Epigenetic Target Information

General Information of the Epigenetic Target (ID: EPITAR00412)
Target Name Metalloproteinase inhibitor 4 (TIMP4)
Synonyms
Tissue inhibitor of metalloproteinases 4; TIMP-4
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Gene Name TIMP4
Sequence
MPGSPRPAPSWVLLLRLLALLRPPGLGEACSCAPAHPQQHICHSALVIRAKISSEKVVPASADPADTEKMLRYEIKQIKMFKGFEKVKDVQYIYTPFDSSLCGVKLEANSQKQYLLTGQVLSDGKVFIHLCNYIEPWEDLSLVQRESLNHHYHLNCGCQITTCYTVPCTISAPNECLWTDWLLERKLYGYQAQHYVCMKHVDGTCSWYRGHLPLRKEFVDIVQP
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Family Protease inhibitor I35 (TIMP) family
Function
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9.
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Gene ID 7079
HGNC ID HGNC:11823
Ensembl Gene ID ENSG00000157150
KEGG ID hsa:7079
Chromosomal Location 3p25.2
RNA Modification Sequencing Data Associated with the Target (ID: EPITAR00412)
Metalloproteinase inhibitor 4 (TIMP4)
N6-methyladenosine (m6A)
In total 8 m6A sequence/site(s) in this target gene
mod ID: M6ASITE059556 Click to Show/Hide the Full List
mod site chr3:12153310-12153311:- [1]
Sequence CTGTTGCCCCTGCCTCCCAAACCCCATTAGTCTAGCCTTGT
Motif Score 2.185083333
Cell/Tissue List HeLa; A549; H1A; H1B; Huh7; GSC-11; MSC
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000287814.5
External Link RMBase: m6A_site_577250
mod ID: M6ASITE059557 Click to Show/Hide the Full List
mod site chr3:12153389-12153390:- [1]
Sequence TAATAAGAAGTGCCAAGTGGACAGTCTGGCCACTGTCAAGG
Motif Score 3.643047619
Cell/Tissue List HeLa; H1A; H1B; A549; Huh7; GSC-11; MSC
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000287814.5
External Link RMBase: m6A_site_577251
mod ID: M6ASITE059558 Click to Show/Hide the Full List
mod site chr3:12153508-12153509:- [1]
Sequence ATCGTTCAGCCCTAGTAGGGACCAGTGACCATCACATCCCT
Motif Score 3.622404762
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000287814.5
External Link RMBase: m6A_site_577252
mod ID: M6ASITE059559 Click to Show/Hide the Full List
mod site chr3:12153654-12153655:- [1]
Sequence CCCCTAACGAGTGCCTCTGGACAGACTGGCTGTTGGAACGA
Motif Score 3.643047619
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000287814.5
External Link RMBase: m6A_site_577253
mod ID: M6ASITE059560 Click to Show/Hide the Full List
mod site chr3:12153698-12153699:- [2]
Sequence ACTCTAGATCACCACCTGCTACACAGTACCCTGTACCATCT
Motif Score 2.078666667
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000287814.5
External Link RMBase: m6A_site_577254
mod ID: M6ASITE059561 Click to Show/Hide the Full List
mod site chr3:12154339-12154340:- [1]
Sequence GAATCATCACTACCATCTGAACTGTGGCTGCCAAGTAAGGG
Motif Score 3.373380952
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000287814.5
External Link RMBase: m6A_site_577255
mod ID: M6ASITE059562 Click to Show/Hide the Full List
mod site chr3:12154405-12154406:- [2]
Sequence CTTCATCCATCTGTGCAACTACATCGAGCCCTGGGAGGACC
Motif Score 2.078666667
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000287814.5
External Link RMBase: m6A_site_577256
mod ID: M6ASITE059563 Click to Show/Hide the Full List
mod site chr3:12158872-12158873:- [1]
Sequence GGGGCCGTCCAGTCCCCCAGACCTCACAGGCTCAGTCGCGG
Motif Score 2.876744048
Cell/Tissue List HeLa; A549; MSC
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000287814.5
External Link RMBase: m6A_site_577257