Epigenetic Target Information

General Information of the Epigenetic Target (ID: EPITAR00268)

Target Name	Protein lin-28 homolog B (LIN28B)
Synonyms	Lin-28B Click to Show/Hide
Gene Name	LIN28B
Sequence	MAEGGASKGGGEEPGKLPEPAEEESQVLRGTGHCKWFNVRMGFGFISMINREGSPLDIPVDVFVHQSKLFMEGFRSLKEGEPVEFTFKKSSKGLESIRVTGPGGSPCLGSERRPKGKTLQKRKPKGDRCYNCGGLDHHAKECSLPPQPKKCHYCQSIMHMVANCPHKNVAQPPASSQGRQEAESQPCTSTLPREVGGGHGCTSPPFPQEARAEISERSGRSPQEASSTKSSIAPEEQSKKGPSVQKRKKT Click to Show/Hide
Family	Lin-28 family
Function	Suppressor of microRNA (miRNA) biogenesis, including that of let-7 and possibly of miR107, miR-143 and miR-200c. Binds primary let-7 transcripts (pri-let-7), including pri-let-7g and pri-let-7a-1, and sequester them in the nucleolus, away from the microprocessor complex, hence preventing their processing into mature miRNA (PubMed:22118463). Does not act on pri-miR21 (PubMed:22118463). The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state of embryonic stem cells by preventing let-7-mediated differentiation. When overexpressed, recruits ZCCHC11/TUT4 uridylyltransferase to pre-let-7 transcripts, leading to their terminal uridylation and degradation (PubMed:19703396). This activity might not be relevant in vivo, as LIN28B-mediated inhibition of let-7 miRNA maturation appears to be ZCCHC11-independent (PubMed:22118463). Interaction with target pre-miRNAs occurs via an 5'-GGAG-3' motif in the pre-miRNA terminal loop. Mediates MYC-induced let-7 repression (By similarity). When overexpressed, isoform 1 stimulates growth of the breast adenocarcinoma cell line MCF-7. Isoform 2 has no effect on cell growth. Click to Show/Hide
Gene ID	389421
HGNC ID	HGNC:32207
Ensembl Gene ID	ENSG00000187772
KEGG ID	hsa:389421
Chromosomal Location	6q16.3-q21

RNA Modification Sequencing Data Associated with the Target (ID: EPITAR00268)

Protein lin-28 homolog B (LIN28B)

Adenosine-to-Inosine editing (A-to-I)

In total 1 m6A sequence/site(s) in this target gene
mod ID: A2ISITE001595		Click to Show/Hide the Full List
mod site	chr6:105055527-105055528:+		[1]
Sequence	GCCCTTCAAAGCACAGCAGCAGGCTTTGTTGTCTGGCAGAG
Transcript ID List	ENST00000345080.5; ENST00000635857.1; ENST00000637759.1
External Link	RMBase: RNA-editing_site_118163

N6-methyladenosine (m6A)

In total 65 m6A sequence/site(s) in this target gene
mod ID: M6ASITE076264		Click to Show/Hide the Full List
mod site	chr6:104937038-104937039:+		[2]
Sequence	TTTCCACAGGCTGGTGTTGAACTCCTGGGCTCAAGCGATTC
Motif Score	3.373380952
Cell/Tissue List	TREX
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000635857.1
External Link	RMBase: m6A_site_728643
mod ID: M6ASITE076265		Click to Show/Hide the Full List
mod site	chr6:104940901-104940902:+		[3]
Sequence	GCTCCCTCAGGAAGTGACAGACTCCAGGCCCCTTCCTCCGC
Motif Score	3.319380952
Cell/Tissue List	HepG2; H1A; H1B; Huh7; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000635857.1; ENST00000637759.1
External Link	RMBase: m6A_site_728644
mod ID: M6ASITE076266		Click to Show/Hide the Full List
mod site	chr6:104940935-104940936:+		[3]
Sequence	CCTCCGCCCCGTCCTTCGGGACTGAACGCCACACACGTCCT
Motif Score	4.065041667
Cell/Tissue List	HepG2; H1A; H1B; Huh7; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000637759.1; ENST00000635857.1
External Link	RMBase: m6A_site_728645
mod ID: M6ASITE076267		Click to Show/Hide the Full List
mod site	chr6:104957128-104957129:+		[4]
Sequence	AAAGAAGGAAAGCACATTAGACCATGCGAGCTAAATTTGTG
Motif Score	2.876744048
Cell/Tissue List	HEK293T; HEK293A-TOA
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000635857.1; ENST00000637759.1; ENST00000345080.5
External Link	RMBase: m6A_site_728649
mod ID: M6ASITE076269		Click to Show/Hide the Full List
mod site	chr6:104958178-104958179:+		[5]
Sequence	AATCCCAGGTTTTGCGCGGAACTGGCCACTGTAAGTGGTTC
Motif Score	3.373380952
Cell/Tissue List	HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000345080.5; ENST00000637759.1; ENST00000635857.1
External Link	RMBase: m6A_site_728650
mod ID: M6ASITE076270		Click to Show/Hide the Full List
mod site	chr6:105026401-105026402:+		[6]
Sequence	GAGTCAATACGGGTAACAGGACCTGGTGGGAGCCCCTGTTT
Motif Score	3.622404762
Cell/Tissue List	hNPCs
Seq Type List	m6A-seq
Transcript ID List	ENST00000637759.1; ENST00000345080.5; ENST00000635857.1
External Link	RMBase: m6A_site_728651
mod ID: M6ASITE076271		Click to Show/Hide the Full List
mod site	chr6:105026437-105026438:+		[6]
Sequence	TGTTTAGGAAGTGAAAGAAGACCCAAAGGGAAGACACTACA
Motif Score	2.876744048
Cell/Tissue List	hNPCs
Seq Type List	m6A-seq
Transcript ID List	ENST00000345080.5; ENST00000637759.1; ENST00000635857.1
External Link	RMBase: m6A_site_728652
mod ID: M6ASITE076272		Click to Show/Hide the Full List
mod site	chr6:105026450-105026451:+		[6]
Sequence	AAAGAAGACCCAAAGGGAAGACACTACAGAAAAGAAAACCA
Motif Score	2.897386905
Cell/Tissue List	HEK293T; hNPCs
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000635857.1; ENST00000345080.5; ENST00000637759.1
External Link	RMBase: m6A_site_728653
mod ID: M6ASITE076273		Click to Show/Hide the Full List
mod site	chr6:105026467-105026468:+		[6]
Sequence	AAGACACTACAGAAAAGAAAACCAAAGGGAGATAGGTAATC
Motif Score	2.185083333
Cell/Tissue List	HEK293T; hNPCs
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000345080.5; ENST00000635857.1; ENST00000637759.1
External Link	RMBase: m6A_site_728654
mod ID: M6ASITE076274		Click to Show/Hide the Full List
mod site	chr6:105078517-105078518:+		[4]
Sequence	CATCATGCACATGGTGGCAAACTGCCCACATAAAAATGTTG
Motif Score	2.627720238
Cell/Tissue List	HEK293T; H1A; H1B; hNPCs; hESCs; fibroblasts; Huh7; HEK293A-TOA; TREX
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000637759.1; ENST00000345080.5; ENST00000635857.1
External Link	RMBase: m6A_site_728655
mod ID: M6ASITE076275		Click to Show/Hide the Full List
mod site	chr6:105078566-105078567:+		[3]
Sequence	CCCGCGAGTTCTCAGGGAAGACAGGAAGCAGAATCCCAGCC
Motif Score	2.897386905
Cell/Tissue List	HepG2; HEK293T; H1A; H1B; hNPCs; hESCs; fibroblasts; Huh7; HEK293A-TOA; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000635857.1; ENST00000637759.1; ENST00000345080.5
External Link	RMBase: m6A_site_728656
mod ID: M6ASITE076276		Click to Show/Hide the Full List
mod site	chr6:105078777-105078778:+		[4]
Sequence	CAGTTCAAAAAAGGAAAAAGACATAACAGGTCTTCTTCATA
Motif Score	2.897386905
Cell/Tissue List	HEK293T; H1A; hNPCs; hESCs; fibroblasts; H1299; Huh7; HEK293A-TOA; TREX
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000637759.1; ENST00000345080.5
External Link	RMBase: m6A_site_728657
mod ID: M6ASITE076277		Click to Show/Hide the Full List
mod site	chr6:105078849-105078850:+		[4]
Sequence	CCTCATGCAAGTATAGGGGAACAGTATTTCACAAGCAGTAG
Motif Score	2.951386905
Cell/Tissue List	HEK293T; hNPCs; Huh7
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000345080.5; ENST00000637759.1
External Link	RMBase: m6A_site_728658
mod ID: M6ASITE076278		Click to Show/Hide the Full List
mod site	chr6:105078859-105078860:+		[7]
Sequence	GTATAGGGGAACAGTATTTCACAAGCAGTAGCTGACCTGGG
Motif Score	2.047297619
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000637759.1; ENST00000345080.5
External Link	RMBase: m6A_site_728659
mod ID: M6ASITE076280		Click to Show/Hide the Full List
mod site	chr6:105078886-105078887:+		[7]
Sequence	GTAGCTGACCTGGGATTTTAACTACTATTGGGGAACTGTGA
Motif Score	2.590089286
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000637759.1; ENST00000345080.5
External Link	RMBase: m6A_site_728660
mod ID: M6ASITE076281		Click to Show/Hide the Full List
mod site	chr6:105078900-105078901:+
Sequence	ATTTTAACTACTATTGGGGAACTGTGAATTTTTTAAACAGA
Motif Score	3.373380952
Cell/Tissue List	HEK293T
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000637759.1; ENST00000345080.5
External Link	RMBase: m6A_site_728661
mod ID: M6ASITE076282		Click to Show/Hide the Full List
mod site	chr6:105079202-105079203:+		[7]
Sequence	TATAGATAGTTTTAAATTTAACCCACTGGAGTTTTCTTGAA
Motif Score	2.147452381
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000345080.5; ENST00000637759.1
External Link	RMBase: m6A_site_728662
mod ID: M6ASITE076283		Click to Show/Hide the Full List
mod site	chr6:105079206-105079207:+		[7]
Sequence	GATAGTTTTAAATTTAACCCACTGGAGTTTTCTTGAAATAC
Motif Score	2.475107143
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000637759.1; ENST00000345080.5
External Link	RMBase: m6A_site_728663
mod ID: M6ASITE076284		Click to Show/Hide the Full List
mod site	chr6:105079225-105079226:+		[7]
Sequence	CACTGGAGTTTTCTTGAAATACCACTTCTTTTATATTATAT
Motif Score	2.089839286
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000637759.1; ENST00000345080.5
External Link	RMBase: m6A_site_728664
mod ID: M6ASITE076285		Click to Show/Hide the Full List
mod site	chr6:105079476-105079477:+		[7]
Sequence	GCTTTTTTGATTCTGGGATAACATAACTCCAGAAAAGACAA
Motif Score	2.168095238
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000637759.1; ENST00000345080.5
External Link	RMBase: m6A_site_728665
mod ID: M6ASITE076286		Click to Show/Hide the Full List
mod site	chr6:105079481-105079482:+		[7]
Sequence	TTTGATTCTGGGATAACATAACTCCAGAAAAGACAATGAAT
Motif Score	2.590089286
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000345080.5; ENST00000637759.1
External Link	RMBase: m6A_site_728666
mod ID: M6ASITE076287		Click to Show/Hide the Full List
mod site	chr6:105079493-105079494:+		[7]
Sequence	ATAACATAACTCCAGAAAAGACAATGAATGTGTAATTTGGG
Motif Score	2.897386905
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000637759.1; ENST00000345080.5
External Link	RMBase: m6A_site_728667
mod ID: M6ASITE076288		Click to Show/Hide the Full List
mod site	chr6:105079764-105079765:+		[7]
Sequence	ACTACTGAAGACCTTAGAGAACTCCAATTGTTTGGCATATA
Motif Score	3.373380952
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000345080.5; ENST00000637759.1
External Link	RMBase: m6A_site_728668
mod ID: M6ASITE076289		Click to Show/Hide the Full List
mod site	chr6:105079935-105079936:+		[7]
Sequence	ATATATGACCTGCAAATGATACGAAAAAGTGCAGCATTTAG
Motif Score	2.084416667
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000345080.5; ENST00000637759.1
External Link	RMBase: m6A_site_728669
mod ID: M6ASITE076291		Click to Show/Hide the Full List
mod site	chr6:105079965-105079966:+		[7]
Sequence	GCAGCATTTAGTGGCAGTTAACAAGAGTGACAAGCCTGGGG
Motif Score	2.168095238
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000345080.5; ENST00000637759.1
External Link	RMBase: m6A_site_728670
mod ID: M6ASITE076292		Click to Show/Hide the Full List
mod site	chr6:105080007-105080008:+		[7]
Sequence	AGAGGTACCAAACCTCTCCCACCAGAGAGCTAGAAGTATTT
Motif Score	2.032470238
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000637759.1; ENST00000345080.5
External Link	RMBase: m6A_site_728671
mod ID: M6ASITE076293		Click to Show/Hide the Full List
mod site	chr6:105080037-105080038:+		[7]
Sequence	TAGAAGTATTTTATACAGTAACTTTGATCTTATGGAAGTGA
Motif Score	2.590089286
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000345080.5; ENST00000637759.1
External Link	RMBase: m6A_site_728672
mod ID: M6ASITE076294		Click to Show/Hide the Full List
mod site	chr6:105080096-105080097:+		[8]
Sequence	AAGTAACCTATATGGTGGATACAGGATGAACATTCAGTGCC
Motif Score	2.110482143
Cell/Tissue List	HEK293
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000345080.5; ENST00000637759.1
External Link	RMBase: m6A_site_728673
mod ID: M6ASITE076295		Click to Show/Hide the Full List
mod site	chr6:105080690-105080691:+		[7]
Sequence	AACTTATTTAAATTATGTAGACAAATCAAAGTGGCATTGCT
Motif Score	2.897386905
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000345080.5
External Link	RMBase: m6A_site_728674
mod ID: M6ASITE076296		Click to Show/Hide the Full List
mod site	chr6:105080741-105080742:+		[7]
Sequence	CAGGCATAATAAGCAAGTTAACAGTAAAATGCAAAACATGA
Motif Score	2.168095238
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000345080.5
External Link	RMBase: m6A_site_728675
mod ID: M6ASITE076297		Click to Show/Hide the Full List
mod site	chr6:105080889-105080890:+		[6]
Sequence	ATGGAAATAGGAAATTATGGACTTCAAAATTGGACACTTCC
Motif Score	4.065041667
Cell/Tissue List	hNPCs
Seq Type List	m6A-seq
Transcript ID List	ENST00000345080.5
External Link	RMBase: m6A_site_728676
mod ID: M6ASITE076298		Click to Show/Hide the Full List
mod site	chr6:105080902-105080903:+		[6]
Sequence	ATTATGGACTTCAAAATTGGACACTTCCTGTTTACAAAAAG
Motif Score	3.643047619
Cell/Tissue List	hNPCs
Seq Type List	m6A-seq
Transcript ID List	ENST00000345080.5
External Link	RMBase: m6A_site_728677
mod ID: M6ASITE076299		Click to Show/Hide the Full List
mod site	chr6:105080960-105080961:+		[7]
Sequence	CATGGTAAAAAAAAATAGAAACACTTGAGAACTATGGTCTT
Motif Score	2.20572619
Cell/Tissue List	HEK293T; hNPCs
Seq Type List	DART-seq; m6A-seq
Transcript ID List	ENST00000345080.5
External Link	RMBase: m6A_site_728678
mod ID: M6ASITE076300		Click to Show/Hide the Full List
mod site	chr6:105080970-105080971:+		[6]
Sequence	AAAAATAGAAACACTTGAGAACTATGGTCTTTATGGGTGCA
Motif Score	3.373380952
Cell/Tissue List	hNPCs
Seq Type List	m6A-seq
Transcript ID List	ENST00000345080.5
External Link	RMBase: m6A_site_728679
mod ID: M6ASITE076302		Click to Show/Hide the Full List
mod site	chr6:105081025-105081026:+		[7]
Sequence	TCATCATCTTACCAGACTAAACTAAGAGCACATACCAAACC
Motif Score	2.627720238
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000345080.5
External Link	RMBase: m6A_site_728680
mod ID: M6ASITE076303		Click to Show/Hide the Full List
mod site	chr6:105081095-105081096:+		[7]
Sequence	TTTTATATGAGAATATTATCACTATTACATAACATACTCAG
Motif Score	2.469291667
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000345080.5
External Link	RMBase: m6A_site_728681
mod ID: M6ASITE076304		Click to Show/Hide the Full List
mod site	chr6:105081169-105081170:+		[7]
Sequence	AATATTTTTGTTGTTTCTTTACAGACTAGTCTACAGTCCTG
Motif Score	2.07285119
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000345080.5
External Link	RMBase: m6A_site_728682
mod ID: M6ASITE076305		Click to Show/Hide the Full List
mod site	chr6:105081173-105081174:+		[7]
Sequence	TTTTTGTTGTTTCTTTACAGACTAGTCTACAGTCCTGCTTA
Motif Score	3.319380952
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000345080.5
External Link	RMBase: m6A_site_728683
mod ID: M6ASITE076306		Click to Show/Hide the Full List
mod site	chr6:105081193-105081194:+		[7]
Sequence	ACTAGTCTACAGTCCTGCTTACTCAAAACAAACCAAATAAC
Motif Score	2.494845238
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000345080.5
External Link	RMBase: m6A_site_728684
mod ID: M6ASITE076307		Click to Show/Hide the Full List
mod site	chr6:105081239-105081240:+		[7]
Sequence	CCTTTATATAAGTATTATGTACTGATGATAGTAACTACCTC
Motif Score	3.278136905
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000345080.5
External Link	RMBase: m6A_site_728685
mod ID: M6ASITE076308		Click to Show/Hide the Full List
mod site	chr6:105081268-105081269:+		[7]
Sequence	AGTAACTACCTCTGAGTTTGACACAGATCAAAATTTTTGAA
Motif Score	2.859755952
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000345080.5
External Link	RMBase: m6A_site_728686
mod ID: M6ASITE076309		Click to Show/Hide the Full List
mod site	chr6:105081328-105081329:+		[7]
Sequence	TATTTTTATTTCATGTGAAAACTCCTCTAAAGCAGATTCCC
Motif Score	2.627720238
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000345080.5
External Link	RMBase: m6A_site_728687
mod ID: M6ASITE076310		Click to Show/Hide the Full List
mod site	chr6:105081352-105081353:+		[7]
Sequence	CTCTAAAGCAGATTCCCTCAACTCTGTGCATATGTGAATAT
Motif Score	2.595904762
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000345080.5
External Link	RMBase: m6A_site_728688
mod ID: M6ASITE076311		Click to Show/Hide the Full List
mod site	chr6:105081399-105081400:+		[7]
Sequence	TGTGAACACATTGTTCATTTACATAGGTAAAATATTACTCT
Motif Score	2.07285119
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000345080.5
External Link	RMBase: m6A_site_728689
mod ID: M6ASITE076313		Click to Show/Hide the Full List
mod site	chr6:105081415-105081416:+		[7]
Sequence	ATTTACATAGGTAAAATATTACTCTGTTTACAGCAAAAGGC
Motif Score	2.494845238
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000345080.5
External Link	RMBase: m6A_site_728690
mod ID: M6ASITE076314		Click to Show/Hide the Full List
mod site	chr6:105081424-105081425:+		[7]
Sequence	GGTAAAATATTACTCTGTTTACAGCAAAAGGCTACCTCATA
Motif Score	2.07285119
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000345080.5
External Link	RMBase: m6A_site_728691
mod ID: M6ASITE076315		Click to Show/Hide the Full List
mod site	chr6:105081510-105081511:+		[7]
Sequence	GTGGCTGATAATTCTCTGGTACAGAACCTTTTTATCTGTAT
Motif Score	2.856142857
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000345080.5
External Link	RMBase: m6A_site_728692
mod ID: M6ASITE076316		Click to Show/Hide the Full List
mod site	chr6:105081567-105081568:+		[7]
Sequence	CAACTGCATGTTTCTGACAAACACTTGTGAATAATGAAGCA
Motif Score	2.20572619
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000345080.5
External Link	RMBase: m6A_site_728693
mod ID: M6ASITE076317		Click to Show/Hide the Full List
mod site	chr6:105081615-105081616:+		[7]
Sequence	TTAGTTAGCAAAGTCTCCAAACATTTCCTTAAAATAATCAT
Motif Score	2.20572619
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000345080.5
External Link	RMBase: m6A_site_728694
mod ID: M6ASITE076318		Click to Show/Hide the Full List
mod site	chr6:105081816-105081817:+		[7]
Sequence	GACGCCAATGTCCTTCATTTACTGTCTGTGCTGCCCTGAAG
Motif Score	2.494845238
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000345080.5
External Link	RMBase: m6A_site_728695
mod ID: M6ASITE076319		Click to Show/Hide the Full List
mod site	chr6:105082095-105082096:+		[7]
Sequence	CTGTAAGCTGATCTTTTGCTACATGGCAGACTATAATGAAA
Motif Score	2.078666667
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000345080.5
External Link	RMBase: m6A_site_728696
mod ID: M6ASITE076320		Click to Show/Hide the Full List
mod site	chr6:105082104-105082105:+		[7]
Sequence	GATCTTTTGCTACATGGCAGACTATAATGAAAACATTTTTA
Motif Score	3.319380952
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000345080.5
External Link	RMBase: m6A_site_728697
mod ID: M6ASITE076321		Click to Show/Hide the Full List
mod site	chr6:105082292-105082293:+		[7]
Sequence	CCACCTCCAATATTGCCGATACTTTTTTTATTCTGGCTCAG
Motif Score	2.53247619
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000345080.5
External Link	RMBase: m6A_site_728698
mod ID: M6ASITE076322		Click to Show/Hide the Full List
mod site	chr6:105082343-105082344:+		[7]
Sequence	CACCAGTGCGGCCCCAAGTTACTGCTGGTTGTATTTAGTTT
Motif Score	2.494845238
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000345080.5
External Link	RMBase: m6A_site_728699
mod ID: M6ASITE076325		Click to Show/Hide the Full List
mod site	chr6:105082392-105082393:+		[7]
Sequence	GAGCCCATAAGTGTTAATAGACTTTGTAACATTCACTATAA
Motif Score	3.319380952
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000345080.5
External Link	RMBase: m6A_site_728700
mod ID: M6ASITE076326		Click to Show/Hide the Full List
mod site	chr6:105082406-105082407:+		[7]
Sequence	TAATAGACTTTGTAACATTCACTATAAGATGAATTATACAG
Motif Score	2.469291667
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000345080.5
External Link	RMBase: m6A_site_728701
mod ID: M6ASITE076327		Click to Show/Hide the Full List
mod site	chr6:105082763-105082764:+		[7]
Sequence	TTTTAAATTTTATATTTGGAACAAAGCTGCAAGTTATGGTA
Motif Score	2.951386905
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000345080.5
External Link	RMBase: m6A_site_728702
mod ID: M6ASITE076328		Click to Show/Hide the Full List
mod site	chr6:105082788-105082789:+		[7]
Sequence	GCTGCAAGTTATGGTAAAGTACTGTACTGTGAGAAGTATTA
Motif Score	3.278136905
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000345080.5
External Link	RMBase: m6A_site_728703
mod ID: M6ASITE076329		Click to Show/Hide the Full List
mod site	chr6:105082793-105082794:+		[7]
Sequence	AAGTTATGGTAAAGTACTGTACTGTGAGAAGTATTATGATA
Motif Score	3.278136905
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000345080.5
External Link	RMBase: m6A_site_728704
mod ID: M6ASITE076330		Click to Show/Hide the Full List
mod site	chr6:105082836-105082837:+		[7]
Sequence	TAATGCATCTGTGGCTTAACACTTGTGAGAGTTACCAGCTT
Motif Score	2.506922619
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000345080.5
External Link	RMBase: m6A_site_728705
mod ID: M6ASITE076331		Click to Show/Hide the Full List
mod site	chr6:105082968-105082969:+		[7]
Sequence	TGGTATTAACAACTAACCGTACTAGAGACCAAAGTGAACCC
Motif Score	3.278136905
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000345080.5
External Link	RMBase: m6A_site_728706
mod ID: M6ASITE076332		Click to Show/Hide the Full List
mod site	chr6:105082975-105082976:+		[7]
Sequence	AACAACTAACCGTACTAGAGACCAAAGTGAACCCTGATTTT
Motif Score	2.876744048
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000345080.5
External Link	RMBase: m6A_site_728707
mod ID: M6ASITE076333		Click to Show/Hide the Full List
mod site	chr6:105083133-105083134:+		[7]
Sequence	GAACTGTATGTTTTTAAAAGACAAAAAAGGGGTAGATGTTT
Motif Score	2.897386905
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000345080.5
External Link	RMBase: m6A_site_728708
mod ID: M6ASITE076334		Click to Show/Hide the Full List
mod site	chr6:105083166-105083167:+		[7]
Sequence	AGATGTTTGGAATGCGTTTCACTCGCATGCAGTCATCTGGA
Motif Score	2.469291667
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000345080.5
External Link	RMBase: m6A_site_728709
mod ID: M6ASITE076336		Click to Show/Hide the Full List
mod site	chr6:105083198-105083199:+		[7]
Sequence	TCATCTGGAGGGACTGAAGCACTGTTTGCCTTTCTGTACAC
Motif Score	3.252583333
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000345080.5
External Link	RMBase: m6A_site_728710

Pseudouridine (Pseudo)

In total 1 m6A sequence/site(s) in this target gene
mod ID: PSESITE000239		Click to Show/Hide the Full List
mod site	chr6:105083163-105083164:+		[9]
Sequence	GGTAGATGTTTGGAATGCGTTTCACTCGCATGCAGTCATCT
Transcript ID List	ENST00000345080.5
External Link	RMBase: Pseudo_site_4309

Ref 1	RADAR: a rigorously annotated database of A-to-I RNA editing. Nucleic Acids Res. 2014 Jan;42(Database issue):D109-13. doi: 10.1093/nar/gkt996. Epub 2013 Oct 25.
Ref 2	Viral and cellular N(6)-methyladenosine and N(6),2'-O-dimethyladenosine epitranscriptomes in the KSHV life cycle. Nat Microbiol. 2018 Jan;3(1):108-120. doi: 10.1038/s41564-017-0056-8. Epub 2017 Nov 6.
Ref 3	Efficacy of MEK inhibition in patients with histiocytic neoplasms. Nature. 2019 Mar;567(7749):521-524. doi: 10.1038/s41586-019-1012-y. Epub 2019 Mar 13.
Ref 4	Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons. Cell. 2012 Jun 22;149(7):1635-46. doi: 10.1016/j.cell.2012.05.003. Epub 2012 May 17.
Ref 5	[Action myoclonias and paranoid alternative psychosis in progressive myoclonic epilepsy (late form of the Lafora type)]. Nervenarzt. 1986 Apr;57(4):233-7.
Ref 6	Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites. Cell Rep. 2014 Jul 10;8(1):284-96. doi: 10.1016/j.celrep.2014.05.048. Epub 2014 Jun 26.
Ref 7	DART-seq: an antibody-free method for global m(6)A detection. Nat Methods. 2019 Dec;16(12):1275-1280. doi: 10.1038/s41592-019-0570-0. Epub 2019 Sep 23.
Ref 8	Single-base mapping of m(6)A by an antibody-independent method. Sci Adv. 2019 Jul 3;5(7):eaax0250. doi: 10.1126/sciadv.aax0250. eCollection 2019 Jul.
Ref 9	Chemical pulldown reveals dynamic pseudouridylation of the mammalian transcriptome. Nat Chem Biol. 2015 Aug;11(8):592-7. doi: 10.1038/nchembio.1836. Epub 2015 Jun 15.

Epigenetic Target Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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