Epigenetic Target Information

General Information of the Epigenetic Target (ID: EPITAR00501)
Target Name A disintegrin and metalloproteinase with thrombospondin motifs 8 (ADAMTS8)
Synonyms
ADAM-TS 8; ADAM-TS8; ADAMTS-8; EC 3.4.24.-; METH-2; METH-8; METH2
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Gene Name ADAMTS8
Sequence
MLPAPAAPRWPPLLLLLLLLLPLARGAPARPAAGGQASELVVPTRLPGSAGELALHLSAFGKGFVLRLAPDDSFLAPEFKIERLGGSGRATGGERGLRGCFFSGTVNGEPESLAAVSLCRGLSGSFLLDGEEFTIQPQGAGGSLAQPHRLQRWGPAGARPLPRGPEWEVETGEGQRQERGDHQEDSEEESQEEEAEGASEPPPPLGATSRTKRFVSEARFVETLLVADASMAAFYGADLQNHILTLMSVAARIYKHPSIKNSINLMVVKVLIVEDEKWGPEVSDNGGLTLRNFCNWQRRFNQPSDRHPEHYDTAILLTRQNFCGQEGLCDTLGVADIGTICDPNKSCSVIEDEGLQAAHTLAHELGHVLSMPHDDSKPCTRLFGPMGKHHVMAPLFVHLNQTLPWSPCSAMYLTELLDGGHGDCLLDAPAAALPLPTGLPGRMALYQLDQQCRQIFGPDFRHCPNTSAQDVCAQLWCHTDGAEPLCHTKNGSLPWADGTPCGPGHLCSEGSCLPEEEVERPKPVADGGWAPWGPWGECSRTCGGGVQFSHRECKDPEPQNGGRYCLGRRAKYQSCHTEECPPDGKSFREQQCEKYNAYNYTDMDGNLLQWVPKYAGVSPRDRCKLFCRARGRSEFKVFEAKVIDGTLCGPETLAICVRGQCVKAGCDHVVDSPRKLDKCGVCGGKGNSCRKVSGSLTPTNYGYNDIVTIPAGATNIDVKQRSHPGVQNDGNYLALKTADGQYLLNGNLAISAIEQDILVKGTILKYSGSIATLERLQSFRPLPEPLTVQLLTVPGEVFPPKVKYTFFVPNDVDFSMQSSKERATTNIIQPLLHAQWVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPCESQLCPL
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Function
Has anti-angiogenic properties.
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Gene ID 11095
HGNC ID HGNC:224
Ensembl Gene ID ENSG00000134917
KEGG ID hsa:11095
Chromosomal Location 11q24.3
RNA Modification Sequencing Data Associated with the Target (ID: EPITAR00501)
A disintegrin and metalloproteinase with thrombospondin motifs 8 (ADAMTS8)
Adenosine-to-Inosine editing (A-to-I)
In total 1 m6A sequence/site(s) in this target gene
mod ID: A2ISITE005306 Click to Show/Hide the Full List
mod site chr11:130426264-130426265:- [1]
Sequence ATCACTGGGAAAGGCAGGGTAGGAAAGACCCAGGGAGAAAC
Transcript ID List ENST00000257359.7
External Link RMBase: RNA-editing_site_26094
N6-methyladenosine (m6A)
In total 23 m6A sequence/site(s) in this target gene
mod ID: M6ASITE009644 Click to Show/Hide the Full List
mod site chr11:130405232-130405233:- [2]
Sequence TGTTTGCAAAGGACTAGCAAACTTAAATGAAAAAAAAAATT
Motif Score 2.627720238
Cell/Tissue List H1B; hESCs; fibroblasts; HEK293A-TOA
Seq Type List m6A-seq
Transcript ID List ENST00000257359.7; ENST00000531752.1
External Link RMBase: m6A_site_170568
mod ID: M6ASITE009645 Click to Show/Hide the Full List
mod site chr11:130405240-130405241:- [2]
Sequence CGTCAGTCTGTTTGCAAAGGACTAGCAAACTTAAATGAAAA
Motif Score 4.065041667
Cell/Tissue List H1B; hESCs; fibroblasts; HEK293A-TOA
Seq Type List m6A-seq
Transcript ID List ENST00000257359.7; ENST00000531752.1
External Link RMBase: m6A_site_170569
mod ID: M6ASITE009646 Click to Show/Hide the Full List
mod site chr11:130405268-130405269:- [2]
Sequence CACTTATTGACTCAGACAGGACACTCAGCGTCAGTCTGTTT
Motif Score 3.643047619
Cell/Tissue List H1B; hESCs; fibroblasts; HEK293A-TOA
Seq Type List m6A-seq
Transcript ID List ENST00000531752.1; ENST00000257359.7
External Link RMBase: m6A_site_170570
mod ID: M6ASITE009647 Click to Show/Hide the Full List
mod site chr11:130405273-130405274:- [2]
Sequence AAGTGCACTTATTGACTCAGACAGGACACTCAGCGTCAGTC
Motif Score 2.897386905
Cell/Tissue List H1B; hESCs; fibroblasts; HEK293A-TOA
Seq Type List m6A-seq
Transcript ID List ENST00000531752.1; ENST00000257359.7
External Link RMBase: m6A_site_170571
mod ID: M6ASITE009648 Click to Show/Hide the Full List
mod site chr11:130405335-130405336:- [2]
Sequence TCAACTGTCCAGTGGACTGGACCTTGCTCGGGTTCAAGTAG
Motif Score 3.622404762
Cell/Tissue List H1A; H1B; hESCs; fibroblasts; HEK293A-TOA
Seq Type List m6A-seq
Transcript ID List ENST00000531752.1; ENST00000257359.7
External Link RMBase: m6A_site_170572
mod ID: M6ASITE009649 Click to Show/Hide the Full List
mod site chr11:130405340-130405341:- [2]
Sequence TATCATCAACTGTCCAGTGGACTGGACCTTGCTCGGGTTCA
Motif Score 4.065041667
Cell/Tissue List H1A; H1B; hESCs; HEK293A-TOA
Seq Type List m6A-seq
Transcript ID List ENST00000257359.7; ENST00000531752.1
External Link RMBase: m6A_site_170573
mod ID: M6ASITE009650 Click to Show/Hide the Full List
mod site chr11:130405364-130405365:- [2]
Sequence GAGAGGGTATGGGGCGGCAGACCCTATCATCAACTGTCCAG
Motif Score 2.876744048
Cell/Tissue List H1A; H1B; hESCs; HEK293A-TOA
Seq Type List m6A-seq
Transcript ID List ENST00000531752.1; ENST00000257359.7
External Link RMBase: m6A_site_170574
mod ID: M6ASITE009651 Click to Show/Hide the Full List
mod site chr11:130405501-130405502:- [2]
Sequence CATGCGGTACTGAGGTGCAGACAAGGGTCTCCACTGTGGTG
Motif Score 2.897386905
Cell/Tissue List H1A; H1B; hESCs; HEK293A-TOA; endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000257359.7; ENST00000531752.1
External Link RMBase: m6A_site_170575
mod ID: M6ASITE009652 Click to Show/Hide the Full List
mod site chr11:130405522-130405523:- [3]
Sequence GGCCAGTCTTGTGCTCCTGGACATGCGGTACTGAGGTGCAG
Motif Score 3.643047619
Cell/Tissue List brain; H1A; H1B; hESCs; HEK293A-TOA; endometrial
Seq Type List m6A-REF-seq; m6A-seq
Transcript ID List ENST00000257359.7; ENST00000531752.1
External Link RMBase: m6A_site_170576
mod ID: M6ASITE009653 Click to Show/Hide the Full List
mod site chr11:130405602-130405603:- [2]
Sequence ACCTGCAACAAGGCTCTGAAACCCGAGGATGCCAAGCCCTG
Motif Score 2.185083333
Cell/Tissue List H1A; H1B; hESCs; HEK293T; HEK293A-TOA; iSLK; endometrial
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000531752.1; ENST00000257359.7
External Link RMBase: m6A_site_170577
mod ID: M6ASITE009654 Click to Show/Hide the Full List
mod site chr11:130405645-130405646:- [2]
Sequence GCGAACTGTAGAGTGCAGGGACCCCTCCGGCCAGGCCTCTG
Motif Score 3.622404762
Cell/Tissue List H1A; H1B; hESCs; HEK293A-TOA; iSLK; endometrial
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000257359.7; ENST00000531752.1
External Link RMBase: m6A_site_170578
mod ID: M6ASITE009655 Click to Show/Hide the Full List
mod site chr11:130405661-130405662:- [2]
Sequence GGGCCGGCTGGCAGAGGCGAACTGTAGAGTGCAGGGACCCC
Motif Score 3.373380952
Cell/Tissue List H1A; H1B; hESCs; HEK293A-TOA; iSLK; endometrial
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000257359.7; ENST00000531752.1
External Link RMBase: m6A_site_170579
mod ID: M6ASITE009656 Click to Show/Hide the Full List
mod site chr11:130405708-130405709:- [2]
Sequence CGCACAGTGGGTGCTGGGGGACTGGTCTGAGTGCTCTAGCA
Motif Score 4.065041667
Cell/Tissue List H1A; H1B; hESCs; fibroblasts; HEK293A-TOA; iSLK; endometrial
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000257359.7; ENST00000531752.1
External Link RMBase: m6A_site_170580
mod ID: M6ASITE009657 Click to Show/Hide the Full List
mod site chr11:130405789-130405790:- [2]
Sequence CTTTGTTCCTAATGACGTGGACTTTAGCATGCAGAGCAGCA
Motif Score 4.065041667
Cell/Tissue List H1A; H1B; hESCs; fibroblasts; HEK293A-TOA; endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000531752.1; ENST00000257359.7
External Link RMBase: m6A_site_170581
mod ID: M6ASITE009658 Click to Show/Hide the Full List
mod site chr11:130405943-130405944:- [4]
Sequence AGGACATCTTGGTGAAGGGGACCATCCTGAAGTACAGCGGC
Motif Score 3.622404762
Cell/Tissue List hESCs; HEK293A-TOA
Seq Type List m6A-seq
Transcript ID List ENST00000531752.1; ENST00000257359.7
External Link RMBase: m6A_site_170582
mod ID: M6ASITE009659 Click to Show/Hide the Full List
mod site chr11:130405960-130405961:- [4]
Sequence CATCTCTGCCATAGAGCAGGACATCTTGGTGAAGGGGACCA
Motif Score 3.643047619
Cell/Tissue List hESCs; HEK293A-TOA
Seq Type List m6A-seq
Transcript ID List ENST00000257359.7; ENST00000531752.1
External Link RMBase: m6A_site_170583
mod ID: M6ASITE009660 Click to Show/Hide the Full List
mod site chr11:130411502-130411503:- [5]
Sequence TTCACACCGTGAGTGCAAGGACCCCGAGCCTCAGAATGGAG
Motif Score 3.622404762
Cell/Tissue List endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000531752.1; ENST00000257359.7
External Link RMBase: m6A_site_170584
mod ID: M6ASITE009661 Click to Show/Hide the Full List
mod site chr11:130411545-130411546:- [5]
Sequence CCTGGGGAGAATGTTCTCGGACCTGTGGAGGAGGAGTACAG
Motif Score 3.622404762
Cell/Tissue List endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000531752.1; ENST00000257359.7
External Link RMBase: m6A_site_170585
mod ID: M6ASITE009662 Click to Show/Hide the Full List
mod site chr11:130411567-130411568:- [5]
Sequence GGAGGCTGGGCACCGTGGGGACCCTGGGGAGAATGTTCTCG
Motif Score 3.622404762
Cell/Tissue List endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000257359.7; ENST00000531752.1
External Link RMBase: m6A_site_170586
mod ID: M6ASITE009663 Click to Show/Hide the Full List
mod site chr11:130427655-130427656:- [2]
Sequence CCCTGGGGGCCACGAGTAGGACCAAGCGGTTTGTGTCTGAG
Motif Score 3.622404762
Cell/Tissue List H1A; H1B; HEK293T; HEK293A-TOA; endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000257359.7
External Link RMBase: m6A_site_170587
mod ID: M6ASITE009664 Click to Show/Hide the Full List
mod site chr11:130427732-130427733:- [2]
Sequence GAGAGGAGACCACCAGGAGGACAGCGAGGAGGAGAGCCAAG
Motif Score 3.643047619
Cell/Tissue List H1A; H1B; hESCs; GSC-11; HEK293T; HEK293A-TOA; endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000257359.7
External Link RMBase: m6A_site_170588
mod ID: M6ASITE009665 Click to Show/Hide the Full List
mod site chr11:130427744-130427745:- [2]
Sequence TCAGAGGCAGGAGAGAGGAGACCACCAGGAGGACAGCGAGG
Motif Score 2.876744048
Cell/Tissue List H1A; H1B; hESCs; GSC-11; HEK293T; HEK293A-TOA; endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000257359.7
External Link RMBase: m6A_site_170589
mod ID: M6ASITE009666 Click to Show/Hide the Full List
mod site chr11:130427794-130427795:- [2]
Sequence GCCCGCCCCCTCCCGCGAGGACCCGAGTGGGAGGTGGAGAC
Motif Score 3.622404762
Cell/Tissue List H1A; H1B; hESCs; GSC-11; HEK293T; HEK293A-TOA; endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000257359.7
External Link RMBase: m6A_site_170590