Epigenetic Target Information

General Information of the Epigenetic Target (ID: EPITAR00408)
Target Name CD274 molecule (CD274)
Synonyms
B7-H; B7H1; PD-L1; PDL1; B7-H1; PDCD1LG1; programmed cell death 1 ligand 1; CD274 antigen
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Gene Name CD274
Sequence
MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGGADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQSDTHLEET
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Family Immunoglobulin superfamily, BTN/MOG family
Function
Plays a critical role in induction and maintenance of immune tolerance to self (PubMed:11015443, PubMed:28813417, PubMed:28813410). As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed:11015443, PubMed:28813417, PubMed:28813410). Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed:10581077). Can also act as a transcription coactivator: in response to hypoxia, translocates into the nucleus via its interaction with phosphorylated STAT3 and promotes transcription of GSDMC, leading to pyroptosis (PubMed:32929201).
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Gene ID 29126
HGNC ID HGNC:17635
Ensembl Gene ID ENSG00000120217
KEGG ID hsa:29126
Chromosomal Location 9p24.1
RNA Modification Sequencing Data Associated with the Target (ID: EPITAR00408)
CD274 molecule (CD274)
N6-methyladenosine (m6A)
In total 20 m6A sequence/site(s) in this target gene
mod ID: M6ASITE087596 Click to Show/Hide the Full List
mod site chr9:5457102-5457103:+ [1]
Sequence TACTGTCACGGTTCCCAAGGACCTATATGTGGTAGAGTATG
Motif Score 3.622404762
Cell/Tissue List HEK293T; fibroblasts; LCLs; Huh7; MSC; TIME
Seq Type List MeRIP-seq; m6A-seq
Transcript ID List ENST00000498261.1; ENST00000381573.8; ENST00000381577.4
External Link RMBase: m6A_site_815416
mod ID: M6ASITE087597 Click to Show/Hide the Full List
mod site chr9:5457163-5457164:+ [1]
Sequence TGCAAATTCCCAGTAGAAAAACAATTAGACCTGGCTGCACT
Motif Score 2.20572619
Cell/Tissue List HEK293T; fibroblasts; GM12878; LCLs; Huh7; MSC; TIME
Seq Type List MeRIP-seq; m6A-seq
Transcript ID List ENST00000498261.1; ENST00000381573.8; ENST00000381577.4
External Link RMBase: m6A_site_815417
mod ID: M6ASITE087598 Click to Show/Hide the Full List
mod site chr9:5457171-5457172:+ [1]
Sequence CCCAGTAGAAAAACAATTAGACCTGGCTGCACTAATTGTCT
Motif Score 2.876744048
Cell/Tissue List HEK293T; fibroblasts; GM12878; LCLs; Huh7; MSC; TIME
Seq Type List MeRIP-seq; m6A-seq
Transcript ID List ENST00000498261.1; ENST00000381573.8; ENST00000381577.4
External Link RMBase: m6A_site_815418
mod ID: M6ASITE087599 Click to Show/Hide the Full List
mod site chr9:5457213-5457214:+ [1]
Sequence TTGGGAAATGGAGGATAAGAACATTATTCAATTTGTGCATG
Motif Score 2.951386905
Cell/Tissue List fibroblasts; GM12878; LCLs; MSC; TIME
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000381577.4; ENST00000381573.8; ENST00000498261.1
External Link RMBase: m6A_site_815419
mod ID: M6ASITE087600 Click to Show/Hide the Full List
mod site chr9:5457243-5457244:+ [1]
Sequence ATTTGTGCATGGAGAGGAAGACCTGAAGGTTCAGCATAGTA
Motif Score 2.876744048
Cell/Tissue List fibroblasts; GM12878; LCLs; MSC; TIME
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000498261.1; ENST00000381577.4; ENST00000381573.8
External Link RMBase: m6A_site_815420
mod ID: M6ASITE087601 Click to Show/Hide the Full List
mod site chr9:5457271-5457272:+ [1]
Sequence GTTCAGCATAGTAGCTACAGACAGAGGGCCCGGCTGTTGAA
Motif Score 2.897386905
Cell/Tissue List fibroblasts; GM12878; LCLs; TIME
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000381577.4; ENST00000498261.1; ENST00000381573.8
External Link RMBase: m6A_site_815421
mod ID: M6ASITE087602 Click to Show/Hide the Full List
mod site chr9:5457294-5457295:+ [2]
Sequence GAGGGCCCGGCTGTTGAAGGACCAGCTCTCCCTGGGAAATG
Motif Score 3.622404762
Cell/Tissue List GM12878; LCLs; TIME
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000381573.8; ENST00000498261.1; ENST00000381577.4
External Link RMBase: m6A_site_815422
mod ID: M6ASITE087603 Click to Show/Hide the Full List
mod site chr9:5462888-5462889:+ [3]
Sequence GTGGATCCAGTCACCTCTGAACATGAACTGACATGTCAGGC
Motif Score 2.951386905
Cell/Tissue List LCLs; CD4T
Seq Type List m6A-seq
Transcript ID List ENST00000381573.8; ENST00000381577.4; ENST00000498261.1; ENST00000474218.1
External Link RMBase: m6A_site_815423
mod ID: M6ASITE087604 Click to Show/Hide the Full List
mod site chr9:5462894-5462895:+ [3]
Sequence CCAGTCACCTCTGAACATGAACTGACATGTCAGGCTGAGGG
Motif Score 3.373380952
Cell/Tissue List LCLs; CD8T; CD4T
Seq Type List m6A-seq; m6A-CLIP/IP
Transcript ID List ENST00000381573.8; ENST00000474218.1; ENST00000381577.4; ENST00000498261.1
External Link RMBase: m6A_site_815424
mod ID: M6ASITE087605 Click to Show/Hide the Full List
mod site chr9:5462898-5462899:+ [4]
Sequence TCACCTCTGAACATGAACTGACATGTCAGGCTGAGGGCTAC
Motif Score 2.859755952
Cell/Tissue List hESC-HEK293T; A549
Seq Type List MAZTER-seq; m6A-CLIP/IP
Transcript ID List ENST00000474218.1; ENST00000381573.8; ENST00000498261.1; ENST00000381577.4
External Link RMBase: m6A_site_815425
mod ID: M6ASITE087606 Click to Show/Hide the Full List
mod site chr9:5462940-5462941:+ [1]
Sequence CCAAGGCCGAAGTCATCTGGACAAGCAGTGACCATCAAGTC
Motif Score 3.643047619
Cell/Tissue List fibroblasts; LCLs; CD4T; endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000492923.1; ENST00000381577.4; ENST00000381573.8; ENST00000498261.1; ENST00000474218.1
External Link RMBase: m6A_site_815426
mod ID: M6ASITE087607 Click to Show/Hide the Full List
mod site chr9:5462973-5462974:+ [1]
Sequence ATCAAGTCCTGAGTGGTAAGACCACCACCACCAATTCCAAG
Motif Score 2.876744048
Cell/Tissue List fibroblasts; LCLs; CD4T; endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000492923.1; ENST00000381573.8; ENST00000474218.1; ENST00000381577.4; ENST00000498261.1
External Link RMBase: m6A_site_815427
mod ID: M6ASITE087608 Click to Show/Hide the Full List
mod site chr9:5466811-5466812:+ [1]
Sequence ATGTGGCATCCAAGATACAAACTCAAAGAAGCAAAGTGGTA
Motif Score 2.627720238
Cell/Tissue List fibroblasts
Seq Type List m6A-seq
Transcript ID List ENST00000381573.8; ENST00000381577.4; ENST00000498261.1
External Link RMBase: m6A_site_815428
mod ID: M6ASITE087609 Click to Show/Hide the Full List
mod site chr9:5467874-5467875:+ [1]
Sequence AGACGTAATCCAGCATTGGAACTTCTGATCTTCAAGCAGGG
Motif Score 3.373380952
Cell/Tissue List fibroblasts; GM12878; LCLs; Huh7; CD4T; TIME
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000381577.4; ENST00000381573.8
External Link RMBase: m6A_site_815429
mod ID: M6ASITE087610 Click to Show/Hide the Full List
mod site chr9:5467979-5467980:+ [5]
Sequence TGGGATGCAGGCAATGTGGGACTTAAAAGGCCCAAGCACTG
Motif Score 4.065041667
Cell/Tissue List HeLa; A549; fibroblasts; GM12878; LCLs; CD8T; Huh7; CD4T; GSC-11; iSLK; MSC; TIME; endometrial
Seq Type List MeRIP-seq; m6A-seq; m6A-CLIP/IP
Transcript ID List ENST00000381573.8; ENST00000381577.4
External Link RMBase: m6A_site_815430
mod ID: M6ASITE087611 Click to Show/Hide the Full List
mod site chr9:5468008-5468009:+ [5]
Sequence GCCCAAGCACTGAAAATGGAACCTGGCGAAAGCAGAGGAGG
Motif Score 2.930744048
Cell/Tissue List HeLa; A549; fibroblasts; GM12878; LCLs; Huh7; CD4T; GSC-11; iSLK; MSC; TIME; endometrial
Seq Type List MeRIP-seq; m6A-seq
Transcript ID List ENST00000381573.8; ENST00000381577.4
External Link RMBase: m6A_site_815431
mod ID: M6ASITE087612 Click to Show/Hide the Full List
mod site chr9:5468052-5468053:+ [5]
Sequence ATGAAGAAAGATGGAGTCAAACAGGGAGCCTGGAGGGAGAC
Motif Score 2.20572619
Cell/Tissue List HeLa; A549; fibroblasts; GM12878; LCLs; Huh7; CD4T; GSC-11; iSLK; MSC; TIME; endometrial
Seq Type List MeRIP-seq; m6A-seq
Transcript ID List ENST00000381573.8; ENST00000381577.4
External Link RMBase: m6A_site_815432
mod ID: M6ASITE087613 Click to Show/Hide the Full List
mod site chr9:5468071-5468072:+ [5]
Sequence AACAGGGAGCCTGGAGGGAGACCTTGATACTTTCAAATGCC
Motif Score 2.876744048
Cell/Tissue List HeLa; A549; fibroblasts; GM12878; LCLs; Huh7; CD4T; GSC-11; iSLK; MSC; TIME; endometrial
Seq Type List MeRIP-seq; m6A-seq
Transcript ID List ENST00000381577.4; ENST00000381573.8
External Link RMBase: m6A_site_815433
mod ID: M6ASITE087614 Click to Show/Hide the Full List
mod site chr9:5468138-5468139:+ [5]
Sequence GGGAGAAAGGATACTTCTGAACAAGGAGCCTCCAAGCAAAT
Motif Score 2.951386905
Cell/Tissue List A549; fibroblasts; GM12878; LCLs; CD4T; GSC-11; MSC; TIME; endometrial
Seq Type List MeRIP-seq; m6A-seq
Transcript ID List ENST00000381573.8; ENST00000381577.4
External Link RMBase: m6A_site_815434
mod ID: M6ASITE087615 Click to Show/Hide the Full List
mod site chr9:5468294-5468295:+ [1]
Sequence AGTCTCAGTGTTGGAACGGGACAGTATTTATGTATGAGTTT
Motif Score 3.643047619
Cell/Tissue List fibroblasts; GM12878; LCLs; TIME
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000381577.4; ENST00000381573.8
External Link RMBase: m6A_site_815435