Epigenetic Target Information

General Information of the Epigenetic Target (ID: EPITAR00341)

Target Name	Ubiquitin-conjugating enzyme E2 C (UBE2C)
Synonyms	(E3-independent) E2 ubiquitin-conjugating enzyme C; E2 ubiquitin-conjugating enzyme C; UbcH10; Ubiquitin carrier protein C; Ubiquitin-protein ligase C; UBCH10 Click to Show/Hide
Gene Name	UBE2C
Sequence	MASQNRDPAATSVAAARKGAEPSGGAARGPVGKRLQQELMTLMMSGDKGISAFPESDNLFKWVGTIHGAAGTVYEDLRYKLSLEFPSGYPYNAPTVKFLTPCYHPNVDTQGNICLDILKEKWSALYDVRTILLSIQSLLGEPNIDSPLNTHAAELWKNPTAFKKYLQETYSKQVTSQEP Click to Show/Hide
Family	Ubiquitin-conjugating enzyme family
Function	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Click to Show/Hide
Gene ID	11065
HGNC ID	HGNC:15937
Ensembl Gene ID	ENSG00000175063
KEGG ID	hsa:11065
Chromosomal Location	20q13.12

RNA Modification Sequencing Data Associated with the Target (ID: EPITAR00341)

Ubiquitin-conjugating enzyme E2 C (UBE2C)

5-methylcytidine (m5C)

In total 4 m6A sequence/site(s) in this target gene
mod ID: M5CSITE002717		Click to Show/Hide the Full List
mod site	chr20:45812632-45812633:+		[1]
Sequence	TTCAAACGCGGGCGGGCGGGCCCGCAGTCCTGCAGTTGCAG
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000617055.4; ENST00000405520.5
External Link	RMBase: m5C_site_29130
mod ID: M5CSITE002718		Click to Show/Hide the Full List
mod site	chr20:45812633-45812634:+		[1]
Sequence	TCAAACGCGGGCGGGCGGGCCCGCAGTCCTGCAGTTGCAGT
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000617055.4; ENST00000405520.5
External Link	RMBase: m5C_site_29131
mod ID: M5CSITE002719		Click to Show/Hide the Full List
mod site	chr20:45812634-45812635:+		[1]
Sequence	CAAACGCGGGCGGGCGGGCCCGCAGTCCTGCAGTTGCAGTC
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000335046.7; ENST00000405520.5; ENST00000617055.4
External Link	RMBase: m5C_site_29132
mod ID: M5CSITE002720		Click to Show/Hide the Full List
mod site	chr20:45816763-45816764:+		[1]
Sequence	CAGGTCACCAGCCAGGAGCCCTGACCCAGGCTGCCCAGCCT
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000405520.5; ENST00000243893.10; ENST00000352551.9; ENST00000496085.1; ENST00000372568.4; ENST00000356455.9; ENST00000335046.7; ENST00000617055.4
External Link	RMBase: m5C_site_29133

N6-methyladenosine (m6A)

In total 23 m6A sequence/site(s) in this target gene
mod ID: M6ASITE053262		Click to Show/Hide the Full List
mod site	chr20:45812708-45812709:+		[2]
Sequence	CGCCCGGATGGCTTCCCAAAACCGCGACCCAGCCGCCACTA
Motif Score	2.185083333
Cell/Tissue List	HeLa; HepG2; A549; H1B; HEK293T; fibroblasts; H1299; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000352551.9; ENST00000243893.10; ENST00000617055.4; ENST00000356455.9; ENST00000335046.7; ENST00000405520.5
External Link	RMBase: m6A_site_533800
mod ID: M6ASITE053263		Click to Show/Hide the Full List
mod site	chr20:45813027-45813028:+		[2]
Sequence	TGAGATTCGAGAGATGGGGGACAGGCCAGGAGCTCAGACCG
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; A549; H1299; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; iSLK; MSC; TREX; TIME; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000405520.5; ENST00000335046.7; ENST00000617055.4; ENST00000356455.9; ENST00000372568.4; ENST00000243893.10; ENST00000352551.9
External Link	RMBase: m6A_site_533801
mod ID: M6ASITE053264		Click to Show/Hide the Full List
mod site	chr20:45813044-45813045:+		[2]
Sequence	GGGACAGGCCAGGAGCTCAGACCGCTCTTTGAGACTCTCCC
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; A549; H1299; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; iSLK; MSC; TREX; TIME; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000405520.5; ENST00000372568.4; ENST00000243893.10; ENST00000352551.9; ENST00000356455.9; ENST00000335046.7; ENST00000617055.4
External Link	RMBase: m6A_site_533802
mod ID: M6ASITE053265		Click to Show/Hide the Full List
mod site	chr20:45813057-45813058:+		[2]
Sequence	AGCTCAGACCGCTCTTTGAGACTCTCCCGAAGGAGAATGGG
Motif Score	3.319380952
Cell/Tissue List	HeLa; HepG2; A549; H1299; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; iSLK; MSC; TREX; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000372568.4; ENST00000352551.9; ENST00000617055.4; ENST00000405520.5; ENST00000356455.9; ENST00000335046.7; ENST00000243893.10
External Link	RMBase: m6A_site_533803
mod ID: M6ASITE053266		Click to Show/Hide the Full List
mod site	chr20:45813097-45813098:+		[2]
Sequence	GAGGGTAGGGGCGCTGCCAGACTCCTTCCCTGGTGGGCCTA
Motif Score	3.319380952
Cell/Tissue List	HeLa; HepG2; A549; MM6; Jurkat; peripheral-blood; GSC-11; iSLK; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000372568.4; ENST00000356455.9; ENST00000352551.9; ENST00000617055.4; ENST00000243893.10; ENST00000405520.5; ENST00000335046.7
External Link	RMBase: m6A_site_533804
mod ID: M6ASITE053267		Click to Show/Hide the Full List
mod site	chr20:45813135-45813136:+		[2]
Sequence	CTAGATGAAGACGCTCAAGGACCCTCGTGACTTGGCCGAGA
Motif Score	3.622404762
Cell/Tissue List	HeLa; MT4; MM6; Jurkat; peripheral-blood; GSC-11; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000243893.10; ENST00000372568.4; ENST00000335046.7; ENST00000405520.5; ENST00000352551.9; ENST00000356455.9; ENST00000617055.4
External Link	RMBase: m6A_site_533805
mod ID: M6ASITE053268		Click to Show/Hide the Full List
mod site	chr20:45813155-45813156:+		[2]
Sequence	ACCCTCGTGACTTGGCCGAGACAGGGGAAGGGAGAAGTTGA
Motif Score	2.897386905
Cell/Tissue List	HeLa; MT4; MM6; Jurkat; peripheral-blood; GSC-11; endometrial; HEC-1-A; GSCs
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000617055.4; ENST00000335046.7; ENST00000372568.4; ENST00000352551.9; ENST00000356455.9; ENST00000405520.5; ENST00000243893.10
External Link	RMBase: m6A_site_533806
mod ID: M6ASITE053269		Click to Show/Hide the Full List
mod site	chr20:45813216-45813217:+		[3]
Sequence	TAAAGCCTGGGGAATTAAGAACATGCCAGAATCATCCCGAG
Motif Score	2.951386905
Cell/Tissue List	HeLa; MT4; Jurkat; peripheral-blood; GSC-11
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000352551.9; ENST00000617055.4; ENST00000356455.9; ENST00000405520.5; ENST00000243893.10; ENST00000335046.7; ENST00000372568.4
External Link	RMBase: m6A_site_533807
mod ID: M6ASITE053270		Click to Show/Hide the Full List
mod site	chr20:45813263-45813264:+		[4]
Sequence	TGGAATTAGGGAGGGTGAGGACTCGCTAGGATCGTCCTGTG
Motif Score	4.065041667
Cell/Tissue List	MT4; peripheral-blood
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000243893.10; ENST00000356455.9; ENST00000405520.5; ENST00000352551.9; ENST00000372568.4; ENST00000335046.7; ENST00000617055.4
External Link	RMBase: m6A_site_533808
mod ID: M6ASITE053271		Click to Show/Hide the Full List
mod site	chr20:45814423-45814424:+		[5]
Sequence	TTCTGCCTTCCCTGAATCAGACAACCTTTTCAAATGGGTAG
Motif Score	2.897386905
Cell/Tissue List	hESC-HEK293T; Huh7; peripheral-blood
Seq Type List	MAZTER-seq; MeRIP-seq; m6A-seq
Transcript ID List	ENST00000405520.5; ENST00000496085.1; ENST00000243893.10; ENST00000335046.7; ENST00000352551.9; ENST00000617055.4; ENST00000372568.4; ENST00000356455.9
External Link	RMBase: m6A_site_533809
mod ID: M6ASITE053272		Click to Show/Hide the Full List
mod site	chr20:45814446-45814447:+		[6]
Sequence	ACCTTTTCAAATGGGTAGGGACCATCCATGGAGCAGCTGGA
Motif Score	3.622404762
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000496085.1; ENST00000617055.4; ENST00000335046.7; ENST00000352551.9; ENST00000243893.10; ENST00000405520.5; ENST00000372568.4; ENST00000356455.9
External Link	RMBase: m6A_site_533810
mod ID: M6ASITE053273		Click to Show/Hide the Full List
mod site	chr20:45814467-45814468:+		[6]
Sequence	CCATCCATGGAGCAGCTGGAACAGTAAGTGTAGGGCTGGGA
Motif Score	2.951386905
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000372568.4; ENST00000352551.9; ENST00000405520.5; ENST00000356455.9; ENST00000335046.7; ENST00000243893.10; ENST00000496085.1; ENST00000617055.4
External Link	RMBase: m6A_site_533811
mod ID: M6ASITE053274		Click to Show/Hide the Full List
mod site	chr20:45815407-45815408:+		[6]
Sequence	AGGCAGTGGGGAGCATCAGAACCAGCTCAACAGTTTGTCTA
Motif Score	2.930744048
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000496085.1; ENST00000372568.4; ENST00000356455.9; ENST00000617055.4; ENST00000335046.7; ENST00000243893.10; ENST00000352551.9; ENST00000405520.5
External Link	RMBase: m6A_site_533812
mod ID: M6ASITE053275		Click to Show/Hide the Full List
mod site	chr20:45815489-45815490:+		[4]
Sequence	TGTGTGGGGCTTGGGTTGGGACATGAGGCTGCTGCTGGAGC
Motif Score	3.643047619
Cell/Tissue List	MT4; Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000496085.1; ENST00000405520.5; ENST00000335046.7; ENST00000352551.9; ENST00000372568.4; ENST00000617055.4; ENST00000356455.9; ENST00000243893.10
External Link	RMBase: m6A_site_533813
mod ID: M6ASITE053276		Click to Show/Hide the Full List
mod site	chr20:45815550-45815551:+		[4]
Sequence	CAAATGCCAGGTATATGAAGACCTGAGGTATAAGCTCTCGC
Motif Score	2.876744048
Cell/Tissue List	MT4; Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000352551.9; ENST00000496085.1; ENST00000335046.7; ENST00000405520.5; ENST00000243893.10; ENST00000617055.4; ENST00000372568.4; ENST00000356455.9
External Link	RMBase: m6A_site_533814
mod ID: M6ASITE053277		Click to Show/Hide the Full List
mod site	chr20:45815595-45815596:+		[5]
Sequence	GTTCCCCAGTGGCTACCCTTACAATGCGCCCACAGTGAAGT
Motif Score	2.07285119
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000352551.9; ENST00000405520.5; ENST00000356455.9; ENST00000617055.4; ENST00000496085.1; ENST00000335046.7; ENST00000243893.10; ENST00000372568.4
External Link	RMBase: m6A_site_533815
mod ID: M6ASITE053278		Click to Show/Hide the Full List
mod site	chr20:45815646-45815647:+		[5]
Sequence	CTGCTATCACCCCAACGTGGACACCCAGGGTAACATATGCC
Motif Score	3.643047619
Cell/Tissue List	hESC-HEK293T; MT4; Huh7
Seq Type List	MAZTER-seq; MeRIP-seq
Transcript ID List	ENST00000405520.5; ENST00000356455.9; ENST00000372568.4; ENST00000243893.10; ENST00000352551.9; ENST00000496085.1; ENST00000335046.7; ENST00000617055.4
External Link	RMBase: m6A_site_533816
mod ID: M6ASITE053279		Click to Show/Hide the Full List
mod site	chr20:45815670-45815671:+		[5]
Sequence	CCAGGGTAACATATGCCTGGACATCCTGAAGGAAAAGTGGT
Motif Score	3.643047619
Cell/Tissue List	hESC-HEK293T; MT4; Huh7
Seq Type List	MAZTER-seq; MeRIP-seq
Transcript ID List	ENST00000496085.1; ENST00000243893.10; ENST00000372568.4; ENST00000405520.5; ENST00000617055.4; ENST00000352551.9; ENST00000356455.9; ENST00000335046.7
External Link	RMBase: m6A_site_533817
mod ID: M6ASITE053280		Click to Show/Hide the Full List
mod site	chr20:45815711-45815712:+		[6]
Sequence	CTGCCCTGTATGATGTCAGGACCATTCTGCTCTCCATCCAG
Motif Score	3.622404762
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000372568.4; ENST00000335046.7; ENST00000356455.9; ENST00000496085.1; ENST00000352551.9; ENST00000617055.4; ENST00000243893.10; ENST00000405520.5
External Link	RMBase: m6A_site_533818
mod ID: M6ASITE053281		Click to Show/Hide the Full List
mod site	chr20:45815859-45815860:+		[5]
Sequence	CTCTCCACCCACAGAACCCAACATTGATAGTCCCTTGAACA
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000356455.9; ENST00000372568.4; ENST00000243893.10; ENST00000352551.9; ENST00000617055.4; ENST00000335046.7; ENST00000496085.1; ENST00000405520.5
External Link	RMBase: m6A_site_533819
mod ID: M6ASITE053282		Click to Show/Hide the Full List
mod site	chr20:45815877-45815878:+		[6]
Sequence	CAACATTGATAGTCCCTTGAACACACATGCTGCCGAGCTCT
Motif Score	2.951386905
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000405520.5; ENST00000352551.9; ENST00000356455.9; ENST00000617055.4; ENST00000243893.10; ENST00000335046.7; ENST00000496085.1; ENST00000372568.4
External Link	RMBase: m6A_site_533820
mod ID: M6ASITE053283		Click to Show/Hide the Full List
mod site	chr20:45815904-45815905:+		[6]
Sequence	TGCTGCCGAGCTCTGGAAAAACCCCACAGGTGAGTCCTCAG
Motif Score	2.185083333
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000496085.1; ENST00000405520.5; ENST00000335046.7; ENST00000617055.4; ENST00000352551.9; ENST00000356455.9; ENST00000243893.10; ENST00000372568.4
External Link	RMBase: m6A_site_533821
mod ID: M6ASITE053284		Click to Show/Hide the Full List
mod site	chr20:45816953-45816954:+		[2]
Sequence	GCATTTTTGTCCTTTTTTAGACAAGTTGTTGCGTTGTAATT
Motif Score	2.897386905
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000243893.10; ENST00000335046.7; ENST00000352551.9; ENST00000372568.4
External Link	RMBase: m6A_site_533822

Ref 1	5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m(5)C reader. Cell Res. 2017 May;27(5):606-625. doi: 10.1038/cr.2017.55. Epub 2017 Apr 18.
Ref 2	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 3	RNA m(6)A methylation regulates the epithelial mesenchymal transition of cancer cells and translation of Snail. Nat Commun. 2019 May 6;10(1):2065. doi: 10.1038/s41467-019-09865-9.
Ref 4	Dynamics of the human and viral m(6)A RNA methylomes during HIV-1 infection of T cells. Nat Microbiol. 2016 Feb 22;1:16011. doi: 10.1038/nmicrobiol.2016.11.
Ref 5	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 6	N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection. Cell Host Microbe. 2016 Nov 9;20(5):654-665. doi: 10.1016/j.chom.2016.09.015. Epub 2016 Oct 20.

Epigenetic Target Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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