Epigenetic Target Information

General Information of the Epigenetic Target (ID: EPITAR00498)

Target Name	Bone morphogenetic protein receptor type 1A (BMPR1A)
Synonyms	ALK3; CD292; ACVRLK3; bone morphogenetic protein receptor, type IA Click to Show/Hide
Gene Name	BMPR1A
Sequence	MPQLYIYIRLLGAYLFIISRVQGQNLDSMLHGTGMKSDSDQKKSENGVTLAPEDTLPFLKCYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCKDSPKAQLRRTIECCRTNLCNQYLQPTLPPVVIGPFFDGSIRWLVLLISMAVCIIAMIIFSSCFCYKHYCKSISSRRRYNRDLEQDEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEVLDESLNKNHFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREVVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTLAKMVESQDVKI Click to Show/Hide
Family	Protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily
Function	On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6. May promote the expression of HAMP, potentially via its interaction with BMP2 (By similarity). Click to Show/Hide
Gene ID	657
HGNC ID	HGNC:1076
Ensembl Gene ID	ENSG00000107779
KEGG ID	hsa:657
Chromosomal Location	10q23.2

RNA Modification Sequencing Data Associated with the Target (ID: EPITAR00498)

Bone morphogenetic protein receptor type 1A (BMPR1A)

Adenosine-to-Inosine editing (A-to-I)

In total 9 m6A sequence/site(s) in this target gene
mod ID: A2ISITE004300		Click to Show/Hide the Full List
mod site	chr10:86764949-86764950:+		[1]
Sequence	AAAACTGATTTTGGCCGGGCATGGTGGCTCATGCCTGTAAT
Transcript ID List	rmsk_3370380; ENST00000372037.7; ENST00000638429.1
External Link	RMBase: RNA-editing_site_17259
mod ID: A2ISITE004301		Click to Show/Hide the Full List
mod site	chr10:86765362-86765363:+		[1]
Sequence	GGGTGTGGTGGCACGCCTGTAATCCCAGGTACTCAGGAGGC
Transcript ID List	ENST00000372037.7; ENST00000638429.1; rmsk_3370382
External Link	RMBase: RNA-editing_site_17260
mod ID: A2ISITE004302		Click to Show/Hide the Full List
mod site	chr10:86774059-86774060:+		[1]
Sequence	AGGGTTTCACCATAATGGCCAGGCTGGTCTCAAACTCCTGA
Transcript ID List	ENST00000638429.1; ENST00000372037.7
External Link	RMBase: RNA-editing_site_17261
mod ID: A2ISITE004303		Click to Show/Hide the Full List
mod site	chr10:86859580-86859581:+		[2]
Sequence	TGTAATCCCAGCACTTTGGAAGGCTGAGGCAGGTGGATCAC
Transcript ID List	ENST00000480152.2; ENST00000638429.1; ENST00000635816.1; rmsk_3370621; ENST00000372037.7; ENST00000636056.1
External Link	RMBase: RNA-editing_site_17262
mod ID: A2ISITE004304		Click to Show/Hide the Full List
mod site	chr10:86859590-86859591:+		[2]
Sequence	GCACTTTGGAAGGCTGAGGCAGGTGGATCACCTGAGGTCAG
Transcript ID List	rmsk_3370621; ENST00000636056.1; ENST00000635816.1; ENST00000480152.2; ENST00000638429.1; ENST00000372037.7
External Link	RMBase: RNA-editing_site_17263
mod ID: A2ISITE004305		Click to Show/Hide the Full List
mod site	chr10:86859599-86859600:+		[2]
Sequence	AAGGCTGAGGCAGGTGGATCACCTGAGGTCAGGAGTTCGAG
Transcript ID List	ENST00000372037.7; ENST00000635816.1; ENST00000636056.1; ENST00000480152.2; rmsk_3370621; ENST00000638429.1
External Link	RMBase: RNA-editing_site_17264
mod ID: A2ISITE004306		Click to Show/Hide the Full List
mod site	chr10:86859609-86859610:+		[2]
Sequence	CAGGTGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGG
Transcript ID List	ENST00000638429.1; ENST00000372037.7; rmsk_3370621; ENST00000635816.1; ENST00000636056.1; ENST00000480152.2
External Link	RMBase: RNA-editing_site_17265
mod ID: A2ISITE004307		Click to Show/Hide the Full List
mod site	chr10:86872891-86872892:+		[1]
Sequence	CCAGGATTACAGCTGAGATTACAGGCGGTCACCACCACAGT
Transcript ID List	ENST00000635816.1; ENST00000372037.7; ENST00000638429.1; ENST00000480152.2; ENST00000636056.1
External Link	RMBase: RNA-editing_site_17266
mod ID: A2ISITE004308		Click to Show/Hide the Full List
mod site	chr10:86926498-86926499:+		[3]
Sequence	CACTGCACTCCAGCCTGGGCAAAAGAGCGAAACTCCATCTC
Transcript ID List	ENST00000638429.1; ENST00000372037.7; rmsk_3370768; ENST00000635816.1; ENST00000636056.1
External Link	RMBase: RNA-editing_site_17267

5-methylcytidine (m5C)

In total 2 m6A sequence/site(s) in this target gene
mod ID: M5CSITE004725		Click to Show/Hide the Full List
mod site	chr10:86838925-86838926:+
Sequence	CATGAGATGGAAGCATAGGTCAAAGCTGTTTGGAGAAAATC
Cell/Tissue List	spleen
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000638429.1; ENST00000635816.1; ENST00000372037.7; ENST00000636056.1
External Link	RMBase: m5C_site_5595
mod ID: M5CSITE004726		Click to Show/Hide the Full List
mod site	chr10:86921645-86921646:+		[4]
Sequence	TACATCATGGCTGACATCTACAGCTTCGGCCTAATCATTTG
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000636056.1; ENST00000372037.7; ENST00000635816.1; ENST00000638429.1
External Link	RMBase: m5C_site_5596

N6-methyladenosine (m6A)

In total 53 m6A sequence/site(s) in this target gene
mod ID: M6ASITE001090		Click to Show/Hide the Full List
mod site	chr10:86838864-86838865:+		[5]
Sequence	TTCTTTTTTTTTCTAAACAGACTTATGAAAATATGCATCAG
Motif Score	3.319380952
Cell/Tissue List	GSC-11; HEK293T
Seq Type List	m6A-seq
Transcript ID List	ENST00000638429.1; ENST00000372037.7; ENST00000636056.1; ENST00000635816.1
External Link	RMBase: m6A_site_108755
mod ID: M6ASITE001091		Click to Show/Hide the Full List
mod site	chr10:86838968-86838969:+		[6]
Sequence	AAGTACAGTTTTATCTAGCCACATCTTGGAGGTAAGGAAAA
Motif Score	2.053113095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000372037.7; ENST00000638429.1; ENST00000480152.2; ENST00000636056.1; ENST00000635816.1
External Link	RMBase: m6A_site_108756
mod ID: M6ASITE001092		Click to Show/Hide the Full List
mod site	chr10:86843431-86843432:+		[7]
Sequence	ACTTTTTTGGTCCCTATTAAACTATGTGGCAGCAAGTCACA
Motif Score	2.627720238
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000636056.1; ENST00000372037.7; ENST00000480152.2; ENST00000635816.1; ENST00000638429.1
External Link	RMBase: m6A_site_108757
mod ID: M6ASITE001093		Click to Show/Hide the Full List
mod site	chr10:86875921-86875922:+		[6]
Sequence	TCAAGTGCTTGCGATCTTTTACAAGAAAATCTCACTGAATG
Motif Score	2.07285119
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000635816.1; ENST00000480152.2; ENST00000372037.7; ENST00000638429.1; ENST00000636056.1
External Link	RMBase: m6A_site_108758
mod ID: M6ASITE001094		Click to Show/Hide the Full List
mod site	chr10:86890106-86890107:+		[7]
Sequence	TGGCACTGGGATGAAATCAGACTCCGACCAGAAAAAGTCAG
Motif Score	3.319380952
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000480152.2; ENST00000638429.1; ENST00000635816.1; ENST00000372037.7; ENST00000636056.1
External Link	RMBase: m6A_site_108759
mod ID: M6ASITE001095		Click to Show/Hide the Full List
mod site	chr10:86890214-86890215:+		[6]
Sequence	TCCAGATGATGCTATTAATAACACATGCATGTAAGTATTTT
Motif Score	2.168095238
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000638429.1; ENST00000636056.1; ENST00000372037.7; ENST00000635816.1
External Link	RMBase: m6A_site_108760
mod ID: M6ASITE001096		Click to Show/Hide the Full List
mod site	chr10:86892135-86892136:+		[6]
Sequence	TTCTGTTTTAGAACTAATGGACATTGCTTTGCCATCATAGA
Motif Score	3.643047619
Cell/Tissue List	hESC-HEK293T; MT4
Seq Type List	MAZTER-seq; MeRIP-seq
Transcript ID List	ENST00000636056.1; ENST00000372037.7; ENST00000635816.1; ENST00000638429.1
External Link	RMBase: m6A_site_108761
mod ID: M6ASITE001097		Click to Show/Hide the Full List
mod site	chr10:86892175-86892176:+		[8]
Sequence	AAGAAGATGACCAGGGAGAAACCACATTAGCTTCAGGGTGT
Motif Score	2.185083333
Cell/Tissue List	MT4
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000372037.7; ENST00000635816.1; ENST00000636056.1; ENST00000638429.1
External Link	RMBase: m6A_site_108762
mod ID: M6ASITE001098		Click to Show/Hide the Full List
mod site	chr10:86892178-86892179:+		[6]
Sequence	AAGATGACCAGGGAGAAACCACATTAGCTTCAGGGTGTATG
Motif Score	2.053113095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000636056.1; ENST00000372037.7; ENST00000635816.1; ENST00000638429.1
External Link	RMBase: m6A_site_108763
mod ID: M6ASITE001099		Click to Show/Hide the Full List
mod site	chr10:86899820-86899821:+		[6]
Sequence	CAAAAGCCCAGCTACGCCGGACAATAGAATGTTGTCGGACC
Motif Score	3.643047619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000372037.7; ENST00000635816.1; ENST00000636056.1; ENST00000638429.1
External Link	RMBase: m6A_site_108764
mod ID: M6ASITE001100		Click to Show/Hide the Full List
mod site	chr10:86899868-86899869:+		[6]
Sequence	GTAACCAGTATTTGCAACCCACACTGCCCCCTGTTGTCATA
Motif Score	2.053113095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000636056.1; ENST00000372037.7; ENST00000638429.1; ENST00000635816.1
External Link	RMBase: m6A_site_108765
mod ID: M6ASITE001101		Click to Show/Hide the Full List
mod site	chr10:86900122-86900123:+		[6]
Sequence	CTTCTCCAGCTGCTTTTGTTACAAGTAAGAAGATATTTATT
Motif Score	2.07285119
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000638429.1; ENST00000635816.1; ENST00000372037.7; ENST00000636056.1
External Link	RMBase: m6A_site_108766
mod ID: M6ASITE001102		Click to Show/Hide the Full List
mod site	chr10:86912290-86912291:+		[9]
Sequence	CGTTACAATCGTGATTTGGAACAGGATGAAGCATTTATTCC
Motif Score	2.951386905
Cell/Tissue List	BGC823
Seq Type List	m6A-seq
Transcript ID List	ENST00000638429.1; ENST00000372037.7; ENST00000636056.1; ENST00000635816.1
External Link	RMBase: m6A_site_108767
mod ID: M6ASITE001103		Click to Show/Hide the Full List
mod site	chr10:86912331-86912332:+		[9]
Sequence	AGTTGGAGAATCACTAAAAGACCTTATTGACCAGTCACAAA
Motif Score	2.876744048
Cell/Tissue List	BGC823
Seq Type List	m6A-seq
Transcript ID List	ENST00000372037.7; ENST00000638429.1; ENST00000636056.1; ENST00000635816.1
External Link	RMBase: m6A_site_108768
mod ID: M6ASITE001104		Click to Show/Hide the Full List
mod site	chr10:86912347-86912348:+		[6]
Sequence	AAAGACCTTATTGACCAGTCACAAAGTTCTGGTAGTGGGTC
Motif Score	2.047297619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000636056.1; ENST00000638429.1; ENST00000635816.1; ENST00000372037.7
External Link	RMBase: m6A_site_108769
mod ID: M6ASITE001105		Click to Show/Hide the Full List
mod site	chr10:86912371-86912372:+		[7]
Sequence	AGTTCTGGTAGTGGGTCTGGACTACCTTTATTGGTAAGTTA
Motif Score	4.065041667
Cell/Tissue List	HeLa; BGC823
Seq Type List	m6A-seq
Transcript ID List	ENST00000635816.1; ENST00000638429.1; ENST00000372037.7; ENST00000636056.1
External Link	RMBase: m6A_site_108770
mod ID: M6ASITE001106		Click to Show/Hide the Full List
mod site	chr10:86917142-86917143:+		[7]
Sequence	TTTCTATAAAGGTTCAGCGAACTATTGCCAAACAGATTCAG
Motif Score	3.373380952
Cell/Tissue List	HeLa; BGC823
Seq Type List	m6A-seq
Transcript ID List	ENST00000636056.1; ENST00000635816.1; ENST00000372037.7; ENST00000638429.1
External Link	RMBase: m6A_site_108771
mod ID: M6ASITE001107		Click to Show/Hide the Full List
mod site	chr10:86917153-86917154:+		[7]
Sequence	GTTCAGCGAACTATTGCCAAACAGATTCAGATGGTCCGGCA
Motif Score	2.20572619
Cell/Tissue List	HeLa; BGC823
Seq Type List	m6A-seq
Transcript ID List	ENST00000372037.7; ENST00000635816.1; ENST00000638429.1; ENST00000636056.1
External Link	RMBase: m6A_site_108772
mod ID: M6ASITE001108		Click to Show/Hide the Full List
mod site	chr10:86919275-86919276:+		[6]
Sequence	ATGACTTCCTGAAATGTGCTACACTGGACACCAGAGCCCTG
Motif Score	2.078666667
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000636056.1; ENST00000638429.1; ENST00000635816.1; ENST00000372037.7
External Link	RMBase: m6A_site_108773
mod ID: M6ASITE001109		Click to Show/Hide the Full List
mod site	chr10:86919282-86919283:+		[6]
Sequence	CCTGAAATGTGCTACACTGGACACCAGAGCCCTGCTTAAAT
Motif Score	3.643047619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000635816.1; ENST00000372037.7; ENST00000636056.1; ENST00000638429.1
External Link	RMBase: m6A_site_108774
mod ID: M6ASITE001110		Click to Show/Hide the Full List
mod site	chr10:86919339-86919340:+		[6]
Sequence	CTGTGGTCTGTGCCACCTGCACACAGAAATTTATGGCACCC
Motif Score	2.830589286
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000635816.1; ENST00000372037.7; ENST00000636056.1; ENST00000638429.1
External Link	RMBase: m6A_site_108775
mod ID: M6ASITE001111		Click to Show/Hide the Full List
mod site	chr10:86919402-86919403:+		[6]
Sequence	TCGAGACCTAAAGAGCAAAAACATCCTCATCAAGAAAAATG
Motif Score	2.20572619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000372037.7; ENST00000635816.1; ENST00000638429.1; ENST00000636056.1
External Link	RMBase: m6A_site_108776
mod ID: M6ASITE001112		Click to Show/Hide the Full List
mod site	chr10:86921688-86921689:+		[10]
Sequence	AGATGGCTCGTCGTTGTATCACAGGAGGTGGGAGTTTGAGT
Motif Score	2.047297619
Cell/Tissue List	HEK293
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000372037.7; ENST00000638429.1; ENST00000635816.1; ENST00000636056.1
External Link	RMBase: m6A_site_108777
mod ID: M6ASITE001113		Click to Show/Hide the Full List
mod site	chr10:86923408-86923409:+		[6]
Sequence	ATACCAATTGCCATATTACAACATGGTACCGAGTGATCCGT
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000635816.1; ENST00000372037.7; ENST00000636056.1; ENST00000638429.1
External Link	RMBase: m6A_site_108778
mod ID: M6ASITE001114		Click to Show/Hide the Full List
mod site	chr10:86923636-86923637:+		[6]
Sequence	AATGTCAGAATGCTGGGCCCACAATCCAGCCTCCAGACTCA
Motif Score	2.053113095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000638429.1; ENST00000372037.7; ENST00000635816.1; ENST00000636056.1
External Link	RMBase: m6A_site_108779
mod ID: M6ASITE001115		Click to Show/Hide the Full List
mod site	chr10:86923652-86923653:+		[7]
Sequence	GCCCACAATCCAGCCTCCAGACTCACAGCATTGAGAATTAA
Motif Score	3.319380952
Cell/Tissue List	HeLa; HEK293T; HepG2; hNPCs; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000636056.1; ENST00000638429.1; ENST00000372037.7; ENST00000635816.1
External Link	RMBase: m6A_site_108780
mod ID: M6ASITE001116		Click to Show/Hide the Full List
mod site	chr10:86923726-86923727:+		[7]
Sequence	TGTAAAAATCTGATGGTTAAACCATCGGAGGAGAAACTCTA
Motif Score	2.185083333
Cell/Tissue List	HeLa; HEK293T; HepG2; hNPCs; fibroblasts; A549; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000638429.1; ENST00000372037.7; ENST00000636056.1; ENST00000635816.1
External Link	RMBase: m6A_site_108781
mod ID: M6ASITE001117		Click to Show/Hide the Full List
mod site	chr10:86923741-86923742:+		[7]
Sequence	GTTAAACCATCGGAGGAGAAACTCTAGACTGCAAGAACTGT
Motif Score	2.627720238
Cell/Tissue List	HeLa; HEK293T; hNPCs; fibroblasts; A549; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000636056.1; ENST00000635816.1; ENST00000638429.1; ENST00000372037.7
External Link	RMBase: m6A_site_108782
mod ID: M6ASITE001118		Click to Show/Hide the Full List
mod site	chr10:86923748-86923749:+		[7]
Sequence	CATCGGAGGAGAAACTCTAGACTGCAAGAACTGTTTTTACC
Motif Score	3.319380952
Cell/Tissue List	HeLa; HEK293T; hNPCs; fibroblasts; A549; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000636056.1; ENST00000372037.7; ENST00000635816.1; ENST00000638429.1
External Link	RMBase: m6A_site_108783
mod ID: M6ASITE001119		Click to Show/Hide the Full List
mod site	chr10:86923757-86923758:+		[7]
Sequence	AGAAACTCTAGACTGCAAGAACTGTTTTTACCCATGGCATG
Motif Score	3.373380952
Cell/Tissue List	HeLa; HEK293T; hNPCs; fibroblasts; A549; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000636056.1; ENST00000372037.7; ENST00000638429.1; ENST00000635816.1
External Link	RMBase: m6A_site_108784
mod ID: M6ASITE001120		Click to Show/Hide the Full List
mod site	chr10:86923820-86923821:+		[7]
Sequence	GATGTTAACTTGGTTCTCAGACTCTTTCTTCACTACGTGTT
Motif Score	3.319380952
Cell/Tissue List	HeLa; HEK293T; hNPCs; fibroblasts; A549; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000635816.1; ENST00000638429.1; ENST00000372037.7; ENST00000636056.1
External Link	RMBase: m6A_site_108785
mod ID: M6ASITE001121		Click to Show/Hide the Full List
mod site	chr10:86923860-86923861:+		[7]
Sequence	TCACAGGCTGCTAATATTAAACCTTTCAGTACTCTTATTAG
Motif Score	2.185083333
Cell/Tissue List	HeLa; HEK293T; hNPCs; hESCs; fibroblasts; A549; Huh7; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000372037.7; ENST00000636056.1; ENST00000635816.1; ENST00000638429.1
External Link	RMBase: m6A_site_108786
mod ID: M6ASITE001122		Click to Show/Hide the Full List
mod site	chr10:86923895-86923896:+		[11]
Sequence	TATTAGGATACAAGCTGGGAACTTCTAAACACTTCATTCTT
Motif Score	3.373380952
Cell/Tissue List	HEK293T; hNPCs; hESCs; fibroblasts; A549; GM12878; Huh7; HEK293A-TOA; iSLK; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000638429.1; ENST00000372037.7; ENST00000635816.1; ENST00000636056.1
External Link	RMBase: m6A_site_108787
mod ID: M6ASITE001123		Click to Show/Hide the Full List
mod site	chr10:86923903-86923904:+		[11]
Sequence	TACAAGCTGGGAACTTCTAAACACTTCATTCTTTATATATG
Motif Score	2.20572619
Cell/Tissue List	HEK293T; hNPCs; hESCs; fibroblasts; A549; GM12878; Huh7; HEK293A-TOA; iSLK; MSC
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000372037.7; ENST00000638429.1; ENST00000635816.1; ENST00000636056.1
External Link	RMBase: m6A_site_108788
mod ID: M6ASITE001124		Click to Show/Hide the Full List
mod site	chr10:86923925-86923926:+		[11]
Sequence	ACTTCATTCTTTATATATGGACAGCTTTATTTTAAATGTGG
Motif Score	3.643047619
Cell/Tissue List	HEK293T; hNPCs; hESCs; fibroblasts; A549; GM12878; Huh7; HEK293A-TOA; iSLK; MSC; TREX
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000638429.1; ENST00000635816.1; ENST00000372037.7; ENST00000636056.1
External Link	RMBase: m6A_site_108789
mod ID: M6ASITE001125		Click to Show/Hide the Full List
mod site	chr10:86923980-86923981:+		[12]
Sequence	TTTTAAGTGGGTTTTTATGAACTGCATCAAGACTTCAATCC
Motif Score	3.373380952
Cell/Tissue List	HEK293T; HeLa; hNPCs; hESCs; fibroblasts; A549; GM12878; Huh7; HEK293A-TOA; iSLK; MSC; TREX
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000635816.1; ENST00000638429.1; ENST00000372037.7; ENST00000636056.1
External Link	RMBase: m6A_site_108790
mod ID: M6ASITE001126		Click to Show/Hide the Full List
mod site	chr10:86923991-86923992:+		[12]
Sequence	TTTTTATGAACTGCATCAAGACTTCAATCCTGATTAGTGTC
Motif Score	3.319380952
Cell/Tissue List	HEK293T; HeLa; hNPCs; hESCs; fibroblasts; A549; GM12878; Huh7; HEK293A-TOA; iSLK; MSC; TREX
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000635816.1; ENST00000636056.1; ENST00000638429.1; ENST00000372037.7
External Link	RMBase: m6A_site_108791
mod ID: M6ASITE001127		Click to Show/Hide the Full List
mod site	chr10:86924111-86924112:+		[7]
Sequence	CAGCAGAGATGGAGAAATAGACTTTGCCTTTTACCTGAGAC
Motif Score	3.319380952
Cell/Tissue List	HeLa; HEK293T; HepG2; hESCs; fibroblasts; A549; GM12878; Huh7; HEK293A-TOA; iSLK; MSC; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000372037.7; ENST00000636056.1; ENST00000638429.1; ENST00000635816.1
External Link	RMBase: m6A_site_108792
mod ID: M6ASITE001128		Click to Show/Hide the Full List
mod site	chr10:86924130-86924131:+		[7]
Sequence	GACTTTGCCTTTTACCTGAGACTTTCAGTTCGTTTGTATTC
Motif Score	3.319380952
Cell/Tissue List	HeLa; HEK293T; HepG2; U2OS; hESCs; fibroblasts; A549; GM12878; Huh7; HEK293A-TOA; iSLK; MSC; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000635816.1; ENST00000638429.1; ENST00000636056.1; ENST00000372037.7
External Link	RMBase: m6A_site_108793
mod ID: M6ASITE001129		Click to Show/Hide the Full List
mod site	chr10:86924163-86924164:+		[7]
Sequence	TTGTATTCTACCTTTGTAAAACAGCCTATAGATGATGATGT
Motif Score	2.20572619
Cell/Tissue List	HeLa; HEK293T; HepG2; hESCs; fibroblasts; A549; GM12878; Huh7; HEK293A-TOA; iSLK; MSC; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000372037.7; ENST00000636056.1; ENST00000635816.1; ENST00000638429.1
External Link	RMBase: m6A_site_108794
mod ID: M6ASITE001130		Click to Show/Hide the Full List
mod site	chr10:86924252-86924253:+		[10]
Sequence	ATGTGTGTGTGTCTCCATGCACATGCACGCCGGGATTCCTC
Motif Score	2.830589286
Cell/Tissue List	kidney; hESC-HEK293T
Seq Type List	m6A-REF-seq; MAZTER-seq
Transcript ID List	ENST00000635816.1; ENST00000372037.7; ENST00000638429.1; ENST00000636056.1
External Link	RMBase: m6A_site_108795
mod ID: M6ASITE001131		Click to Show/Hide the Full List
mod site	chr10:86924387-86924388:+		[6]
Sequence	CCAAGATTCGCCAATCTCATACAAGCCATTTACTTTGCAAG
Motif Score	2.110482143
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000638429.1; ENST00000372037.7; ENST00000635816.1; ENST00000636056.1
External Link	RMBase: m6A_site_108796
mod ID: M6ASITE001132		Click to Show/Hide the Full List
mod site	chr10:86924440-86924441:+		[6]
Sequence	CCCACCAGCTTTATTTTTTAACATGAAAGCTGATGCCAAGG
Motif Score	2.168095238
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000636056.1; ENST00000635816.1; ENST00000638429.1; ENST00000372037.7
External Link	RMBase: m6A_site_108797
mod ID: M6ASITE001133		Click to Show/Hide the Full List
mod site	chr10:86924592-86924593:+		[6]
Sequence	TATTGCCATGAACCATGCTTACAAAGAAAGCACTTCTTATT
Motif Score	2.07285119
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000636056.1; ENST00000372037.7; ENST00000638429.1; ENST00000635816.1
External Link	RMBase: m6A_site_108798
mod ID: M6ASITE001134		Click to Show/Hide the Full List
mod site	chr10:86924683-86924684:+		[13]
Sequence	TATATTCTTTATTCTCAGTAACTTTTAAAAGGGAAGTTATT
Motif Score	2.590089286
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000372037.7; ENST00000636056.1; ENST00000638429.1; ENST00000635816.1
External Link	RMBase: m6A_site_108799
mod ID: M6ASITE001135		Click to Show/Hide the Full List
mod site	chr10:86924751-86924752:+		[6]
Sequence	TGCAAATCACCCACTCCTTTACAACCATACTTTATATATGT
Motif Score	2.07285119
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000372037.7; ENST00000635816.1; ENST00000636056.1; ENST00000638429.1
External Link	RMBase: m6A_site_108800
mod ID: M6ASITE001136		Click to Show/Hide the Full List
mod site	chr10:86924776-86924777:+		[6]
Sequence	CATACTTTATATATGTACATACATTCATACTGTAGAAACCA
Motif Score	2.110482143
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000635816.1; ENST00000638429.1; ENST00000372037.7; ENST00000636056.1
External Link	RMBase: m6A_site_108801
mod ID: M6ASITE001137		Click to Show/Hide the Full List
mod site	chr10:86925035-86925036:+		[10]
Sequence	AACTGTCAAATATGTTCTGGACAGCTAAATCATTTGAGATT
Motif Score	3.643047619
Cell/Tissue List	kidney
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000635816.1; ENST00000372037.7; ENST00000638429.1; ENST00000636056.1
External Link	RMBase: m6A_site_108802
mod ID: M6ASITE001138		Click to Show/Hide the Full List
mod site	chr10:86925092-86925093:+		[6]
Sequence	CTATTCCCTAACTTGTGAAGACAATGAAAAATCAGGCAGAA
Motif Score	2.897386905
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000635816.1; ENST00000638429.1; ENST00000636056.1; ENST00000372037.7
External Link	RMBase: m6A_site_108803
mod ID: M6ASITE001139		Click to Show/Hide the Full List
mod site	chr10:86925143-86925144:+		[6]
Sequence	TCTAGTCAGTATCTGTAGCTACACTGTATAACTGTTCTTCA
Motif Score	2.078666667
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000636056.1; ENST00000372037.7; ENST00000638429.1; ENST00000635816.1
External Link	RMBase: m6A_site_108804
mod ID: M6ASITE001140		Click to Show/Hide the Full List
mod site	chr10:86929678-86929679:+		[14]
Sequence	GATGCAGCCTGGTAAAGAAGACTCAGTGATTTCTGGGAACT
Motif Score	3.319380952
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000636056.1; ENST00000372037.7; ENST00000635816.1; ENST00000638429.1
External Link	RMBase: m6A_site_108805
mod ID: M6ASITE001141		Click to Show/Hide the Full List
mod site	chr10:86929696-86929697:+		[14]
Sequence	AGACTCAGTGATTTCTGGGAACTGCAAATGCTTGCCAGCTT
Motif Score	3.373380952
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000636056.1; ENST00000372037.7; ENST00000638429.1; ENST00000635816.1
External Link	RMBase: m6A_site_108806
mod ID: M6ASITE001142		Click to Show/Hide the Full List
mod site	chr10:86929734-86929735:+		[14]
Sequence	CTTTCCTTCTGTCTGTGGAAACACTGAATAAATGTATTCAT
Motif Score	2.20572619
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000638429.1; ENST00000635816.1; ENST00000636056.1; ENST00000372037.7
External Link	RMBase: m6A_site_108807

Ref 1	RADAR: a rigorously annotated database of A-to-I RNA editing. Nucleic Acids Res. 2014 Jan;42(Database issue):D109-13. doi: 10.1093/nar/gkt996. Epub 2013 Oct 25.
Ref 2	Systematic identification of abundant A-to-I editing sites in the human transcriptome. Nat Biotechnol. 2004 Aug;22(8):1001-5. doi: 10.1038/nbt996. Epub 2004 Jul 18.
Ref 3	Comprehensive analysis of RNA-Seq data reveals extensive RNA editing in a human transcriptome. Nat Biotechnol. 2012 Feb 12;30(3):253-60. doi: 10.1038/nbt.2122.
Ref 4	5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m(5)C reader. Cell Res. 2017 May;27(5):606-625. doi: 10.1038/cr.2017.55. Epub 2017 Apr 18.
Ref 5	m(6)A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells by Sustaining FOXM1 Expression and Cell Proliferation Program. Cancer Cell. 2017 Apr 10;31(4):591-606.e6. doi: 10.1016/j.ccell.2017.02.013. Epub 2017 Mar 23.
Ref 6	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 7	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 8	Dynamics of the human and viral m(6)A RNA methylomes during HIV-1 infection of T cells. Nat Microbiol. 2016 Feb 22;1:16011. doi: 10.1038/nmicrobiol.2016.11.
Ref 9	METTL3-mediated N6-methyladenosine modification is critical for epithelial-mesenchymal transition and metastasis of gastric cancer. Mol Cancer. 2019 Oct 13;18(1):142. doi: 10.1186/s12943-019-1065-4.
Ref 10	Single-base mapping of m(6)A by an antibody-independent method. Sci Adv. 2019 Jul 3;5(7):eaax0250. doi: 10.1126/sciadv.aax0250. eCollection 2019 Jul.
Ref 11	Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons. Cell. 2012 Jun 22;149(7):1635-46. doi: 10.1016/j.cell.2012.05.003. Epub 2012 May 17.
Ref 12	Viral N(6)-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus. Nat Commun. 2019 Oct 9;10(1):4595. doi: 10.1038/s41467-019-12504-y.
Ref 13	DART-seq: an antibody-free method for global m(6)A detection. Nat Methods. 2019 Dec;16(12):1275-1280. doi: 10.1038/s41592-019-0570-0. Epub 2019 Sep 23.
Ref 14	N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection. Cell Host Microbe. 2016 Nov 9;20(5):654-665. doi: 10.1016/j.chom.2016.09.015. Epub 2016 Oct 20.

Epigenetic Target Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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