Epigenetic Target Information

General Information of the Epigenetic Target (ID: EPITAR00200)
Target Name Phosphoenolpyruvate carboxykinase [GTP], mitochondrial (PCK2)
Synonyms
PEPCK-M; EC 4.1.1.32; Phosphoenolpyruvate carboxykinase 2, mitochondrial; mtPCK2
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Gene Name PCK2
Sequence
MAALYRPGLRLNWHGLSPLGWPSCRSIQTLRVLSGDLGQLPTGIRDFVEHSARLCQPEGIHICDGTEAENTATLTLLEQQGLIRKLPKYNNCWLARTDPKDVARVESKTVIVTPSQRDTVPLPPGGARGQLGNWMSPADFQRAVDERFPGCMQGRTMYVLPFSMGPVGSPLSRIGVQLTDSAYVVASMRIMTRLGTPVLQALGDGDFVKCLHSVGQPLTGQGEPVSQWPCNPEKTLIGHVPDQREIISFGSGYGGNSLLGKKCFALRIASRLARDEGWLAEHMLILGITSPAGKKRYVAAAFPSACGKTNLAMMRPALPGWKVECVGDDIAWMRFDSEGRLRAINPENGFFGVAPGTSATTNPNAMATIQSNTIFTNVAETSDGGVYWEGIDQPLPPGVTVTSWLGKPWKPGDKEPCAHPNSRFCAPARQCPIMDPAWEAPEGVPIDAIIFGGRRPKGVPLVYEAFNWRHGVFVGSAMRSESTAAAEHKGKIIMHDPFAMRPFFGYNFGHYLEHWLSMEGRKGAQLPRIFHVNWFRRDEAGHFLWPGFGENARVLDWICRRLEGEDSARETPIGLVPKEGALDLSGLRAIDTTQLFSLPKDFWEQEVRDIRSYLTEQVNQDLPKEVLAELEALERRVHKM
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Family Phosphoenolpyruvate carboxykinase [GTP] family
Function
Mitochondrial phosphoenolpyruvate carboxykinase that catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (PubMed:28955899). Can play an active role in glyceroneogenesis and gluconeogenesis (PubMed:28955899).
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Gene ID 5106
HGNC ID HGNC:8725
Ensembl Gene ID ENSG00000100889
KEGG ID hsa:5106
Chromosomal Location 14q11.2-q12
RNA Modification Sequencing Data Associated with the Target (ID: EPITAR00200)
Phosphoenolpyruvate carboxykinase [GTP], mitochondrial (PCK2)
N4-acetylcytidine (ac4C)
In total 1 m6A sequence/site(s) in this target gene
mod ID: AC4SITE000189 Click to Show/Hide the Full List
mod site chr14:24103721-24103722:+ [1]
Sequence TGCTAGACTGGATCTGCCGGCGGTTAGAGGGGGAGGACAGT
Cell/Tissue List H1
Seq Type List ac4C-seq
Transcript ID List ENST00000545054.6; ENST00000559250.5; ENST00000559171.1; ENST00000216780.8; ENST00000557969.1; ENST00000561286.5; ENST00000558096.5
External Link RMBase: ac4C_site_529
5-methylcytidine (m5C)
In total 1 m6A sequence/site(s) in this target gene
mod ID: M5CSITE000221 Click to Show/Hide the Full List
mod site chr14:24099121-24099122:+ [2]
Sequence GTGCCCGACCAGCGGGAGATCATCTCCTTCGGCAGCGGCTA
Seq Type List Bisulfite-seq
Transcript ID List ENST00000545054.6; ENST00000560736.5; ENST00000561286.5; ENST00000559250.5; ENST00000558674.5; ENST00000559503.1; ENST00000561050.5; ENST00000396973.8; ENST00000216780.8; ENST00000558096.5
External Link RMBase: m5C_site_12588
N6-methyladenosine (m6A)
In total 27 m6A sequence/site(s) in this target gene
mod ID: M6ASITE019102 Click to Show/Hide the Full List
mod site chr14:24097078-24097079:+ [3]
Sequence CTGAGGCTGAGAATACTGCCACACTGACCCTGCTGGAGCAG
Motif Score 2.053113095
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000559250.5; ENST00000560106.5; ENST00000561050.5; ENST00000558096.5; ENST00000216780.8; ENST00000396973.8; ENST00000545054.6; ENST00000561286.5; ENST00000558674.5; ENST00000560736.5; ENST00000559584.5; ENST00000559837.5
External Link RMBase: m6A_site_241087
mod ID: M6ASITE019103 Click to Show/Hide the Full List
mod site chr14:24097127-24097128:+ [3]
Sequence CATCCGAAAGCTCCCCAAGTACAATAACTGGTAAGCCTTGG
Motif Score 2.856142857
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000216780.8; ENST00000560106.5; ENST00000561050.5; ENST00000558096.5; ENST00000545054.6; ENST00000560736.5; ENST00000559250.5; ENST00000559584.5; ENST00000396973.8; ENST00000561286.5; ENST00000559837.5; ENST00000558674.5
External Link RMBase: m6A_site_241088
mod ID: M6ASITE019104 Click to Show/Hide the Full List
mod site chr14:24098215-24098216:+ [4]
Sequence CCCCCAGCTGGCTGGCCCGCACAGACCCCAAGGATGTGGCA
Motif Score 2.830589286
Cell/Tissue List HEK293
Seq Type List m6A-REF-seq
Transcript ID List ENST00000561286.5; ENST00000396973.8; ENST00000560736.5; ENST00000560106.5; ENST00000545054.6; ENST00000559584.5; ENST00000561050.5; ENST00000559250.5; ENST00000558096.5; ENST00000559837.5; ENST00000216780.8; ENST00000558674.5
External Link RMBase: m6A_site_241089
mod ID: M6ASITE019105 Click to Show/Hide the Full List
mod site chr14:24098279-24098280:+ [4]
Sequence TGTAACTCCTTCTCAGCGGGACACGGTACCACTCCCGCCTG
Motif Score 3.643047619
Cell/Tissue List kidney; hESC-HEK293T
Seq Type List m6A-REF-seq; MAZTER-seq
Transcript ID List ENST00000396973.8; ENST00000216780.8; ENST00000558674.5; ENST00000558096.5; ENST00000559837.5; ENST00000545054.6; ENST00000561050.5; ENST00000560736.5; ENST00000560106.5; ENST00000561286.5; ENST00000559250.5
External Link RMBase: m6A_site_241090
mod ID: M6ASITE019106 Click to Show/Hide the Full List
mod site chr14:24098599-24098600:+ [3]
Sequence GTATTATGACCCGACTGGGGACACCTGTGCTTCAGGCCCTG
Motif Score 3.643047619
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000561050.5; ENST00000558096.5; ENST00000396973.8; ENST00000545054.6; ENST00000559837.5; ENST00000559250.5; ENST00000216780.8; ENST00000558674.5; ENST00000559503.1; ENST00000560736.5; ENST00000561286.5
External Link RMBase: m6A_site_241091
mod ID: M6ASITE019107 Click to Show/Hide the Full List
mod site chr14:24098673-24098674:+ [3]
Sequence GTGGGCCAGCCCCTGACAGGACAAGGTAAGCACCTGCTCTG
Motif Score 3.643047619
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000558674.5; ENST00000559837.5; ENST00000559503.1; ENST00000561286.5; ENST00000396973.8; ENST00000545054.6; ENST00000561050.5; ENST00000559250.5; ENST00000216780.8; ENST00000560736.5; ENST00000558096.5
External Link RMBase: m6A_site_241092
mod ID: M6ASITE019108 Click to Show/Hide the Full List
mod site chr14:24099228-24099229:+ [4]
Sequence TGAGGGCTGGCTGGCAGAGCACATGCTGGTGAGGGCCTGGT
Motif Score 2.830589286
Cell/Tissue List kidney; liver
Seq Type List m6A-REF-seq
Transcript ID List ENST00000558674.5; ENST00000558096.5; ENST00000561286.5; ENST00000561050.5; ENST00000559250.5; ENST00000396973.8; ENST00000559503.1; ENST00000545054.6; ENST00000216780.8
External Link RMBase: m6A_site_241093
mod ID: M6ASITE019109 Click to Show/Hide the Full List
mod site chr14:24100080-24100081:+ [3]
Sequence CCAATCCCAACGCCATGGCTACAATCCAGAGTAACACTATT
Motif Score 2.078666667
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000545054.6; ENST00000396973.8; ENST00000561286.5; ENST00000561050.5; ENST00000559250.5; ENST00000216780.8; ENST00000558674.5; ENST00000559503.1; ENST00000558096.5
External Link RMBase: m6A_site_241094
mod ID: M6ASITE019110 Click to Show/Hide the Full List
mod site chr14:24102755-24102756:+ [3]
Sequence TGTATTTCCTCTGCCAGGTGACAAGGAGCCCTGTGCACATC
Motif Score 2.859755952
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000557969.1; ENST00000561286.5; ENST00000216780.8; ENST00000545054.6; ENST00000558096.5; ENST00000559250.5; ENST00000559503.1; ENST00000559171.1
External Link RMBase: m6A_site_241095
mod ID: M6ASITE019111 Click to Show/Hide the Full List
mod site chr14:24102779-24102780:+ [5]
Sequence GGAGCCCTGTGCACATCCCAACTCTCGATTTTGTGCCCCGG
Motif Score 2.595904762
Cell/Tissue List HEK293T
Seq Type List DART-seq
Transcript ID List ENST00000559250.5; ENST00000558096.5; ENST00000557969.1; ENST00000561286.5; ENST00000559171.1; ENST00000545054.6; ENST00000216780.8; ENST00000559503.1
External Link RMBase: m6A_site_241096
mod ID: M6ASITE019112 Click to Show/Hide the Full List
mod site chr14:24103247-24103248:+ [3]
Sequence GAGTCCACTGCTGCAGCAGAACACAAAGGTGAGCACCCTCA
Motif Score 2.951386905
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000545054.6; ENST00000559250.5; ENST00000561286.5; ENST00000559171.1; ENST00000558096.5; ENST00000557969.1; ENST00000216780.8
External Link RMBase: m6A_site_241097
mod ID: M6ASITE019113 Click to Show/Hide the Full List
mod site chr14:24103557-24103558:+ [3]
Sequence CATGCGGCCCTTTTTTGGCTACAACTTCGGGCACTACCTGG
Motif Score 2.078666667
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000216780.8; ENST00000545054.6; ENST00000559250.5; ENST00000559171.1; ENST00000558096.5; ENST00000557969.1; ENST00000561286.5
External Link RMBase: m6A_site_241098
mod ID: M6ASITE019114 Click to Show/Hide the Full List
mod site chr14:24103579-24103580:+ [4]
Sequence AACTTCGGGCACTACCTGGAACACTGGCTGAGCATGGAAGG
Motif Score 2.951386905
Cell/Tissue List kidney; liver
Seq Type List m6A-REF-seq
Transcript ID List ENST00000216780.8; ENST00000559171.1; ENST00000559250.5; ENST00000561286.5; ENST00000557969.1; ENST00000545054.6; ENST00000558096.5
External Link RMBase: m6A_site_241099
mod ID: M6ASITE019115 Click to Show/Hide the Full List
mod site chr14:24103707-24103708:+ [6]
Sequence GGAGAATGCTCGGGTGCTAGACTGGATCTGCCGGCGGTTAG
Motif Score 3.319380952
Cell/Tissue List AML
Seq Type List miCLIP
Transcript ID List ENST00000216780.8; ENST00000559250.5; ENST00000559171.1; ENST00000557969.1; ENST00000545054.6; ENST00000561286.5; ENST00000558096.5
External Link RMBase: m6A_site_241100
mod ID: M6ASITE019116 Click to Show/Hide the Full List
mod site chr14:24103737-24103738:+ [3]
Sequence CCGGCGGTTAGAGGGGGAGGACAGTGCCCGAGAGACACCCA
Motif Score 3.643047619
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000216780.8; ENST00000558096.5; ENST00000545054.6; ENST00000559250.5; ENST00000561286.5; ENST00000559171.1
External Link RMBase: m6A_site_241101
mod ID: M6ASITE019117 Click to Show/Hide the Full List
mod site chr14:24103751-24103752:+ [4]
Sequence GGGAGGACAGTGCCCGAGAGACACCCATTGGGCTGGTGCCA
Motif Score 2.897386905
Cell/Tissue List HEK293; kidney; liver
Seq Type List m6A-REF-seq
Transcript ID List ENST00000545054.6; ENST00000216780.8; ENST00000558096.5; ENST00000559250.5; ENST00000561286.5; ENST00000559171.1
External Link RMBase: m6A_site_241102
mod ID: M6ASITE019118 Click to Show/Hide the Full List
mod site chr14:24103812-24103813:+ [3]
Sequence CAGCGGCCTCAGAGCTATAGACACCACTCAGCTGTTCTCCC
Motif Score 2.897386905
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000558096.5; ENST00000545054.6; ENST00000559171.1; ENST00000559250.5; ENST00000216780.8; ENST00000561286.5
External Link RMBase: m6A_site_241103
mod ID: M6ASITE019119 Click to Show/Hide the Full List
mod site chr14:24103842-24103843:+ [7]
Sequence GCTGTTCTCCCTCCCCAAGGACTTCTGGGAACAGGAGGTTC
Motif Score 4.065041667
Cell/Tissue List A549
Seq Type List m6A-CLIP/IP
Transcript ID List ENST00000558096.5; ENST00000545054.6; ENST00000216780.8; ENST00000561286.5; ENST00000559171.1; ENST00000559250.5
External Link RMBase: m6A_site_241104
mod ID: M6ASITE019120 Click to Show/Hide the Full List
mod site chr14:24103866-24103867:+ [3]
Sequence CTGGGAACAGGAGGTTCGTGACATTCGGAGCTACCTGACAG
Motif Score 2.859755952
Cell/Tissue List hESC-HEK293T; AML
Seq Type List MAZTER-seq; miCLIP
Transcript ID List ENST00000545054.6; ENST00000561286.5; ENST00000559171.1; ENST00000216780.8; ENST00000558096.5; ENST00000559250.5
External Link RMBase: m6A_site_241105
mod ID: M6ASITE019121 Click to Show/Hide the Full List
mod site chr14:24103883-24103884:+ [4]
Sequence GTGACATTCGGAGCTACCTGACAGAGCAGGTCAACCAGGAT
Motif Score 2.859755952
Cell/Tissue List HEK293
Seq Type List m6A-REF-seq
Transcript ID List ENST00000559171.1; ENST00000216780.8; ENST00000558096.5; ENST00000561286.5; ENST00000559250.5; ENST00000545054.6
External Link RMBase: m6A_site_241106
mod ID: M6ASITE019122 Click to Show/Hide the Full List
mod site chr14:24103945-24103946:+ [5]
Sequence GAGCTTGAGGCCCTGGAGAGACGTGTGCACAAAATGTGACC
Motif Score 2.871321429
Cell/Tissue List HEK293T; A549
Seq Type List DART-seq; m6A-CLIP/IP
Transcript ID List ENST00000559171.1; ENST00000216780.8; ENST00000545054.6; ENST00000558096.5; ENST00000561286.5; ENST00000559250.5
External Link RMBase: m6A_site_241107
mod ID: M6ASITE019123 Click to Show/Hide the Full List
mod site chr14:24103953-24103954:+ [5]
Sequence GGCCCTGGAGAGACGTGTGCACAAAATGTGACCTGAGGCCC
Motif Score 2.830589286
Cell/Tissue List HEK293T
Seq Type List DART-seq
Transcript ID List ENST00000558096.5; ENST00000559171.1; ENST00000559250.5; ENST00000561286.5; ENST00000216780.8; ENST00000545054.6
External Link RMBase: m6A_site_241108
mod ID: M6ASITE019124 Click to Show/Hide the Full List
mod site chr14:24103989-24103990:+ [4]
Sequence GGCCCTAGTCTAGCAAGAGGACATAGCACCCTCATCTGGGA
Motif Score 3.643047619
Cell/Tissue List liver; hESC-HEK293T
Seq Type List m6A-REF-seq; MAZTER-seq
Transcript ID List ENST00000558096.5; ENST00000559250.5; ENST00000559171.1; ENST00000561286.5; ENST00000216780.8; ENST00000545054.6
External Link RMBase: m6A_site_241109
mod ID: M6ASITE019125 Click to Show/Hide the Full List
mod site chr14:24104053-24104054:+ [5]
Sequence ATATGAGCAATTTGATATTAACTAACATCTTCAATGTGCCA
Motif Score 2.590089286
Cell/Tissue List HEK293T
Seq Type List DART-seq
Transcript ID List ENST00000559171.1; ENST00000216780.8; ENST00000558096.5; ENST00000559250.5; ENST00000561286.5
External Link RMBase: m6A_site_241110
mod ID: M6ASITE019126 Click to Show/Hide the Full List
mod site chr14:24104057-24104058:+ [3]
Sequence GAGCAATTTGATATTAACTAACATCTTCAATGTGCCATAGA
Motif Score 2.168095238
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000559250.5; ENST00000559171.1; ENST00000216780.8; ENST00000558096.5; ENST00000561286.5
External Link RMBase: m6A_site_241111
mod ID: M6ASITE019127 Click to Show/Hide the Full List
mod site chr14:24104077-24104078:+ [7]
Sequence ACATCTTCAATGTGCCATAGACCTTCCCACAAAGACTGTCC
Motif Score 2.876744048
Cell/Tissue List A549
Seq Type List m6A-CLIP/IP
Transcript ID List ENST00000559250.5; ENST00000559171.1; ENST00000216780.8; ENST00000558096.5; ENST00000561286.5
External Link RMBase: m6A_site_241112
mod ID: M6ASITE019128 Click to Show/Hide the Full List
mod site chr14:24104091-24104092:+ [6]
Sequence CCATAGACCTTCCCACAAAGACTGTCCAATAATAAGAGATG
Motif Score 3.319380952
Cell/Tissue List AML
Seq Type List miCLIP
Transcript ID List ENST00000559250.5; ENST00000558096.5; ENST00000559171.1; ENST00000561286.5; ENST00000216780.8
External Link RMBase: m6A_site_241113