Epigenetic Target Information

General Information of the Epigenetic Target (ID: EPITAR00506)

Target Name	Eomesodermin homolog (EOMES)
Synonyms	T-box brain protein 2; T-brain-2; TBR-2; TBR2 Click to Show/Hide
Gene Name	EOMES
Sequence	MQLGEQLLVSSVNLPGAHFYPLESARGGSGGSAGHLPSAAPSPQKLDLDKASKKFSGSLSCEAVSGEPAAASAGAPAAMLSDTDAGDAFASAAAVAKPGPPDGRKGSPCGEEELPSAAAAAAAAAAAAAATARYSMDSLSSERYYLQSPGPQGSELAAPCSLFPYQAAAGAPHGPVYPAPNGARYPYGSMLPPGGFPAAVCPPGRAQFGPGAGAGSGAGGSSGGGGGPGTYQYSQGAPLYGPYPGAAAAGSCGGLGGLGVPGSGFRAHVYLCNRPLWLKFHRHQTEMIITKQGRRMFPFLSFNINGLNPTAHYNVFVEVVLADPNHWRFQGGKWVTCGKADNNMQGNKMYVHPESPNTGSHWMRQEISFGKLKLTNNKGANNNNTQMIVLQSLHKYQPRLHIVEVTEDGVEDLNEPSKTQTFTFSETQFIAVTAYQNTDITQLKIDHNPFAKGFRDNYDSSHQIVPGGRYGVQSFFPEPFVNTLPQARYYNGERTVPQTNGLLSPQQSEEVANPPQRWLVTPVQQPGTNKLDISSYESEYTSSTLLPYGIKSLPLQTSHALGYYPDPTFPAMAGWGGRGSYQRKMAAGLPWTSRTSPTVFSEDQLSKEKVKEEIGSSWIETPPSIKSLDSNDSGVYTSACKRRRLSPSNSSNENSPSIKCEDINAEEYSKDTSKGMGGYYAFYTTP Click to Show/Hide
Function	Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex (PubMed:17353897). Required for differentiation and migration of unipolar dendritic brush cells (PubMed:33488348). Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes (PubMed:17566017). {ECO:0000269\|PubMed:17353897, ECO:0000269\|PubMed:17566017, ECO:0000269\|PubMed:33488348}. Click to Show/Hide
Gene ID	8320
HGNC ID	HGNC:3372
Ensembl Gene ID	ENSG00000163508
KEGG ID	hsa:8320
Chromosomal Location	3p24.1

RNA Modification Sequencing Data Associated with the Target (ID: EPITAR00506)

Eomesodermin homolog (EOMES)

N6-methyladenosine (m6A)

In total 20 m6A sequence/site(s) in this target gene
mod ID: M6ASITE059981		Click to Show/Hide the Full List
mod site	chr3:27717024-27717025:-		[1]
Sequence	AGCTAACTTTTTGCAGATGGACTTGGTGGTGTTTTTTGTTG
Motif Score	4.065041667
Cell/Tissue List	HEK293T; GM12878
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000449599.3; ENST00000295743.8; ENST00000461503.2
External Link	RMBase: m6A_site_581042
mod ID: M6ASITE059982		Click to Show/Hide the Full List
mod site	chr3:27717118-27717119:-		[2]
Sequence	TGCTGAAGAGTATAGTAAAGACACCTCAAAAGGCATGGGAG
Motif Score	2.897386905
Cell/Tissue List	HEK293T; GM12878; CD8T; endometrial
Seq Type List	MeRIP-seq; m6A-seq; m6A-CLIP/IP
Transcript ID List	ENST00000461503.2; ENST00000295743.8; ENST00000449599.3
External Link	RMBase: m6A_site_581043
mod ID: M6ASITE059983		Click to Show/Hide the Full List
mod site	chr3:27717145-27717146:-		[2]
Sequence	ACCCTCCATAAAGTGTGAGGACATTAATGCTGAAGAGTATA
Motif Score	3.643047619
Cell/Tissue List	HEK293T; GM12878; CD8T; endometrial
Seq Type List	MeRIP-seq; m6A-seq; m6A-CLIP/IP
Transcript ID List	ENST00000449599.3; ENST00000295743.8; ENST00000461503.2
External Link	RMBase: m6A_site_581044
mod ID: M6ASITE059984		Click to Show/Hide the Full List
mod site	chr3:27717269-27717270:-		[3]
Sequence	TTGGCTCTTCTTGGATAGAGACACCCCCTTCCATCAAATCT
Motif Score	2.897386905
Cell/Tissue List	HepG2; HEK293T; A549; H1A; H1B; GM12878; CD4T; HEK293A-TOA; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000461503.2; ENST00000295743.8; ENST00000449599.3
External Link	RMBase: m6A_site_581045
mod ID: M6ASITE059985		Click to Show/Hide the Full List
mod site	chr3:27717347-27717348:-		[4]
Sequence	GACTACCATGGACCTCCAGAACAAGCCCCACTGTGTTCTCT
Motif Score	2.951386905
Cell/Tissue List	HEK293T; A549; H1A; H1B; GM12878; CD4T; HEK293A-TOA; endometrial
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000461503.2; ENST00000449599.3; ENST00000295743.8
External Link	RMBase: m6A_site_581046
mod ID: M6ASITE059986		Click to Show/Hide the Full List
mod site	chr3:27717356-27717357:-		[4]
Sequence	TGGCAGCTGGACTACCATGGACCTCCAGAACAAGCCCCACT
Motif Score	3.622404762
Cell/Tissue List	HEK293T; A549; H1A; H1B; GM12878; HEK293A-TOA
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000449599.3; ENST00000295743.8; ENST00000461503.2
External Link	RMBase: m6A_site_581047
mod ID: M6ASITE059987		Click to Show/Hide the Full List
mod site	chr3:27717366-27717367:-		[4]
Sequence	CAGAGGAAGATGGCAGCTGGACTACCATGGACCTCCAGAAC
Motif Score	4.065041667
Cell/Tissue List	HEK293T; A549; H1A; H1B; GM12878; LCLs; HEK293A-TOA
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000295743.8; ENST00000461503.2; ENST00000449599.3
External Link	RMBase: m6A_site_581048
mod ID: M6ASITE059988		Click to Show/Hide the Full List
mod site	chr3:27717433-27717434:-		[4]
Sequence	TGCCCTGGGGTATTACCCAGACCCAACCTTTCCTGCAATGG
Motif Score	2.876744048
Cell/Tissue List	HEK293T; A549; HepG2; H1A; H1B; GM12878; LCLs; HEK293A-TOA
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000449599.3; ENST00000461503.2; ENST00000295743.8
External Link	RMBase: m6A_site_581049
mod ID: M6ASITE059989		Click to Show/Hide the Full List
mod site	chr3:27717461-27717462:-		[4]
Sequence	TTAAATCCTTGCCCCTTCAGACATCCCATGCCCTGGGGTAT
Motif Score	2.897386905
Cell/Tissue List	HEK293T; A549; H1A; H1B; GM12878; LCLs; HEK293A-TOA
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000461503.2; ENST00000449599.3; ENST00000295743.8
External Link	RMBase: m6A_site_581050
mod ID: M6ASITE059990		Click to Show/Hide the Full List
mod site	chr3:27717535-27717536:-		[5]
Sequence	ACCTGGGACCAACAAACTAGACATCAGTTCCTATGAATCTG
Motif Score	2.897386905
Cell/Tissue List	HeLa; HEK293T; H1A; H1B; GM12878; CD8T
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000449599.3; ENST00000461503.2; ENST00000295743.8
External Link	RMBase: m6A_site_581051
mod ID: M6ASITE059991		Click to Show/Hide the Full List
mod site	chr3:27717540-27717541:-		[5]
Sequence	CAGCAACCTGGGACCAACAAACTAGACATCAGTTCCTATGA
Motif Score	2.627720238
Cell/Tissue List	HeLa; HEK293T; H1A; H1B; GM12878
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000295743.8; ENST00000461503.2; ENST00000449599.3
External Link	RMBase: m6A_site_581052
mod ID: M6ASITE059992		Click to Show/Hide the Full List
mod site	chr3:27717548-27717549:-		[5]
Sequence	CGCCTGTCCAGCAACCTGGGACCAACAAACTAGACATCAGT
Motif Score	3.622404762
Cell/Tissue List	HeLa; HEK293T; H1A; H1B; GM12878; CD8T
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000295743.8; ENST00000461503.2; ENST00000449599.3
External Link	RMBase: m6A_site_581053
mod ID: M6ASITE059993		Click to Show/Hide the Full List
mod site	chr3:27717635-27717636:-		[6]
Sequence	GCGAGAGAACCGTGCCACAGACCAACGGCCTCCTTTCACCC
Motif Score	2.876744048
Cell/Tissue List	HEK293T; H1A; GM12878
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000449599.3; ENST00000461503.2; ENST00000295743.8
External Link	RMBase: m6A_site_581054
mod ID: M6ASITE059994		Click to Show/Hide the Full List
mod site	chr3:27717647-27717648:-		[6]
Sequence	GCTATTATAATGGCGAGAGAACCGTGCCACAGACCAACGGC
Motif Score	2.930744048
Cell/Tissue List	HEK293T; H1A; GM12878
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000461503.2; ENST00000295743.8; ENST00000449599.3
External Link	RMBase: m6A_site_581055
mod ID: M6ASITE059995		Click to Show/Hide the Full List
mod site	chr3:27721441-27721442:-		[6]
Sequence	TCAAATTCCACCGCCACCAAACTGAGATGATCATTACGAAA
Motif Score	2.627720238
Cell/Tissue List	H1B
Seq Type List	m6A-seq
Transcript ID List	ENST00000449599.3; ENST00000461503.2; ENST00000295743.8
External Link	RMBase: m6A_site_581056
mod ID: M6ASITE059996		Click to Show/Hide the Full List
mod site	chr3:27721532-27721533:-		[6]
Sequence	GCGGCGGGATCTTGCGGAGGACTGGGGGGCCTGGGGGTTCC
Motif Score	4.065041667
Cell/Tissue List	H1B
Seq Type List	m6A-seq
Transcript ID List	ENST00000295743.8; ENST00000449599.3; ENST00000461503.2
External Link	RMBase: m6A_site_581057
mod ID: M6ASITE059997		Click to Show/Hide the Full List
mod site	chr3:27721772-27721773:-		[6]
Sequence	GCGGCTGGGGCGCCCCACGGACCTGTGTACCCGGCTCCTAA
Motif Score	3.622404762
Cell/Tissue List	H1A; H1B
Seq Type List	m6A-seq
Transcript ID List	ENST00000295743.8; ENST00000449599.3; ENST00000461503.2
External Link	RMBase: m6A_site_581058
mod ID: M6ASITE059998		Click to Show/Hide the Full List
mod site	chr3:27721884-27721885:-		[6]
Sequence	CACTGCGCGCTACTCCATGGACAGCCTGAGCTCCGAGCGGT
Motif Score	3.643047619
Cell/Tissue List	H1A; H1B
Seq Type List	m6A-seq
Transcript ID List	ENST00000295743.8; ENST00000461503.2; ENST00000449599.3
External Link	RMBase: m6A_site_581059
mod ID: M6ASITE059999		Click to Show/Hide the Full List
mod site	chr3:27722148-27722149:-		[6]
Sequence	TCCTCAGAAGTTGGACTTAGACAAAGCGTCCAAGAAGTTTT
Motif Score	2.897386905
Cell/Tissue List	H1B
Seq Type List	m6A-seq
Transcript ID List	ENST00000461503.2; ENST00000449599.3; ENST00000295743.8
External Link	RMBase: m6A_site_581060
mod ID: M6ASITE060000		Click to Show/Hide the Full List
mod site	chr3:27722154-27722155:-		[6]
Sequence	CCCCTCTCCTCAGAAGTTGGACTTAGACAAAGCGTCCAAGA
Motif Score	4.065041667
Cell/Tissue List	H1B
Seq Type List	m6A-seq
Transcript ID List	ENST00000461503.2; ENST00000449599.3; ENST00000295743.8
External Link	RMBase: m6A_site_581061

Ref 1	Structure and thermodynamics of N6-methyladenosine in RNA: a spring-loaded base modification. J Am Chem Soc. 2015 Feb 11;137(5):2107-15. doi: 10.1021/ja513080v. Epub 2015 Feb 2.
Ref 2	Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons. Cell. 2012 Jun 22;149(7):1635-46. doi: 10.1016/j.cell.2012.05.003. Epub 2012 May 17.
Ref 3	Histone H3 trimethylation at lysine 36 guides m(6)A RNA modification co-transcriptionally. Nature. 2019 Mar;567(7748):414-419. doi: 10.1038/s41586-019-1016-7. Epub 2019 Mar 13.
Ref 4	Viral N(6)-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus. Nat Commun. 2019 Oct 9;10(1):4595. doi: 10.1038/s41467-019-12504-y.
Ref 5	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 6	m(6)A RNA modification controls cell fate transition in mammalian embryonic stem cells. Cell Stem Cell. 2014 Dec 4;15(6):707-19. doi: 10.1016/j.stem.2014.09.019. Epub 2014 Oct 16.

Epigenetic Target Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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