Epigenetic Target Information

General Information of the Epigenetic Target (ID: EPITAR00417)

Target Name	HOP homeobox (HOPX)
Synonyms	LAGY; HOP; OB1; NECC1; SMAP31 Click to Show/Hide
Gene Name	HOPX
Sequence	MSAETASGPTEDQVEILEYNFNKVDKHPDSTTLCLIAAEAGLSEEETQKWFKQRLAKWRRSEGLPSECRSVTD Click to Show/Hide
Function	Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (By similarity). May act as a tumor suppressor. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding (PubMed:27708256). Click to Show/Hide
Gene ID	84525
HGNC ID	HGNC:24961
Ensembl Gene ID	ENSG00000171476
KEGG ID	hsa:84525
Chromosomal Location	4q12

RNA Modification Sequencing Data Associated with the Target (ID: EPITAR00417)

HOP homeobox (HOPX)

Adenosine-to-Inosine editing (A-to-I)

In total 27 m6A sequence/site(s) in this target gene
mod ID: A2ISITE000349		Click to Show/Hide the Full List
mod site	chr4:56648509-56648510:-		[1]
Sequence	TATGTGTATCTTCTGTGTAAAGCAGTGGCTTCACTGGAAAA
Transcript ID List	ENST00000503639.7; ENST00000555760.6; ENST00000337881.11; ENST00000317745.11; ENST00000508121.2; ENST00000381260.7; ENST00000553379.6; ENST00000556376.6; ENST00000556614.6; ENST00000381255.7; ENST00000503864.2; ENST00000554144.5; ENST00000420433.6
External Link	RMBase: RNA-editing_site_104890
mod ID: A2ISITE000350		Click to Show/Hide the Full List
mod site	chr4:56667762-56667763:-		[2]
Sequence	ATTAGGGATTAGCAAAATGCAGGTCTGTTAGGATGCTGGAG
Transcript ID List	ENST00000554144.5; ENST00000556376.6; ENST00000605395.1; ENST00000508121.2; ENST00000337881.11; ENST00000420433.6; ENST00000381260.7
External Link	RMBase: RNA-editing_site_104891
mod ID: A2ISITE000351		Click to Show/Hide the Full List
mod site	chr4:56667766-56667767:-		[2]
Sequence	TGCTATTAGGGATTAGCAAAATGCAGGTCTGTTAGGATGCT
Transcript ID List	ENST00000554144.5; ENST00000381260.7; ENST00000337881.11; ENST00000605395.1; ENST00000508121.2; ENST00000556376.6; ENST00000420433.6
External Link	RMBase: RNA-editing_site_104892
mod ID: A2ISITE000352		Click to Show/Hide the Full List
mod site	chr4:56667769-56667770:-		[2]
Sequence	TGCTGCTATTAGGGATTAGCAAAATGCAGGTCTGTTAGGAT
Transcript ID List	ENST00000381260.7; ENST00000337881.11; ENST00000556376.6; ENST00000605395.1; ENST00000508121.2; ENST00000420433.6; ENST00000554144.5
External Link	RMBase: RNA-editing_site_104893
mod ID: A2ISITE000353		Click to Show/Hide the Full List
mod site	chr4:56667772-56667773:-		[2]
Sequence	CACTGCTGCTATTAGGGATTAGCAAAATGCAGGTCTGTTAG
Transcript ID List	ENST00000605395.1; ENST00000554144.5; ENST00000420433.6; ENST00000556376.6; ENST00000381260.7; ENST00000508121.2; ENST00000337881.11
External Link	RMBase: RNA-editing_site_104894
mod ID: A2ISITE000354		Click to Show/Hide the Full List
mod site	chr4:56667779-56667780:-		[2]
Sequence	TAGGTATCACTGCTGCTATTAGGGATTAGCAAAATGCAGGT
Transcript ID List	ENST00000420433.6; ENST00000554144.5; ENST00000605395.1; ENST00000508121.2; ENST00000337881.11; ENST00000556376.6; ENST00000381260.7
External Link	RMBase: RNA-editing_site_104895
mod ID: A2ISITE000355		Click to Show/Hide the Full List
mod site	chr4:56667782-56667783:-		[2]
Sequence	ACCTAGGTATCACTGCTGCTATTAGGGATTAGCAAAATGCA
Transcript ID List	ENST00000605395.1; ENST00000508121.2; ENST00000337881.11; ENST00000554144.5; ENST00000381260.7; ENST00000556376.6; ENST00000420433.6
External Link	RMBase: RNA-editing_site_104896
mod ID: A2ISITE000356		Click to Show/Hide the Full List
mod site	chr4:56667798-56667799:-		[2]
Sequence	AAAATGCTCCTGTTGAACCTAGGTATCACTGCTGCTATTAG
Transcript ID List	ENST00000337881.11; ENST00000420433.6; ENST00000381260.7; ENST00000508121.2; ENST00000556376.6; ENST00000605395.1; ENST00000554144.5
External Link	RMBase: RNA-editing_site_104897
mod ID: A2ISITE000357		Click to Show/Hide the Full List
mod site	chr4:56667802-56667803:-		[2]
Sequence	AGTAAAAATGCTCCTGTTGAACCTAGGTATCACTGCTGCTA
Transcript ID List	ENST00000556376.6; ENST00000420433.6; ENST00000605395.1; ENST00000381260.7; ENST00000508121.2; ENST00000554144.5; ENST00000337881.11
External Link	RMBase: RNA-editing_site_104898
mod ID: A2ISITE000358		Click to Show/Hide the Full List
mod site	chr4:56667815-56667816:-		[2]
Sequence	TTAGGTAGAGAATAGTAAAAATGCTCCTGTTGAACCTAGGT
Transcript ID List	ENST00000381260.7; ENST00000508121.2; ENST00000337881.11; ENST00000554144.5; ENST00000556376.6; ENST00000420433.6; ENST00000605395.1
External Link	RMBase: RNA-editing_site_104899
mod ID: A2ISITE000359		Click to Show/Hide the Full List
mod site	chr4:56667816-56667817:-		[2]
Sequence	CTTAGGTAGAGAATAGTAAAAATGCTCCTGTTGAACCTAGG
Transcript ID List	ENST00000508121.2; ENST00000556376.6; ENST00000337881.11; ENST00000420433.6; ENST00000554144.5; ENST00000381260.7; ENST00000605395.1
External Link	RMBase: RNA-editing_site_104900
mod ID: A2ISITE000360		Click to Show/Hide the Full List
mod site	chr4:56667819-56667820:-		[2]
Sequence	TCACTTAGGTAGAGAATAGTAAAAATGCTCCTGTTGAACCT
Transcript ID List	ENST00000420433.6; ENST00000554144.5; ENST00000556376.6; ENST00000508121.2; ENST00000337881.11; ENST00000381260.7; ENST00000605395.1
External Link	RMBase: RNA-editing_site_104901
mod ID: A2ISITE000361		Click to Show/Hide the Full List
mod site	chr4:56667829-56667830:-		[2]
Sequence	GTTAAATTTCTCACTTAGGTAGAGAATAGTAAAAATGCTCC
Transcript ID List	ENST00000605395.1; ENST00000508121.2; ENST00000420433.6; ENST00000556376.6; ENST00000554144.5; ENST00000337881.11; ENST00000381260.7
External Link	RMBase: RNA-editing_site_104902
mod ID: A2ISITE000362		Click to Show/Hide the Full List
mod site	chr4:56667845-56667846:-		[2]
Sequence	TTATTATACATAAAATGTTAAATTTCTCACTTAGGTAGAGA
Transcript ID List	ENST00000556376.6; ENST00000337881.11; ENST00000381260.7; ENST00000605395.1; ENST00000420433.6; ENST00000554144.5; ENST00000508121.2
External Link	RMBase: RNA-editing_site_104903
mod ID: A2ISITE000363		Click to Show/Hide the Full List
mod site	chr4:56667846-56667847:-		[2]
Sequence	TTTATTATACATAAAATGTTAAATTTCTCACTTAGGTAGAG
Transcript ID List	ENST00000381260.7; ENST00000508121.2; ENST00000605395.1; ENST00000556376.6; ENST00000337881.11; ENST00000554144.5; ENST00000420433.6
External Link	RMBase: RNA-editing_site_104904
mod ID: A2ISITE000364		Click to Show/Hide the Full List
mod site	chr4:56667851-56667852:-		[2]
Sequence	GTCCCTTTATTATACATAAAATGTTAAATTTCTCACTTAGG
Transcript ID List	ENST00000420433.6; ENST00000554144.5; ENST00000337881.11; ENST00000556376.6; ENST00000381260.7; ENST00000508121.2; ENST00000605395.1
External Link	RMBase: RNA-editing_site_104905
mod ID: A2ISITE000365		Click to Show/Hide the Full List
mod site	chr4:56667854-56667855:-		[2]
Sequence	CGGGTCCCTTTATTATACATAAAATGTTAAATTTCTCACTT
Transcript ID List	ENST00000605395.1; ENST00000381260.7; ENST00000337881.11; ENST00000508121.2; ENST00000556376.6; ENST00000420433.6; ENST00000554144.5
External Link	RMBase: RNA-editing_site_104906
mod ID: A2ISITE000366		Click to Show/Hide the Full List
mod site	chr4:56667863-56667864:-		[2]
Sequence	CCTGGATATCGGGTCCCTTTATTATACATAAAATGTTAAAT
Transcript ID List	ENST00000420433.6; ENST00000381260.7; ENST00000337881.11; ENST00000554144.5; ENST00000556376.6; ENST00000605395.1; ENST00000508121.2
External Link	RMBase: RNA-editing_site_104907
mod ID: A2ISITE000367		Click to Show/Hide the Full List
mod site	chr4:56667876-56667877:-		[2]
Sequence	TGTCCCAGGCAAACCTGGATATCGGGTCCCTTTATTATACA
Transcript ID List	ENST00000556376.6; ENST00000605395.1; ENST00000337881.11; ENST00000420433.6; ENST00000508121.2; ENST00000381260.7; ENST00000554144.5
External Link	RMBase: RNA-editing_site_104908
mod ID: A2ISITE000368		Click to Show/Hide the Full List
mod site	chr4:56667898-56667899:-		[2]
Sequence	TACAACAGGCGTACATCAGAAGTGTCCCAGGCAAACCTGGA
Transcript ID List	ENST00000556376.6; ENST00000337881.11; ENST00000420433.6; ENST00000381260.7; ENST00000554144.5; ENST00000508121.2; ENST00000605395.1
External Link	RMBase: RNA-editing_site_104909
mod ID: A2ISITE000369		Click to Show/Hide the Full List
mod site	chr4:56667901-56667902:-		[2]
Sequence	CAGTACAACAGGCGTACATCAGAAGTGTCCCAGGCAAACCT
Transcript ID List	ENST00000337881.11; ENST00000420433.6; ENST00000508121.2; ENST00000605395.1; ENST00000556376.6; ENST00000554144.5; ENST00000381260.7
External Link	RMBase: RNA-editing_site_104910
mod ID: A2ISITE000370		Click to Show/Hide the Full List
mod site	chr4:56667928-56667929:-		[2]
Sequence	CCATCTTGAAATTATTAATAATTACACCAGTACAACAGGCG
Transcript ID List	ENST00000381260.7; ENST00000556376.6; ENST00000420433.6; ENST00000554144.5; ENST00000508121.2; ENST00000337881.11; ENST00000605395.1
External Link	RMBase: RNA-editing_site_104911
mod ID: A2ISITE000371		Click to Show/Hide the Full List
mod site	chr4:56667929-56667930:-		[2]
Sequence	TCCATCTTGAAATTATTAATAATTACACCAGTACAACAGGC
Transcript ID List	ENST00000554144.5; ENST00000556376.6; ENST00000605395.1; ENST00000381260.7; ENST00000508121.2; ENST00000420433.6; ENST00000337881.11
External Link	RMBase: RNA-editing_site_104912
mod ID: A2ISITE000372		Click to Show/Hide the Full List
mod site	chr4:56667953-56667954:-		[2]
Sequence	CCAGCCTGGATGACAGAGTGAGACTCCATCTTGAAATTATT
Transcript ID List	ENST00000508121.2; ENST00000554144.5; ENST00000337881.11; ENST00000381260.7; ENST00000556376.6; ENST00000605395.1; rmsk_1319036; ENST00000420433.6
External Link	RMBase: RNA-editing_site_104913
mod ID: A2ISITE000373		Click to Show/Hide the Full List
mod site	chr4:56679060-56679061:-		[3]
Sequence	TTTGCTATGTTGCCCAGGCTAGTCCCAAACTCCTGAGCTCA
Transcript ID List	ENST00000605395.1; ENST00000420433.6; ENST00000508121.2; ENST00000506661.2; ENST00000381260.7; ENST00000337881.11; ENST00000554144.5; ENST00000556376.6
External Link	RMBase: RNA-editing_site_104914
mod ID: A2ISITE000374		Click to Show/Hide the Full List
mod site	chr4:56679537-56679538:-		[3]
Sequence	TTGCAGTGAGCTGAGATTGTACCACTGCGCTCCAGCCTGGG
Transcript ID List	ENST00000508121.2; ENST00000381260.7; ENST00000605395.1; ENST00000337881.11; ENST00000420433.6; ENST00000554144.5; ENST00000506661.2; ENST00000556376.6; rmsk_1319063
External Link	RMBase: RNA-editing_site_104915
mod ID: A2ISITE000375		Click to Show/Hide the Full List
mod site	chr4:56679758-56679759:-		[3]
Sequence	GTGGCTGGGTGCGGTGGCCCACGCCTGTAATCCCAGCACTT
Transcript ID List	ENST00000556376.6; ENST00000420433.6; ENST00000554144.5; ENST00000337881.11; rmsk_1319063; ENST00000508121.2; ENST00000506661.2; ENST00000605395.1; ENST00000381260.7
External Link	RMBase: RNA-editing_site_104916

N6-methyladenosine (m6A)

In total 9 m6A sequence/site(s) in this target gene
mod ID: M6ASITE065875		Click to Show/Hide the Full List
mod site	chr4:56648438-56648439:-		[4]
Sequence	TGATGACAGATGGTGTGAAAACCATCTAAGTTTGCTTTTGA
Motif Score	2.185083333
Cell/Tissue List	BGC823
Seq Type List	m6A-seq
Transcript ID List	ENST00000317745.11; ENST00000381255.7; ENST00000556376.6; ENST00000503864.2; ENST00000503639.7; ENST00000556614.6; ENST00000553379.6; ENST00000554144.5; ENST00000337881.11; ENST00000381260.7; ENST00000508121.2; ENST00000420433.6; ENST00000555760.6
External Link	RMBase: m6A_site_638697
mod ID: M6ASITE065876		Click to Show/Hide the Full List
mod site	chr4:56648854-56648855:-		[5]
Sequence	GGCTACCTTTTAGAAAGGGAACAGGCATTTCAGTTTTTCTG
Motif Score	2.951386905
Cell/Tissue List	GSCs
Seq Type List	m6A-seq
Transcript ID List	ENST00000556614.6; ENST00000381260.7; ENST00000555760.6; ENST00000381255.7; ENST00000503864.2; ENST00000503639.7; ENST00000556376.6; ENST00000420433.6; ENST00000337881.11; ENST00000554144.5; ENST00000553379.6; ENST00000317745.11; ENST00000508121.2
External Link	RMBase: m6A_site_638698
mod ID: M6ASITE065877		Click to Show/Hide the Full List
mod site	chr4:56655861-56655862:-		[6]
Sequence	CAGGCCTTTCCGAGGAGGAGACCCAGGTGCGTCCCCACACG
Motif Score	2.876744048
Cell/Tissue List	CD4T; endometrial; GSCs
Seq Type List	m6A-seq
Transcript ID List	ENST00000508121.2; ENST00000553379.6; ENST00000381255.7; ENST00000554144.5; ENST00000555760.6; ENST00000317745.11; ENST00000556614.6; ENST00000381260.7; ENST00000556376.6; ENST00000337881.11; ENST00000503639.7; ENST00000420433.6
External Link	RMBase: m6A_site_638699
mod ID: M6ASITE065878		Click to Show/Hide the Full List
mod site	chr4:56655965-56655966:-		[6]
Sequence	CGCGAGCGGCCCCACAGAGGACCAGGTGGAAATCCTGGAGT
Motif Score	3.622404762
Cell/Tissue List	CD4T; HEK293T; GSCs
Seq Type List	m6A-seq
Transcript ID List	ENST00000381260.7; ENST00000337881.11; ENST00000553379.6; ENST00000420433.6; ENST00000508121.2; ENST00000555760.6; ENST00000381255.7; ENST00000503639.7; ENST00000317745.11; ENST00000554144.5; ENST00000556376.6; ENST00000556614.6
External Link	RMBase: m6A_site_638700
mod ID: M6ASITE065879		Click to Show/Hide the Full List
mod site	chr4:56655972-56655973:-		[7]
Sequence	CGGAGACCGCGAGCGGCCCCACAGAGGACCAGGTGGAAATC
Motif Score	2.053113095
Cell/Tissue List	brain
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000317745.11; ENST00000555760.6; ENST00000553379.6; ENST00000337881.11; ENST00000556376.6; ENST00000420433.6; ENST00000503639.7; ENST00000381255.7; ENST00000508121.2; ENST00000381260.7; ENST00000554144.5; ENST00000556614.6
External Link	RMBase: m6A_site_638701
mod ID: M6ASITE065880		Click to Show/Hide the Full List
mod site	chr4:56655987-56655988:-		[6]
Sequence	CAGGGACCATGTCGGCGGAGACCGCGAGCGGCCCCACAGAG
Motif Score	2.876744048
Cell/Tissue List	CD4T; HEK293T; GSCs
Seq Type List	m6A-seq
Transcript ID List	ENST00000337881.11; ENST00000555760.6; ENST00000420433.6; ENST00000381260.7; ENST00000554144.5; ENST00000503639.7; ENST00000556376.6; ENST00000553379.6; ENST00000317745.11; ENST00000381255.7; ENST00000508121.2; ENST00000556614.6
External Link	RMBase: m6A_site_638702
mod ID: M6ASITE065881		Click to Show/Hide the Full List
mod site	chr4:56656002-56656003:-		[6]
Sequence	CTGCCCCGCAGCGCGCAGGGACCATGTCGGCGGAGACCGCG
Motif Score	3.622404762
Cell/Tissue List	CD4T; HEK293T; GSCs
Seq Type List	m6A-seq
Transcript ID List	ENST00000508121.2; ENST00000381260.7; ENST00000556376.6; ENST00000555760.6; ENST00000317745.11; ENST00000554144.5; ENST00000556614.6; ENST00000503639.7; ENST00000381255.7; ENST00000337881.11; ENST00000420433.6; ENST00000553379.6
External Link	RMBase: m6A_site_638703
mod ID: M6ASITE065882		Click to Show/Hide the Full List
mod site	chr4:56656463-56656464:-		[8]
Sequence	CTAGTCGCGGACTCGGGCGAACCCACCCTCGCGATCTGTCA
Motif Score	2.930744048
Cell/Tissue List	TIME
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000420433.6; ENST00000337881.11; ENST00000556376.6; ENST00000556614.6; ENST00000508121.2; ENST00000555760.6; ENST00000381260.7; ENST00000317745.11; ENST00000381255.7; ENST00000554144.5; ENST00000553379.6
External Link	RMBase: m6A_site_638704
mod ID: M6ASITE065883		Click to Show/Hide the Full List
mod site	chr4:56656473-56656474:-		[8]
Sequence	CGGAGGCCGGCTAGTCGCGGACTCGGGCGAACCCACCCTCG
Motif Score	4.065041667
Cell/Tissue List	TIME
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000553379.6; ENST00000337881.11; ENST00000556614.6; ENST00000420433.6; ENST00000508121.2; ENST00000381255.7; ENST00000381260.7; ENST00000554144.5; ENST00000555760.6; ENST00000317745.11; ENST00000556376.6
External Link	RMBase: m6A_site_638705

Ref 1	RADAR: a rigorously annotated database of A-to-I RNA editing. Nucleic Acids Res. 2014 Jan;42(Database issue):D109-13. doi: 10.1093/nar/gkt996. Epub 2013 Oct 25.
Ref 2	Identification of widespread ultra-edited human RNAs. PLoS Genet. 2011 Oct;7(10):e1002317. doi: 10.1371/journal.pgen.1002317. Epub 2011 Oct 20.
Ref 3	Systematic identification of abundant A-to-I editing sites in the human transcriptome. Nat Biotechnol. 2004 Aug;22(8):1001-5. doi: 10.1038/nbt996. Epub 2004 Jul 18.
Ref 4	METTL3-mediated N6-methyladenosine modification is critical for epithelial-mesenchymal transition and metastasis of gastric cancer. Mol Cancer. 2019 Oct 13;18(1):142. doi: 10.1186/s12943-019-1065-4.
Ref 5	m(6)A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells. Cell Rep. 2017 Mar 14;18(11):2622-2634. doi: 10.1016/j.celrep.2017.02.059.
Ref 6	N(6)-methyladenosine of HIV-1 RNA regulates viral infection and HIV-1 Gag protein expression. Elife. 2016 Jul 2;5:e15528. doi: 10.7554/eLife.15528.
Ref 7	Single-base mapping of m(6)A by an antibody-independent method. Sci Adv. 2019 Jul 3;5(7):eaax0250. doi: 10.1126/sciadv.aax0250. eCollection 2019 Jul.
Ref 8	Viral and cellular N(6)-methyladenosine and N(6),2'-O-dimethyladenosine epitranscriptomes in the KSHV life cycle. Nat Microbiol. 2018 Jan;3(1):108-120. doi: 10.1038/s41564-017-0056-8. Epub 2017 Nov 6.

Epigenetic Target Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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