Epigenetic Target Information

General Information of the Epigenetic Target (ID: EPITAR00361)

Target Name	Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A)
Synonyms	Tumor necrosis factor receptor 1; TNF-R1; Tumor necrosis factor receptor type I; TNF-RI; TNFR-I; p55; p60; CD antigen CD120a; TBPI Click to Show/Hide
Gene Name	TNFRSF1A
Sequence	MGLSTVPDLLLPLVLLELLVGIYPSGVIGLVPHLGDREKRDSVCPQGKYIHPQNNSICCTKCHKGTYLYNDCPGPGQDTDCRECESGSFTASENHLRHCLSCSKCRKEMGQVEISSCTVDRDTVCGCRKNQYRHYWSENLFQCFNCSLCLNGTVHLSCQEKQNTVCTCHAGFFLRENECVSCSNCKKSLECTKLCLPQIENVKGTEDSGTTVLLPLVIFFGLCLLSLLFIGLMYRYQRWKSKLYSIVCGKSTPEKEGELEGTTTKPLAPNPSFSPTPGFTPTLGFSPVPSSTFTSSSTYTPGDCPNFAAPRREVAPPYQGADPILATALASDPIPNPLQKWEDSAHKPQSLDTDDPATLYAVVENVPPLRWKEFVRRLGLSDHEIDRLELQNGRCLREAQYSMLATWRRRTPRREATLELLGRVLRDMDLLGCLEDIEEALCGPAALPPAPSLLR Click to Show/Hide
Function	Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. Click to Show/Hide
Gene ID	7132
HGNC ID	HGNC:11916
Ensembl Gene ID	ENSG00000067182
KEGG ID	hsa:7132
Chromosomal Location	12p13.31

RNA Modification Sequencing Data Associated with the Target (ID: EPITAR00361)

Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A)

N4-acetylcytidine (ac4C)

In total 1 m6A sequence/site(s) in this target gene
mod ID: AC4SITE000169		Click to Show/Hide the Full List
mod site	chr12:6330010-6330011:-
Sequence	CCCAAACCCAAGCTTCAGTCCCACTCCAGGCTTCACCCCCA
Cell/Tissue List	DLD1
Seq Type List	acRIP-seq
Transcript ID List	ENST00000162749.6; ENST00000534885.5; ENST00000537842.5; ENST00000543359.5; ENST00000536717.5; ENST00000543995.5; ENST00000540022.5
External Link	RMBase: ac4C_site_385

5-methylcytidine (m5C)

In total 2 m6A sequence/site(s) in this target gene
mod ID: M5CSITE005425		Click to Show/Hide the Full List
mod site	chr12:6329008-6329009:-		[1]
Sequence	AGCAAGGCTGCTCGGGGGCCCCTGGTTCGTCCCTGAGCCTT
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000162749.6; ENST00000534885.5
External Link	RMBase: m5C_site_9449
mod ID: M5CSITE005426		Click to Show/Hide the Full List
mod site	chr12:6333496-6333497:-		[1]
Sequence	GAAATGGGTCAGGTGGAGATCTCTTCTTGCACAGTGGACCG
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000534885.5; ENST00000437813.7; ENST00000543995.5; ENST00000366159.8; ENST00000440083.6; ENST00000536194.1; ENST00000543048.5; ENST00000162749.6; ENST00000539372.5; ENST00000540022.5
External Link	RMBase: m5C_site_9450

N6-methyladenosine (m6A)

In total 40 m6A sequence/site(s) in this target gene
mod ID: M6ASITE010256		Click to Show/Hide the Full List
mod site	chr12:6328803-6328804:-		[2]
Sequence	GCCTTCAGCTGGAGCTGTGGACTTTTGTACATACACTAAAA
Motif Score	4.065041667
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; U2OS; H1A; H1B; hESCs; fibroblasts; GM12878; H1299; MM6; Huh7; CD4T; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; NB4
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000534885.5; ENST00000162749.6
External Link	RMBase: m6A_site_173836
mod ID: M6ASITE010257		Click to Show/Hide the Full List
mod site	chr12:6328831-6328832:-		[2]
Sequence	AAGGCAGGGGCGAGCACGGAACAATGGGGCCTTCAGCTGGA
Motif Score	2.951386905
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; kidney; liver; A549; hESC-HEK293T; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; CD8T; H1299; MM6; Huh7; CD4T; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; NB4; AML
Seq Type List	m6A-seq; MeRIP-seq; m6A-REF-seq; MAZTER-seq; m6A-CLIP/IP; miCLIP
Transcript ID List	ENST00000162749.6; ENST00000534885.5
External Link	RMBase: m6A_site_173837
mod ID: M6ASITE010258		Click to Show/Hide the Full List
mod site	chr12:6328859-6328860:-		[2]
Sequence	ACAAGCACATAGCAAGCTGAACTGTCCTAAGGCAGGGGCGA
Motif Score	3.373380952
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; H1299; MM6; Huh7; CD4T; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000162749.6; ENST00000534885.5
External Link	RMBase: m6A_site_173838
mod ID: M6ASITE010259		Click to Show/Hide the Full List
mod site	chr12:6328873-6328874:-		[3]
Sequence	TGCCCTCTGCCTGGACAAGCACATAGCAAGCTGAACTGTCC
Motif Score	2.830589286
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000162749.6; ENST00000534885.5
External Link	RMBase: m6A_site_173839
mod ID: M6ASITE010260		Click to Show/Hide the Full List
mod site	chr12:6328879-6328880:-		[2]
Sequence	CTCCTGTGCCCTCTGCCTGGACAAGCACATAGCAAGCTGAA
Motif Score	3.643047619
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; hESC-HEK293T; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; H1299; MM6; Huh7; CD4T; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; NB4
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List	ENST00000162749.6; ENST00000534885.5
External Link	RMBase: m6A_site_173840
mod ID: M6ASITE010261		Click to Show/Hide the Full List
mod site	chr12:6328907-6328908:-		[2]
Sequence	ATCATGTTACACTAATAGAAACTTGGCACTCCTGTGCCCTC
Motif Score	2.627720238
Cell/Tissue List	HeLa; CD34; HEK293T; A549; HepG2; U2OS; H1A; H1B; hESCs; fibroblasts; GM12878; H1299; MM6; Huh7; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000162749.6; ENST00000534885.5
External Link	RMBase: m6A_site_173841
mod ID: M6ASITE010262		Click to Show/Hide the Full List
mod site	chr12:6328917-6328918:-		[4]
Sequence	TTTTAAATCAATCATGTTACACTAATAGAAACTTGGCACTC
Motif Score	2.506922619
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000534885.5; ENST00000162749.6
External Link	RMBase: m6A_site_173842
mod ID: M6ASITE010263		Click to Show/Hide the Full List
mod site	chr12:6328919-6328920:-		[4]
Sequence	GTTTTTAAATCAATCATGTTACACTAATAGAAACTTGGCAC
Motif Score	2.07285119
Cell/Tissue List	HEK293T; hESC-HEK293T
Seq Type List	DART-seq; MAZTER-seq
Transcript ID List	ENST00000534885.5; ENST00000162749.6
External Link	RMBase: m6A_site_173843
mod ID: M6ASITE010264		Click to Show/Hide the Full List
mod site	chr12:6329141-6329142:-		[4]
Sequence	CAGCTGCCTGCGCGCCGCCGACAGTCAGCGCTGTGCGCGCG
Motif Score	2.865571429
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000536717.5; ENST00000162749.6; ENST00000534885.5
External Link	RMBase: m6A_site_173844
mod ID: M6ASITE010265		Click to Show/Hide the Full List
mod site	chr12:6329174-6329175:-		[4]
Sequence	TGGTGCTAACCCCTCGATGTACATAGCTTTTCTCAGCTGCC
Motif Score	2.856142857
Cell/Tissue List	HEK293T; hESC-HEK293T
Seq Type List	DART-seq; MAZTER-seq
Transcript ID List	ENST00000162749.6; ENST00000543995.5; ENST00000536717.5; ENST00000534885.5
External Link	RMBase: m6A_site_173845
mod ID: M6ASITE010266		Click to Show/Hide the Full List
mod site	chr12:6329282-6329283:-		[2]
Sequence	CCCTGCGGGCAGCTCTAAGGACCGTCCTGCGAGATCGCCTT
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; fibroblasts; GM12878; LCLs; H1299; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000534885.5; ENST00000536717.5; ENST00000543995.5; ENST00000540022.5; ENST00000162749.6
External Link	RMBase: m6A_site_173846
mod ID: M6ASITE010267		Click to Show/Hide the Full List
mod site	chr12:6329372-6329373:-		[2]
Sequence	CCTGCTGGGCTGCCTGGAGGACATCGAGGAGGCGCTTTGCG
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; HEK293T; kidney; A549; hESC-HEK293T; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; H1299; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4; AML
Seq Type List	m6A-seq; MeRIP-seq; m6A-REF-seq; MAZTER-seq; m6A-CLIP/IP; miCLIP
Transcript ID List	ENST00000536717.5; ENST00000540022.5; ENST00000543995.5; ENST00000162749.6; ENST00000534885.5
External Link	RMBase: m6A_site_173847
mod ID: M6ASITE010268		Click to Show/Hide the Full List
mod site	chr12:6329393-6329394:-		[2]
Sequence	ACGCGTGCTCCGCGACATGGACCTGCTGGGCTGCCTGGAGG
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; CD8T; H1299; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000162749.6; ENST00000543995.5; ENST00000534885.5; ENST00000536717.5; ENST00000540022.5
External Link	RMBase: m6A_site_173848
mod ID: M6ASITE010269		Click to Show/Hide the Full List
mod site	chr12:6329399-6329400:-		[3]
Sequence	GCTGGGACGCGTGCTCCGCGACATGGACCTGCTGGGCTGCC
Motif Score	2.865571429
Cell/Tissue List	hESC-HEK293T; CD8T; A549
Seq Type List	MAZTER-seq; m6A-CLIP/IP
Transcript ID List	ENST00000534885.5; ENST00000536717.5; ENST00000540022.5; ENST00000543995.5; ENST00000162749.6
External Link	RMBase: m6A_site_173849
mod ID: M6ASITE010270		Click to Show/Hide the Full List
mod site	chr12:6329413-6329414:-		[5]
Sequence	GCCACGCTGGAGCTGCTGGGACGCGTGCTCCGCGACATGGA
Motif Score	3.616982143
Cell/Tissue List	CD8T
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000536717.5; ENST00000540022.5; ENST00000543995.5; ENST00000162749.6; ENST00000534885.5
External Link	RMBase: m6A_site_173850
mod ID: M6ASITE010271		Click to Show/Hide the Full List
mod site	chr12:6329779-6329780:-		[2]
Sequence	CCACAAGCCACAGAGCCTAGACAGTGAGTTTCTCCCGCGGC
Motif Score	2.897386905
Cell/Tissue List	HeLa; CD34; HepG2; U2OS; A549; MM6; Huh7; peripheral-blood; HEK293T; iSLK; MSC; TIME; endometrial; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000162749.6; ENST00000543359.5; ENST00000543995.5; ENST00000534885.5; ENST00000536717.5; ENST00000540022.5
External Link	RMBase: m6A_site_173851
mod ID: M6ASITE010272		Click to Show/Hide the Full List
mod site	chr12:6329790-6329791:-		[4]
Sequence	GAGGACAGCGCCCACAAGCCACAGAGCCTAGACAGTGAGTT
Motif Score	2.053113095
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000540022.5; ENST00000536717.5; ENST00000534885.5; ENST00000543359.5; ENST00000162749.6; ENST00000543995.5
External Link	RMBase: m6A_site_173852
mod ID: M6ASITE010273		Click to Show/Hide the Full List
mod site	chr12:6329806-6329807:-		[2]
Sequence	CCCCCTTCAGAAGTGGGAGGACAGCGCCCACAAGCCACAGA
Motif Score	3.643047619
Cell/Tissue List	HeLa; CD34; HepG2; A549; MM6; Huh7; peripheral-blood; HEK293T; iSLK; MSC; TIME; endometrial; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000543359.5; ENST00000534885.5; ENST00000536717.5; ENST00000540022.5; ENST00000543995.5; ENST00000162749.6
External Link	RMBase: m6A_site_173853
mod ID: M6ASITE010274		Click to Show/Hide the Full List
mod site	chr12:6330025-6330026:-		[6]
Sequence	TACTAAGCCCCTGGCCCCAAACCCAAGCTTCAGTCCCACTC
Motif Score	2.185083333
Cell/Tissue List	CD34; HepG2; HeLa; A549; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000543359.5; ENST00000543995.5; ENST00000540022.5; ENST00000537842.5; ENST00000534885.5; ENST00000536717.5; ENST00000162749.6
External Link	RMBase: m6A_site_173854
mod ID: M6ASITE010275		Click to Show/Hide the Full List
mod site	chr12:6330050-6330051:-		[6]
Sequence	TTCAGGGGGAGCTTGAAGGAACTACTACTAAGCCCCTGGCC
Motif Score	3.373380952
Cell/Tissue List	CD34; HeLa; Huh7; AML
Seq Type List	m6A-seq; MeRIP-seq; miCLIP
Transcript ID List	ENST00000543995.5; ENST00000537842.5; ENST00000540022.5; ENST00000162749.6; ENST00000534885.5; ENST00000536717.5; ENST00000543359.5
External Link	RMBase: m6A_site_173855
mod ID: M6ASITE010276		Click to Show/Hide the Full List
mod site	chr12:6330280-6330281:-		[3]
Sequence	CCTCAGTTTGTGGGAAATCGACACCTGAAAAAGAGGTGAGA
Motif Score	2.865571429
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000536717.5; ENST00000543995.5; ENST00000535038.1; ENST00000540022.5; ENST00000162749.6; ENST00000534885.5; ENST00000543359.5; ENST00000537842.5
External Link	RMBase: m6A_site_173856
mod ID: M6ASITE010277		Click to Show/Hide the Full List
mod site	chr12:6330478-6330479:-		[6]
Sequence	CTCAGTTCATACCGCTGGGGACTCTGGGCAGAAGGTGGCCC
Motif Score	4.065041667
Cell/Tissue List	CD34; HeLa; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000543359.5; ENST00000536717.5; ENST00000543995.5; ENST00000540022.5; ENST00000162749.6; ENST00000535038.1; ENST00000534885.5; ENST00000539372.5; ENST00000537842.5
External Link	RMBase: m6A_site_173857
mod ID: M6ASITE010278		Click to Show/Hide the Full List
mod site	chr12:6330705-6330706:-		[7]
Sequence	CTGCTTTGTCTGCAGGCACCACAGTGCTGTTGCCCCTGGTC
Motif Score	2.053113095
Cell/Tissue List	brain
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000534885.5; ENST00000537842.5; ENST00000539372.5; ENST00000543995.5; ENST00000162749.6; ENST00000540022.5; ENST00000536717.5; ENST00000535038.1; ENST00000543359.5
External Link	RMBase: m6A_site_173858
mod ID: M6ASITE010279		Click to Show/Hide the Full List
mod site	chr12:6331180-6331181:-		[2]
Sequence	CACTGCTAGCCAAGGAATGAACTGGAATTTACACCCTGACC
Motif Score	3.373380952
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000539372.5; ENST00000540022.5; ENST00000537842.5; ENST00000536717.5; ENST00000534885.5; ENST00000543359.5; ENST00000162749.6; ENST00000543995.5
External Link	RMBase: m6A_site_173859
mod ID: M6ASITE010280		Click to Show/Hide the Full List
mod site	chr12:6333131-6333132:-		[3]
Sequence	TACAGGCCAGGAGAAACAGAACACCGTGTGCACCTGCCATG
Motif Score	2.951386905
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000440083.6; ENST00000540022.5; ENST00000162749.6; ENST00000543048.5; ENST00000437813.7; ENST00000539372.5; ENST00000366159.8; ENST00000534885.5; ENST00000543995.5; ENST00000537842.5
External Link	RMBase: m6A_site_173860
mod ID: M6ASITE010281		Click to Show/Hide the Full List
mod site	chr12:6333422-6333423:-		[8]
Sequence	CCGGCATTATTGGAGTGAAAACCTTTTCCAGTGCTTCAATT
Motif Score	2.185083333
Cell/Tissue List	HepG2; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000540022.5; ENST00000537842.5; ENST00000440083.6; ENST00000543048.5; ENST00000366159.8; ENST00000162749.6; ENST00000534885.5; ENST00000437813.7; ENST00000543995.5; ENST00000539372.5
External Link	RMBase: m6A_site_173861
mod ID: M6ASITE010282		Click to Show/Hide the Full List
mod site	chr12:6333449-6333450:-		[8]
Sequence	CGTGTGTGGCTGCAGGAAGAACCAGTACCGGCATTATTGGA
Motif Score	2.930744048
Cell/Tissue List	HepG2; Huh7; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000543048.5; ENST00000540022.5; ENST00000440083.6; ENST00000539372.5; ENST00000366159.8; ENST00000437813.7; ENST00000534885.5; ENST00000543995.5; ENST00000162749.6
External Link	RMBase: m6A_site_173862
mod ID: M6ASITE010283		Click to Show/Hide the Full List
mod site	chr12:6333473-6333474:-		[7]
Sequence	TTCTTGCACAGTGGACCGGGACACCGTGTGTGGCTGCAGGA
Motif Score	3.643047619
Cell/Tissue List	kidney; hESC-HEK293T; HepG2; Huh7; endometrial
Seq Type List	m6A-REF-seq; MAZTER-seq; m6A-seq; MeRIP-seq
Transcript ID List	ENST00000543048.5; ENST00000534885.5; ENST00000540022.5; ENST00000366159.8; ENST00000437813.7; ENST00000536194.1; ENST00000543995.5; ENST00000162749.6; ENST00000539372.5; ENST00000440083.6
External Link	RMBase: m6A_site_173863
mod ID: M6ASITE010284		Click to Show/Hide the Full List
mod site	chr12:6333479-6333480:-		[8]
Sequence	GATCTCTTCTTGCACAGTGGACCGGGACACCGTGTGTGGCT
Motif Score	3.622404762
Cell/Tissue List	HepG2; Huh7; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000539372.5; ENST00000536194.1; ENST00000437813.7; ENST00000162749.6; ENST00000366159.8; ENST00000534885.5; ENST00000543995.5; ENST00000440083.6; ENST00000540022.5; ENST00000543048.5
External Link	RMBase: m6A_site_173864
mod ID: M6ASITE010285		Click to Show/Hide the Full List
mod site	chr12:6333486-6333487:-		[7]
Sequence	AGGTGGAGATCTCTTCTTGCACAGTGGACCGGGACACCGTG
Motif Score	2.830589286
Cell/Tissue List	liver
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000539372.5; ENST00000366159.8; ENST00000534885.5; ENST00000440083.6; ENST00000536194.1; ENST00000543048.5; ENST00000543995.5; ENST00000437813.7; ENST00000540022.5; ENST00000162749.6
External Link	RMBase: m6A_site_173865
mod ID: M6ASITE010286		Click to Show/Hide the Full List
mod site	chr12:6333767-6333768:-		[3]
Sequence	GCTTCAGAAAACCACCTCAGACACTGCCTCAGCTGCTCCAA
Motif Score	2.897386905
Cell/Tissue List	hESC-HEK293T; endometrial
Seq Type List	MAZTER-seq; m6A-seq
Transcript ID List	ENST00000536194.1; ENST00000540022.5; ENST00000440083.6; ENST00000162749.6; ENST00000543995.5; ENST00000539372.5; ENST00000543048.5; ENST00000437813.7; ENST00000366159.8; ENST00000534885.5; ENST00000535958.1
External Link	RMBase: m6A_site_173866
mod ID: M6ASITE010287		Click to Show/Hide the Full List
mod site	chr12:6333777-6333778:-		[9]
Sequence	CTCCTTCACCGCTTCAGAAAACCACCTCAGACACTGCCTCA
Motif Score	2.185083333
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000539372.5; ENST00000543048.5; ENST00000540022.5; ENST00000534885.5; ENST00000536194.1; ENST00000440083.6; ENST00000366159.8; ENST00000543995.5; ENST00000535958.1; ENST00000162749.6; ENST00000437813.7
External Link	RMBase: m6A_site_173867
mod ID: M6ASITE010288		Click to Show/Hide the Full List
mod site	chr12:6333852-6333853:-		[3]
Sequence	ATTCACAGGAACCTACTTGTACAATGACTGTCCAGGCCCGG
Motif Score	2.856142857
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000162749.6; ENST00000543048.5; ENST00000437813.7; ENST00000366159.8; ENST00000534885.5; ENST00000536194.1; ENST00000440083.6; ENST00000543995.5; ENST00000540022.5; ENST00000539372.5; ENST00000535958.1
External Link	RMBase: m6A_site_173868
mod ID: M6ASITE010289		Click to Show/Hide the Full List
mod site	chr12:6334095-6334096:-		[3]
Sequence	GATTTGCTGTACCAAGTGCCACAAAGGTAGGGGCAAGTGGA
Motif Score	2.053113095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000535958.1; ENST00000543048.5; ENST00000538363.1; ENST00000366159.8; ENST00000539372.5; ENST00000536194.1; ENST00000543995.5; ENST00000162749.6; ENST00000540022.5; ENST00000534885.5; ENST00000440083.6; ENST00000437813.7
External Link	RMBase: m6A_site_173869
mod ID: M6ASITE010290		Click to Show/Hide the Full List
mod site	chr12:6334176-6334177:-		[10]
Sequence	ACTGGTCCCTCACCTAGGGGACAGGGAGAAGAGAGATAGTG
Motif Score	3.643047619
Cell/Tissue List	peripheral-blood
Seq Type List	m6A-seq
Transcript ID List	ENST00000534885.5; ENST00000539372.5; ENST00000540022.5; ENST00000535958.1; ENST00000440083.6; ENST00000538363.1; ENST00000437813.7; ENST00000543995.5; ENST00000162749.6; ENST00000536194.1; ENST00000543048.5; ENST00000366159.8
External Link	RMBase: m6A_site_173870
mod ID: M6ASITE010291		Click to Show/Hide the Full List
mod site	chr12:6334196-6334197:-		[2]
Sequence	TACCCCTCAGGGGTTATTGGACTGGTCCCTCACCTAGGGGA
Motif Score	4.065041667
Cell/Tissue List	HeLa; Huh7; peripheral-blood; endometrial; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000534885.5; ENST00000162749.6; ENST00000538363.1; ENST00000539372.5; ENST00000535958.1; ENST00000543048.5; ENST00000543995.5; ENST00000540022.5; ENST00000366159.8; ENST00000536194.1; ENST00000440083.6; ENST00000437813.7
External Link	RMBase: m6A_site_173871
mod ID: M6ASITE010292		Click to Show/Hide the Full List
mod site	chr12:6341862-6341863:-		[3]
Sequence	GCCCCAGCACTGCCGCTGCCACACTGCCCTGAGCCCAAATG
Motif Score	2.053113095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000440083.6; ENST00000543048.5; ENST00000535958.1; ENST00000538363.1; ENST00000536194.1; ENST00000534885.5; ENST00000162749.6; ENST00000543995.5; ENST00000540022.5; ENST00000539372.5
External Link	RMBase: m6A_site_173872
mod ID: M6ASITE010293		Click to Show/Hide the Full List
mod site	chr12:6341901-6341902:-		[2]
Sequence	AGGCACTTGGGACGTCCTGGACAGACCGAGTCCCGGGAAGC
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; A549; Huh7; peripheral-blood; iSLK; MSC; TIME; endometrial; HEC-1-A; NB4; MM6
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000536194.1; ENST00000534885.5; ENST00000440083.6; ENST00000543995.5; ENST00000543048.5; ENST00000535958.1; ENST00000162749.6; ENST00000540022.5; ENST00000539372.5; ENST00000538363.1
External Link	RMBase: m6A_site_173873
mod ID: M6ASITE010294		Click to Show/Hide the Full List
mod site	chr12:6341971-6341972:-		[2]
Sequence	TGGGGTTCAAGATCACTGGGACCAGGCCGTGATCTCTATGC
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; fibroblasts; Huh7; peripheral-blood; HEK293A-TOA; iSLK; MSC; TIME; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000538363.1; ENST00000535958.1; ENST00000543995.5; ENST00000539372.5; ENST00000162749.6; ENST00000534885.5; ENST00000540022.5; ENST00000543048.5; ENST00000536194.1; ENST00000440083.6
External Link	RMBase: m6A_site_173874
mod ID: M6ASITE010295		Click to Show/Hide the Full List
mod site	chr12:6342014-6342015:-		[2]
Sequence	ATTTTCTCAGAATTCTCTGGACTGAGGCTCCAGTTCTGGCC
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; fibroblasts; Huh7; HEK293A-TOA; iSLK; MSC; TIME; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000162749.6; ENST00000536194.1; ENST00000540022.5; ENST00000535958.1; ENST00000440083.6; ENST00000534885.5
External Link	RMBase: m6A_site_173875

Ref 1	5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m(5)C reader. Cell Res. 2017 May;27(5):606-625. doi: 10.1038/cr.2017.55. Epub 2017 Apr 18.
Ref 2	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 3	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 4	DART-seq: an antibody-free method for global m(6)A detection. Nat Methods. 2019 Dec;16(12):1275-1280. doi: 10.1038/s41592-019-0570-0. Epub 2019 Sep 23.
Ref 5	A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation. Genes Dev. 2015 Oct 1;29(19):2037-53. doi: 10.1101/gad.269415.115. Epub 2015 Sep 24.
Ref 6	Suppression of m(6)A reader Ythdf2 promotes hematopoietic stem cell expansion. Cell Res. 2018 Sep;28(9):904-917. doi: 10.1038/s41422-018-0072-0. Epub 2018 Jul 31.
Ref 7	Single-base mapping of m(6)A by an antibody-independent method. Sci Adv. 2019 Jul 3;5(7):eaax0250. doi: 10.1126/sciadv.aax0250. eCollection 2019 Jul.
Ref 8	Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Nature. 2012 Apr 29;485(7397):201-6. doi: 10.1038/nature11112.
Ref 9	m(6)A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer. Nat Cell Biol. 2018 Sep;20(9):1074-1083. doi: 10.1038/s41556-018-0174-4. Epub 2018 Aug 27.
Ref 10	R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m(6)A/MYC/CEBPA Signaling. Cell. 2018 Jan 11;172(1-2):90-105.e23. doi: 10.1016/j.cell.2017.11.031. Epub 2017 Dec 14.

Epigenetic Target Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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