\|PubMed:20005845, ECO:0000269\|PubMed:30367047, ECO:0000269\|PubMed:32528174, ECO:0000269\|PubMed:9736715}. Click to Show/Hide
Gene ID	3611
HGNC ID	HGNC:6040
Ensembl Gene ID	ENSG00000166333
KEGG ID	hsa:3611
Chromosomal Location	11p15.4

RNA Modification Sequencing Data Associated with the Target (ID: EPITAR00512)

Scaffold protein ILK (ILK)

N1-methyladenosine (m1A)

In total 1 m6A sequence/site(s) in this target gene
mod ID: M1ASITE000015		Click to Show/Hide the Full List
mod site	chr11:6608084-6608085:+		[1]
Sequence	CCCTTGCACTGGGCCTGCCGAGAGGGCCGCTCTGCTGTGGT
Cell/Tissue List	HEK293T
Seq Type List	m1A-seq
Transcript ID List	ENST00000524735.1; ENST00000396751.6; ENST00000532063.5; ENST00000526711.5; ENST00000526114.5; ENST00000528995.5; ENST00000537806.5; ENST00000527121.5; ENST00000530016.5; ENST00000299421.8; ENST00000526318.2; ENST00000420936.6
External Link	RMBase: m1A_site_171

N6-methyladenosine (m6A)

In total 52 m6A sequence/site(s) in this target gene
mod ID: M6ASITE003652		Click to Show/Hide the Full List
mod site	chr11:6603836-6603837:+		[2]
Sequence	GTCCCGGTGAGTGCGAGAGGACCCGCGCCCCCTGTCACCCC
Motif Score	3.622404762
Cell/Tissue List	HeLa; HEK293T
Seq Type List	m6A-seq
Transcript ID List	ENST00000526711.5; ENST00000526114.5; ENST00000534565.1; ENST00000420936.6; ENST00000527121.5; ENST00000299421.8; ENST00000530016.5; ENST00000396751.6; ENST00000528995.5; ENST00000532063.5; ENST00000537806.5
External Link	RMBase: m6A_site_129260
mod ID: M6ASITE003653		Click to Show/Hide the Full List
mod site	chr11:6603905-6603906:+		[2]
Sequence	CGGAGCCAACCCTGGGGAGGACCCCCGGTCCCCTCTCCCAG
Motif Score	3.622404762
Cell/Tissue List	HeLa; HEK293T
Seq Type List	m6A-seq
Transcript ID List	ENST00000528995.5; ENST00000396751.6; ENST00000299421.8; ENST00000420936.6; ENST00000526114.5; ENST00000526711.5; ENST00000537806.5; ENST00000534565.1; ENST00000527121.5; ENST00000532063.5; ENST00000530016.5
External Link	RMBase: m6A_site_129261
mod ID: M6ASITE003654		Click to Show/Hide the Full List
mod site	chr11:6603942-6603943:+		[3]
Sequence	CCAGAGTATACGGAGCCTGAACCTCCCCACTTCCCCCAACT
Motif Score	2.930744048
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000299421.8; ENST00000534565.1; ENST00000528995.5; ENST00000526711.5; ENST00000396751.6; ENST00000420936.6; ENST00000537806.5; ENST00000526114.5; ENST00000527121.5; ENST00000532063.5; ENST00000530016.5
External Link	RMBase: m6A_site_129262
mod ID: M6ASITE003655		Click to Show/Hide the Full List
mod site	chr11:6603998-6603999:+		[3]
Sequence	GTCTAGTTGCCTGCTCTCGGACATCCGTTCAGCAGACACTA
Motif Score	3.643047619
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000528995.5; ENST00000534565.1; ENST00000396751.6; ENST00000526711.5; ENST00000537806.5; ENST00000299421.8; ENST00000530016.5; ENST00000526114.5; ENST00000532063.5; ENST00000527121.5; ENST00000420936.6
External Link	RMBase: m6A_site_129263
mod ID: M6ASITE003656		Click to Show/Hide the Full List
mod site	chr11:6604013-6604014:+		[3]
Sequence	CTCGGACATCCGTTCAGCAGACACTACCTCTTCGTCACCCC
Motif Score	2.897386905
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000396751.6; ENST00000537806.5; ENST00000526114.5; ENST00000534565.1; ENST00000530016.5; ENST00000528995.5; ENST00000526711.5; ENST00000420936.6; ENST00000299421.8; ENST00000527121.5; ENST00000532063.5
External Link	RMBase: m6A_site_129264
mod ID: M6ASITE003657		Click to Show/Hide the Full List
mod site	chr11:6604072-6604073:+		[4]
Sequence	CTTTACCTCGCGTCTAGAGGACACAGCCAGGGATCATCCCG
Motif Score	3.643047619
Cell/Tissue List	MT4; Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000420936.6; ENST00000537806.5; ENST00000530016.5; ENST00000527121.5; ENST00000534565.1; ENST00000528995.5; ENST00000526711.5; ENST00000532063.5; ENST00000396751.6; ENST00000526114.5; ENST00000299421.8
External Link	RMBase: m6A_site_129265
mod ID: M6ASITE003658		Click to Show/Hide the Full List
mod site	chr11:6604102-6604103:+		[3]
Sequence	GGATCATCCCGCAGCCCCGAACTCCTTCACAGACCCCCACT
Motif Score	3.373380952
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000530016.5; ENST00000528995.5; ENST00000396751.6; ENST00000526711.5; ENST00000534565.1; ENST00000526114.5; ENST00000527121.5; ENST00000299421.8; ENST00000537806.5; ENST00000532063.5; ENST00000420936.6
External Link	RMBase: m6A_site_129266
mod ID: M6ASITE003659		Click to Show/Hide the Full List
mod site	chr11:6604114-6604115:+		[3]
Sequence	AGCCCCGAACTCCTTCACAGACCCCCACTAGCCGGGGACGC
Motif Score	2.876744048
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000420936.6; ENST00000299421.8; ENST00000534565.1; ENST00000530016.5; ENST00000527121.5; ENST00000532063.5; ENST00000526711.5; ENST00000537806.5; ENST00000528995.5; ENST00000396751.6; ENST00000526114.5
External Link	RMBase: m6A_site_129267
mod ID: M6ASITE003660		Click to Show/Hide the Full List
mod site	chr11:6604162-6604163:+		[3]
Sequence	GCCCCCTACCCCCAACACAAACACTTCTCTCCTGTAGAGGA
Motif Score	2.20572619
Cell/Tissue List	Huh7; endometrial
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000534565.1; ENST00000537806.5; ENST00000299421.8; ENST00000526114.5; ENST00000420936.6; ENST00000396751.6; ENST00000528995.5; ENST00000527121.5; ENST00000526711.5; ENST00000530016.5; ENST00000532063.5
External Link	RMBase: m6A_site_129268
mod ID: M6ASITE003661		Click to Show/Hide the Full List
mod site	chr11:6604250-6604251:+		[5]
Sequence	AGGCTTCCCCAATCCAGGGGACTCGGCGCCGGGACGCTGCT
Motif Score	4.065041667
Cell/Tissue List	HepG2; Huh7; peripheral-blood; HEK293T; endometrial; MM6
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000527121.5; ENST00000534565.1; ENST00000526711.5; ENST00000420936.6; ENST00000532063.5; ENST00000537806.5; ENST00000530016.5; ENST00000526114.5; ENST00000299421.8; ENST00000528995.5; ENST00000396751.6
External Link	RMBase: m6A_site_129271
mod ID: M6ASITE003662		Click to Show/Hide the Full List
mod site	chr11:6604278-6604279:+		[6]
Sequence	CCGGGACGCTGCTATGGACGACATTTTCACTCAGTGCCGGG
Motif Score	2.865571429
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000526114.5; ENST00000526711.5; ENST00000534565.1; ENST00000528995.5; ENST00000627400.1; ENST00000527121.5; ENST00000420936.6; ENST00000530016.5; ENST00000532063.5; ENST00000299421.8; ENST00000396751.6; ENST00000537806.5
External Link	RMBase: m6A_site_129272
mod ID: M6ASITE003663		Click to Show/Hide the Full List
mod site	chr11:6604332-6604333:+		[7]
Sequence	CGCCGTTCGCCTGTGGCTGGACAACACGGAGAACGACCTCA
Motif Score	3.643047619
Cell/Tissue List	HepG2; hESC-HEK293T; Huh7; peripheral-blood; endometrial; MM6
Seq Type List	m6A-seq; MAZTER-seq; MeRIP-seq
Transcript ID List	ENST00000532063.5; ENST00000420936.6; ENST00000627400.1; ENST00000537806.5; ENST00000526114.5; ENST00000396751.6; ENST00000527121.5; ENST00000530016.5; ENST00000528995.5; ENST00000534565.1; ENST00000526318.2; ENST00000299421.8; ENST00000526711.5
External Link	RMBase: m6A_site_129273
mod ID: M6ASITE003664		Click to Show/Hide the Full List
mod site	chr11:6604335-6604336:+		[6]
Sequence	CGTTCGCCTGTGGCTGGACAACACGGAGAACGACCTCAACC
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000530016.5; ENST00000532063.5; ENST00000526114.5; ENST00000420936.6; ENST00000528995.5; ENST00000526318.2; ENST00000299421.8; ENST00000627400.1; ENST00000534565.1; ENST00000396751.6; ENST00000537806.5; ENST00000526711.5; ENST00000527121.5
External Link	RMBase: m6A_site_129274
mod ID: M6ASITE003665		Click to Show/Hide the Full List
mod site	chr11:6604592-6604593:+		[2]
Sequence	GAGCTTTCCAGCCTCAGTAGACTGCATGGCCAAAGGCTAGG
Motif Score	3.319380952
Cell/Tissue List	HeLa; MT4; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000526711.5; ENST00000396751.6; ENST00000532063.5; ENST00000530016.5; ENST00000537806.5; ENST00000299421.8; ENST00000627400.1; ENST00000534565.1; ENST00000527121.5; ENST00000526114.5; ENST00000420936.6; ENST00000526318.2; ENST00000528995.5
External Link	RMBase: m6A_site_129275
mod ID: M6ASITE003666		Click to Show/Hide the Full List
mod site	chr11:6604636-6604637:+		[2]
Sequence	CAAGGCACAGAGCAGAGAGAACAGGAAATTGTCTGGAGTTC
Motif Score	2.951386905
Cell/Tissue List	HeLa; MT4; Huh7; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000530016.5; ENST00000534565.1; ENST00000526318.2; ENST00000537806.5; ENST00000627400.1; ENST00000396751.6; ENST00000299421.8; ENST00000526114.5; ENST00000528995.5; ENST00000527121.5; ENST00000526711.5; ENST00000532063.5; ENST00000420936.6
External Link	RMBase: m6A_site_129276
mod ID: M6ASITE003667		Click to Show/Hide the Full List
mod site	chr11:6604717-6604718:+		[2]
Sequence	TTGGGTACAAGAGGAAAAGAACAGGACATAAGACTGTAGAG
Motif Score	2.951386905
Cell/Tissue List	HeLa; Huh7; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000532063.5; ENST00000396751.6; ENST00000530016.5; ENST00000526318.2; ENST00000420936.6; ENST00000527121.5; ENST00000526114.5; ENST00000299421.8; ENST00000528995.5; ENST00000627400.1; ENST00000526711.5; ENST00000534565.1; ENST00000537806.5
External Link	RMBase: m6A_site_129277
mod ID: M6ASITE003668		Click to Show/Hide the Full List
mod site	chr11:6607897-6607898:+		[3]
Sequence	CAGGGGAAGGTCTGAAATGGACAGCTTTGGGAGTTGCTGGC
Motif Score	3.643047619
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000530016.5; ENST00000299421.8; ENST00000527121.5; ENST00000420936.6; ENST00000528995.5; ENST00000537806.5; ENST00000526318.2; ENST00000524735.1; ENST00000526114.5; ENST00000532063.5; ENST00000396751.6; ENST00000526711.5
External Link	RMBase: m6A_site_129281
mod ID: M6ASITE003669		Click to Show/Hide the Full List
mod site	chr11:6608146-6608147:+		[8]
Sequence	GGCACGGATCAATGTAATGAACCGTGGGGATGACACCCCCC
Motif Score	2.930744048
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000526318.2; ENST00000526114.5; ENST00000420936.6; ENST00000532063.5; ENST00000528995.5; ENST00000396751.6; ENST00000524735.1; ENST00000527121.5; ENST00000530016.5; ENST00000526711.5; ENST00000299421.8; ENST00000537806.5
External Link	RMBase: m6A_site_129282
mod ID: M6ASITE003670		Click to Show/Hide the Full List
mod site	chr11:6608158-6608159:+		[6]
Sequence	TGTAATGAACCGTGGGGATGACACCCCCCTGCATCTGGCAG
Motif Score	2.859755952
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000526318.2; ENST00000526114.5; ENST00000530016.5; ENST00000528995.5; ENST00000396751.6; ENST00000527121.5; ENST00000526711.5; ENST00000524735.1; ENST00000537806.5; ENST00000299421.8; ENST00000532063.5; ENST00000420936.6
External Link	RMBase: m6A_site_129283
mod ID: M6ASITE003671		Click to Show/Hide the Full List
mod site	chr11:6608345-6608346:+		[2]
Sequence	ACACCAGTATCTCATTTGGAACTGACTGTACTTTCTGCCTC
Motif Score	3.373380952
Cell/Tissue List	HeLa; CD34
Seq Type List	m6A-seq
Transcript ID List	ENST00000528995.5; ENST00000526114.5; ENST00000526711.5; ENST00000527121.5; ENST00000420936.6; ENST00000530016.5; ENST00000299421.8; ENST00000524735.1; ENST00000537806.5; ENST00000528784.5; ENST00000396751.6; ENST00000526318.2; ENST00000532063.5
External Link	RMBase: m6A_site_129284
mod ID: M6ASITE003672		Click to Show/Hide the Full List
mod site	chr11:6608412-6608413:+		[2]
Sequence	GCTATTGCAGTACAAGGCAGACATCAATGCAGTGAATGAAC
Motif Score	2.897386905
Cell/Tissue List	HeLa; CD34
Seq Type List	m6A-seq
Transcript ID List	ENST00000530016.5; ENST00000527121.5; ENST00000524735.1; ENST00000528995.5; ENST00000528784.5; ENST00000526711.5; ENST00000299421.8; ENST00000526318.2; ENST00000526114.5; ENST00000420936.6; ENST00000396751.6; ENST00000532063.5; ENST00000537806.5
External Link	RMBase: m6A_site_129287
mod ID: M6ASITE003673		Click to Show/Hide the Full List
mod site	chr11:6608431-6608432:+		[2]
Sequence	GACATCAATGCAGTGAATGAACACGGGAATGTGCCCCTGCA
Motif Score	2.951386905
Cell/Tissue List	HeLa; CD34; hESC-HEK293T
Seq Type List	m6A-seq; MAZTER-seq
Transcript ID List	ENST00000526114.5; ENST00000528784.5; ENST00000396751.6; ENST00000526711.5; ENST00000299421.8; ENST00000530016.5; ENST00000420936.6; ENST00000537806.5; ENST00000526318.2; ENST00000532063.5; ENST00000528995.5; ENST00000527121.5
External Link	RMBase: m6A_site_129288
mod ID: M6ASITE003674		Click to Show/Hide the Full List
mod site	chr11:6608730-6608731:+		[6]
Sequence	GGCCCTTGTCAGCATCTGTAACAAGTATGGAGAGATGCCTG
Motif Score	2.168095238
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000526711.5; ENST00000532063.5; ENST00000396751.6; ENST00000527121.5; ENST00000299421.8; ENST00000530016.5; ENST00000420936.6; ENST00000526318.2; ENST00000528995.5; ENST00000526114.5; ENST00000537806.5; ENST00000528784.5
External Link	RMBase: m6A_site_129292
mod ID: M6ASITE003675		Click to Show/Hide the Full List
mod site	chr11:6608754-6608755:+		[2]
Sequence	GTATGGAGAGATGCCTGTGGACAAAGCCAAGGCACCCCTGA
Motif Score	3.643047619
Cell/Tissue List	HeLa; hESC-HEK293T
Seq Type List	m6A-seq; MAZTER-seq
Transcript ID List	ENST00000526318.2; ENST00000530016.5; ENST00000528995.5; ENST00000527121.5; ENST00000534706.1; ENST00000526114.5; ENST00000528784.5; ENST00000526711.5; ENST00000420936.6; ENST00000532063.5; ENST00000299421.8; ENST00000537806.5; ENST00000396751.6
External Link	RMBase: m6A_site_129293
mod ID: M6ASITE003676		Click to Show/Hide the Full List
mod site	chr11:6608925-6608926:+		[9]
Sequence	GAATCTCAACCGTATTCCATACAAGGACACATTCTGGAAGG
Motif Score	2.110482143
Cell/Tissue List	HEK293; hESC-HEK293T
Seq Type List	m6A-REF-seq; MAZTER-seq
Transcript ID List	ENST00000527121.5; ENST00000526711.5; ENST00000526114.5; ENST00000299421.8; ENST00000537806.5; ENST00000420936.6; ENST00000528995.5; ENST00000530016.5; ENST00000532063.5; ENST00000526318.2; ENST00000528784.5; ENST00000534706.1; ENST00000396751.6
External Link	RMBase: m6A_site_129298
mod ID: M6ASITE003677		Click to Show/Hide the Full List
mod site	chr11:6608931-6608932:+		[8]
Sequence	CAACCGTATTCCATACAAGGACACATTCTGGAAGGGGACCA
Motif Score	3.643047619
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000528995.5; ENST00000526114.5; ENST00000537806.5; ENST00000527121.5; ENST00000396751.6; ENST00000526711.5; ENST00000299421.8; ENST00000420936.6; ENST00000528784.5; ENST00000532063.5; ENST00000534706.1; ENST00000526318.2; ENST00000530016.5
External Link	RMBase: m6A_site_129299
mod ID: M6ASITE003678		Click to Show/Hide the Full List
mod site	chr11:6608948-6608949:+		[8]
Sequence	AGGACACATTCTGGAAGGGGACCACCCGCACTCGGCCCCGT
Motif Score	3.622404762
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000396751.6; ENST00000532063.5; ENST00000526114.5; ENST00000528784.5; ENST00000527121.5; ENST00000526318.2; ENST00000530016.5; ENST00000420936.6; ENST00000299421.8; ENST00000526711.5; ENST00000528995.5; ENST00000537806.5; ENST00000534706.1
External Link	RMBase: m6A_site_129300
mod ID: M6ASITE003679		Click to Show/Hide the Full List
mod site	chr11:6609078-6609079:+		[8]
Sequence	CCACACTCTTAGGAAATGGAACCCTGAACAAACACTCTGGC
Motif Score	2.930744048
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000537806.5; ENST00000526711.5; ENST00000530016.5; ENST00000528784.5; ENST00000532063.5; ENST00000396751.6; ENST00000526318.2; ENST00000299421.8; ENST00000526114.5; ENST00000420936.6; ENST00000528995.5; ENST00000534706.1; ENST00000527121.5
External Link	RMBase: m6A_site_129301
mod ID: M6ASITE003680		Click to Show/Hide the Full List
mod site	chr11:6609085-6609086:+		[6]
Sequence	CTTAGGAAATGGAACCCTGAACAAACACTCTGGCATTGACT
Motif Score	2.951386905
Cell/Tissue List	hESC-HEK293T; endometrial
Seq Type List	MAZTER-seq; m6A-seq
Transcript ID List	ENST00000526711.5; ENST00000420936.6; ENST00000532063.5; ENST00000396751.6; ENST00000527121.5; ENST00000537806.5; ENST00000530016.5; ENST00000526114.5; ENST00000528995.5; ENST00000526318.2; ENST00000299421.8; ENST00000528784.5; ENST00000534706.1
External Link	RMBase: m6A_site_129302
mod ID: M6ASITE003681		Click to Show/Hide the Full List
mod site	chr11:6609110-6609111:+		[9]
Sequence	CACTCTGGCATTGACTTCAAACAGCTTAACTTCCTGACGAA
Motif Score	2.20572619
Cell/Tissue List	liver; HEK293T; endometrial
Seq Type List	m6A-REF-seq; m6A-seq
Transcript ID List	ENST00000528784.5; ENST00000396751.6; ENST00000534706.1; ENST00000532063.5; ENST00000420936.6; ENST00000537806.5; ENST00000530016.5; ENST00000528995.5; ENST00000299421.8; ENST00000526711.5; ENST00000526114.5; ENST00000527121.5; ENST00000526318.2
External Link	RMBase: m6A_site_129303
mod ID: M6ASITE003682		Click to Show/Hide the Full List
mod site	chr11:6609190-6609191:+		[10]
Sequence	TCTTGCCCTTCCCTCACTAAACCCCCATAAATTACTTGCTT
Motif Score	2.185083333
Cell/Tissue List	HEK293T; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000420936.6; ENST00000528995.5; ENST00000396751.6; ENST00000532063.5; ENST00000526711.5; ENST00000299421.8; ENST00000526318.2; ENST00000530016.5; ENST00000537806.5; ENST00000527121.5; ENST00000534706.1; ENST00000528784.5
External Link	RMBase: m6A_site_129304
mod ID: M6ASITE003683		Click to Show/Hide the Full List
mod site	chr11:6609326-6609327:+		[6]
Sequence	GGGCCGCTGGCAGGGCAATGACATTGTCGTGAAGGTGCTGA
Motif Score	2.859755952
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000420936.6; ENST00000537806.5; ENST00000396751.6; ENST00000532063.5; ENST00000528995.5; ENST00000299421.8; ENST00000534706.1; ENST00000527121.5; ENST00000530016.5; ENST00000526711.5; ENST00000528784.5; ENST00000526318.2
External Link	RMBase: m6A_site_129308
mod ID: M6ASITE003684		Click to Show/Hide the Full List
mod site	chr11:6609356-6609357:+		[7]
Sequence	GAAGGTGCTGAAGGTTCGAGACTGGAGTACAAGGAAGAGCA
Motif Score	3.319380952
Cell/Tissue List	HepG2; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000527121.5; ENST00000420936.6; ENST00000299421.8; ENST00000537806.5; ENST00000528995.5; ENST00000396751.6; ENST00000528784.5; ENST00000534706.1; ENST00000532063.5; ENST00000526711.5; ENST00000530016.5; ENST00000526318.2
External Link	RMBase: m6A_site_129310
mod ID: M6ASITE003685		Click to Show/Hide the Full List
mod site	chr11:6609364-6609365:+		[6]
Sequence	TGAAGGTTCGAGACTGGAGTACAAGGAAGAGCAGGGACTTC
Motif Score	2.856142857
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000528995.5; ENST00000530016.5; ENST00000396751.6; ENST00000532063.5; ENST00000526318.2; ENST00000420936.6; ENST00000527121.5; ENST00000534706.1; ENST00000528784.5; ENST00000526711.5; ENST00000537806.5; ENST00000299421.8
External Link	RMBase: m6A_site_129311
mod ID: M6ASITE003686		Click to Show/Hide the Full List
mod site	chr11:6609380-6609381:+		[7]
Sequence	GAGTACAAGGAAGAGCAGGGACTTCAATGAAGAGTGTCCCC
Motif Score	4.065041667
Cell/Tissue List	HepG2; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000528784.5; ENST00000530016.5; ENST00000526711.5; ENST00000532063.5; ENST00000526318.2; ENST00000420936.6; ENST00000527121.5; ENST00000537806.5; ENST00000534706.1; ENST00000528995.5; ENST00000396751.6; ENST00000299421.8
External Link	RMBase: m6A_site_129312
mod ID: M6ASITE003687		Click to Show/Hide the Full List
mod site	chr11:6609587-6609588:+		[6]
Sequence	CTCCTCATCCTACTCTCATCACACACTGGATGCCGTATGGA
Motif Score	2.047297619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000396751.6; ENST00000537806.5; ENST00000420936.6; ENST00000532063.5; ENST00000299421.8; ENST00000526711.5; ENST00000530016.5; ENST00000534706.1; ENST00000528995.5; ENST00000528784.5; ENST00000526318.2
External Link	RMBase: m6A_site_129316
mod ID: M6ASITE003688		Click to Show/Hide the Full List
mod site	chr11:6609625-6609626:+		[6]
Sequence	GGATCCCTCTACAATGTACTACATGAAGGCACCAGTGAGTA
Motif Score	2.078666667
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000532063.5; ENST00000537806.5; ENST00000299421.8; ENST00000526318.2; ENST00000396751.6; ENST00000530016.5; ENST00000528784.5; ENST00000526711.5; ENST00000534706.1; ENST00000528995.5; ENST00000420936.6
External Link	RMBase: m6A_site_129317
mod ID: M6ASITE003689		Click to Show/Hide the Full List
mod site	chr11:6609735-6609736:+		[2]
Sequence	CCTCTCAGATTTCGTCGTGGACCAGAGCCAGGCTGTGAAGT
Motif Score	3.622404762
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000530016.5; ENST00000532063.5; ENST00000299421.8; ENST00000526711.5; ENST00000534706.1; ENST00000528995.5; ENST00000526318.2; ENST00000420936.6; ENST00000528784.5; ENST00000537806.5; ENST00000396751.6
External Link	RMBase: m6A_site_129318
mod ID: M6ASITE003690		Click to Show/Hide the Full List
mod site	chr11:6609765-6609766:+		[2]
Sequence	GGCTGTGAAGTTTGCTTTGGACATGGCAAGGGGCATGGCCT
Motif Score	3.643047619
Cell/Tissue List	HeLa; hESC-HEK293T
Seq Type List	m6A-seq; MAZTER-seq
Transcript ID List	ENST00000532063.5; ENST00000528995.5; ENST00000526711.5; ENST00000420936.6; ENST00000528784.5; ENST00000534706.1; ENST00000530016.5; ENST00000537806.5; ENST00000299421.8; ENST00000396751.6; ENST00000526318.2
External Link	RMBase: m6A_site_129320
mod ID: M6ASITE003691		Click to Show/Hide the Full List
mod site	chr11:6609945-6609946:+		[2]
Sequence	TCTTCCTCAGATTGATGAGGACATGACTGCCCGAATTAGCA
Motif Score	3.643047619
Cell/Tissue List	HeLa; hESC-HEK293T
Seq Type List	m6A-seq; MAZTER-seq
Transcript ID List	ENST00000530016.5; ENST00000528995.5; ENST00000528784.5; ENST00000526318.2; ENST00000526711.5; ENST00000537806.5; ENST00000420936.6; ENST00000532063.5; ENST00000299421.8; ENST00000396751.6
External Link	RMBase: m6A_site_129322
mod ID: M6ASITE003692		Click to Show/Hide the Full List
mod site	chr11:6610168-6610169:+		[2]
Sequence	TCTGCAGAAGAAGCCTGAAGACACAAACAGACGCTCAGCAG
Motif Score	2.897386905
Cell/Tissue List	HeLa; hESC-HEK293T; endometrial
Seq Type List	m6A-seq; MAZTER-seq
Transcript ID List	ENST00000526711.5; ENST00000532063.5; ENST00000396751.6; ENST00000299421.8; ENST00000530016.5; ENST00000526318.2; ENST00000537806.5; ENST00000420936.6; ENST00000528995.5
External Link	RMBase: m6A_site_129325
mod ID: M6ASITE003693		Click to Show/Hide the Full List
mod site	chr11:6610174-6610175:+		[2]
Sequence	GAAGAAGCCTGAAGACACAAACAGACGCTCAGCAGACATGT
Motif Score	2.20572619
Cell/Tissue List	HeLa; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000528995.5; ENST00000530016.5; ENST00000420936.6; ENST00000537806.5; ENST00000526318.2; ENST00000299421.8; ENST00000532063.5; ENST00000526711.5; ENST00000396751.6
External Link	RMBase: m6A_site_129326
mod ID: M6ASITE003694		Click to Show/Hide the Full List
mod site	chr11:6610189-6610190:+		[8]
Sequence	CACAAACAGACGCTCAGCAGACATGTGGAGTTTTGCAGTGC
Motif Score	2.897386905
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000526711.5; ENST00000537806.5; ENST00000299421.8; ENST00000526318.2; ENST00000420936.6; ENST00000530016.5; ENST00000396751.6; ENST00000528995.5; ENST00000532063.5
External Link	RMBase: m6A_site_129327
mod ID: M6ASITE003695		Click to Show/Hide the Full List
mod site	chr11:6610220-6610221:+		[8]
Sequence	TTTGCAGTGCTTCTGTGGGAACTGGTGACACGGGAGGTACC
Motif Score	3.373380952
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000528995.5; ENST00000526318.2; ENST00000530016.5; ENST00000299421.8; ENST00000526711.5; ENST00000396751.6; ENST00000532063.5; ENST00000420936.6; ENST00000537806.5
External Link	RMBase: m6A_site_129329
mod ID: M6ASITE003696		Click to Show/Hide the Full List
mod site	chr11:6610227-6610228:+		[6]
Sequence	TGCTTCTGTGGGAACTGGTGACACGGGAGGTACCCTTTGCT
Motif Score	2.859755952
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000532063.5; ENST00000537806.5; ENST00000530016.5; ENST00000396751.6; ENST00000526318.2; ENST00000299421.8; ENST00000526711.5; ENST00000528995.5; ENST00000420936.6
External Link	RMBase: m6A_site_129330
mod ID: M6ASITE003697		Click to Show/Hide the Full List
mod site	chr11:6610570-6610571:+		[6]
Sequence	TGCAAAGCGACCCAAATTTGACATGATTGTGCCTATCCTTG
Motif Score	2.859755952
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000299421.8; ENST00000526711.5; ENST00000526318.2; ENST00000420936.6; ENST00000528995.5; ENST00000537806.5; ENST00000530016.5; ENST00000532063.5; ENST00000396751.6
External Link	RMBase: m6A_site_129331
mod ID: M6ASITE003698		Click to Show/Hide the Full List
mod site	chr11:6610603-6610604:+		[9]
Sequence	TATCCTTGAGAAGATGCAGGACAAGTAGGACTGGAAGGTCC
Motif Score	3.643047619
Cell/Tissue List	liver; hESC-HEK293T; A549; MT4; MM6; Huh7; endometrial
Seq Type List	m6A-REF-seq; MAZTER-seq; m6A-seq; MeRIP-seq
Transcript ID List	ENST00000526711.5; ENST00000532063.5; ENST00000528995.5; ENST00000396751.6; ENST00000530016.5; ENST00000526318.2; ENST00000537806.5; ENST00000420936.6; ENST00000299421.8
External Link	RMBase: m6A_site_129332
mod ID: M6ASITE003699		Click to Show/Hide the Full List
mod site	chr11:6610612-6610613:+		[11]
Sequence	GAAGATGCAGGACAAGTAGGACTGGAAGGTCCTTGCCTGAA
Motif Score	4.065041667
Cell/Tissue List	HeLa; HEK293T; A549; MT4; MM6; Huh7; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000299421.8; ENST00000537806.5; ENST00000396751.6; ENST00000420936.6; ENST00000528995.5; ENST00000532063.5; ENST00000526318.2; ENST00000526711.5
External Link	RMBase: m6A_site_129333
mod ID: M6ASITE003700		Click to Show/Hide the Full List
mod site	chr11:6610632-6610633:+		[12]
Sequence	ACTGGAAGGTCCTTGCCTGAACTCCAGAGGTGTCGGGACAT
Motif Score	3.373380952
Cell/Tissue List	HEK293T; HeLa; A549; MT4; MM6; Huh7; endometrial; HEC-1-A
Seq Type List	DART-seq; m6A-seq; MeRIP-seq
Transcript ID List	ENST00000532063.5; ENST00000528995.5; ENST00000526711.5; ENST00000299421.8; ENST00000537806.5; ENST00000396751.6; ENST00000420936.6; ENST00000526318.2
External Link	RMBase: m6A_site_129335
mod ID: M6ASITE003701		Click to Show/Hide the Full List
mod site	chr11:6610649-6610650:+		[9]
Sequence	TGAACTCCAGAGGTGTCGGGACATGGTTGGGGGAATGCACC
Motif Score	3.643047619
Cell/Tissue List	brain; hESC-HEK293T; HeLa; A549; MT4; MM6; Huh7; endometrial; HEC-1-A
Seq Type List	m6A-REF-seq; MAZTER-seq; m6A-seq; MeRIP-seq
Transcript ID List	ENST00000526711.5; ENST00000528995.5; ENST00000396751.6; ENST00000299421.8; ENST00000420936.6; ENST00000526318.2; ENST00000537806.5; ENST00000532063.5
External Link	RMBase: m6A_site_129336
mod ID: M6ASITE003702		Click to Show/Hide the Full List
mod site	chr11:6610806-6610807:+		[9]
Sequence	TCAGAGCTTTGTCACTTGCCACATGGTGTCTCCCAACATGG
Motif Score	2.053113095
Cell/Tissue List	HEK293; hESC-HEK293T
Seq Type List	m6A-REF-seq; MAZTER-seq
Transcript ID List	ENST00000537806.5; ENST00000528995.5; ENST00000532063.5; ENST00000526318.2; ENST00000396751.6; ENST00000299421.8; ENST00000526711.5; ENST00000420936.6
External Link	RMBase: m6A_site_129338
mod ID: M6ASITE003703		Click to Show/Hide the Full List
mod site	chr11:6610869-6610870:+		[13]
Sequence	CAATAAAGTTTATTATGAAAACAGGCTGGTGTGGGGACATG
Motif Score	2.20572619
Cell/Tissue List	HEK293T; HeLa; Huh7; HEK293A-TOA
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000532063.5; ENST00000526711.5; ENST00000526318.2; ENST00000299421.8; ENST00000396751.6
External Link	RMBase: m6A_site_129341

Pseudouridine (Pseudo)

In total 1 m6A sequence/site(s) in this target gene
mod ID: PSESITE000314		Click to Show/Hide the Full List
mod site	chr11:6609580-6609581:+		[14]
Sequence	CCACCTGCTCCTCATCCTACTCTCATCACACACTGGATGCC
Transcript ID List	ENST00000396751.6; ENST00000532063.5; ENST00000420936.6; ENST00000534706.1; ENST00000526318.2; ENST00000526711.5; ENST00000530016.5; ENST00000537806.5; ENST00000528995.5; ENST00000528784.5; ENST00000299421.8
External Link	RMBase: Pseudo_site_816

Ref 1	The m1A landscape on cytosolic and mitochondrial mRNA at single-base resolution. Nature. 2017 Nov 9;551(7679):251-255. doi: 10.1038/nature24456. Epub 2017 Oct 25.
Ref 2	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 3	N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection. Cell Host Microbe. 2016 Nov 9;20(5):654-665. doi: 10.1016/j.chom.2016.09.015. Epub 2016 Oct 20.
Ref 4	Dynamics of the human and viral m(6)A RNA methylomes during HIV-1 infection of T cells. Nat Microbiol. 2016 Feb 22;1:16011. doi: 10.1038/nmicrobiol.2016.11.
Ref 5	Efficacy of MEK inhibition in patients with histiocytic neoplasms. Nature. 2019 Mar;567(7749):521-524. doi: 10.1038/s41586-019-1012-y. Epub 2019 Mar 13.
Ref 6	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 7	Histone H3 trimethylation at lysine 36 guides m(6)A RNA modification co-transcriptionally. Nature. 2019 Mar;567(7748):414-419. doi: 10.1038/s41586-019-1016-7. Epub 2019 Mar 13.
Ref 8	m(6)A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer. Nat Cell Biol. 2018 Sep;20(9):1074-1083. doi: 10.1038/s41556-018-0174-4. Epub 2018 Aug 27.
Ref 9	Single-base mapping of m(6)A by an antibody-independent method. Sci Adv. 2019 Jul 3;5(7):eaax0250. doi: 10.1126/sciadv.aax0250. eCollection 2019 Jul.
Ref 10	Dynamics of Human and Viral RNA Methylation during Zika Virus Infection. Cell Host Microbe. 2016 Nov 9;20(5):666-673. doi: 10.1016/j.chom.2016.10.002. Epub 2016 Oct 20.
Ref 11	N6-methyladenosine-dependent regulation of messenger RNA stability. Nature. 2014 Jan 2;505(7481):117-20. doi: 10.1038/nature12730. Epub 2013 Nov 27.
Ref 12	DART-seq: an antibody-free method for global m(6)A detection. Nat Methods. 2019 Dec;16(12):1275-1280. doi: 10.1038/s41592-019-0570-0. Epub 2019 Sep 23.
Ref 13	Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons. Cell. 2012 Jun 22;149(7):1635-46. doi: 10.1016/j.cell.2012.05.003. Epub 2012 May 17.
Ref 14	Chemical pulldown reveals dynamic pseudouridylation of the mammalian transcriptome. Nat Chem Biol. 2015 Aug;11(8):592-7. doi: 10.1038/nchembio.1836. Epub 2015 Jun 15.

Epigenetic Target Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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