Epigenetic Target Information

General Information of the Epigenetic Target (ID: EPITAR00398)
Target Name Interleukin-11 (IL11)
Gene Name IL11
Sequence
MNCVCRLVLVVLSLWPDTAVAPGPPPGPPRVSPDPRAELDSTVLLTRSLLADTRQLAAQLRDKFPADGDHNLDSLPTLAMSAGALGALQLPGVLTRLRADLLSYLRHVQWLRRAGGSSLKTLEPELGTLQARLDRLLRRLQLLMSRLALPQPPPDPPAPPLAPPSSAWGGIRAAHAILGGLHLTLDWAVRGLLLLKTRL
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Family IL-6 superfamily
Function
Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and IL11RA activates a signaling cascade that promotes cell proliferation. Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling'.
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Gene ID 3589
HGNC ID HGNC:5966
Ensembl Gene ID ENSG00000095752
KEGG ID hsa:3589
Chromosomal Location 19q13.42
RNA Modification Sequencing Data Associated with the Target (ID: EPITAR00398)
Interleukin-11 (IL11)
Adenosine-to-Inosine editing (A-to-I)
In total 2 m6A sequence/site(s) in this target gene
mod ID: A2ISITE009299 Click to Show/Hide the Full List
mod site chr19:55369154-55369155:- [1]
Sequence CTCCCTAAGGCCGGGAGTCCAGGCCCCAGACCCTCCTCCCC
Transcript ID List ENST00000264563.7; ENST00000587093.1; rmsk_5036976; ENST00000590625.5; ENST00000585513.1
External Link RMBase: RNA-editing_site_73060
mod ID: A2ISITE009300 Click to Show/Hide the Full List
mod site chr19:55369167-55369168:- [1]
Sequence CTCCAGCTCCATCCTCCCTAAGGCCGGGAGTCCAGGCCCCA
Transcript ID List ENST00000585513.1; ENST00000587093.1; ENST00000590625.5; rmsk_5036976; ENST00000264563.7
External Link RMBase: RNA-editing_site_73061
5-methylcytidine (m5C)
In total 13 m6A sequence/site(s) in this target gene
mod ID: M5CSITE002113 Click to Show/Hide the Full List
mod site chr19:55364755-55364756:-
Sequence TGGTGGCTCACGCCTGTAATCCTGGCACTTTGGGAGGACGA
Cell/Tissue List T24
Seq Type List Bisulfite-seq
Transcript ID List ENST00000264563.7; rmsk_5036966
External Link RMBase: m5C_site_25544
mod ID: M5CSITE002114 Click to Show/Hide the Full List
mod site chr19:55364762-55364763:-
Sequence CCAGGCATGGTGGCTCACGCCTGTAATCCTGGCACTTTGGG
Cell/Tissue List T24
Seq Type List Bisulfite-seq
Transcript ID List rmsk_5036966; ENST00000264563.7
External Link RMBase: m5C_site_25545
mod ID: M5CSITE002115 Click to Show/Hide the Full List
mod site chr19:55364763-55364764:-
Sequence GCCAGGCATGGTGGCTCACGCCTGTAATCCTGGCACTTTGG
Cell/Tissue List T24
Seq Type List Bisulfite-seq
Transcript ID List ENST00000264563.7; rmsk_5036966
External Link RMBase: m5C_site_25546
mod ID: M5CSITE002116 Click to Show/Hide the Full List
mod site chr19:55364765-55364766:-
Sequence TGGCCAGGCATGGTGGCTCACGCCTGTAATCCTGGCACTTT
Cell/Tissue List T24
Seq Type List Bisulfite-seq
Transcript ID List rmsk_5036966; ENST00000264563.7
External Link RMBase: m5C_site_25547
mod ID: M5CSITE002117 Click to Show/Hide the Full List
mod site chr19:55364767-55364768:-
Sequence ATTGGCCAGGCATGGTGGCTCACGCCTGTAATCCTGGCACT
Cell/Tissue List T24
Seq Type List Bisulfite-seq
Transcript ID List ENST00000264563.7; rmsk_5036966
External Link RMBase: m5C_site_25548
mod ID: M5CSITE002118 Click to Show/Hide the Full List
mod site chr19:55364769-55364770:-
Sequence ACATTGGCCAGGCATGGTGGCTCACGCCTGTAATCCTGGCA
Cell/Tissue List T24
Seq Type List Bisulfite-seq
Transcript ID List rmsk_5036966; ENST00000264563.7
External Link RMBase: m5C_site_25549
mod ID: M5CSITE002119 Click to Show/Hide the Full List
mod site chr19:55365071-55365072:- [2]
Sequence GCTGGGATTACAGGTGTGAGCCACCACACCTGACCCATAGG
Seq Type List Bisulfite-seq
Transcript ID List ENST00000264563.7
External Link RMBase: m5C_site_25550
mod ID: M5CSITE002120 Click to Show/Hide the Full List
mod site chr19:55365081-55365082:- [2]
Sequence CTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCACACCT
Seq Type List Bisulfite-seq
Transcript ID List ENST00000264563.7
External Link RMBase: m5C_site_25551
mod ID: M5CSITE002121 Click to Show/Hide the Full List
mod site chr19:55365700-55365701:- [2]
Sequence CTTCCCCATCTAGGCCTGGGCAGGAACATATATTATTTATT
Seq Type List Bisulfite-seq
Transcript ID List ENST00000264563.7; ENST00000590625.5; ENST00000585513.1
External Link RMBase: m5C_site_25552
mod ID: M5CSITE002122 Click to Show/Hide the Full List
mod site chr19:55365705-55365706:- [2]
Sequence TGGCTCTTCCCCATCTAGGCCTGGGCAGGAACATATATTAT
Seq Type List Bisulfite-seq
Transcript ID List ENST00000590625.5; ENST00000585513.1; ENST00000264563.7
External Link RMBase: m5C_site_25553
mod ID: M5CSITE002123 Click to Show/Hide the Full List
mod site chr19:55365869-55365870:- [2]
Sequence AGACAGTCCTTCCGTGAGGCCTGGGGGGCATCTGTGCCTTA
Seq Type List Bisulfite-seq
Transcript ID List ENST00000264563.7; ENST00000590625.5; ENST00000585513.1
External Link RMBase: m5C_site_25554
mod ID: M5CSITE002124 Click to Show/Hide the Full List
mod site chr19:55365917-55365918:- [2]
Sequence GGGCGAAACAGCCAGGTGATCCCCCCGCCATTATCTCCCCC
Seq Type List Bisulfite-seq
Transcript ID List ENST00000585513.1; ENST00000264563.7; ENST00000590625.5
External Link RMBase: m5C_site_25555
mod ID: M5CSITE002125 Click to Show/Hide the Full List
mod site chr19:55368283-55368284:- [2]
Sequence GCCGGGCAGGTGGCTCTTCCCTGAAGACCCTGGAGCCCGAG
Seq Type List Bisulfite-seq
Transcript ID List ENST00000264563.7; ENST00000585513.1; ENST00000590625.5; ENST00000587093.1
External Link RMBase: m5C_site_25556
N6-methyladenosine (m6A)
In total 30 m6A sequence/site(s) in this target gene
mod ID: M6ASITE042398 Click to Show/Hide the Full List
mod site chr19:55364688-55364689:- [3]
Sequence GTTCGAGACCGGCCTGCGAGACATGGCAAAACCCTGTCTCA
Motif Score 2.897386905
Cell/Tissue List HepG2
Seq Type List m6A-seq
Transcript ID List rmsk_5036966; ENST00000264563.7
External Link RMBase: m6A_site_454436
mod ID: M6ASITE042399 Click to Show/Hide the Full List
mod site chr19:55364701-55364702:- [3]
Sequence CTGAAGTCCAAGAGTTCGAGACCGGCCTGCGAGACATGGCA
Motif Score 2.876744048
Cell/Tissue List HepG2
Seq Type List m6A-seq
Transcript ID List ENST00000264563.7; rmsk_5036966
External Link RMBase: m6A_site_454437
mod ID: M6ASITE042400 Click to Show/Hide the Full List
mod site chr19:55364847-55364848:- [4]
Sequence CCCAGCCGCCCGGAGCAGGGACTGTCATTCAGGGAGGCTAA
Motif Score 4.065041667
Cell/Tissue List HeLa; HepG2; fibroblasts; A549; HEK293A-TOA; iSLK; endometrial
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000264563.7; rmsk_5036967
External Link RMBase: m6A_site_454438
mod ID: M6ASITE042401 Click to Show/Hide the Full List
mod site chr19:55364928-55364929:- [5]
Sequence TTCACCATAGCAAACTGGAAACAATCTAGATATCCAACAGT
Motif Score 2.20572619
Cell/Tissue List HEK293A-TOA
Seq Type List m6A-seq
Transcript ID List ENST00000264563.7; rmsk_5036967
External Link RMBase: m6A_site_454439
mod ID: M6ASITE042402 Click to Show/Hide the Full List
mod site chr19:55364935-55364936:- [5]
Sequence GGCTGTGTTCACCATAGCAAACTGGAAACAATCTAGATATC
Motif Score 2.627720238
Cell/Tissue List HEK293A-TOA
Seq Type List m6A-seq
Transcript ID List rmsk_5036967; ENST00000264563.7
External Link RMBase: m6A_site_454440
mod ID: M6ASITE042403 Click to Show/Hide the Full List
mod site chr19:55366017-55366018:- [4]
Sequence GGGGACTGCTGCTGCTGAAGACTCGGCTGTGACCCGGGGCC
Motif Score 3.319380952
Cell/Tissue List HeLa; HepG2
Seq Type List m6A-seq
Transcript ID List ENST00000590625.5; ENST00000264563.7; ENST00000585513.1
External Link RMBase: m6A_site_454441
mod ID: M6ASITE042404 Click to Show/Hide the Full List
mod site chr19:55366033-55366034:- [4]
Sequence CTTGACTGGGCCGTGAGGGGACTGCTGCTGCTGAAGACTCG
Motif Score 4.065041667
Cell/Tissue List HeLa; HepG2
Seq Type List m6A-seq
Transcript ID List ENST00000590625.5; ENST00000264563.7; ENST00000585513.1
External Link RMBase: m6A_site_454442
mod ID: M6ASITE042405 Click to Show/Hide the Full List
mod site chr19:55366142-55366143:- [4]
Sequence CCTGCCCCAGCCACCCCCGGACCCGCCGGCGCCCCCGCTGG
Motif Score 3.622404762
Cell/Tissue List HeLa; HepG2
Seq Type List m6A-seq
Transcript ID List ENST00000585513.1; ENST00000264563.7; ENST00000590625.5
External Link RMBase: m6A_site_454443
mod ID: M6ASITE042406 Click to Show/Hide the Full List
mod site chr19:55368237-55368238:- [3]
Sequence CACCCTGCAGGCCCGACTGGACCGGCTGCTGCGCCGGCTGC
Motif Score 3.622404762
Cell/Tissue List HepG2
Seq Type List m6A-seq
Transcript ID List ENST00000264563.7; ENST00000585513.1; ENST00000590625.5
External Link RMBase: m6A_site_454444
mod ID: M6ASITE042407 Click to Show/Hide the Full List
mod site chr19:55368277-55368278:- [3]
Sequence CAGGTGGCTCTTCCCTGAAGACCCTGGAGCCCGAGCTGGGC
Motif Score 2.876744048
Cell/Tissue List HepG2
Seq Type List m6A-seq
Transcript ID List ENST00000585513.1; ENST00000264563.7; ENST00000590625.5
External Link RMBase: m6A_site_454445
mod ID: M6ASITE042408 Click to Show/Hide the Full List
mod site chr19:55368339-55368340:- [3]
Sequence GCTGACAAGGCTGCGAGCGGACCTACTGTCCTACCTGCGGC
Motif Score 3.622404762
Cell/Tissue List HepG2
Seq Type List m6A-seq
Transcript ID List ENST00000590625.5; ENST00000264563.7; ENST00000585513.1; ENST00000587093.1
External Link RMBase: m6A_site_454446
mod ID: M6ASITE042409 Click to Show/Hide the Full List
mod site chr19:55368543-55368544:- [4]
Sequence CAAATTCCCAGCTGACGGGGACCACAACCTGGATTCCCTGC
Motif Score 3.622404762
Cell/Tissue List HeLa; HepG2
Seq Type List m6A-seq
Transcript ID List ENST00000585513.1; ENST00000587093.1; ENST00000264563.7; ENST00000590625.5
External Link RMBase: m6A_site_454447
mod ID: M6ASITE042410 Click to Show/Hide the Full List
mod site chr19:55368564-55368565:- [4]
Sequence CTTTTTTCCCTGCCAGAGGGACAAATTCCCAGCTGACGGGG
Motif Score 3.643047619
Cell/Tissue List HeLa; HepG2
Seq Type List m6A-seq
Transcript ID List ENST00000590625.5; ENST00000585513.1; ENST00000587093.1; ENST00000264563.7
External Link RMBase: m6A_site_454448
mod ID: M6ASITE042411 Click to Show/Hide the Full List
mod site chr19:55368793-55368794:- [4]
Sequence GACCCGCTCTCTCCTGGCGGACACGCGGCAGCTGGCTGCAC
Motif Score 3.643047619
Cell/Tissue List HeLa; HepG2; endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000585513.1; ENST00000264563.7; ENST00000587093.1; ENST00000590625.5
External Link RMBase: m6A_site_454449
mod ID: M6ASITE042412 Click to Show/Hide the Full List
mod site chr19:55368829-55368830:- [4]
Sequence AGACCCTCGGGCCGAGCTGGACAGCACCGTGCTCCTGACCC
Motif Score 3.643047619
Cell/Tissue List HeLa; HepG2; GSC-11; NB4
Seq Type List m6A-seq
Transcript ID List ENST00000585513.1; ENST00000590625.5; ENST00000587093.1; ENST00000264563.7
External Link RMBase: m6A_site_454450
mod ID: M6ASITE042413 Click to Show/Hide the Full List
mod site chr19:55368847-55368848:- [4]
Sequence CCCCCCTCGAGTTTCCCCAGACCCTCGGGCCGAGCTGGACA
Motif Score 2.876744048
Cell/Tissue List HeLa; HepG2; GSC-11; endometrial; NB4
Seq Type List m6A-seq
Transcript ID List ENST00000590625.5; ENST00000585513.1; ENST00000587093.1; ENST00000264563.7
External Link RMBase: m6A_site_454451
mod ID: M6ASITE042414 Click to Show/Hide the Full List
mod site chr19:55368983-55368984:- [4]
Sequence CCCAGGCCCTCCTCTCTCAGACCCGGAGTCCAGCCTGAGCT
Motif Score 2.876744048
Cell/Tissue List HeLa; HepG2; A549; GSC-11; endometrial
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List rmsk_5036976; ENST00000587093.1; ENST00000585513.1; ENST00000264563.7; ENST00000590625.5
External Link RMBase: m6A_site_454452
mod ID: M6ASITE042415 Click to Show/Hide the Full List
mod site chr19:55369018-55369019:- [4]
Sequence CCCAGTTCCTCCTCCCTCAGACCCGGGAGTCCAGGCCCAGG
Motif Score 2.876744048
Cell/Tissue List HeLa; HepG2; GSC-11; endometrial
Seq Type List m6A-seq
Transcript ID List rmsk_5036976; ENST00000264563.7; ENST00000587093.1; ENST00000585513.1; ENST00000590625.5
External Link RMBase: m6A_site_454453
mod ID: M6ASITE042416 Click to Show/Hide the Full List
mod site chr19:55369040-55369041:- [4]
Sequence CAGACCCAGGAGGAGTCCAGACCCCAGTTCCTCCTCCCTCA
Motif Score 2.876744048
Cell/Tissue List HeLa; HepG2; GSC-11; endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000585513.1; ENST00000264563.7; rmsk_5036976; ENST00000587093.1; ENST00000590625.5
External Link RMBase: m6A_site_454454
mod ID: M6ASITE042417 Click to Show/Hide the Full List
mod site chr19:55369057-55369058:- [4]
Sequence CCCAGCCTCTCCTCCCTCAGACCCAGGAGGAGTCCAGACCC
Motif Score 2.876744048
Cell/Tissue List HeLa; HepG2; GSC-11; endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000264563.7; rmsk_5036976; ENST00000587093.1; ENST00000590625.5; ENST00000585513.1
External Link RMBase: m6A_site_454455
mod ID: M6ASITE042418 Click to Show/Hide the Full List
mod site chr19:55369094-55369095:- [4]
Sequence CCCAGGCCTTCCTCCCTCAGACCTAGGAGTCCAGGCCCCCA
Motif Score 2.876744048
Cell/Tissue List HeLa; HepG2; GSC-11; endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000587093.1; ENST00000590625.5; ENST00000264563.7; ENST00000585513.1; rmsk_5036976
External Link RMBase: m6A_site_454456
mod ID: M6ASITE042419 Click to Show/Hide the Full List
mod site chr19:55369116-55369117:- [4]
Sequence CCCGAGACCCAGGAGTCCAGACCCCAGGCCTTCCTCCCTCA
Motif Score 2.876744048
Cell/Tissue List HeLa; HepG2; GSC-11; endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000585513.1; ENST00000587093.1; rmsk_5036976; ENST00000590625.5; ENST00000264563.7
External Link RMBase: m6A_site_454457
mod ID: M6ASITE042420 Click to Show/Hide the Full List
mod site chr19:55369130-55369131:- [4]
Sequence CCCAGACCCTCCTCCCCGAGACCCAGGAGTCCAGACCCCAG
Motif Score 2.876744048
Cell/Tissue List HeLa; HepG2; GSC-11; endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000585513.1; ENST00000587093.1; ENST00000590625.5; ENST00000264563.7; rmsk_5036976
External Link RMBase: m6A_site_454458
mod ID: M6ASITE042421 Click to Show/Hide the Full List
mod site chr19:55369145-55369146:- [4]
Sequence GCCGGGAGTCCAGGCCCCAGACCCTCCTCCCCGAGACCCAG
Motif Score 2.876744048
Cell/Tissue List HeLa; HepG2; GSC-11; endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000264563.7; ENST00000587093.1; ENST00000585513.1; rmsk_5036976; ENST00000590625.5
External Link RMBase: m6A_site_454459
mod ID: M6ASITE042422 Click to Show/Hide the Full List
mod site chr19:55369189-55369190:- [4]
Sequence GTTCCACCCTGGGACTTAAGACCTCCAGCTCCATCCTCCCT
Motif Score 2.876744048
Cell/Tissue List HeLa; HepG2; GSC-11; endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000590625.5; rmsk_5036976; ENST00000585513.1; ENST00000264563.7; ENST00000587093.1
External Link RMBase: m6A_site_454460
mod ID: M6ASITE042423 Click to Show/Hide the Full List
mod site chr19:55369196-55369197:- [4]
Sequence CGCGGGCGTTCCACCCTGGGACTTAAGACCTCCAGCTCCAT
Motif Score 4.065041667
Cell/Tissue List HeLa; HepG2; GSC-11
Seq Type List m6A-seq
Transcript ID List ENST00000587093.1; ENST00000585513.1; rmsk_5036976; ENST00000264563.7; ENST00000590625.5
External Link RMBase: m6A_site_454461
mod ID: M6ASITE042424 Click to Show/Hide the Full List
mod site chr19:55370305-55370306:- [4]
Sequence CTGGCCCTGTGGGGACATGAACTGTAAGTTGGTTCATGGGG
Motif Score 3.373380952
Cell/Tissue List HeLa; HepG2; GSC-11; iSLK
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000585513.1; ENST00000590625.5; ENST00000264563.7
External Link RMBase: m6A_site_454462
mod ID: M6ASITE042425 Click to Show/Hide the Full List
mod site chr19:55370311-55370312:- [4]
Sequence GAACCCCTGGCCCTGTGGGGACATGAACTGTAAGTTGGTTC
Motif Score 3.643047619
Cell/Tissue List HeLa; HepG2; GSC-11; iSLK
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000590625.5; ENST00000585513.1; ENST00000264563.7
External Link RMBase: m6A_site_454463
mod ID: M6ASITE042426 Click to Show/Hide the Full List
mod site chr19:55370329-55370330:- [4]
Sequence CCTGCCCCCTGCCCTGGGGAACCCCTGGCCCTGTGGGGACA
Motif Score 2.930744048
Cell/Tissue List HeLa; HepG2; GSC-11; iSLK
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000590625.5; ENST00000264563.7; ENST00000585513.1
External Link RMBase: m6A_site_454464
mod ID: M6ASITE042427 Click to Show/Hide the Full List
mod site chr19:55370377-55370378:- [4]
Sequence CGGGGCTCCCCCGGCAGCGGACAGGGAAGGGTTAAAGGCCC
Motif Score 3.643047619
Cell/Tissue List HeLa; HepG2; A549; GSC-11; iSLK
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000264563.7; ENST00000585513.1; ENST00000590625.5
External Link RMBase: m6A_site_454465