Epigenetic Target Information

General Information of the Epigenetic Target (ID: EPITAR00504)
Target Name Cyclin-dependent kinase 3 (CDK3)
Synonyms
EC 2.7.11.22; Cell division protein kinase 3
    Click to Show/Hide
Gene Name CDK3
Sequence
MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKHPNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFSSPEPSPAARQYVLQRFRH
    Click to Show/Hide
Family Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily
Function
Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner.
    Click to Show/Hide
Gene ID 1018
HGNC ID HGNC:1772
Ensembl Gene ID ENSG00000250506
KEGG ID hsa:1018
Chromosomal Location 17q25.1
RNA Modification Sequencing Data Associated with the Target (ID: EPITAR00504)
Cyclin-dependent kinase 3 (CDK3)
5-methylcytidine (m5C)
In total 1 m6A sequence/site(s) in this target gene
mod ID: M5CSITE001281 Click to Show/Hide the Full List
mod site chr17:76001454-76001455:+
Sequence TTCCAGAAGGTAGAGAAGATCGGAGAGGGCACCTATGGGGT
Cell/Tissue List spleen
Seq Type List Bisulfite-seq
Transcript ID List ENST00000425876.6; ENST00000448471.2; ENST00000567351.5; ENST00000649294.1; ENST00000588812.5; ENST00000569284.1
External Link RMBase: m5C_site_19937
N6-methyladenosine (m6A)
In total 10 m6A sequence/site(s) in this target gene
mod ID: M6ASITE035438 Click to Show/Hide the Full List
mod site chr17:76000941-76000942:+ [1]
Sequence ATGTGTACCCAGAGCCTGGGACTGGCTGGGCTGGGCAGTGA
Motif Score 4.065041667
Cell/Tissue List HeLa; HepG2; HEK293T; H1A; H1B; hESCs; GM12878; A549; MM6; CD4T; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; NB4
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000649294.1; ENST00000569284.1; ENST00000448471.2; ENST00000567351.5; ENST00000588812.5
External Link RMBase: m6A_site_383147
mod ID: M6ASITE035439 Click to Show/Hide the Full List
mod site chr17:76001164-76001165:+ [1]
Sequence AGCCTGGGGGTCCTGGCTGAACTGGGCTGGGTGAAGGGGGC
Motif Score 3.373380952
Cell/Tissue List HeLa; CD34
Seq Type List m6A-seq
Transcript ID List ENST00000448471.2; ENST00000649294.1; ENST00000567351.5; ENST00000588812.5; ENST00000569284.1
External Link RMBase: m6A_site_383148
mod ID: M6ASITE035440 Click to Show/Hide the Full List
mod site chr17:76001492-76001493:+ [1]
Sequence GGTGGTGTACAAGGCCAAGAACAGGGAGACAGGGCAGCTGG
Motif Score 2.951386905
Cell/Tissue List HeLa; HepG2; A549; Huh7
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000448471.2; ENST00000569284.1; ENST00000567351.5; ENST00000588812.5; ENST00000425876.6; ENST00000649294.1
External Link RMBase: m6A_site_383149
mod ID: M6ASITE035441 Click to Show/Hide the Full List
mod site chr17:76001500-76001501:+ [1]
Sequence ACAAGGCCAAGAACAGGGAGACAGGGCAGCTGGTGGCCCTG
Motif Score 2.897386905
Cell/Tissue List HeLa; HepG2; A549; Huh7
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000649294.1; ENST00000425876.6; ENST00000567351.5; ENST00000448471.2; ENST00000569284.1; ENST00000588812.5
External Link RMBase: m6A_site_383150
mod ID: M6ASITE035442 Click to Show/Hide the Full List
mod site chr17:76001532-76001533:+ [1]
Sequence GTGGCCCTGAAGAAGATCAGACTGGATTTGTGAGTGCTGGG
Motif Score 3.319380952
Cell/Tissue List HeLa; HepG2; A549; Huh7; endometrial
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000588812.5; ENST00000448471.2; ENST00000567351.5; ENST00000425876.6; ENST00000569284.1; ENST00000649294.1
External Link RMBase: m6A_site_383151
mod ID: M6ASITE035443 Click to Show/Hide the Full List
mod site chr17:76001927-76001928:+ [1]
Sequence GAGATCTCGCTGCTCAAGGAACTGAAGCACCCCAACATCGT
Motif Score 3.373380952
Cell/Tissue List HeLa; endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000649294.1; ENST00000569284.1; ENST00000586261.2; ENST00000448471.2; ENST00000588812.5; ENST00000425876.6; ENST00000567351.5
External Link RMBase: m6A_site_383152
mod ID: M6ASITE035444 Click to Show/Hide the Full List
mod site chr17:76002725-76002726:+ [1]
Sequence TAAAGAGTGTTTGGGGCTGGACATGGCTCACGCCCGTAATC
Motif Score 3.643047619
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000425876.6; ENST00000448471.2; ENST00000649294.1; ENST00000567351.5; ENST00000586261.2; ENST00000569284.1
External Link RMBase: m6A_site_383153
mod ID: M6ASITE035445 Click to Show/Hide the Full List
mod site chr17:76003387-76003388:+ [2]
Sequence TCTGGAGCCAGAGGGCAGGGACCTGCTCATGGTAGGTGCAT
Motif Score 3.622404762
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000569284.1; ENST00000448471.2; ENST00000649294.1; ENST00000567351.5; ENST00000425876.6
External Link RMBase: m6A_site_383154
mod ID: M6ASITE035446 Click to Show/Hide the Full List
mod site chr17:76005339-76005340:+ [2]
Sequence GCCAGCGGATCACAGCCAAGACTGCCCTGGCCCACCCGTAC
Motif Score 3.319380952
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000425876.6; ENST00000569284.1; ENST00000448471.2; ENST00000567351.5; ENST00000649294.1
External Link RMBase: m6A_site_383157
mod ID: M6ASITE035447 Click to Show/Hide the Full List
mod site chr17:76005844-76005845:+ [1]
Sequence CCAGTTCAGTCCCAAGTTAAACAGGAGGGAGTGAGGGAGAG
Motif Score 2.20572619
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000649294.1; ENST00000448471.2; ENST00000425876.6; ENST00000569284.1; ENST00000567351.5
External Link RMBase: m6A_site_383158