Epigenetic Target Information

General Information of the Epigenetic Target (ID: EPITAR00433)

Target Name	Gap junction alpha-1 protein (GJA1)
Synonyms	Connexin-43; Cx43; Gap junction 43 kDa heart protein Click to Show/Hide
Gene Name	GJA1
Sequence	MGDWSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPGCENVCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKLNKKEEELKVAQTDGVNVDMHLKQIEIKKFKYGIEEHGKVKMRGGLLRTYIISILFKSIFEVAFLLIQWYIYGFSLSAVYTCKRDPCPHQVDCFLSRPTEKTIFIIFMLVVSLVSLALNIIELFYVFFKGVKDRVKGKSDPYHATSGALSPAKDCGSQKYAYFNGCSSPTAPLSPMSPPGYKLVTGDRNNSSCRNYNKQASEQNWANYSAEQNRMGQAGSTISNSHAQPFDFPDDNQNSKKLAAGHELQPLAIVDQRPSSRASSRASSRPRPDDLEI Click to Show/Hide
Family	Connexin family, Alpha-type (group II) subfamily
Function	Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity). May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles (By similarity). Click to Show/Hide
Gene ID	2697
HGNC ID	HGNC:4274
Ensembl Gene ID	ENSG00000152661
KEGG ID	hsa:2697
Chromosomal Location	6q22.31

RNA Modification Sequencing Data Associated with the Target (ID: EPITAR00433)

Gap junction alpha-1 protein (GJA1)

N4-acetylcytidine (ac4C)

In total 1 m6A sequence/site(s) in this target gene
mod ID: AC4SITE000112		Click to Show/Hide the Full List
mod site	chr6:121448083-121448084:+		[1]
Sequence	ACCAGGTGTTAATTTTGATCCGGTGGAGGTGGTACTCAACA
Cell/Tissue List	H1
Seq Type List	ac4C-seq
Transcript ID List	ENST00000647564.1; ENST00000650427.1; ENST00000649132.1; ENST00000649003.1; ENST00000282561.4
External Link	RMBase: ac4C_site_1617

2'-O-Methylation (2'-O-Me)

In total 1 m6A sequence/site(s) in this target gene
mod ID: 2OMSITE000413		Click to Show/Hide the Full List
mod site	chr6:121443632-121443633:+		[2]
Sequence	AATAAAGACTATACTTTCAGGGATCATTTCTATAGTTTGTT
Cell/Tissue List	HEK293
Seq Type List	RiboMeth-seq
Transcript ID List	ENST00000282561.4; ENST00000649132.1; ENST00000650427.1; ENST00000647564.1; ENST00000649003.1; rmsk_2058536
External Link	RMBase: Nm_site_5969

Other RNA modification (m2,2,7Gpp(pN))

In total 1 m6A sequence/site(s) in this target gene
mod ID: RNASITE000001		Click to Show/Hide the Full List
mod site	chr6:121443615-121443616:+		[3]
Sequence	TTTTTTTATAGAATGTAAATAAAGACTATACTTTCAGGGAT
Cell/Tissue List	nucleoplasmic
Transcript ID List	ENST00000282561.4; ENST00000650427.1; ENST00000647564.1; ENST00000649003.1; ENST00000649132.1
External Link	RMBase: otherMod_site_1067

N6-methyladenosine (m6A)

In total 65 m6A sequence/site(s) in this target gene
mod ID: M6ASITE076896		Click to Show/Hide the Full List
mod site	chr6:121435614-121435615:+		[4]
Sequence	AGTTGAGTCAGTGGCTTGAAACTTTTAAAAGCTCTGTGCTC
Motif Score	2.627720238
Cell/Tissue List	fibroblasts; A549; MSC; TIME
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000649132.1; ENST00000649003.1
External Link	RMBase: m6A_site_732519
mod ID: M6ASITE076897		Click to Show/Hide the Full List
mod site	chr6:121435709-121435710:+		[4]
Sequence	AGGCGTGAGGAAAGTACCAAACAGCAGCGGAGTTTTAAACT
Motif Score	2.20572619
Cell/Tissue List	fibroblasts; A549; Huh7; HEK293A-TOA; MSC; TIME
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000649132.1; ENST00000282561.4; ENST00000649003.1
External Link	RMBase: m6A_site_732520
mod ID: M6ASITE076898		Click to Show/Hide the Full List
mod site	chr6:121435727-121435728:+		[4]
Sequence	AAACAGCAGCGGAGTTTTAAACTTTAAATAGACAGGTCTGA
Motif Score	2.627720238
Cell/Tissue List	fibroblasts; A549; Huh7; HEK293A-TOA; MSC; TIME
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000649132.1; ENST00000282561.4; ENST00000649003.1
External Link	RMBase: m6A_site_732521
mod ID: M6ASITE076899		Click to Show/Hide the Full List
mod site	chr6:121435738-121435739:+		[5]
Sequence	GAGTTTTAAACTTTAAATAGACAGGTCTGAGTGCCTGAACT
Motif Score	2.897386905
Cell/Tissue List	A549; fibroblasts; Huh7; HEK293A-TOA; MSC; TIME
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000649003.1; ENST00000282561.4; ENST00000649132.1
External Link	RMBase: m6A_site_732522
mod ID: M6ASITE076900		Click to Show/Hide the Full List
mod site	chr6:121435756-121435757:+		[5]
Sequence	AGACAGGTCTGAGTGCCTGAACTTGCCTTTTCATTTTACTT
Motif Score	3.373380952
Cell/Tissue List	A549; fibroblasts; Huh7; HEK293A-TOA; MSC; TIME
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000282561.4; ENST00000649132.1; ENST00000649003.1
External Link	RMBase: m6A_site_732523
mod ID: M6ASITE076901		Click to Show/Hide the Full List
mod site	chr6:121437386-121437387:+		[5]
Sequence	TTTTTCTTTTTTCCTCTTAAACTTGCTGAATCCCACTATCT
Motif Score	2.627720238
Cell/Tissue List	A549; Huh7; MSC; TIME
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000649003.1; ENST00000282561.4; ENST00000649132.1; ENST00000650427.1
External Link	RMBase: m6A_site_732524
mod ID: M6ASITE076902		Click to Show/Hide the Full List
mod site	chr6:121446845-121446846:+		[6]
Sequence	TTTCAGGTGGTGCCCAGGCAACATGGGTGACTGGAGCGCCT
Motif Score	2.173910714
Cell/Tissue List	brain; hESC-HEK293T
Seq Type List	m6A-REF-seq; MAZTER-seq
Transcript ID List	ENST00000649132.1; ENST00000647564.1; ENST00000650427.1; ENST00000282561.4; ENST00000649003.1
External Link	RMBase: m6A_site_732525
mod ID: M6ASITE076903		Click to Show/Hide the Full List
mod site	chr6:121446873-121446874:+		[7]
Sequence	GACTGGAGCGCCTTAGGCAAACTCCTTGACAAGGTTCAAGC
Motif Score	2.627720238
Cell/Tissue List	HEK293T; H1A; HEK293A-TOA; endometrial
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000282561.4; ENST00000649003.1; ENST00000649132.1; ENST00000650427.1; ENST00000647564.1
External Link	RMBase: m6A_site_732526
mod ID: M6ASITE076904		Click to Show/Hide the Full List
mod site	chr6:121446881-121446882:+		[6]
Sequence	CGCCTTAGGCAAACTCCTTGACAAGGTTCAAGCCTACTCAA
Motif Score	2.859755952
Cell/Tissue List	brain; hESC-HEK293T
Seq Type List	m6A-REF-seq; MAZTER-seq
Transcript ID List	ENST00000647564.1; ENST00000282561.4; ENST00000649003.1; ENST00000649132.1; ENST00000650427.1
External Link	RMBase: m6A_site_732527
mod ID: M6ASITE076905		Click to Show/Hide the Full List
mod site	chr6:121446961-121446962:+		[6]
Sequence	TCCGAATCCTGCTGCTGGGGACAGCGGTTGAGTCAGCCTGG
Motif Score	3.643047619
Cell/Tissue List	HEK293T; kidney; H1A; H1B; A549; HEK293A-TOA; endometrial
Seq Type List	MeRIP-seq; m6A-REF-seq; m6A-seq
Transcript ID List	ENST00000647564.1; ENST00000649132.1; ENST00000282561.4; ENST00000650427.1; ENST00000649003.1
External Link	RMBase: m6A_site_732528
mod ID: M6ASITE076906		Click to Show/Hide the Full List
mod site	chr6:121447010-121447011:+		[6]
Sequence	GCAGTCTGCCTTTCGTTGTAACACTCAGCAACCTGGTTGTG
Motif Score	2.168095238
Cell/Tissue List	brain; HEK293; hESC-HEK293T
Seq Type List	m6A-REF-seq; MAZTER-seq
Transcript ID List	ENST00000649132.1; ENST00000647564.1; ENST00000282561.4; ENST00000650427.1; ENST00000649003.1
External Link	RMBase: m6A_site_732529
mod ID: M6ASITE076907		Click to Show/Hide the Full List
mod site	chr6:121447046-121447047:+		[8]
Sequence	TTGTGAAAATGTCTGCTATGACAAGTCTTTCCCAATCTCTC
Motif Score	2.859755952
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000282561.4; ENST00000647564.1; ENST00000649132.1; ENST00000650427.1; ENST00000649003.1
External Link	RMBase: m6A_site_732530
mod ID: M6ASITE076908		Click to Show/Hide the Full List
mod site	chr6:121447111-121447112:+		[8]
Sequence	TCATATTTGTGTCTGTACCCACACTCTTGTACCTGGCTCAT
Motif Score	2.053113095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000649003.1; ENST00000282561.4; ENST00000647564.1; ENST00000650427.1; ENST00000649132.1
External Link	RMBase: m6A_site_732531
mod ID: M6ASITE076909		Click to Show/Hide the Full List
mod site	chr6:121447161-121447162:+		[5]
Sequence	GTGATGCGAAAGGAAGAGAAACTGAACAAGAAAGAGGAAGA
Motif Score	2.627720238
Cell/Tissue List	HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; Huh7; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; endometrial; NB4
Seq Type List	MeRIP-seq; m6A-seq; m6A-CLIP/IP
Transcript ID List	ENST00000649003.1; ENST00000649132.1; ENST00000282561.4; ENST00000650427.1; ENST00000647564.1
External Link	RMBase: m6A_site_732532
mod ID: M6ASITE076910		Click to Show/Hide the Full List
mod site	chr6:121447166-121447167:+		[5]
Sequence	GCGAAAGGAAGAGAAACTGAACAAGAAAGAGGAAGAACTCA
Motif Score	2.951386905
Cell/Tissue List	HEK293T; A549; hESC-HEK293T; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; Huh7; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; endometrial; NB4
Seq Type List	MeRIP-seq; MAZTER-seq; m6A-seq
Transcript ID List	ENST00000650427.1; ENST00000282561.4; ENST00000649132.1; ENST00000647564.1; ENST00000649003.1
External Link	RMBase: m6A_site_732533
mod ID: M6ASITE076911		Click to Show/Hide the Full List
mod site	chr6:121447182-121447183:+		[5]
Sequence	CTGAACAAGAAAGAGGAAGAACTCAAGGTTGCCCAAACTGA
Motif Score	3.373380952
Cell/Tissue List	HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; Huh7; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; endometrial; NB4
Seq Type List	MeRIP-seq; m6A-seq; m6A-CLIP/IP
Transcript ID List	ENST00000649003.1; ENST00000647564.1; ENST00000282561.4; ENST00000650427.1; ENST00000649132.1
External Link	RMBase: m6A_site_732534
mod ID: M6ASITE076912		Click to Show/Hide the Full List
mod site	chr6:121447198-121447199:+		[5]
Sequence	AAGAACTCAAGGTTGCCCAAACTGATGGTGTCAATGTGGAC
Motif Score	2.627720238
Cell/Tissue List	HEK293T; A549; Brain; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; Huh7; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; NB4
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000649003.1; ENST00000647564.1; ENST00000649132.1; ENST00000650427.1; ENST00000282561.4
External Link	RMBase: m6A_site_732535
mod ID: M6ASITE076913		Click to Show/Hide the Full List
mod site	chr6:121447217-121447218:+		[6]
Sequence	AACTGATGGTGTCAATGTGGACATGCACTTGAAGCAGATTG
Motif Score	3.643047619
Cell/Tissue List	HEK293T; brain; A549; hESC-HEK293T; Brain; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; Huh7; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; NB4
Seq Type List	MeRIP-seq; m6A-REF-seq; MAZTER-seq; m6A-seq
Transcript ID List	ENST00000282561.4; ENST00000650427.1; ENST00000649003.1; ENST00000649132.1; ENST00000647564.1
External Link	RMBase: m6A_site_732536
mod ID: M6ASITE076914		Click to Show/Hide the Full List
mod site	chr6:121447223-121447224:+		[9]
Sequence	TGGTGTCAATGTGGACATGCACTTGAAGCAGATTGAGATAA
Motif Score	3.252583333
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000650427.1; ENST00000282561.4; ENST00000649132.1; ENST00000647564.1; ENST00000649003.1
External Link	RMBase: m6A_site_732537
mod ID: M6ASITE076915		Click to Show/Hide the Full List
mod site	chr6:121447306-121447307:+		[5]
Sequence	TGCGAGGGGGGTTGCTGCGAACCTACATCATCAGTATCCTC
Motif Score	2.930744048
Cell/Tissue List	HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; Huh7; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; NB4
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000649132.1; ENST00000647564.1; ENST00000649003.1; ENST00000282561.4; ENST00000650427.1
External Link	RMBase: m6A_site_732538
mod ID: M6ASITE076916		Click to Show/Hide the Full List
mod site	chr6:121447310-121447311:+		[8]
Sequence	AGGGGGGTTGCTGCGAACCTACATCATCAGTATCCTCTTCA
Motif Score	2.078666667
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000647564.1; ENST00000282561.4; ENST00000649003.1; ENST00000650427.1; ENST00000649132.1
External Link	RMBase: m6A_site_732539
mod ID: M6ASITE076917		Click to Show/Hide the Full List
mod site	chr6:121447370-121447371:+		[8]
Sequence	CTTCTTGCTGATCCAGTGGTACATCTATGGATTCAGCTTGA
Motif Score	2.856142857
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000282561.4; ENST00000650427.1; ENST00000649132.1; ENST00000649003.1; ENST00000647564.1
External Link	RMBase: m6A_site_732540
mod ID: M6ASITE076918		Click to Show/Hide the Full List
mod site	chr6:121447436-121447437:+		[5]
Sequence	TCCCTGCCCACATCAGGTGGACTGTTTCCTCTCTCGCCCCA
Motif Score	4.065041667
Cell/Tissue List	HEK293T; A549; U2OS; H1B; hESCs; fibroblasts; Huh7; HEK293A-TOA; iSLK; MSC; TIME; endometrial; NB4
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000650427.1; ENST00000647564.1; ENST00000282561.4; ENST00000649132.1; ENST00000649003.1
External Link	RMBase: m6A_site_732541
mod ID: M6ASITE076919		Click to Show/Hide the Full List
mod site	chr6:121447465-121447466:+		[5]
Sequence	TCTCTCGCCCCACGGAGAAAACCATCTTCATCATCTTCATG
Motif Score	2.185083333
Cell/Tissue List	HEK293T; A549; U2OS; H1A; H1B; hESCs; fibroblasts; Huh7; HEK293A-TOA; iSLK; MSC; TIME; endometrial; NB4
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000647564.1; ENST00000649003.1; ENST00000650427.1; ENST00000282561.4; ENST00000649132.1
External Link	RMBase: m6A_site_732542
mod ID: M6ASITE076920		Click to Show/Hide the Full List
mod site	chr6:121447527-121447528:+		[5]
Sequence	CTGGCCTTGAATATCATTGAACTCTTCTATGTTTTCTTCAA
Motif Score	3.373380952
Cell/Tissue List	HEK293T; A549; HepG2; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; Huh7; HEK293A-TOA; iSLK; MSC; TIME; endometrial; NB4
Seq Type List	MeRIP-seq; m6A-seq; m6A-CLIP/IP
Transcript ID List	ENST00000649132.1; ENST00000649003.1; ENST00000650427.1; ENST00000647564.1; ENST00000282561.4
External Link	RMBase: m6A_site_732543
mod ID: M6ASITE076921		Click to Show/Hide the Full List
mod site	chr6:121447594-121447595:+		[10]
Sequence	AGAGCGACCCTTACCATGCGACCAGTGGTGCGCTGAGCCCT
Motif Score	2.844928571
Cell/Tissue List	A549
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000647564.1; ENST00000650427.1; ENST00000649003.1; ENST00000649132.1; ENST00000282561.4
External Link	RMBase: m6A_site_732544
mod ID: M6ASITE076922		Click to Show/Hide the Full List
mod site	chr6:121447622-121447623:+		[5]
Sequence	TGCGCTGAGCCCTGCCAAAGACTGTGGGTCTCAAAAATATG
Motif Score	3.319380952
Cell/Tissue List	HEK293T; A549; HepG2; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; Huh7; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; NB4
Seq Type List	MeRIP-seq; m6A-seq; m6A-CLIP/IP
Transcript ID List	ENST00000282561.4; ENST00000649003.1; ENST00000650427.1; ENST00000647564.1; ENST00000649132.1
External Link	RMBase: m6A_site_732545
mod ID: M6ASITE076923		Click to Show/Hide the Full List
mod site	chr6:121447727-121447728:+		[5]
Sequence	GCTGGTTACTGGCGACAGAAACAATTCTTCTTGCCGCAATT
Motif Score	2.20572619
Cell/Tissue List	HEK293T; A549; hESC-HEK293T; HepG2; U2OS; H1B; hNPCs; hESCs; fibroblasts; Huh7; HEK293A-TOA; iSLK; MSC; TIME; endometrial; NB4
Seq Type List	MeRIP-seq; MAZTER-seq; m6A-seq; m6A-CLIP/IP
Transcript ID List	ENST00000649132.1; ENST00000282561.4; ENST00000649003.1; ENST00000650427.1; ENST00000647564.1
External Link	RMBase: m6A_site_732546
mod ID: M6ASITE076924		Click to Show/Hide the Full List
mod site	chr6:121447772-121447773:+		[5]
Sequence	CAAGCAAGCAAGTGAGCAAAACTGGGCTAATTACAGTGCAG
Motif Score	2.627720238
Cell/Tissue List	HEK293T; A549; HepG2; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; Huh7; HEK293A-TOA; iSLK; MSC; TIME; endometrial; NB4
Seq Type List	MeRIP-seq; m6A-seq; m6A-CLIP/IP
Transcript ID List	ENST00000647564.1; ENST00000282561.4; ENST00000650427.1; ENST00000649003.1; ENST00000649132.1
External Link	RMBase: m6A_site_732547
mod ID: M6ASITE076925		Click to Show/Hide the Full List
mod site	chr6:121447794-121447795:+		[5]
Sequence	TGGGCTAATTACAGTGCAGAACAAAATCGAATGGGGCAGGC
Motif Score	2.951386905
Cell/Tissue List	HEK293T; A549; hESC-HEK293T; HepG2; Brain; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; Huh7; HEK293A-TOA; iSLK; MSC; TIME; endometrial; NB4
Seq Type List	MeRIP-seq; MAZTER-seq; m6A-seq
Transcript ID List	ENST00000650427.1; ENST00000647564.1; ENST00000649132.1; ENST00000282561.4; ENST00000649003.1
External Link	RMBase: m6A_site_732548
mod ID: M6ASITE076926		Click to Show/Hide the Full List
mod site	chr6:121447884-121447885:+		[5]
Sequence	GATAACCAGAATTCTAAAAAACTAGCTGCTGGACATGAATT
Motif Score	2.627720238
Cell/Tissue List	HEK293T; A549; HepG2; Brain; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; Huh7; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; NB4
Seq Type List	MeRIP-seq; m6A-seq; m6A-CLIP/IP
Transcript ID List	ENST00000649003.1; ENST00000647564.1; ENST00000282561.4; ENST00000650427.1; ENST00000649132.1
External Link	RMBase: m6A_site_732549
mod ID: M6ASITE076927		Click to Show/Hide the Full List
mod site	chr6:121447896-121447897:+		[6]
Sequence	TCTAAAAAACTAGCTGCTGGACATGAATTACAGCCACTAGC
Motif Score	3.643047619
Cell/Tissue List	HEK293T; brain; A549; hESC-HEK293T; HepG2; Brain; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; Huh7; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; NB4
Seq Type List	MeRIP-seq; m6A-REF-seq; MAZTER-seq; m6A-seq
Transcript ID List	ENST00000650427.1; ENST00000649003.1; ENST00000649132.1; ENST00000282561.4; ENST00000647564.1
External Link	RMBase: m6A_site_732550
mod ID: M6ASITE076928		Click to Show/Hide the Full List
mod site	chr6:121447925-121447926:+		[5]
Sequence	ACAGCCACTAGCCATTGTGGACCAGCGACCTTCAAGCAGAG
Motif Score	3.622404762
Cell/Tissue List	HEK293T; A549; HepG2; Brain; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; Huh7; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; NB4
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000649003.1; ENST00000649132.1; ENST00000282561.4; ENST00000650427.1; ENST00000647564.1
External Link	RMBase: m6A_site_732551
mod ID: M6ASITE076929		Click to Show/Hide the Full List
mod site	chr6:121447968-121447969:+		[5]
Sequence	AGCAGTCGTGCCAGCAGCAGACCTCGGCCTGATGACCTGGA
Motif Score	2.876744048
Cell/Tissue List	HEK293T; A549; HepG2; Brain; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; Huh7; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000649003.1; ENST00000650427.1; ENST00000649132.1; ENST00000282561.4; ENST00000647564.1
External Link	RMBase: m6A_site_732552
mod ID: M6ASITE076930		Click to Show/Hide the Full List
mod site	chr6:121448127-121448128:+		[5]
Sequence	TTATTCATGAGGCTTAGAAAACACAAAGACATTAGAATACC
Motif Score	2.20572619
Cell/Tissue List	HEK293T; A549; H1A; H1B; hNPCs; hESCs; fibroblasts; Huh7; HEK293A-TOA; iSLK; MSC; TIME
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000649003.1; ENST00000647564.1; ENST00000282561.4; ENST00000649132.1; ENST00000650427.1
External Link	RMBase: m6A_site_732553
mod ID: M6ASITE076931		Click to Show/Hide the Full List
mod site	chr6:121448135-121448136:+		[5]
Sequence	GAGGCTTAGAAAACACAAAGACATTAGAATACCTAGGTTCA
Motif Score	2.897386905
Cell/Tissue List	HEK293T; A549; H1A; H1B; hNPCs; hESCs; fibroblasts; Huh7; HEK293A-TOA; iSLK; MSC; TIME
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000649132.1; ENST00000650427.1; ENST00000282561.4; ENST00000649003.1; ENST00000647564.1
External Link	RMBase: m6A_site_732554
mod ID: M6ASITE076932		Click to Show/Hide the Full List
mod site	chr6:121448238-121448239:+		[9]
Sequence	TAAAGTAGTGGATTCAAAGAACTTAGATTATAAATAAGAGT
Motif Score	3.373380952
Cell/Tissue List	HEK293T; A549; hNPCs; hESCs; fibroblasts; Huh7; HEK293A-TOA
Seq Type List	MeRIP-seq; DART-seq; m6A-seq
Transcript ID List	ENST00000650427.1; ENST00000647564.1; ENST00000649132.1; ENST00000649003.1; ENST00000282561.4
External Link	RMBase: m6A_site_732555
mod ID: M6ASITE076933		Click to Show/Hide the Full List
mod site	chr6:121448272-121448273:+		[9]
Sequence	TAAGAGTTCCATTAGGTGATACATAGATAAGGGCTTTTTCT
Motif Score	2.110482143
Cell/Tissue List	HEK293T; hESC-HEK293T
Seq Type List	DART-seq; MAZTER-seq
Transcript ID List	ENST00000650427.1; ENST00000282561.4; ENST00000649003.1; ENST00000649132.1; ENST00000647564.1
External Link	RMBase: m6A_site_732556
mod ID: M6ASITE076934		Click to Show/Hide the Full List
mod site	chr6:121448301-121448302:+		[5]
Sequence	AGGGCTTTTTCTCCCCGCAAACACCCCTAAGAATGGTTCTG
Motif Score	2.20572619
Cell/Tissue List	HEK293T; A549; hESC-HEK293T; fibroblasts; Huh7
Seq Type List	MeRIP-seq; MAZTER-seq; m6A-seq
Transcript ID List	ENST00000649003.1; ENST00000647564.1; ENST00000649132.1; ENST00000650427.1; ENST00000282561.4
External Link	RMBase: m6A_site_732557
mod ID: M6ASITE076935		Click to Show/Hide the Full List
mod site	chr6:121448377-121448378:+		[11]
Sequence	TATTTTTGTTTTACCAAGAAACTGAAATAATTCTGGCCAGG
Motif Score	2.627720238
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000647564.1; ENST00000282561.4; ENST00000650427.1; ENST00000649132.1; ENST00000649003.1
External Link	RMBase: m6A_site_732558
mod ID: M6ASITE076936		Click to Show/Hide the Full List
mod site	chr6:121448414-121448415:+		[8]
Sequence	CAGGAATAAATACTTCCTGAACATCTTAGGTCTTTTCAACA
Motif Score	2.951386905
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000650427.1; ENST00000647564.1; ENST00000649003.1; ENST00000282561.4; ENST00000649132.1
External Link	RMBase: m6A_site_732559
mod ID: M6ASITE076937		Click to Show/Hide the Full List
mod site	chr6:121448473-121448474:+		[8]
Sequence	GTCCTTAAGTCCCTGCTAAAACATTCCATTGTTAAAATTTG
Motif Score	2.20572619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000282561.4; ENST00000650427.1; ENST00000649003.1; ENST00000649132.1; ENST00000647564.1
External Link	RMBase: m6A_site_732560
mod ID: M6ASITE076938		Click to Show/Hide the Full List
mod site	chr6:121448589-121448590:+		[8]
Sequence	GGTATCAGTTTAAAATTCAGACAAGGCCCACAGAATAAGAT
Motif Score	2.897386905
Cell/Tissue List	hESC-HEK293T; Huh7
Seq Type List	MAZTER-seq; MeRIP-seq
Transcript ID List	ENST00000650427.1; ENST00000647564.1; ENST00000649132.1; ENST00000282561.4; ENST00000649003.1
External Link	RMBase: m6A_site_732561
mod ID: M6ASITE076939		Click to Show/Hide the Full List
mod site	chr6:121448656-121448657:+		[8]
Sequence	TTCTTTTTCCATCCACTTGCACAATATCATTACCATCACTT
Motif Score	2.830589286
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000282561.4; ENST00000647564.1; ENST00000649132.1; ENST00000650427.1; ENST00000649003.1
External Link	RMBase: m6A_site_732562
mod ID: M6ASITE076940		Click to Show/Hide the Full List
mod site	chr6:121448702-121448703:+		[8]
Sequence	TCATTCCTCAGCTACTACTCACATTCATTTAATGGTTTCTG
Motif Score	2.047297619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000649003.1; ENST00000649132.1; ENST00000282561.4; ENST00000650427.1; ENST00000647564.1
External Link	RMBase: m6A_site_732563
mod ID: M6ASITE076941		Click to Show/Hide the Full List
mod site	chr6:121448807-121448808:+		[8]
Sequence	CAAGCCATGCTTAATATTTAACAATCACTTATATGTGTGTC
Motif Score	2.168095238
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000282561.4; ENST00000647564.1; ENST00000650427.1; ENST00000649132.1; ENST00000649003.1
External Link	RMBase: m6A_site_732564
mod ID: M6ASITE076942		Click to Show/Hide the Full List
mod site	chr6:121448859-121448860:+		[9]
Sequence	TTTGTTTGTCATGTATTGGTACAAGCAGATACAGTATAAAC
Motif Score	2.856142857
Cell/Tissue List	HEK293T; hESC-HEK293T
Seq Type List	DART-seq; MAZTER-seq
Transcript ID List	ENST00000650427.1; ENST00000649132.1; ENST00000282561.4; ENST00000649003.1
External Link	RMBase: m6A_site_732565
mod ID: M6ASITE076943		Click to Show/Hide the Full List
mod site	chr6:121448907-121448908:+		[8]
Sequence	CACAGATTTGAAAATAATGCACATATGGTGTTCAAATTTGA
Motif Score	2.830589286
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000282561.4; ENST00000649132.1; ENST00000650427.1; ENST00000649003.1
External Link	RMBase: m6A_site_732566
mod ID: M6ASITE076944		Click to Show/Hide the Full List
mod site	chr6:121448971-121448972:+		[8]
Sequence	TGTGGGCCAATATGGTGTTTACATTATATAATTCCTGCTGT
Motif Score	2.07285119
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000650427.1; ENST00000649003.1; ENST00000282561.4; ENST00000649132.1
External Link	RMBase: m6A_site_732567
mod ID: M6ASITE076945		Click to Show/Hide the Full List
mod site	chr6:121449121-121449122:+		[9]
Sequence	GATATAGCAGTAATGCTATTACTGAAATGAATTTCCTTTTT
Motif Score	2.494845238
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000649132.1; ENST00000649003.1; ENST00000650427.1; ENST00000282561.4
External Link	RMBase: m6A_site_732568
mod ID: M6ASITE076946		Click to Show/Hide the Full List
mod site	chr6:121449183-121449184:+		[9]
Sequence	TTGAATGATAGAATTTTAGTACTGTAAACAGGCTTTAGTCA
Motif Score	3.278136905
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000649003.1; ENST00000650427.1; ENST00000282561.4; ENST00000649132.1
External Link	RMBase: m6A_site_732569
mod ID: M6ASITE076947		Click to Show/Hide the Full List
mod site	chr6:121449190-121449191:+		[4]
Sequence	ATAGAATTTTAGTACTGTAAACAGGCTTTAGTCATTAATGT
Motif Score	2.20572619
Cell/Tissue List	hNPCs; hESCs; A549
Seq Type List	m6A-seq
Transcript ID List	ENST00000282561.4; ENST00000649132.1; ENST00000649003.1; ENST00000650427.1
External Link	RMBase: m6A_site_732570
mod ID: M6ASITE076948		Click to Show/Hide the Full List
mod site	chr6:121449216-121449217:+		[9]
Sequence	TTTAGTCATTAATGTGAGAGACTTAGAAAAAATGCTTAGAG
Motif Score	3.319380952
Cell/Tissue List	HEK293T; hNPCs; hESCs; A549
Seq Type List	DART-seq; m6A-seq; m6A-CLIP/IP
Transcript ID List	ENST00000282561.4; ENST00000649003.1; ENST00000650427.1; ENST00000649132.1
External Link	RMBase: m6A_site_732571
mod ID: M6ASITE076949		Click to Show/Hide the Full List
mod site	chr6:121449240-121449241:+		[4]
Sequence	AGAAAAAATGCTTAGAGTGGACTATTAAATGTGCCTAAATG
Motif Score	4.065041667
Cell/Tissue List	hNPCs; hESCs; A549
Seq Type List	m6A-seq; m6A-CLIP/IP
Transcript ID List	ENST00000650427.1; ENST00000282561.4; ENST00000649132.1; ENST00000649003.1
External Link	RMBase: m6A_site_732572
mod ID: M6ASITE076950		Click to Show/Hide the Full List
mod site	chr6:121449302-121449303:+		[8]
Sequence	CTTGGGTTTTCCTACTTAATACACAGTAATTCAGAACTTGT
Motif Score	2.110482143
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000649003.1; ENST00000650427.1; ENST00000649132.1; ENST00000282561.4
External Link	RMBase: m6A_site_732573
mod ID: M6ASITE076951		Click to Show/Hide the Full List
mod site	chr6:121449317-121449318:+		[7]
Sequence	TTAATACACAGTAATTCAGAACTTGTATTCTATTATGAGTT
Motif Score	3.373380952
Cell/Tissue List	HEK293T; hNPCs; hESCs
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000650427.1; ENST00000649132.1; ENST00000649003.1; ENST00000282561.4
External Link	RMBase: m6A_site_732574
mod ID: M6ASITE076952		Click to Show/Hide the Full List
mod site	chr6:121449427-121449428:+		[8]
Sequence	TTGAAAGAGGATTCAGTAGTACACATACAACTAATTTATTT
Motif Score	2.856142857
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000282561.4; ENST00000649003.1; ENST00000650427.1; ENST00000649132.1
External Link	RMBase: m6A_site_732575
mod ID: M6ASITE076953		Click to Show/Hide the Full List
mod site	chr6:121449450-121449451:+		[7]
Sequence	CATACAACTAATTTATTTGAACTATATGTTGAAGACATCTA
Motif Score	3.373380952
Cell/Tissue List	HEK293T; hNPCs; fibroblasts; A549
Seq Type List	MeRIP-seq; m6A-seq; m6A-CLIP/IP
Transcript ID List	ENST00000649132.1; ENST00000650427.1; ENST00000282561.4; ENST00000649003.1
External Link	RMBase: m6A_site_732576
mod ID: M6ASITE076954		Click to Show/Hide the Full List
mod site	chr6:121449464-121449465:+		[8]
Sequence	ATTTGAACTATATGTTGAAGACATCTACCAGTTTCTCCAAA
Motif Score	2.897386905
Cell/Tissue List	HEK293T; hESC-HEK293T; hNPCs; fibroblasts; A549
Seq Type List	MeRIP-seq; MAZTER-seq; m6A-seq
Transcript ID List	ENST00000649132.1; ENST00000650427.1; ENST00000282561.4; ENST00000649003.1
External Link	RMBase: m6A_site_732577
mod ID: M6ASITE076955		Click to Show/Hide the Full List
mod site	chr6:121449498-121449499:+		[9]
Sequence	CTCCAAATGCCTTTTTTAAAACTCATCACAGAAGATTGGTG
Motif Score	2.627720238
Cell/Tissue List	HEK293T; hNPCs; fibroblasts; A549
Seq Type List	MeRIP-seq; DART-seq; m6A-seq
Transcript ID List	ENST00000649003.1; ENST00000649132.1; ENST00000282561.4; ENST00000650427.1
External Link	RMBase: m6A_site_732578
mod ID: M6ASITE076956		Click to Show/Hide the Full List
mod site	chr6:121449569-121449570:+		[7]
Sequence	CATGCATGTCAGCTACATAAACAGTTTTGTACAATGAAAAT
Motif Score	2.20572619
Cell/Tissue List	HEK293T; fibroblasts; A549
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000649003.1; ENST00000282561.4; ENST00000649132.1; ENST00000650427.1
External Link	RMBase: m6A_site_732579
mod ID: M6ASITE076957		Click to Show/Hide the Full List
mod site	chr6:121449604-121449605:+		[8]
Sequence	GAAAATTACTAATTTGTTTGACATTCCATGTTAAACTACGG
Motif Score	2.859755952
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000649132.1; ENST00000282561.4; ENST00000650427.1; ENST00000649003.1
External Link	RMBase: m6A_site_732580
mod ID: M6ASITE076958		Click to Show/Hide the Full List
mod site	chr6:121449618-121449619:+
Sequence	TGTTTGACATTCCATGTTAAACTACGGTCATGTTCAGCTTC
Motif Score	2.627720238
Cell/Tissue List	HEK293T
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000649003.1; ENST00000282561.4; ENST00000650427.1; ENST00000649132.1
External Link	RMBase: m6A_site_732581
mod ID: M6ASITE076959		Click to Show/Hide the Full List
mod site	chr6:121449655-121449656:+
Sequence	CTTCATTGCATGTAATGTAGACCTAGTCCATCAGATCATGT
Motif Score	2.876744048
Cell/Tissue List	HEK293T
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000650427.1; ENST00000649003.1; ENST00000649132.1; ENST00000282561.4
External Link	RMBase: m6A_site_732582
mod ID: M6ASITE076960		Click to Show/Hide the Full List
mod site	chr6:121449722-121449723:+		[8]
Sequence	AAAGTTTTAATTTAGTATAAACATAGCTTCTATATTCCGTG
Motif Score	2.20572619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000649132.1; ENST00000282561.4
External Link	RMBase: m6A_site_732583

Pseudouridine (Pseudo)

In total 2 m6A sequence/site(s) in this target gene
mod ID: PSESITE000241		Click to Show/Hide the Full List
mod site	chr6:121443623-121443624:+		[12]
Sequence	TAGAATGTAAATAAAGACTATACTTTCAGGGATCATTTCTA
Transcript ID List	ENST00000649132.1; ENST00000647564.1; ENST00000649003.1; rmsk_2058536; ENST00000650427.1; ENST00000282561.4
External Link	RMBase: Pseudo_site_4332
mod ID: PSESITE000242		Click to Show/Hide the Full List
mod site	chr6:121443627-121443628:+		[13]
Sequence	ATGTAAATAAAGACTATACTTTCAGGGATCATTTCTATAGT
Transcript ID List	ENST00000649003.1; ENST00000649132.1; ENST00000282561.4; rmsk_2058536; ENST00000647564.1; ENST00000650427.1
External Link	RMBase: Pseudo_site_4333

Ref 1	NAT10-mediated N4-acetylcytidine mRNA modification regulates self-renewal in human embryonic stem cells. Nucleic Acids Res. 2023 Sep 8;51(16):8514-8531. doi: 10.1093/nar/gkad628.
Ref 2	High-throughput identification of C/D box snoRNA targets with CLIP and RiboMeth-seq. Nucleic Acids Res. 2017 Mar 17;45(5):2341-2353. doi: 10.1093/nar/gkw1321.
Ref 3	MODOMICS: a database of RNA modification pathways. 2017 update. Nucleic Acids Res. 2018 Jan 4;46(D1):D303-D307. doi: 10.1093/nar/gkx1030.
Ref 4	Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites. Cell Rep. 2014 Jul 10;8(1):284-96. doi: 10.1016/j.celrep.2014.05.048. Epub 2014 Jun 26.
Ref 5	Viral N(6)-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus. Nat Commun. 2019 Oct 9;10(1):4595. doi: 10.1038/s41467-019-12504-y.
Ref 6	Single-base mapping of m(6)A by an antibody-independent method. Sci Adv. 2019 Jul 3;5(7):eaax0250. doi: 10.1126/sciadv.aax0250. eCollection 2019 Jul.
Ref 7	Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons. Cell. 2012 Jun 22;149(7):1635-46. doi: 10.1016/j.cell.2012.05.003. Epub 2012 May 17.
Ref 8	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 9	DART-seq: an antibody-free method for global m(6)A detection. Nat Methods. 2019 Dec;16(12):1275-1280. doi: 10.1038/s41592-019-0570-0. Epub 2019 Sep 23.
Ref 10	A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation. Genes Dev. 2015 Oct 1;29(19):2037-53. doi: 10.1101/gad.269415.115. Epub 2015 Sep 24.
Ref 11	N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection. Cell Host Microbe. 2016 Nov 9;20(5):654-665. doi: 10.1016/j.chom.2016.09.015. Epub 2016 Oct 20.
Ref 12	snOPY: a small nucleolar RNA orthological gene database. BMC Res Notes. 2013 Oct 23;6:426. doi: 10.1186/1756-0500-6-426.
Ref 13	snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D158-62. doi: 10.1093/nar/gkj002.

Epigenetic Target Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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