Epigenetic Target Information

General Information of the Epigenetic Target (ID: EPITAR00345)

Target Name	PDH kinase 1 (PDK1)
Synonyms	Pyruvate dehydrogenase kinase isoform 1; PDH kinase 1; PDHK1 Click to Show/Hide
Gene Name	PDK1
Sequence	MRLARLLRGAALAGPGPGLRAAGFSRSFSSDSGSSPASERGVPGQVDFYARFSPSPLSMKQFLDFGSVNACEKTSFMFLRQELPVRLANIMKEISLLPDNLLRTPSVQLVQSWYIQSLQELLDFKDKSAEDAKAIYDFTDTVIRIRNRHNDVIPTMAQGVIEYKESFGVDPVTSQNVQYFLDRFYMSRISIRMLLNQHSLLFGGKGKGSPSHRKHIGSINPNCNVLEVIKDGYENARRLCDLYYINSPELELEELNAKSPGQPIQVVYVPSHLYHMVFELFKNAMRATMEHHANRGVYPPIQVHVTLGNEDLTVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVETSRAVPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYIKALSTDSIERLPVYNKAAWKHYNTNHEADDWCVPSREPKDMTTFRSA Click to Show/Hide
Family	PDK/BCKDK protein kinase family
Function	Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress. Click to Show/Hide
Gene ID	5163
HGNC ID	HGNC:8809
Ensembl Gene ID	ENSG00000152256
KEGG ID	hsa:5163
Chromosomal Location	2q31.1

RNA Modification Sequencing Data Associated with the Target (ID: EPITAR00345)

PDH kinase 1 (PDK1)

Adenosine-to-Inosine editing (A-to-I)

In total 11 m6A sequence/site(s) in this target gene
mod ID: A2ISITE010097		Click to Show/Hide the Full List
mod site	chr2:172565420-172565421:+		[1]
Sequence	TCAAGCGATTGTCTTGCCTCAGCCTCCCCAGTAGCCGGGAT
Transcript ID List	ENST00000431718.5; ENST00000392571.6; ENST00000410055.5; ENST00000282077.7; ENST00000416991.5
External Link	RMBase: RNA-editing_site_81639
mod ID: A2ISITE010098		Click to Show/Hide the Full List
mod site	chr2:172566501-172566502:+		[1]
Sequence	GGGAGGTGGAGGCTGCAGTGAGCCGAGATAGCGCCACTGCA
Transcript ID List	ENST00000282077.7; ENST00000410055.5; ENST00000416991.5; ENST00000392571.6; rmsk_743661; ENST00000431718.5
External Link	RMBase: RNA-editing_site_81640
mod ID: A2ISITE010099		Click to Show/Hide the Full List
mod site	chr2:172572960-172572961:+		[1]
Sequence	TGACCAAATGATATTCTGTTATATGGATATAACACCTTTGG
Transcript ID List	ENST00000392571.6; ENST00000466437.1; ENST00000410055.5; ENST00000282077.7
External Link	RMBase: RNA-editing_site_81641
mod ID: A2ISITE010100		Click to Show/Hide the Full List
mod site	chr2:172580706-172580707:+		[1]
Sequence	CAGGTAGAAACAACCCAAATATCTATCAGCTAATGAATGGA
Transcript ID List	ENST00000392571.6; rmsk_743684; ENST00000466437.1; ENST00000410055.5; ENST00000282077.7
External Link	RMBase: RNA-editing_site_81642
mod ID: A2ISITE010101		Click to Show/Hide the Full List
mod site	chr2:172580843-172580844:+		[1]
Sequence	AAGACATTATGCTAAGTGAAAGAAGCCAATCACAAAAGGCC
Transcript ID List	ENST00000282077.7; ENST00000410055.5; rmsk_743684; ENST00000466437.1; ENST00000392571.6
External Link	RMBase: RNA-editing_site_81643
mod ID: A2ISITE010102		Click to Show/Hide the Full List
mod site	chr2:172580851-172580852:+		[1]
Sequence	ATGCTAAGTGAAAGAAGCCAATCACAAAAGGCCACATATTA
Transcript ID List	rmsk_743684; ENST00000392571.6; ENST00000466437.1; ENST00000410055.5; ENST00000282077.7
External Link	RMBase: RNA-editing_site_81644
mod ID: A2ISITE010103		Click to Show/Hide the Full List
mod site	chr2:172585386-172585387:+		[2]
Sequence	CCACGCTGGAGTGCAGTGGTACGATCTTGGCTCACTGTGAC
Transcript ID List	ENST00000410055.5; ENST00000282077.7; ENST00000466437.1; ENST00000392571.6
External Link	RMBase: RNA-editing_site_81645
mod ID: A2ISITE010104		Click to Show/Hide the Full List
mod site	chr2:172597159-172597160:+		[2]
Sequence	TCTTTTGCCCAGGATGGAGTACAGTGGCATGGTCAAGGCTC
Transcript ID List	ENST00000410055.5; ENST00000282077.7
External Link	RMBase: RNA-editing_site_81646
mod ID: A2ISITE010105		Click to Show/Hide the Full List
mod site	chr2:172607141-172607142:+		[1]
Sequence	CCAAAATTAAAATCCAAAATAGCCAAGCATGGTGGCTCACG
Transcript ID List	ENST00000282077.7
External Link	RMBase: RNA-editing_site_81647
mod ID: A2ISITE010106		Click to Show/Hide the Full List
mod site	chr2:172607146-172607147:+		[2]
Sequence	ATTAAAATCCAAAATAGCCAAGCATGGTGGCTCACGCCTAT
Transcript ID List	rmsk_743725; ENST00000282077.7
External Link	RMBase: RNA-editing_site_81648
mod ID: A2ISITE010107		Click to Show/Hide the Full List
mod site	chr2:172607165-172607166:+		[2]
Sequence	AAGCATGGTGGCTCACGCCTATAATCCCAACTACTCCAGAG
Transcript ID List	rmsk_743725; ENST00000282077.7
External Link	RMBase: RNA-editing_site_81649

5-methylcytidine (m5C)

In total 2 m6A sequence/site(s) in this target gene
mod ID: M5CSITE002430		Click to Show/Hide the Full List
mod site	chr2:172562791-172562792:+
Sequence	AGTTTATGCTGTATGGCCTGCAAGATGATGTAAGTAATATG
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000439519.1; ENST00000410055.5; ENST00000436490.5; ENST00000443353.5; ENST00000416991.5; ENST00000282077.7; ENST00000431718.5; ENST00000392571.6
External Link	RMBase: m5C_site_27465
mod ID: M5CSITE002431		Click to Show/Hide the Full List
mod site	chr2:172564623-172564624:+
Sequence	CTGTCACCAGCCAGAATGTTCAGTACTTTTTGGATCGATTC
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000431718.5; ENST00000416991.5; ENST00000439519.1; ENST00000436490.5; ENST00000282077.7; ENST00000392571.6; ENST00000410055.5; ENST00000443353.5
External Link	RMBase: m5C_site_27466

N6-methyladenosine (m6A)

In total 66 m6A sequence/site(s) in this target gene
mod ID: M6ASITE048096		Click to Show/Hide the Full List
mod site	chr2:172556110-172556111:+		[3]
Sequence	CTCGGCAGAGGCGCGGGGAAACCTGGCGTACTGGCTGTGGC
Motif Score	2.185083333
Cell/Tissue List	MT4; HEK293T; iSLK
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000443353.5; ENST00000282077.7; ENST00000431718.5; ENST00000410055.5; ENST00000436490.5; ENST00000392571.6
External Link	RMBase: m6A_site_499680
mod ID: M6ASITE048097		Click to Show/Hide the Full List
mod site	chr2:172556143-172556144:+		[3]
Sequence	GCTGTGGCTTCTCTAGCGGGACTCGGCATGAGGCTGGCGCG
Motif Score	4.065041667
Cell/Tissue List	MT4; HEK293T; iSLK
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000410055.5; ENST00000436490.5; ENST00000392571.6; ENST00000431718.5; ENST00000443353.5; ENST00000282077.7
External Link	RMBase: m6A_site_499681
mod ID: M6ASITE048098		Click to Show/Hide the Full List
mod site	chr2:172556241-172556242:+		[4]
Sequence	CAGCCGCAGCTTCAGCTCGGACTCGGGCTCCAGCCCGGCGT
Motif Score	4.065041667
Cell/Tissue List	Jurkat; HEK293T; iSLK
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000410055.5; ENST00000436490.5; ENST00000392571.6; ENST00000431718.5; ENST00000443353.5; ENST00000282077.7
External Link	RMBase: m6A_site_499682
mod ID: M6ASITE048099		Click to Show/Hide the Full List
mod site	chr2:172556289-172556290:+		[5]
Sequence	CGGCGTTCCGGGCCAGGTGGACTTCTACGCGCGCTTCTCGC
Motif Score	4.065041667
Cell/Tissue List	HeLa; Jurkat; HEK293T; iSLK; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000431718.5; ENST00000436490.5; ENST00000410055.5; ENST00000443353.5; ENST00000282077.7; ENST00000392571.6
External Link	RMBase: m6A_site_499683
mod ID: M6ASITE048100		Click to Show/Hide the Full List
mod site	chr2:172556340-172556341:+		[5]
Sequence	CTCCATGAAGCAGTTCCTGGACTTCGGTGAGTGCGGCCCGG
Motif Score	4.065041667
Cell/Tissue List	HeLa; HEK293T
Seq Type List	m6A-seq
Transcript ID List	ENST00000443353.5; ENST00000416991.5; ENST00000392571.6; ENST00000436490.5; ENST00000410055.5; ENST00000431718.5; ENST00000282077.7
External Link	RMBase: m6A_site_499685
mod ID: M6ASITE048101		Click to Show/Hide the Full List
mod site	chr2:172556574-172556575:+		[5]
Sequence	CTTTGACCGTATTGTTGAAAACAAACCAGCTGGGCCGCGGG
Motif Score	2.20572619
Cell/Tissue List	HeLa; HEK293T
Seq Type List	m6A-seq
Transcript ID List	ENST00000416991.5; ENST00000436490.5; ENST00000439519.1; ENST00000392571.6; ENST00000443353.5; ENST00000431718.5; ENST00000410055.5; ENST00000282077.7
External Link	RMBase: m6A_site_499687
mod ID: M6ASITE048102		Click to Show/Hide the Full List
mod site	chr2:172558840-172558841:+		[6]
Sequence	ACACCATCCGTTCAATTGGTACAAAGCTGGTAAGATTCTCA
Motif Score	2.856142857
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000436490.5; ENST00000410055.5; ENST00000443353.5; ENST00000282077.7; ENST00000416991.5; ENST00000392571.6; ENST00000439519.1; ENST00000431718.5
External Link	RMBase: m6A_site_499688
mod ID: M6ASITE048103		Click to Show/Hide the Full List
mod site	chr2:172562257-172562258:+		[6]
Sequence	GGAGCTTCTTGATTTTAAGGACAAAAGTGCTGAGGATGCTA
Motif Score	3.643047619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000410055.5; ENST00000431718.5; ENST00000392571.6; ENST00000443353.5; ENST00000282077.7; ENST00000439519.1; ENST00000436490.5; ENST00000416991.5
External Link	RMBase: m6A_site_499689
mod ID: M6ASITE048104		Click to Show/Hide the Full List
mod site	chr2:172564579-172564580:+		[6]
Sequence	GGCCCAGGGTGTGATTGAATACAAGGAGAGCTTTGGGGTGG
Motif Score	2.110482143
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000443353.5; ENST00000436490.5; ENST00000282077.7; ENST00000392571.6; ENST00000439519.1; ENST00000410055.5; ENST00000416991.5; ENST00000431718.5
External Link	RMBase: m6A_site_499690
mod ID: M6ASITE048105		Click to Show/Hide the Full List
mod site	chr2:172564645-172564646:+		[6]
Sequence	GTACTTTTTGGATCGATTCTACATGAGTCGCATTTCAATTA
Motif Score	2.078666667
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000443353.5; ENST00000282077.7; ENST00000416991.5; ENST00000439519.1; ENST00000431718.5; ENST00000392571.6; ENST00000436490.5; ENST00000410055.5
External Link	RMBase: m6A_site_499691
mod ID: M6ASITE048106		Click to Show/Hide the Full List
mod site	chr2:172565023-172565024:+		[5]
Sequence	GGAAGTCCATCTCATCGAAAACACATTGGAAGCATAAATCC
Motif Score	2.20572619
Cell/Tissue List	HeLa; hESC-HEK293T
Seq Type List	m6A-seq; MAZTER-seq
Transcript ID List	ENST00000392571.6; ENST00000439519.1; ENST00000416991.5; ENST00000443353.5; ENST00000410055.5; ENST00000431718.5; ENST00000282077.7
External Link	RMBase: m6A_site_499692
mod ID: M6ASITE048107		Click to Show/Hide the Full List
mod site	chr2:172565046-172565047:+		[5]
Sequence	CATTGGAAGCATAAATCCAAACTGCAATGTACTTGAAGTTA
Motif Score	2.627720238
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000416991.5; ENST00000439519.1; ENST00000392571.6; ENST00000443353.5; ENST00000282077.7; ENST00000410055.5; ENST00000431718.5
External Link	RMBase: m6A_site_499693
mod ID: M6ASITE048108		Click to Show/Hide the Full List
mod site	chr2:172566910-172566911:+		[5]
Sequence	TATTATATTAACTCTCCCGAACTAGAACTTGAAGAACTAAA
Motif Score	3.373380952
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000410055.5; ENST00000416991.5; ENST00000431718.5; ENST00000282077.7; ENST00000392571.6
External Link	RMBase: m6A_site_499694
mod ID: M6ASITE048109		Click to Show/Hide the Full List
mod site	chr2:172566916-172566917:+		[5]
Sequence	ATTAACTCTCCCGAACTAGAACTTGAAGAACTAAATGGTAA
Motif Score	3.373380952
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000392571.6; ENST00000416991.5; ENST00000282077.7; ENST00000431718.5; ENST00000410055.5
External Link	RMBase: m6A_site_499695
mod ID: M6ASITE048110		Click to Show/Hide the Full List
mod site	chr2:172566925-172566926:+		[5]
Sequence	CCCGAACTAGAACTTGAAGAACTAAATGGTAAGCCTGATGT
Motif Score	3.373380952
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000431718.5; ENST00000410055.5; ENST00000282077.7; ENST00000392571.6; ENST00000416991.5
External Link	RMBase: m6A_site_499696
mod ID: M6ASITE048111		Click to Show/Hide the Full List
mod site	chr2:172568753-172568754:+		[5]
Sequence	TCTGTAGCAAAATCACCAGGACAGCCAATACAAGTGGTTTA
Motif Score	3.643047619
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000416991.5; ENST00000392571.6; ENST00000282077.7; ENST00000410055.5; ENST00000431718.5
External Link	RMBase: m6A_site_499697
mod ID: M6ASITE048112		Click to Show/Hide the Full List
mod site	chr2:172586332-172586333:+		[6]
Sequence	AATTGACAGACTTTTCAACTACATGTATTCAACTGCACCAA
Motif Score	2.078666667
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000466437.1; ENST00000392571.6; ENST00000410055.5; ENST00000282077.7
External Link	RMBase: m6A_site_499698
mod ID: M6ASITE048113		Click to Show/Hide the Full List
mod site	chr2:172592975-172592976:+		[6]
Sequence	CCCATATCACGTCTTTACGCACAATACTTCCAAGGAGACCT
Motif Score	2.830589286
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000466437.1; ENST00000282077.7; ENST00000392571.6; ENST00000410055.5
External Link	RMBase: m6A_site_499699
mod ID: M6ASITE048114		Click to Show/Hide the Full List
mod site	chr2:172593024-172593025:+		[7]
Sequence	ATTCCCTAGAGGGTTACGGGACAGATGCAGTTATCTACATT
Motif Score	3.643047619
Cell/Tissue List	HEK293
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000410055.5; ENST00000392571.6; ENST00000282077.7; ENST00000466437.1
External Link	RMBase: m6A_site_499700
mod ID: M6ASITE048115		Click to Show/Hide the Full List
mod site	chr2:172595841-172595842:+		[5]
Sequence	TTTTCAGGCTCTGTCAACAGACTCAATAGAAAGACTCCCAG
Motif Score	3.319380952
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000282077.7; ENST00000392571.6; ENST00000410055.5; ENST00000466437.1
External Link	RMBase: m6A_site_499701
mod ID: M6ASITE048116		Click to Show/Hide the Full List
mod site	chr2:172595854-172595855:+		[5]
Sequence	TCAACAGACTCAATAGAAAGACTCCCAGTGTATAACAAAGC
Motif Score	3.319380952
Cell/Tissue List	HeLa; HEK293A-TOA
Seq Type List	m6A-seq
Transcript ID List	ENST00000466437.1; ENST00000392571.6; ENST00000282077.7; ENST00000410055.5
External Link	RMBase: m6A_site_499702
mod ID: M6ASITE048117		Click to Show/Hide the Full List
mod site	chr2:172595892-172595893:+		[6]
Sequence	AGCTGCCTGGAAGCATTACAACACCAACCACGAGGCTGATG
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000392571.6; ENST00000410055.5; ENST00000466437.1; ENST00000282077.7
External Link	RMBase: m6A_site_499703
mod ID: M6ASITE048118		Click to Show/Hide the Full List
mod site	chr2:172595935-172595936:+		[5]
Sequence	TGGTGCGTCCCCAGCAGAGAACCCAAAGACATGACGACGTT
Motif Score	2.930744048
Cell/Tissue List	HeLa; fibroblasts; HEK293A-TOA
Seq Type List	m6A-seq
Transcript ID List	ENST00000466437.1; ENST00000410055.5; ENST00000282077.7; ENST00000392571.6
External Link	RMBase: m6A_site_499704
mod ID: M6ASITE048119		Click to Show/Hide the Full List
mod site	chr2:172595943-172595944:+		[5]
Sequence	CCCCAGCAGAGAACCCAAAGACATGACGACGTTCCGCAGTG
Motif Score	2.897386905
Cell/Tissue List	HeLa; fibroblasts; HEK293A-TOA
Seq Type List	m6A-seq
Transcript ID List	ENST00000392571.6; ENST00000282077.7; ENST00000466437.1; ENST00000410055.5
External Link	RMBase: m6A_site_499705
mod ID: M6ASITE048120		Click to Show/Hide the Full List
mod site	chr2:172595969-172595970:+		[5]
Sequence	CGACGTTCCGCAGTGCCTAGACACACTTGGGACATCGGAAA
Motif Score	2.897386905
Cell/Tissue List	HeLa; fibroblasts; HEK293A-TOA
Seq Type List	m6A-seq
Transcript ID List	ENST00000282077.7; ENST00000410055.5
External Link	RMBase: m6A_site_499706
mod ID: M6ASITE048121		Click to Show/Hide the Full List
mod site	chr2:172595980-172595981:+		[6]
Sequence	AGTGCCTAGACACACTTGGGACATCGGAAAATCCAAATGTG
Motif Score	3.643047619
Cell/Tissue List	hESC-HEK293T; fibroblasts
Seq Type List	MAZTER-seq; m6A-seq
Transcript ID List	ENST00000282077.7; ENST00000410055.5
External Link	RMBase: m6A_site_499707
mod ID: M6ASITE048122		Click to Show/Hide the Full List
mod site	chr2:172596037-172596038:+		[8]
Sequence	TGGAAGGTATGGTGTTCAGAACTATATTATACCAAGTACTT
Motif Score	3.373380952
Cell/Tissue List	fibroblasts
Seq Type List	m6A-seq
Transcript ID List	ENST00000410055.5; ENST00000282077.7
External Link	RMBase: m6A_site_499708
mod ID: M6ASITE048123		Click to Show/Hide the Full List
mod site	chr2:172596072-172596073:+		[6]
Sequence	GTACTTTATTTATCGTTTTCACAAAACTATTTGAGTAGAAT
Motif Score	2.047297619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000282077.7; ENST00000410055.5
External Link	RMBase: m6A_site_499709
mod ID: M6ASITE048124		Click to Show/Hide the Full List
mod site	chr2:172596077-172596078:+		[8]
Sequence	TTATTTATCGTTTTCACAAAACTATTTGAGTAGAATAAATG
Motif Score	2.627720238
Cell/Tissue List	fibroblasts
Seq Type List	m6A-seq
Transcript ID List	ENST00000282077.7; ENST00000410055.5
External Link	RMBase: m6A_site_499710
mod ID: M6ASITE048125		Click to Show/Hide the Full List
mod site	chr2:172596101-172596102:+		[8]
Sequence	TTTGAGTAGAATAAATGGAAACTGAATTCCATTTGTGCCCG
Motif Score	2.627720238
Cell/Tissue List	fibroblasts
Seq Type List	m6A-seq
Transcript ID List	ENST00000282077.7; ENST00000410055.5
External Link	RMBase: m6A_site_499711
mod ID: M6ASITE048126		Click to Show/Hide the Full List
mod site	chr2:172596157-172596158:+		[6]
Sequence	GATGAAATTGCACCTATTTTACACTTATATTTTCACAGTTA
Motif Score	2.07285119
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000410055.5; ENST00000282077.7
External Link	RMBase: m6A_site_499712
mod ID: M6ASITE048127		Click to Show/Hide the Full List
mod site	chr2:172596195-172596196:+		[6]
Sequence	TTAATTGAACATATTTTTAAACAACTGTAGTTTTGGGCAAC
Motif Score	2.20572619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000410055.5; ENST00000282077.7
External Link	RMBase: m6A_site_499713
mod ID: M6ASITE048128		Click to Show/Hide the Full List
mod site	chr2:172596198-172596199:+		[9]
Sequence	ATTGAACATATTTTTAAACAACTGTAGTTTTGGGCAACTTT
Motif Score	2.595904762
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000410055.5; ENST00000282077.7
External Link	RMBase: m6A_site_499714
mod ID: M6ASITE048129		Click to Show/Hide the Full List
mod site	chr2:172596318-172596319:+		[6]
Sequence	TTCATTTATGTTTGCTAGAAACATTTTCTAAATGATAGTGA
Motif Score	2.20572619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000282077.7; ENST00000410055.5
External Link	RMBase: m6A_site_499715
mod ID: M6ASITE048130		Click to Show/Hide the Full List
mod site	chr2:172596441-172596442:+		[6]
Sequence	TGTTTATCAGTGACTTGACTACAAGTAAAGCAGAAAACAGT
Motif Score	2.078666667
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000410055.5; ENST00000282077.7
External Link	RMBase: m6A_site_499716
mod ID: M6ASITE048131		Click to Show/Hide the Full List
mod site	chr2:172596500-172596501:+		[6]
Sequence	CCAGCCACCCTTCGGCGTCTACATGCATTGTCTTAGCTCTG
Motif Score	2.078666667
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000410055.5; ENST00000282077.7
External Link	RMBase: m6A_site_499717
mod ID: M6ASITE048132		Click to Show/Hide the Full List
mod site	chr2:172596656-172596657:+		[5]
Sequence	GGGAAATTTTTATACTGAAAACAAACAAACAAACTAGCAGC
Motif Score	2.20572619
Cell/Tissue List	HeLa; hESC-HEK293T
Seq Type List	m6A-seq; MAZTER-seq
Transcript ID List	ENST00000282077.7; ENST00000410055.5
External Link	RMBase: m6A_site_499718
mod ID: M6ASITE048133		Click to Show/Hide the Full List
mod site	chr2:172596664-172596665:+		[5]
Sequence	TTTATACTGAAAACAAACAAACAAACTAGCAGCTACTAAAA
Motif Score	2.20572619
Cell/Tissue List	HeLa; hESC-HEK293T
Seq Type List	m6A-seq; MAZTER-seq
Transcript ID List	ENST00000410055.5; ENST00000282077.7
External Link	RMBase: m6A_site_499719
mod ID: M6ASITE048134		Click to Show/Hide the Full List
mod site	chr2:172596723-172596724:+		[5]
Sequence	CAAAGTAATATGTCTCCAAAACTGAACTGATTGCTTGTTGA
Motif Score	2.627720238
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000282077.7; ENST00000410055.5
External Link	RMBase: m6A_site_499720
mod ID: M6ASITE048135		Click to Show/Hide the Full List
mod site	chr2:172596728-172596729:+		[5]
Sequence	TAATATGTCTCCAAAACTGAACTGATTGCTTGTTGAGATTA
Motif Score	3.373380952
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000410055.5; ENST00000282077.7
External Link	RMBase: m6A_site_499721
mod ID: M6ASITE048136		Click to Show/Hide the Full List
mod site	chr2:172596800-172596801:+		[6]
Sequence	TTCTGCATCCTACTCCAGATACACTGAATCGGAATCCCTAG
Motif Score	2.110482143
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000282077.7; ENST00000410055.5; rmsk_743710
External Link	RMBase: m6A_site_499722
mod ID: M6ASITE048137		Click to Show/Hide the Full List
mod site	chr2:172596938-172596939:+		[6]
Sequence	ACACAGCATTTGCTAAAGTAACATCTGTAGGTTTTGGTTTC
Motif Score	2.168095238
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000410055.5; ENST00000282077.7
External Link	RMBase: m6A_site_499723
mod ID: M6ASITE048138		Click to Show/Hide the Full List
mod site	chr2:172596994-172596995:+		[5]
Sequence	AGATTTATAGACTCGAGGAGACAGAAACTGAATCCCACACC
Motif Score	2.897386905
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000410055.5; ENST00000282077.7
External Link	RMBase: m6A_site_499724
mod ID: M6ASITE048139		Click to Show/Hide the Full List
mod site	chr2:172597000-172597001:+		[5]
Sequence	ATAGACTCGAGGAGACAGAAACTGAATCCCACACCTGGTGC
Motif Score	2.627720238
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000282077.7; ENST00000410055.5
External Link	RMBase: m6A_site_499725
mod ID: M6ASITE048140		Click to Show/Hide the Full List
mod site	chr2:172597049-172597050:+		[5]
Sequence	GCATAATTAGAAGCAGAAGAACAAAATGCCACGTAACCAAA
Motif Score	2.951386905
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000282077.7; ENST00000410055.5
External Link	RMBase: m6A_site_499726
mod ID: M6ASITE048141		Click to Show/Hide the Full List
mod site	chr2:172597395-172597396:+		[9]
Sequence	GATTACAGGCGTGAGCCACCACACATGGCCTATTGCACAAG
Motif Score	2.053113095
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000282077.7; ENST00000410055.5
External Link	RMBase: m6A_site_499727
mod ID: M6ASITE048142		Click to Show/Hide the Full List
mod site	chr2:172597421-172597422:+		[9]
Sequence	GGCCTATTGCACAAGTCTTGACAAACAACATATATTTTCTA
Motif Score	2.859755952
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000410055.5; ENST00000282077.7
External Link	RMBase: m6A_site_499728
mod ID: M6ASITE048143		Click to Show/Hide the Full List
mod site	chr2:172597425-172597426:+		[9]
Sequence	TATTGCACAAGTCTTGACAAACAACATATATTTTCTAAAAC
Motif Score	2.20572619
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000410055.5; ENST00000282077.7
External Link	RMBase: m6A_site_499729
mod ID: M6ASITE048144		Click to Show/Hide the Full List
mod site	chr2:172597708-172597709:+		[9]
Sequence	GGAGACTGTGTCATTTAGAGACTGTGTTGTTAGTTATCCCT
Motif Score	3.319380952
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000282077.7; ENST00000410055.5
External Link	RMBase: m6A_site_499730
mod ID: M6ASITE048145		Click to Show/Hide the Full List
mod site	chr2:172597731-172597732:+		[6]
Sequence	GTGTTGTTAGTTATCCCTCAACATCTTCTAAGGTGGCAGGA
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000282077.7; ENST00000410055.5
External Link	RMBase: m6A_site_499731
mod ID: M6ASITE048146		Click to Show/Hide the Full List
mod site	chr2:172598013-172598014:+		[9]
Sequence	AGAGCTGCTTAGCTAATCTGACCAAATGTTGGGAAAAATGT
Motif Score	2.839113095
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000282077.7; ENST00000410055.5
External Link	RMBase: m6A_site_499732
mod ID: M6ASITE048147		Click to Show/Hide the Full List
mod site	chr2:172598076-172598077:+		[6]
Sequence	AATTATGGATTTTGTGAAAAACAATAGAACATGTTAATGAG
Motif Score	2.20572619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000410055.5; ENST00000282077.7
External Link	RMBase: m6A_site_499733
mod ID: M6ASITE048148		Click to Show/Hide the Full List
mod site	chr2:172598084-172598085:+		[9]
Sequence	ATTTTGTGAAAAACAATAGAACATGTTAATGAGTAATTTAT
Motif Score	2.951386905
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000282077.7; ENST00000410055.5
External Link	RMBase: m6A_site_499734
mod ID: M6ASITE048149		Click to Show/Hide the Full List
mod site	chr2:172598209-172598210:+		[6]
Sequence	GTATTTGTTTCCTAAATGAAACATTTGTACAACATTTGATG
Motif Score	2.20572619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000410055.5; ENST00000282077.7
External Link	RMBase: m6A_site_499735
mod ID: M6ASITE048150		Click to Show/Hide the Full List
mod site	chr2:172598217-172598218:+		[9]
Sequence	TTCCTAAATGAAACATTTGTACAACATTTGATGTTTTTACT
Motif Score	2.856142857
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000282077.7; ENST00000410055.5
External Link	RMBase: m6A_site_499736
mod ID: M6ASITE048151		Click to Show/Hide the Full List
mod site	chr2:172598353-172598354:+		[10]
Sequence	TAGCTTATTTTTAAGGTAAAACAGCTTTTTACTCTGTTATT
Motif Score	2.20572619
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000282077.7; ENST00000410055.5
External Link	RMBase: m6A_site_499737
mod ID: M6ASITE048152		Click to Show/Hide the Full List
mod site	chr2:172598363-172598364:+		[9]
Sequence	TTAAGGTAAAACAGCTTTTTACTCTGTTATTGTGGTAATGG
Motif Score	2.494845238
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000282077.7; ENST00000410055.5
External Link	RMBase: m6A_site_499738
mod ID: M6ASITE048153		Click to Show/Hide the Full List
mod site	chr2:172598384-172598385:+		[7]
Sequence	CTCTGTTATTGTGGTAATGGACAGAATATTACATACAAAAA
Motif Score	3.643047619
Cell/Tissue List	brain; HEK293T; Huh7
Seq Type List	m6A-REF-seq; DART-seq; MeRIP-seq
Transcript ID List	ENST00000282077.7; ENST00000410055.5
External Link	RMBase: m6A_site_499739
mod ID: M6ASITE048154		Click to Show/Hide the Full List
mod site	chr2:172598398-172598399:+		[9]
Sequence	TAATGGACAGAATATTACATACAAAAATATTCTGGGAGAGC
Motif Score	2.110482143
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000410055.5; ENST00000282077.7
External Link	RMBase: m6A_site_499740
mod ID: M6ASITE048155		Click to Show/Hide the Full List
mod site	chr2:172598505-172598506:+		[6]
Sequence	TGTCCACCAGCATTAATGTAACACAGTGTAGTTATGAAAAT
Motif Score	2.168095238
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000410055.5; ENST00000282077.7
External Link	RMBase: m6A_site_499741
mod ID: M6ASITE048156		Click to Show/Hide the Full List
mod site	chr2:172598547-172598548:+		[9]
Sequence	TATTGAAGGACAGGAAGTGGACACGAAGTGATTTTTGTAAC
Motif Score	3.643047619
Cell/Tissue List	HEK293T; hESC-HEK293T
Seq Type List	DART-seq; MAZTER-seq
Transcript ID List	ENST00000410055.5; ENST00000282077.7
External Link	RMBase: m6A_site_499742
mod ID: M6ASITE048157		Click to Show/Hide the Full List
mod site	chr2:172598591-172598592:+		[6]
Sequence	AGCAGTTAATGAATGTGCCAACATTTTCTAGGAAGGGACAG
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000410055.5; ENST00000282077.7
External Link	RMBase: m6A_site_499743
mod ID: M6ASITE048158		Click to Show/Hide the Full List
mod site	chr2:172598640-172598641:+		[9]
Sequence	TTCTGCTCTGTAGTTAAAATACTGGCTGGCTTTTGATGTCT
Motif Score	2.53247619
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000410055.5; ENST00000282077.7
External Link	RMBase: m6A_site_499744
mod ID: M6ASITE048159		Click to Show/Hide the Full List
mod site	chr2:172598775-172598776:+		[6]
Sequence	TGTATGGCAATAAACTGAAAACATGGATCAACCCTTCTTTT
Motif Score	2.20572619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000410055.5; ENST00000282077.7
External Link	RMBase: m6A_site_499745
mod ID: M6ASITE048160		Click to Show/Hide the Full List
mod site	chr2:172608543-172608544:+		[10]
Sequence	CTGCTGTAAGTCTATGTGAAACCAAATCCGTGGATTTACCA
Motif Score	2.185083333
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000282077.7
External Link	RMBase: m6A_site_499746
mod ID: M6ASITE048161		Click to Show/Hide the Full List
mod site	chr2:172608586-172608587:+		[10]
Sequence	GGCCATTTTATCACCTCCAAACTATCTTTTATTTTTTTGAA
Motif Score	2.627720238
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000282077.7
External Link	RMBase: m6A_site_499747

Ref 1	RADAR: a rigorously annotated database of A-to-I RNA editing. Nucleic Acids Res. 2014 Jan;42(Database issue):D109-13. doi: 10.1093/nar/gkt996. Epub 2013 Oct 25.
Ref 2	Comprehensive analysis of RNA-Seq data reveals extensive RNA editing in a human transcriptome. Nat Biotechnol. 2012 Feb 12;30(3):253-60. doi: 10.1038/nbt.2122.
Ref 3	Dynamics of the human and viral m(6)A RNA methylomes during HIV-1 infection of T cells. Nat Microbiol. 2016 Feb 22;1:16011. doi: 10.1038/nmicrobiol.2016.11.
Ref 4	N(6)-methyladenosine of HIV-1 RNA regulates viral infection and HIV-1 Gag protein expression. Elife. 2016 Jul 2;5:e15528. doi: 10.7554/eLife.15528.
Ref 5	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 6	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 7	Single-base mapping of m(6)A by an antibody-independent method. Sci Adv. 2019 Jul 3;5(7):eaax0250. doi: 10.1126/sciadv.aax0250. eCollection 2019 Jul.
Ref 8	Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites. Cell Rep. 2014 Jul 10;8(1):284-96. doi: 10.1016/j.celrep.2014.05.048. Epub 2014 Jun 26.
Ref 9	DART-seq: an antibody-free method for global m(6)A detection. Nat Methods. 2019 Dec;16(12):1275-1280. doi: 10.1038/s41592-019-0570-0. Epub 2019 Sep 23.
Ref 10	N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection. Cell Host Microbe. 2016 Nov 9;20(5):654-665. doi: 10.1016/j.chom.2016.09.015. Epub 2016 Oct 20.

Epigenetic Target Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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