Epigenetic Target Information

General Information of the Epigenetic Target (ID: EPITAR00419)

Target Name	Tripartite motif containing 28 (TRIM28)
Synonyms	TIF1B; KAP1; TF1B; RNF96; PPP1R157; KAP-1; TIF1-beta; TIF1beta; tripartite motif-containing 28 Click to Show/Hide
Gene Name	TRIM28
Sequence	MAASAAAASAAAASAASGSPGPGEGSAGGEKRSTAPSAAASASASAAASSPAGGGAEALELLEHCGVCRERLRPEREPRLLPCLHSACSACLGPAAPAAANSSGDGGAAGDGTVVDCPVCKQQCFSKDIVENYFMRDSGSKAATDAQDANQCCTSCEDNAPATSYCVECSEPLCETCVEAHQRVKYTKDHTVRSTGPAKSRDGERTVYCNVHKHEPLVLFCESCDTLTCRDCQLNAHKDHQYQFLEDAVRNQRKLLASLVKRLGDKHATLQKSTKEVRSSIRQVSDVQKRVQVDVKMAILQIMKELNKRGRVLVNDAQKVTEGQQERLERQHWTMTKIQKHQEHILRFASWALESDNNTALLLSKKLIYFQLHRALKMIVDPVEPHGEMKFQWDLNAWTKSAEAFGKIVAERPGTNSTGPAPMAPPRAPGPLSKQGSGSSQPMEVQEGYGFGSGDDPYSSAEPHVSGVKRSRSGEGEVSGLMRKVPRVSLERLDLDLTADSQPPVFKVFPGSTTEDYNLIVIERGAAAAATGQPGTAPAGTPGAPPLAGMAIVKEEETEAAIGAPPTATEGPETKPVLMALAEGPGAEGPRLASPSGSTSSGLEVVAPEGTSAPGGGPGTLDDSATICRVCQKPGDLVMCNQCEFCFHLDCHLPALQDVPGEEWSCSLCHVLPDLKEEDGSLSLDGADSTGVVAKLSPANQRKCERVLLALFCHEPCRPLHQLATDSTFSLDQPGGTLDLTLIRARLQEKLSPPYSSPQEFAQDVGRMFKQFNKLTEDKADVQSIIGLQRFFETRMNEAFGDTKFSAVLVEPPPMSLPGAGLSSQELSGGPGDGP Click to Show/Hide
Family	TRIM/RBCC family
Function	Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also a corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteasomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). Click to Show/Hide
Gene ID	10155
HGNC ID	HGNC:16384
Ensembl Gene ID	ENSG00000130726
KEGG ID	hsa:10155
Chromosomal Location	19q13.43

RNA Modification Sequencing Data Associated with the Target (ID: EPITAR00419)

Tripartite motif containing 28 (TRIM28)

N4-acetylcytidine (ac4C)

In total 2 m6A sequence/site(s) in this target gene
mod ID: AC4SITE000008		Click to Show/Hide the Full List
mod site	chr19:58547849-58547850:+		[1]
Sequence	TGGATGTCAAGATGGCCATCCTGCAGATCATGAAGGAGCTG
Cell/Tissue List	H1
Seq Type List	ac4C-seq
Transcript ID List	ENST00000253024.10; ENST00000597995.1; ENST00000597423.1; ENST00000594806.5; ENST00000597172.5; ENST00000597618.5; ENST00000601150.5; ENST00000341753.10
External Link	RMBase: ac4C_site_1062
mod ID: AC4SITE000009		Click to Show/Hide the Full List
mod site	chr19:58548335-58548336:+
Sequence	CCCTCAAGATGATTGTGGATCCCGTGGAGCCACATGGCGAG
Cell/Tissue List	DLD1
Seq Type List	acRIP-seq
Transcript ID List	ENST00000601150.5; ENST00000597136.1; ENST00000341753.10; ENST00000597172.5; ENST00000253024.10; ENST00000597995.1
External Link	RMBase: ac4C_site_1063

Adenosine-to-Inosine editing (A-to-I)

In total 1 m6A sequence/site(s) in this target gene
mod ID: A2ISITE009307		Click to Show/Hide the Full List
mod site	chr19:58549786-58549787:+		[2]
Sequence	GCTCCCTGACCTGAAGGAGGAGGATGGCAGCCTCAGCCTGG
Transcript ID List	ENST00000598355.1; ENST00000253024.10; ENST00000597136.1; ENST00000595974.5; ENST00000600840.1; ENST00000341753.10
External Link	RMBase: RNA-editing_site_73887

5-methylcytidine (m5C)

In total 10 m6A sequence/site(s) in this target gene
mod ID: M5CSITE002127		Click to Show/Hide the Full List
mod site	chr19:58544466-58544467:+		[3]
Sequence	GCCTCGGCTCTTTCTGCGAGCGGGCGCGCGGGCGAGCGGTT
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000594806.5; ENST00000253024.10; ENST00000593582.5
External Link	RMBase: m5C_site_25829
mod ID: M5CSITE002128		Click to Show/Hide the Full List
mod site	chr19:58545046-58545047:+		[4]
Sequence	CTGCTTAGGGCCCGCGGCCCCCGCCGCCGCCAACAGCTCGG
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000253024.10; ENST00000594806.5; ENST00000341753.10; ENST00000593582.5
External Link	RMBase: m5C_site_25830
mod ID: M5CSITE002129		Click to Show/Hide the Full List
mod site	chr19:58545049-58545050:+		[4]
Sequence	CTTAGGGCCCGCGGCCCCCGCCGCCGCCAACAGCTCGGGGG
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000594806.5; ENST00000341753.10; ENST00000593582.5; ENST00000253024.10
External Link	RMBase: m5C_site_25831
mod ID: M5CSITE002130		Click to Show/Hide the Full List
mod site	chr19:58545050-58545051:+		[4]
Sequence	TTAGGGCCCGCGGCCCCCGCCGCCGCCAACAGCTCGGGGGA
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000594806.5; ENST00000593582.5; ENST00000253024.10; ENST00000341753.10
External Link	RMBase: m5C_site_25832
mod ID: M5CSITE002131		Click to Show/Hide the Full List
mod site	chr19:58545074-58545075:+		[4]
Sequence	GCCAACAGCTCGGGGGACGGCGGGGCGGCGGGCGACGGCAC
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000593582.5; ENST00000594806.5; ENST00000341753.10; ENST00000253024.10
External Link	RMBase: m5C_site_25833
mod ID: M5CSITE002132		Click to Show/Hide the Full List
mod site	chr19:58545079-58545080:+		[4]
Sequence	CAGCTCGGGGGACGGCGGGGCGGCGGGCGACGGCACCGGTA
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000253024.10; ENST00000594806.5; ENST00000341753.10; ENST00000593582.5
External Link	RMBase: m5C_site_25834
mod ID: M5CSITE002133		Click to Show/Hide the Full List
mod site	chr19:58545082-58545083:+		[4]
Sequence	CTCGGGGGACGGCGGGGCGGCGGGCGACGGCACCGGTAAGT
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000341753.10; ENST00000593582.5; ENST00000594806.5; ENST00000253024.10
External Link	RMBase: m5C_site_25835
mod ID: M5CSITE002134		Click to Show/Hide the Full List
mod site	chr19:58545086-58545087:+		[4]
Sequence	GGGGACGGCGGGGCGGCGGGCGACGGCACCGGTAAGTACGA
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000593582.5; ENST00000341753.10; ENST00000594806.5; ENST00000253024.10
External Link	RMBase: m5C_site_25836
mod ID: M5CSITE002135		Click to Show/Hide the Full List
mod site	chr19:58548984-58548985:+		[3]
Sequence	ATGCCAGGTTGCTGCATCTACAGGTCCCGCTCAGGTGAGGG
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000597136.1; ENST00000601150.5; ENST00000253024.10; ENST00000341753.10; ENST00000595028.1; ENST00000597995.1
External Link	RMBase: m5C_site_25837
mod ID: M5CSITE002136		Click to Show/Hide the Full List
mod site	chr19:58549490-58549491:+		[4]
Sequence	AGGGCTGGAGGTGGTGGCTCCTGAGGGTACCTCAGCCCCAG
Cell/Tissue List	testis; HeLa
Seq Type List	Bisulfite-seq; m5C-RIP-seq
Transcript ID List	ENST00000341753.10; ENST00000595974.5; ENST00000253024.10; ENST00000597136.1
External Link	RMBase: m5C_site_25838

N6-methyladenosine (m6A)

In total 45 m6A sequence/site(s) in this target gene
mod ID: M6ASITE042667		Click to Show/Hide the Full List
mod site	chr19:58544316-58544317:+		[5]
Sequence	GGGTTGGCGGTGGTGGAAGGACTAGGAGTTGGCGCGTGCGT
Motif Score	4.065041667
Cell/Tissue List	HeLa; A549; H1A; H1B; peripheral-blood; GSC-11; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000593582.5; ENST00000253024.10
External Link	RMBase: m6A_site_458505
mod ID: M6ASITE042668		Click to Show/Hide the Full List
mod site	chr19:58545202-58545203:+		[5]
Sequence	GCGAGAGGATGGGGGCCCGGACAGGGCACGGGAAATACTTT
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; U2OS; MM6; peripheral-blood; GSC-11; HEK293T
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000253024.10; ENST00000597968.1; ENST00000594806.5; ENST00000593582.5; ENST00000341753.10
External Link	RMBase: m6A_site_458506
mod ID: M6ASITE042669		Click to Show/Hide the Full List
mod site	chr19:58545270-58545271:+		[5]
Sequence	GTGCTGGCCGCTGAGATGGGACATCTGACTAAAGTTGGAGA
Motif Score	3.643047619
Cell/Tissue List	HeLa; MT4; MM6; Jurkat; peripheral-blood; GSC-11; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000593582.5; ENST00000597968.1; ENST00000594806.5; ENST00000253024.10; ENST00000341753.10
External Link	RMBase: m6A_site_458507
mod ID: M6ASITE042670		Click to Show/Hide the Full List
mod site	chr19:58545388-58545389:+		[6]
Sequence	GGGCCATAACCTGGGTGGGAACTTGTAACAGTCTCCCACAT
Motif Score	3.373380952
Cell/Tissue List	peripheral-blood
Seq Type List	m6A-seq
Transcript ID List	ENST00000597968.1; ENST00000341753.10; ENST00000253024.10; ENST00000593582.5; ENST00000594806.5
External Link	RMBase: m6A_site_458508
mod ID: M6ASITE042671		Click to Show/Hide the Full List
mod site	chr19:58545430-58545431:+		[5]
Sequence	CCTGCTTCTCGAAGTGGTGGACTGTCCCGTGTGCAAGCAAC
Motif Score	4.065041667
Cell/Tissue List	HeLa; peripheral-blood
Seq Type List	m6A-seq
Transcript ID List	ENST00000593582.5; ENST00000253024.10; ENST00000597968.1; ENST00000341753.10; ENST00000594806.5
External Link	RMBase: m6A_site_458509
mod ID: M6ASITE042672		Click to Show/Hide the Full List
mod site	chr19:58545449-58545450:+		[7]
Sequence	GACTGTCCCGTGTGCAAGCAACAGTGCTTCTCCAAAGACAT
Motif Score	2.173910714
Cell/Tissue List	HEK293
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000594806.5; ENST00000593582.5; ENST00000597968.1; ENST00000253024.10; ENST00000341753.10
External Link	RMBase: m6A_site_458510
mod ID: M6ASITE042673		Click to Show/Hide the Full List
mod site	chr19:58545466-58545467:+		[5]
Sequence	GCAACAGTGCTTCTCCAAAGACATCGTGGAGAATTATTTCA
Motif Score	2.897386905
Cell/Tissue List	HeLa; hESC-HEK293T; HepG2; peripheral-blood
Seq Type List	m6A-seq; MAZTER-seq
Transcript ID List	ENST00000597968.1; ENST00000341753.10; ENST00000593582.5; ENST00000594806.5; ENST00000253024.10
External Link	RMBase: m6A_site_458511
mod ID: M6ASITE042674		Click to Show/Hide the Full List
mod site	chr19:58545532-58545533:+		[5]
Sequence	CACCGACGCCCAGGATGCGAACCAGGTGCGTCCTATCTCAG
Motif Score	2.930744048
Cell/Tissue List	HeLa; HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000594806.5; ENST00000253024.10; ENST00000593582.5; ENST00000597968.1; ENST00000341753.10
External Link	RMBase: m6A_site_458512
mod ID: M6ASITE042675		Click to Show/Hide the Full List
mod site	chr19:58545835-58545836:+		[5]
Sequence	GCTCGGAGCCTCTGTGTGAGACCTGTGTAGAGGCGCACCAG
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000594806.5; ENST00000593582.5; ENST00000341753.10; ENST00000253024.10; ENST00000597968.1
External Link	RMBase: m6A_site_458513
mod ID: M6ASITE042676		Click to Show/Hide the Full List
mod site	chr19:58545866-58545867:+		[8]
Sequence	GGCGCACCAGCGGGTGAAGTACACCAAGGACCATACTGTGC
Motif Score	2.856142857
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000593582.5; ENST00000594806.5; ENST00000341753.10; ENST00000597968.1; ENST00000253024.10
External Link	RMBase: m6A_site_458514
mod ID: M6ASITE042677		Click to Show/Hide the Full List
mod site	chr19:58545875-58545876:+		[5]
Sequence	GCGGGTGAAGTACACCAAGGACCATACTGTGCGCTCTACTG
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000597968.1; ENST00000593582.5; ENST00000594806.5; ENST00000253024.10; ENST00000341753.10
External Link	RMBase: m6A_site_458515
mod ID: M6ASITE042678		Click to Show/Hide the Full List
mod site	chr19:58547421-58547422:+		[8]
Sequence	CGTACTGTCTATTGCAACGTACACAAGCATGAACCCCTTGT
Motif Score	2.856142857
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000341753.10; ENST00000597423.1; ENST00000253024.10; ENST00000593582.5; ENST00000597618.5; ENST00000594806.5
External Link	RMBase: m6A_site_458516
mod ID: M6ASITE042679		Click to Show/Hide the Full List
mod site	chr19:58547433-58547434:+		[5]
Sequence	TGCAACGTACACAAGCATGAACCCCTTGTGCTGTTTTGTGA
Motif Score	2.930744048
Cell/Tissue List	HeLa; HepG2; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000597423.1; ENST00000341753.10; ENST00000594806.5; ENST00000253024.10; ENST00000597618.5; ENST00000593582.5
External Link	RMBase: m6A_site_458517
mod ID: M6ASITE042680		Click to Show/Hide the Full List
mod site	chr19:58547480-58547481:+		[5]
Sequence	TGATACTCTCACCTGCCGAGACTGCCAGCTCAATGCCCACA
Motif Score	3.319380952
Cell/Tissue List	HeLa; HepG2; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000594806.5; ENST00000597423.1; ENST00000341753.10; ENST00000597618.5; ENST00000593582.5; ENST00000253024.10
External Link	RMBase: m6A_site_458518
mod ID: M6ASITE042681		Click to Show/Hide the Full List
mod site	chr19:58547498-58547499:+		[7]
Sequence	AGACTGCCAGCTCAATGCCCACAAGGACCACCAGTGAGTCC
Motif Score	2.053113095
Cell/Tissue List	kidney; hESC-HEK293T
Seq Type List	m6A-REF-seq; MAZTER-seq
Transcript ID List	ENST00000597423.1; ENST00000253024.10; ENST00000593582.5; ENST00000597618.5; ENST00000594806.5; ENST00000341753.10
External Link	RMBase: m6A_site_458519
mod ID: M6ASITE042682		Click to Show/Hide the Full List
mod site	chr19:58547504-58547505:+		[5]
Sequence	CCAGCTCAATGCCCACAAGGACCACCAGTGAGTCCCAAGGC
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000597423.1; ENST00000594806.5; ENST00000597618.5; ENST00000593582.5; ENST00000253024.10; ENST00000341753.10
External Link	RMBase: m6A_site_458520
mod ID: M6ASITE042683		Click to Show/Hide the Full List
mod site	chr19:58547576-58547577:+		[5]
Sequence	CCGTAGCTTAGTGCTCAGGAACACATCTGTCTGCTCTCAGG
Motif Score	2.951386905
Cell/Tissue List	HeLa; HepG2; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000597423.1; ENST00000597618.5; ENST00000594806.5; ENST00000341753.10; ENST00000253024.10; ENST00000593582.5; ENST00000597172.5
External Link	RMBase: m6A_site_458521
mod ID: M6ASITE042684		Click to Show/Hide the Full List
mod site	chr19:58547625-58547626:+		[5]
Sequence	CTTAGAGGATGCAGTGAGGAACCAGCGCAAGCTCCTGGCCT
Motif Score	2.930744048
Cell/Tissue List	HeLa; HepG2; HEK293T; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000593582.5; ENST00000597423.1; ENST00000253024.10; ENST00000594806.5; ENST00000597172.5; ENST00000341753.10; ENST00000597618.5
External Link	RMBase: m6A_site_458522
mod ID: M6ASITE042685		Click to Show/Hide the Full List
mod site	chr19:58547667-58547668:+		[5]
Sequence	ACTGGTGAAGCGCCTTGGGGACAAACATGCAACATTGCAGA
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; hESC-HEK293T; endometrial
Seq Type List	m6A-seq; MAZTER-seq
Transcript ID List	ENST00000253024.10; ENST00000597423.1; ENST00000341753.10; ENST00000597618.5; ENST00000597172.5; ENST00000594806.5
External Link	RMBase: m6A_site_458523
mod ID: M6ASITE042686		Click to Show/Hide the Full List
mod site	chr19:58547678-58547679:+		[8]
Sequence	GCCTTGGGGACAAACATGCAACATTGCAGAAGAGCACCAAG
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000597172.5; ENST00000597423.1; ENST00000594806.5; ENST00000253024.10; ENST00000597618.5; ENST00000341753.10
External Link	RMBase: m6A_site_458524
mod ID: M6ASITE042687		Click to Show/Hide the Full List
mod site	chr19:58548078-58548079:+		[5]
Sequence	GCCTGGAGCGGCAGCACTGGACCATGACCAAGATCCAGAAG
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; Huh7; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000341753.10; ENST00000253024.10; ENST00000597995.1; ENST00000597172.5; ENST00000601150.5; ENST00000597423.1
External Link	RMBase: m6A_site_458525
mod ID: M6ASITE042688		Click to Show/Hide the Full List
mod site	chr19:58548109-58548110:+		[8]
Sequence	GATCCAGAAGCACCAGGAGCACATTCTGCGCTTTGCCTCTT
Motif Score	2.830589286
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000601150.5; ENST00000341753.10; ENST00000597423.1; ENST00000597172.5; ENST00000597995.1; ENST00000253024.10
External Link	RMBase: m6A_site_458526
mod ID: M6ASITE042689		Click to Show/Hide the Full List
mod site	chr19:58548151-58548152:+		[8]
Sequence	GGCTCTGGAGAGTGACAACAACACAGCCCTTTTGCTTTCTA
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000341753.10; ENST00000597172.5; ENST00000597423.1; ENST00000253024.10; ENST00000597995.1; ENST00000601150.5
External Link	RMBase: m6A_site_458527
mod ID: M6ASITE042690		Click to Show/Hide the Full List
mod site	chr19:58548346-58548347:+		[8]
Sequence	ATTGTGGATCCCGTGGAGCCACATGGCGAGATGAAGTTTCA
Motif Score	2.053113095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000597172.5; ENST00000341753.10; ENST00000601150.5; ENST00000597136.1; ENST00000597995.1; ENST00000253024.10
External Link	RMBase: m6A_site_458528
mod ID: M6ASITE042691		Click to Show/Hide the Full List
mod site	chr19:58548372-58548373:+		[5]
Sequence	CGAGATGAAGTTTCAGTGGGACCTCAATGCCTGGACCAAGA
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000601150.5; ENST00000597136.1; ENST00000597172.5; ENST00000253024.10; ENST00000597995.1; ENST00000341753.10
External Link	RMBase: m6A_site_458529
mod ID: M6ASITE042692		Click to Show/Hide the Full List
mod site	chr19:58548386-58548387:+		[5]
Sequence	AGTGGGACCTCAATGCCTGGACCAAGAGTGCCGAGGCCTTT
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000597136.1; ENST00000601150.5; ENST00000597172.5; ENST00000253024.10; ENST00000597995.1; ENST00000341753.10
External Link	RMBase: m6A_site_458530
mod ID: M6ASITE042693		Click to Show/Hide the Full List
mod site	chr19:58548520-58548521:+		[7]
Sequence	AGCGTCCTGGCACTAACTCAACAGGCCCTGCACCCATGGCC
Motif Score	2.173910714
Cell/Tissue List	HEK293
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000253024.10; ENST00000597995.1; ENST00000597172.5; ENST00000601150.5; ENST00000341753.10; ENST00000597136.1
External Link	RMBase: m6A_site_458531
mod ID: M6ASITE042694		Click to Show/Hide the Full List
mod site	chr19:58549058-58549059:+		[5]
Sequence	AGTGAGCCTTGAACGCCTGGACCTGGACCTCACAGCTGACA
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; peripheral-blood; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000597995.1; ENST00000253024.10; ENST00000341753.10; ENST00000595028.1; ENST00000601150.5; ENST00000597136.1
External Link	RMBase: m6A_site_458532
mod ID: M6ASITE042695		Click to Show/Hide the Full List
mod site	chr19:58549064-58549065:+		[5]
Sequence	CCTTGAACGCCTGGACCTGGACCTCACAGCTGACAGCCAGC
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; peripheral-blood; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000601150.5; ENST00000597995.1; ENST00000341753.10; ENST00000253024.10; ENST00000595028.1; ENST00000597136.1
External Link	RMBase: m6A_site_458533
mod ID: M6ASITE042696		Click to Show/Hide the Full List
mod site	chr19:58549124-58549125:+		[5]
Sequence	CCCAGGCAGTACCACTGAGGACTACAACCTTATTGTTATTG
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; peripheral-blood; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000253024.10; ENST00000597136.1; ENST00000341753.10; ENST00000601150.5; ENST00000595028.1
External Link	RMBase: m6A_site_458534
mod ID: M6ASITE042697		Click to Show/Hide the Full List
mod site	chr19:58549127-58549128:+		[8]
Sequence	AGGCAGTACCACTGAGGACTACAACCTTATTGTTATTGAAC
Motif Score	2.078666667
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000253024.10; ENST00000601150.5; ENST00000341753.10; ENST00000595028.1; ENST00000597136.1
External Link	RMBase: m6A_site_458535
mod ID: M6ASITE042698		Click to Show/Hide the Full List
mod site	chr19:58549183-58549184:+		[5]
Sequence	CAGCTACCGGCCAGCCAGGGACTGCGCCTGCAGGAACCCCT
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; peripheral-blood; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000595028.1; ENST00000601150.5; ENST00000341753.10; ENST00000253024.10; ENST00000597136.1
External Link	RMBase: m6A_site_458536
mod ID: M6ASITE042699		Click to Show/Hide the Full List
mod site	chr19:58549198-58549199:+		[5]
Sequence	CAGGGACTGCGCCTGCAGGAACCCCTGGTGCCCCACCCCTG
Motif Score	2.930744048
Cell/Tissue List	HeLa; HepG2; peripheral-blood; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000595028.1; ENST00000253024.10; ENST00000601150.5; ENST00000341753.10; ENST00000597136.1
External Link	RMBase: m6A_site_458537
mod ID: M6ASITE042700		Click to Show/Hide the Full List
mod site	chr19:58549387-58549388:+		[5]
Sequence	CTGCCACTGAGGGCCCTGAGACCAAACCTGTGCTTATGGCT
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; peripheral-blood; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000597136.1; ENST00000253024.10; ENST00000341753.10; ENST00000595028.1
External Link	RMBase: m6A_site_458538
mod ID: M6ASITE042701		Click to Show/Hide the Full List
mod site	chr19:58549392-58549393:+		[5]
Sequence	ACTGAGGGCCCTGAGACCAAACCTGTGCTTATGGCTCTTGC
Motif Score	2.185083333
Cell/Tissue List	HeLa; HepG2; peripheral-blood; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000595028.1; ENST00000341753.10; ENST00000253024.10; ENST00000597136.1
External Link	RMBase: m6A_site_458539
mod ID: M6ASITE042702		Click to Show/Hide the Full List
mod site	chr19:58549525-58549526:+		[5]
Sequence	CCCCAGGTGGTGGCCCGGGAACCCTGGATGACAGTGCCACC
Motif Score	2.930744048
Cell/Tissue List	HeLa; HepG2; peripheral-blood; AML
Seq Type List	m6A-seq; miCLIP
Transcript ID List	ENST00000597136.1; ENST00000595974.5; ENST00000253024.10; ENST00000341753.10
External Link	RMBase: m6A_site_458540
mod ID: M6ASITE042703		Click to Show/Hide the Full List
mod site	chr19:58549535-58549536:+		[8]
Sequence	TGGCCCGGGAACCCTGGATGACAGTGCCACCATTTGCCGTG
Motif Score	2.859755952
Cell/Tissue List	hESC-HEK293T; AML
Seq Type List	MAZTER-seq; miCLIP
Transcript ID List	ENST00000595974.5; ENST00000597136.1; ENST00000341753.10; ENST00000253024.10
External Link	RMBase: m6A_site_458541
mod ID: M6ASITE042704		Click to Show/Hide the Full List
mod site	chr19:58549616-58549617:+		[5]
Sequence	TGAGTTTTGTTTCCACCTGGACTGTCACCTGCCGGCCCTGC
Motif Score	4.065041667
Cell/Tissue List	HeLa; AML
Seq Type List	m6A-seq; miCLIP
Transcript ID List	ENST00000600840.1; ENST00000597136.1; ENST00000341753.10; ENST00000253024.10; ENST00000595974.5
External Link	RMBase: m6A_site_458542
mod ID: M6ASITE042705		Click to Show/Hide the Full List
mod site	chr19:58549698-58549699:+		[5]
Sequence	CTGGGTGTTGGGCTGTCTGGACAGGATCATGTGCAGACCCT
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000253024.10; ENST00000598355.1; ENST00000341753.10; ENST00000597136.1; ENST00000600840.1; ENST00000595974.5
External Link	RMBase: m6A_site_458543
mod ID: M6ASITE042706		Click to Show/Hide the Full List
mod site	chr19:58549714-58549715:+		[5]
Sequence	CTGGACAGGATCATGTGCAGACCCTTATTTTCTTCACCCTA
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000253024.10; ENST00000595974.5; ENST00000597136.1; ENST00000598355.1; ENST00000600840.1; ENST00000341753.10
External Link	RMBase: m6A_site_458544
mod ID: M6ASITE042707		Click to Show/Hide the Full List
mod site	chr19:58549816-58549817:+		[9]
Sequence	CCTCAGCCTGGATGGTGCAGACAGCACTGGCGTGGTGGCCA
Motif Score	2.897386905
Cell/Tissue List	HepG2; brain; endometrial
Seq Type List	m6A-seq; m6A-REF-seq
Transcript ID List	ENST00000598355.1; ENST00000597136.1; ENST00000253024.10; ENST00000600840.1; ENST00000595974.5; ENST00000341753.10
External Link	RMBase: m6A_site_458545
mod ID: M6ASITE042708		Click to Show/Hide the Full List
mod site	chr19:58550270-58550271:+		[8]
Sequence	CCGCATGTTCAAGCAATTCAACAAGTTAACTGAGGTGAGCC
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000341753.10; ENST00000598355.1; ENST00000597136.1; ENST00000253024.10; ENST00000595974.5
External Link	RMBase: m6A_site_458546
mod ID: M6ASITE042709		Click to Show/Hide the Full List
mod site	chr19:58550377-58550378:+		[8]
Sequence	GCATTCCTGCTTGGCCCAGGACAAGGCAGACGTGCAGTCCA
Motif Score	3.643047619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000597136.1; ENST00000253024.10; ENST00000341753.10; ENST00000598355.1; ENST00000595974.5
External Link	RMBase: m6A_site_458547
mod ID: M6ASITE042710		Click to Show/Hide the Full List
mod site	chr19:58550449-58550450:+		[8]
Sequence	CATGAACGAGGCCTTCGGTGACACCAAGTTCTCTGCTGTGC
Motif Score	2.859755952
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000597136.1; ENST00000253024.10; ENST00000598355.1; ENST00000341753.10
External Link	RMBase: m6A_site_458548
mod ID: M6ASITE042711		Click to Show/Hide the Full List
mod site	chr19:58550703-58550704:+		[5]
Sequence	CTTCTGTGGATTTAATAAAAACTTCACCAGTTCCTCAGGCG
Motif Score	2.627720238
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000341753.10; ENST00000597136.1; ENST00000253024.10
External Link	RMBase: m6A_site_458549

N7-methylguanosine (m7G)

In total 1 m6A sequence/site(s) in this target gene
mod ID: m7GSITE000065		Click to Show/Hide the Full List
mod site	chr19:58544818-58544819:+		[10]
Sequence	GGCCGCCTCTGGCAGCCCGGGCCCGGGCGAGGGCTCCGCTG
Cell/Tissue List	A549; HeLa; HepG2
Seq Type List	BoRed-seq&m7G-RIP-seq; m7G-seq
Transcript ID List	ENST00000593582.5; ENST00000253024.10; ENST00000341753.10; ENST00000594806.5
External Link	RMBase: m7G_site_508

2'-O-Methylation (2'-O-Me)

In total 1 m6A sequence/site(s) in this target gene
mod ID: 2OMSITE000215		Click to Show/Hide the Full List
mod site	chr19:58545831-58545832:+		[11]
Sequence	GAGTGCTCGGAGCCTCTGTGTGAGACCTGTGTAGAGGCGCA
Cell/Tissue List	HEK293
Seq Type List	Nm-seq
Transcript ID List	ENST00000597968.1; ENST00000594806.5; ENST00000593582.5; ENST00000253024.10; ENST00000341753.10
External Link	RMBase: Nm_site_2978

Ref 1	NAT10-mediated N4-acetylcytidine mRNA modification regulates self-renewal in human embryonic stem cells. Nucleic Acids Res. 2023 Sep 8;51(16):8514-8531. doi: 10.1093/nar/gkad628.
Ref 2	RADAR: a rigorously annotated database of A-to-I RNA editing. Nucleic Acids Res. 2014 Jan;42(Database issue):D109-13. doi: 10.1093/nar/gkt996. Epub 2013 Oct 25.
Ref 3	5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m(5)C reader. Cell Res. 2017 May;27(5):606-625. doi: 10.1038/cr.2017.55. Epub 2017 Apr 18.
Ref 4	Transcriptome-wide profiling of multiple RNA modifications simultaneously at single-base resolution. Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):6784-6789. doi: 10.1073/pnas.1817334116. Epub 2019 Mar 14.
Ref 5	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 6	R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m(6)A/MYC/CEBPA Signaling. Cell. 2018 Jan 11;172(1-2):90-105.e23. doi: 10.1016/j.cell.2017.11.031. Epub 2017 Dec 14.
Ref 7	Single-base mapping of m(6)A by an antibody-independent method. Sci Adv. 2019 Jul 3;5(7):eaax0250. doi: 10.1126/sciadv.aax0250. eCollection 2019 Jul.
Ref 8	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 9	Histone H3 trimethylation at lysine 36 guides m(6)A RNA modification co-transcriptionally. Nature. 2019 Mar;567(7748):414-419. doi: 10.1038/s41586-019-1016-7. Epub 2019 Mar 13.
Ref 10	METTL1 Promotes let-7 MicroRNA Processing via m7G Methylation. Mol Cell. 2019 Jun 20;74(6):1278-1290.e9. doi: 10.1016/j.molcel.2019.03.040. Epub 2019 Apr 25.
Ref 11	Nm-seq maps 2'-O-methylation sites in human mRNA with base precision. Nat Methods. 2017 Jul;14(7):695-698. doi: 10.1038/nmeth.4294. Epub 2017 May 15.

Epigenetic Target Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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