Epigenetic Target Information

General Information of the Epigenetic Target (ID: EPITAR00359)
Target Name MARCKS-related protein (MARCKSL1)
Synonyms
MARCKS-like protein 1; Macrophage myristoylated alanine-rich C kinase substrate; Mac-MARCKS; MacMARCKS; MLP; MRP
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Gene Name MARCKSL1
Sequence
MGSQSSKAPRGDVTAEEAAGASPAKANGQENGHVKSNGDLSPKGEGESPPVNGTDEAAGATGDAIEPAPPSQGAEAKGEVPPKETPKKKKKFSFKKPFKLSGLSFKRNRKEGGGDSSASSPTEEEQEQGEIGACSDEGTAQEGKAAATPESQEPQAKGAEASAASEEEAGPQATEPSTPSGPESGPTPASAEQNE
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Family MARCKS family
Function
Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration (By similarity). When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration (By similarity). May be involved in coupling the protein kinase C and calmodulin signal transduction systems (By similarity).
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Gene ID 65108
HGNC ID HGNC:7142
Ensembl Gene ID ENSG00000175130
KEGG ID hsa:65108
Chromosomal Location 1p35.1
RNA Modification Sequencing Data Associated with the Target (ID: EPITAR00359)
MARCKS-related protein (MARCKSL1)
N4-acetylcytidine (ac4C)
In total 2 m6A sequence/site(s) in this target gene
mod ID: AC4SITE000183 Click to Show/Hide the Full List
mod site chr1:32334977-32334978:-
Sequence GATGCCATCGAGCCAGCACCCCCTAGCCAGGGTGCTGAGGC
Cell/Tissue List DLD1
Seq Type List acRIP-seq
Transcript ID List ENST00000329421.8
External Link RMBase: ac4C_site_48
mod ID: AC4SITE000184 Click to Show/Hide the Full List
mod site chr1:32335028-32335029:- [1]
Sequence GGGGAGTCGCCCCCTGTGAACGGAACAGATGAGGCAGCCGG
Cell/Tissue List H1
Seq Type List ac4C-seq
Transcript ID List ENST00000329421.8
External Link RMBase: ac4C_site_49
2'-O-Methylation (2'-O-Me)
In total 1 m6A sequence/site(s) in this target gene
mod ID: 2OMSITE000044 Click to Show/Hide the Full List
mod site chr1:32335023-32335024:- [2]
Sequence GTCGCCCCCTGTGAACGGAACAGATGAGGCAGCCGGGGCCA
Cell/Tissue List HeLa
Seq Type List Nm-seq
Transcript ID List ENST00000329421.8
External Link RMBase: Nm_site_132
5-methylcytidine (m5C)
In total 1 m6A sequence/site(s) in this target gene
mod ID: M5CSITE001275 Click to Show/Hide the Full List
mod site chr1:32336018-32336019:-
Sequence CCCATCATGGGCAGCCAGAGCTCCAAGGCTCCCCGGGGCGA
Cell/Tissue List HEK293T
Seq Type List Bisulfite-seq
Transcript ID List ENST00000329421.8
External Link RMBase: m5C_site_1980
N6-methyladenosine (m6A)
In total 19 m6A sequence/site(s) in this target gene
mod ID: M6ASITE014134 Click to Show/Hide the Full List
mod site chr1:32333899-32333900:- [3]
Sequence TTTTTTTTCTAACTGCTAAAACCATTCTCTTCCACCTGGTT
Motif Score 2.185083333
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000329421.8
External Link RMBase: m6A_site_19881
mod ID: M6ASITE014135 Click to Show/Hide the Full List
mod site chr1:32333908-32333909:- [4]
Sequence GTACTTTTTTTTTTTTTCTAACTGCTAAAACCATTCTCTTC
Motif Score 2.590089286
Cell/Tissue List HEK293T
Seq Type List DART-seq
Transcript ID List ENST00000329421.8
External Link RMBase: m6A_site_19882
mod ID: M6ASITE014136 Click to Show/Hide the Full List
mod site chr1:32333939-32333940:- [3]
Sequence AAATAACTTTTAATGGCCAAACCCCAGATTTGTACTTTTTT
Motif Score 2.185083333
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000329421.8
External Link RMBase: m6A_site_19883
mod ID: M6ASITE014137 Click to Show/Hide the Full List
mod site chr1:32333967-32333968:- [4]
Sequence TTCTTGTCTTTTTTTCTCCCACTGTTGTAAATAACTTTTAA
Motif Score 2.475107143
Cell/Tissue List HEK293T
Seq Type List DART-seq
Transcript ID List ENST00000329421.8
External Link RMBase: m6A_site_19884
mod ID: M6ASITE014138 Click to Show/Hide the Full List
mod site chr1:32333989-32333990:- [4]
Sequence GAGGTCTGTAATGTGAAACAACTTCTTGTCTTTTTTTCTCC
Motif Score 2.595904762
Cell/Tissue List HEK293T
Seq Type List DART-seq
Transcript ID List ENST00000329421.8
External Link RMBase: m6A_site_19885
mod ID: M6ASITE014139 Click to Show/Hide the Full List
mod site chr1:32333992-32333993:- [3]
Sequence GGGGAGGTCTGTAATGTGAAACAACTTCTTGTCTTTTTTTC
Motif Score 2.20572619
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000329421.8
External Link RMBase: m6A_site_19886
mod ID: M6ASITE014140 Click to Show/Hide the Full List
mod site chr1:32334044-32334045:- [4]
Sequence TCAACTGTGTCTCTTTTTTGACTTGGTAAGCAAGTATTAGG
Motif Score 3.28175
Cell/Tissue List HEK293T
Seq Type List DART-seq
Transcript ID List ENST00000329421.8
External Link RMBase: m6A_site_19887
mod ID: M6ASITE014141 Click to Show/Hide the Full List
mod site chr1:32334080-32334081:- [3]
Sequence AATGTCTTACTCAAGTTCAAACCTCCAGCCTGTGAATCAAC
Motif Score 2.185083333
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000329421.8
External Link RMBase: m6A_site_19888
mod ID: M6ASITE014142 Click to Show/Hide the Full List
mod site chr1:32334092-32334093:- [4]
Sequence TAGGTTTTTATAAATGTCTTACTCAAGTTCAAACCTCCAGC
Motif Score 2.494845238
Cell/Tissue List HEK293T
Seq Type List DART-seq
Transcript ID List ENST00000329421.8
External Link RMBase: m6A_site_19889
mod ID: M6ASITE014143 Click to Show/Hide the Full List
mod site chr1:32334125-32334126:- [3]
Sequence TGGCACCTGGGCTGGGGAGGACACTGCCCCGTCTAGGTTTT
Motif Score 3.643047619
Cell/Tissue List HeLa; HEK293T
Seq Type List m6A-seq; DART-seq
Transcript ID List ENST00000329421.8
External Link RMBase: m6A_site_19890
mod ID: M6ASITE014144 Click to Show/Hide the Full List
mod site chr1:32334199-32334200:- [3]
Sequence TGGGGTGCTTATACTCCCAAACCTTGAGTGTCCAGCCTTCC
Motif Score 2.185083333
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000329421.8
External Link RMBase: m6A_site_19891
mod ID: M6ASITE014145 Click to Show/Hide the Full List
mod site chr1:32334526-32334527:- [3]
Sequence CTTGTGAGGTCACTGCCTGGACCTGGTGCCCTGGCTGCCTT
Motif Score 3.622404762
Cell/Tissue List HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hESCs; fibroblasts; GM12878; LCLs; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; GSCs; NB4
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000329421.8
External Link RMBase: m6A_site_19892
mod ID: M6ASITE014146 Click to Show/Hide the Full List
mod site chr1:32334557-32334558:- [3]
Sequence GTGATCTCTAAGCTGCAAAAACTGTGCTGTCCTTGTGAGGT
Motif Score 2.627720238
Cell/Tissue List HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hESCs; fibroblasts; GM12878; LCLs; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; GSCs; NB4; AML
Seq Type List m6A-seq; MeRIP-seq; miCLIP
Transcript ID List ENST00000329421.8
External Link RMBase: m6A_site_19893
mod ID: M6ASITE014147 Click to Show/Hide the Full List
mod site chr1:32334725-32334726:- [3]
Sequence GCCACCCCTGAGAGCCAGGAACCCCAGGCCAAGGGGGCAGA
Motif Score 2.930744048
Cell/Tissue List HeLa; HepG2; HEK293T; U2OS; H1A; H1B; A549; LCLs; MT4; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; TIME; TREX; endometrial; GSCs; NB4
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000329421.8
External Link RMBase: m6A_site_19894
mod ID: M6ASITE014148 Click to Show/Hide the Full List
mod site chr1:32334820-32334821:- [5]
Sequence ATTCTTCTGCCTCCTCACCCACAGAGGAAGAGCAGGAGCAG
Motif Score 2.053113095
Cell/Tissue List HEK293
Seq Type List m6A-REF-seq
Transcript ID List ENST00000329421.8
External Link RMBase: m6A_site_19895
mod ID: M6ASITE014149 Click to Show/Hide the Full List
mod site chr1:32334931-32334932:- [3]
Sequence GGGAGGTCCCCCCCAAGGAGACCCCCAAGAAGAAGAAGAAA
Motif Score 2.876744048
Cell/Tissue List HeLa; HepG2; U2OS; LCLs; A549; MM6; Huh7; Jurkat; peripheral-blood; GSC-11; HEK293T; TREX; endometrial; NB4
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000329421.8
External Link RMBase: m6A_site_19896
mod ID: M6ASITE014150 Click to Show/Hide the Full List
mod site chr1:32335024-32335025:- [3]
Sequence AGTCGCCCCCTGTGAACGGAACAGATGAGGCAGCCGGGGCC
Motif Score 2.951386905
Cell/Tissue List HeLa; HepG2; A549; U2OS; hNPCs; hESCs; fibroblasts; LCLs; MT4; MM6; Huh7; Jurkat; CD4T; peripheral-blood; HEK293T; TREX; endometrial; NB4
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000329421.8
External Link RMBase: m6A_site_19897
mod ID: M6ASITE014151 Click to Show/Hide the Full List
mod site chr1:32335068-32335069:- [3]
Sequence CCACGTGAAAAGCAATGGAGACTTATCCCCCAAGGGTGAAG
Motif Score 3.319380952
Cell/Tissue List HeLa; HepG2; A549; U2OS; hNPCs; hESCs; fibroblasts; LCLs; MT4; MM6; Huh7; Jurkat; CD4T; peripheral-blood; HEK293T; TREX; endometrial; NB4
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000329421.8
External Link RMBase: m6A_site_19898
mod ID: M6ASITE014156 Click to Show/Hide the Full List
mod site chr1:32336041-32336042:- [3]
Sequence CTCCAAGCGCCCCCCAGCAGACCCCCATCATGGGCAGCCAG
Motif Score 2.876744048
Cell/Tissue List HeLa; HepG2; A549; U2OS; LCLs; MT4; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293T; endometrial; NB4
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000329421.8
External Link RMBase: m6A_site_19899