Epigenetic Target Information

General Information of the Epigenetic Target (ID: EPITAR00369)

Target Name	Beta-catenin-interacting protein 1 (CTNNBIP1)
Synonyms	Inhibitor of beta-catenin and Tcf-4 Click to Show/Hide
Gene Name	CTNNBIP1
Sequence	MNREGAPGKSPEEMYIQQKVRVLLMLRKMGSNLTASEEEFLRTYAGVVNSQLSQLPPHSIDQGAEDVVMAFSRSETEDRRQ Click to Show/Hide
Family	CTNNBIP1 family
Function	Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the Wnt signaling pathway. Click to Show/Hide
Gene ID	56998
HGNC ID	HGNC:16913
Ensembl Gene ID	ENSG00000178585
KEGG ID	hsa:56998
Chromosomal Location	1p36.22

RNA Modification Sequencing Data Associated with the Target (ID: EPITAR00369)

Beta-catenin-interacting protein 1 (CTNNBIP1)

Adenosine-to-Inosine editing (A-to-I)

In total 2 m6A sequence/site(s) in this target gene
mod ID: A2ISITE000697		Click to Show/Hide the Full List
mod site	chr1:9863964-9863965:-		[1]
Sequence	AAATATCTGTGGTCATGGGTAGATCAGCAGAAACCAGGCTG
Transcript ID List	ENST00000377263.6; ENST00000377258.5; ENST00000377256.1; ENST00000400904.7
External Link	RMBase: RNA-editing_site_1095
mod ID: A2ISITE000699		Click to Show/Hide the Full List
mod site	chr1:9887536-9887537:-		[1]
Sequence	CTAATTTTTGTAATTTTAGTAGAGACAGGGTTTTACTATGT
Transcript ID List	ENST00000377258.5; ENST00000400904.7; ENST00000377263.6
External Link	RMBase: RNA-editing_site_1096

5-methylcytidine (m5C)

In total 2 m6A sequence/site(s) in this target gene
mod ID: M5CSITE005146		Click to Show/Hide the Full List
mod site	chr1:9848976-9848977:-
Sequence	ACCAAATCTTTCCCCTTTCTCGGGGCTTGGGGCTCGGGCCG
Cell/Tissue List	frontalcortex
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000377263.6
External Link	RMBase: m5C_site_733
mod ID: M5CSITE005147		Click to Show/Hide the Full List
mod site	chr1:9849423-9849424:-
Sequence	CAGCTCTGGAGTTCTCTCATCGGAGGCCCATGCCCTCCACT
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000377263.6
External Link	RMBase: m5C_site_734

N6-methyladenosine (m6A)

In total 32 m6A sequence/site(s) in this target gene
mod ID: M6ASITE061711		Click to Show/Hide the Full List
mod site	chr1:9848297-9848298:-		[2]
Sequence	TCTGTTGGAGAAAGAAATTAACAATAAAGAATTTTCATAGG
Motif Score	2.168095238
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000377263.6
External Link	RMBase: m6A_site_5983
mod ID: M6ASITE061712		Click to Show/Hide the Full List
mod site	chr1:9848401-9848402:-		[2]
Sequence	TCACAGGCCTTGCTTTTGTAACAATGATGACCCCGGCCTGT
Motif Score	2.168095238
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000377263.6
External Link	RMBase: m6A_site_5984
mod ID: M6ASITE061713		Click to Show/Hide the Full List
mod site	chr1:9848419-9848420:-		[3]
Sequence	AGCCTGTCCTTGTCACGATCACAGGCCTTGCTTTTGTAACA
Motif Score	2.047297619
Cell/Tissue List	kidney
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000377263.6
External Link	RMBase: m6A_site_5985
mod ID: M6ASITE061714		Click to Show/Hide the Full List
mod site	chr1:9848480-9848481:-		[3]
Sequence	GTAGCTCCTATAAAGGGCCCACACCTGGTGGATACCTGGTT
Motif Score	2.053113095
Cell/Tissue List	liver; hESC-HEK293T
Seq Type List	m6A-REF-seq; MAZTER-seq
Transcript ID List	ENST00000377263.6
External Link	RMBase: m6A_site_5986
mod ID: M6ASITE061715		Click to Show/Hide the Full List
mod site	chr1:9848523-9848524:-		[2]
Sequence	TGGAGTCAGGTGTCGAGGCCACATTGCTGGCTGCCCCCTCT
Motif Score	2.053113095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000377263.6
External Link	RMBase: m6A_site_5987
mod ID: M6ASITE061716		Click to Show/Hide the Full List
mod site	chr1:9848670-9848671:-		[2]
Sequence	CATGTGCTGTGTGAGTGAGCACACCCGTGTGCACACTCATA
Motif Score	2.830589286
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000377263.6
External Link	RMBase: m6A_site_5988
mod ID: M6ASITE061717		Click to Show/Hide the Full List
mod site	chr1:9848746-9848747:-		[2]
Sequence	CAGCTGTGGGGAACACAGCTACAACCCTACCCTGGCAGGGA
Motif Score	2.078666667
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000377263.6
External Link	RMBase: m6A_site_5989
mod ID: M6ASITE061718		Click to Show/Hide the Full List
mod site	chr1:9848817-9848818:-		[4]
Sequence	GATTCGAGCATCAGGCTAAGACCCTGTGTCCTCCACCATGC
Motif Score	2.876744048
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000377263.6
External Link	RMBase: m6A_site_5990
mod ID: M6ASITE061719		Click to Show/Hide the Full List
mod site	chr1:9849509-9849510:-		[5]
Sequence	CCCAGGAGACCTCCAGCTAAACACCAACCCCTGACCTACCC
Motif Score	2.20572619
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000377263.6
External Link	RMBase: m6A_site_5991
mod ID: M6ASITE061720		Click to Show/Hide the Full List
mod site	chr1:9849521-9849522:-		[5]
Sequence	TGGCTCACAAGGCCCAGGAGACCTCCAGCTAAACACCAACC
Motif Score	2.876744048
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000377263.6
External Link	RMBase: m6A_site_5992
mod ID: M6ASITE061721		Click to Show/Hide the Full List
mod site	chr1:9849562-9849563:-		[5]
Sequence	GAGGTCTCTGGGAGCCCAGAACCCACATAAAAGCCCCAGCT
Motif Score	2.930744048
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000377263.6
External Link	RMBase: m6A_site_5993
mod ID: M6ASITE061722		Click to Show/Hide the Full List
mod site	chr1:9849602-9849603:-		[5]
Sequence	CCCAGTGTGAGACCCCAAAGACTCTGGAGGTCATCTGGCGG
Motif Score	3.319380952
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000377263.6
External Link	RMBase: m6A_site_5994
mod ID: M6ASITE061723		Click to Show/Hide the Full List
mod site	chr1:9849611-9849612:-		[5]
Sequence	GGAGCTTCTCCCAGTGTGAGACCCCAAAGACTCTGGAGGTC
Motif Score	2.876744048
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000377263.6
External Link	RMBase: m6A_site_5995
mod ID: M6ASITE061769		Click to Show/Hide the Full List
mod site	chr1:9849975-9849976:-		[2]
Sequence	TGAGGGTCCACCTGGAGAGTACATTTGCTTTAATGAGTGCA
Motif Score	2.856142857
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000377263.6
External Link	RMBase: m6A_site_5996
mod ID: M6ASITE061770		Click to Show/Hide the Full List
mod site	chr1:9850108-9850109:-		[2]
Sequence	AAGAACTTGCTGCTGCCTTCACATTTGGGGTTTGTGTTTGA
Motif Score	2.047297619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000377263.6; ENST00000400904.7
External Link	RMBase: m6A_site_5997
mod ID: M6ASITE061771		Click to Show/Hide the Full List
mod site	chr1:9850131-9850132:-		[4]
Sequence	CGCTTTGCAATATTTATTACACAAAGAACTTGCTGCTGCCT
Motif Score	2.084928571
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000377263.6; ENST00000400904.7
External Link	RMBase: m6A_site_5998
mod ID: M6ASITE061772		Click to Show/Hide the Full List
mod site	chr1:9850133-9850134:-		[4]
Sequence	TGCGCTTTGCAATATTTATTACACAAAGAACTTGCTGCTGC
Motif Score	2.07285119
Cell/Tissue List	HEK293T; hESC-HEK293T
Seq Type List	DART-seq; MAZTER-seq
Transcript ID List	ENST00000400904.7; ENST00000377263.6
External Link	RMBase: m6A_site_5999
mod ID: M6ASITE061773		Click to Show/Hide the Full List
mod site	chr1:9850159-9850160:-		[5]
Sequence	TTTGACTTGAAAAGAAAGAAACCAAGTGCGCTTTGCAATAT
Motif Score	2.185083333
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000400904.7; ENST00000377263.6
External Link	RMBase: m6A_site_6000
mod ID: M6ASITE061774		Click to Show/Hide the Full List
mod site	chr1:9850175-9850176:-		[4]
Sequence	GACATTAGTCGTTATATTTGACTTGAAAAGAAAGAAACCAA
Motif Score	3.28175
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000400904.7; ENST00000377263.6
External Link	RMBase: m6A_site_6001
mod ID: M6ASITE061775		Click to Show/Hide the Full List
mod site	chr1:9850194-9850195:-		[5]
Sequence	TGCAGAAAACAGGGTCTGGGACATTAGTCGTTATATTTGAC
Motif Score	3.643047619
Cell/Tissue List	HeLa; HEK293T; hESC-HEK293T
Seq Type List	m6A-seq; DART-seq; MAZTER-seq
Transcript ID List	ENST00000377263.6; ENST00000400904.7
External Link	RMBase: m6A_site_6002
mod ID: M6ASITE061795		Click to Show/Hide the Full List
mod site	chr1:9850206-9850207:-		[5]
Sequence	CCCTATTTTGAATGCAGAAAACAGGGTCTGGGACATTAGTC
Motif Score	2.20572619
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000377263.6; ENST00000400904.7
External Link	RMBase: m6A_site_6003
mod ID: M6ASITE061800		Click to Show/Hide the Full List
mod site	chr1:9850233-9850234:-		[3]
Sequence	CAGGTGTTCTGCTGATATCAACAGCTTCCCTATTTTGAATG
Motif Score	2.173910714
Cell/Tissue List	kidney
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000400904.7; ENST00000377263.6
External Link	RMBase: m6A_site_6004
mod ID: M6ASITE061801		Click to Show/Hide the Full List
mod site	chr1:9850309-9850310:-		[4]
Sequence	AGGTCTGATTGGCTGCTTAAACTGGAAAGGATCTGTGATTG
Motif Score	2.627720238
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000400904.7; ENST00000377263.6
External Link	RMBase: m6A_site_6005
mod ID: M6ASITE061802		Click to Show/Hide the Full List
mod site	chr1:9850429-9850430:-		[4]
Sequence	ACCTTTTATTTTTATTTCTGACTCTTATTTTTTAAAAAATT
Motif Score	3.28175
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000400904.7; ENST00000377263.6
External Link	RMBase: m6A_site_6006
mod ID: M6ASITE061803		Click to Show/Hide the Full List
mod site	chr1:9850449-9850450:-		[6]
Sequence	TTAAATCTTGACCAACAGAAACCTTTTATTTTTATTTCTGA
Motif Score	2.185083333
Cell/Tissue List	hESCs
Seq Type List	m6A-seq
Transcript ID List	ENST00000400904.7; ENST00000377263.6; ENST00000377258.5
External Link	RMBase: m6A_site_6007
mod ID: M6ASITE061804		Click to Show/Hide the Full List
mod site	chr1:9850482-9850483:-		[6]
Sequence	GTGATTGGCTGCAGGAAGAAACTTTTTTATTTTTTAAATCT
Motif Score	2.627720238
Cell/Tissue List	hESCs
Seq Type List	m6A-seq
Transcript ID List	ENST00000400904.7; ENST00000377263.6; ENST00000377258.5
External Link	RMBase: m6A_site_6008
mod ID: M6ASITE061805		Click to Show/Hide the Full List
mod site	chr1:9850506-9850507:-		[6]
Sequence	TAATTGGCTTAAAGGGATGGACTTGTGATTGGCTGCAGGAA
Motif Score	4.065041667
Cell/Tissue List	hESCs
Seq Type List	m6A-seq
Transcript ID List	ENST00000400904.7; ENST00000377263.6; ENST00000377258.5
External Link	RMBase: m6A_site_6009
mod ID: M6ASITE061806		Click to Show/Hide the Full List
mod site	chr1:9850544-9850545:-		[2]
Sequence	TGGGGCTGGCATCAAGGGAGACACCAGTGGTGCGTTTATAA
Motif Score	2.897386905
Cell/Tissue List	hESC-HEK293T; hESCs
Seq Type List	MAZTER-seq; m6A-seq
Transcript ID List	ENST00000377258.5; ENST00000377263.6; ENST00000400904.7
External Link	RMBase: m6A_site_6010
mod ID: M6ASITE061807		Click to Show/Hide the Full List
mod site	chr1:9850700-9850701:-		[7]
Sequence	GTAGCTGCAAAGCCCTTGGAACACCCTGGATGCTGTTGAGG
Motif Score	2.951386905
Cell/Tissue List	HepG2; hESC-HEK293T; peripheral-blood
Seq Type List	m6A-seq; MAZTER-seq
Transcript ID List	ENST00000377258.5; ENST00000377256.1; ENST00000377263.6; ENST00000400904.7
External Link	RMBase: m6A_site_6011
mod ID: M6ASITE061808		Click to Show/Hide the Full List
mod site	chr1:9850730-9850731:-		[8]
Sequence	TTCCAGGTCGGAGACGGAAGACCGGAGGCAGTAGCTGCAAA
Motif Score	2.876744048
Cell/Tissue List	HepG2; peripheral-blood
Seq Type List	m6A-seq
Transcript ID List	ENST00000377256.1; ENST00000377258.5; ENST00000400904.7; ENST00000377263.6
External Link	RMBase: m6A_site_6012
mod ID: M6ASITE061809		Click to Show/Hide the Full List
mod site	chr1:9872020-9872021:-		[2]
Sequence	GAAGAGTCCGGAGGAGATGTACATTCAGCAGAAGGTCCGAG
Motif Score	2.856142857
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000377256.1; ENST00000377263.6; ENST00000377258.5; ENST00000400904.7
External Link	RMBase: m6A_site_6013
mod ID: M6ASITE061810		Click to Show/Hide the Full List
mod site	chr1:9872059-9872060:-		[7]
Sequence	AGAGCCAGGCAGGGGGATGAACCGCGAGGGAGCTCCCGGGA
Motif Score	2.930744048
Cell/Tissue List	HepG2; endometrial; NB4
Seq Type List	m6A-seq
Transcript ID List	ENST00000377263.6; ENST00000400904.7; ENST00000377256.1; ENST00000377258.5
External Link	RMBase: m6A_site_6014

Ref 1	RADAR: a rigorously annotated database of A-to-I RNA editing. Nucleic Acids Res. 2014 Jan;42(Database issue):D109-13. doi: 10.1093/nar/gkt996. Epub 2013 Oct 25.
Ref 2	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 3	Single-base mapping of m(6)A by an antibody-independent method. Sci Adv. 2019 Jul 3;5(7):eaax0250. doi: 10.1126/sciadv.aax0250. eCollection 2019 Jul.
Ref 4	DART-seq: an antibody-free method for global m(6)A detection. Nat Methods. 2019 Dec;16(12):1275-1280. doi: 10.1038/s41592-019-0570-0. Epub 2019 Sep 23.
Ref 5	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 6	Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites. Cell Rep. 2014 Jul 10;8(1):284-96. doi: 10.1016/j.celrep.2014.05.048. Epub 2014 Jun 26.
Ref 7	Histone H3 trimethylation at lysine 36 guides m(6)A RNA modification co-transcriptionally. Nature. 2019 Mar;567(7748):414-419. doi: 10.1038/s41586-019-1016-7. Epub 2019 Mar 13.
Ref 8	Efficacy of MEK inhibition in patients with histiocytic neoplasms. Nature. 2019 Mar;567(7749):521-524. doi: 10.1038/s41586-019-1012-y. Epub 2019 Mar 13.

Epigenetic Target Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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