Epigenetic Target Information

General Information of the Epigenetic Target (ID: EPITAR00198)

Target Name	CD24 molecule (CD24)
Synonyms	CD24A; CD24 antigen (small cell lung carcinoma cluster 4 antigen) Click to Show/Hide
Gene Name	CD24
Sequence	MGRAMVARLGLGLLLLALLLPTQIYSSETTTGTSSNSSQSTSNSGLAPNPTNATTKAAGGALQSTASLFVVSLSLLHLYS Click to Show/Hide
Family	CD24 family
Function	May have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells (PubMed:11313396). In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity (By similarity). Click to Show/Hide
Gene ID	100133941
HGNC ID	HGNC:1645
Ensembl Gene ID	ENSG00000272398
KEGG ID	hsa:100133941
Chromosomal Location	6q21

RNA Modification Sequencing Data Associated with the Target (ID: EPITAR00198)

CD24 molecule (CD24)

N4-acetylcytidine (ac4C)

In total 1 m6A sequence/site(s) in this target gene
mod ID: AC4SITE000109		Click to Show/Hide the Full List
mod site	chr6:106974658-106974659:-		[1]
Sequence	CTGCTAGACGCGCCGCGCACCGACGGAGGGGACATGGGCAG
Cell/Tissue List	H1
Seq Type List	ac4C-seq
Transcript ID List	ENST00000610952.1; ENST00000615659.1; ENST00000620405.1; ENST00000619869.1; ENST00000619133.4; ENST00000606017.2; ENST00000621311.1
External Link	RMBase: ac4C_site_1611

N6-methyladenosine (m6A)

In total 23 m6A sequence/site(s) in this target gene
mod ID: M6ASITE076434		Click to Show/Hide the Full List
mod site	chr6:106970149-106970150:-		[2]
Sequence	ATAAACCTTTTTAAAAATAGACACTCCCCGAAGTCTTTTGT
Motif Score	2.897386905
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000606017.2; ENST00000619133.4
External Link	RMBase: m6A_site_729096
mod ID: M6ASITE076435		Click to Show/Hide the Full List
mod site	chr6:106970165-106970166:-		[2]
Sequence	AACTGCCTCGACACACATAAACCTTTTTAAAAATAGACACT
Motif Score	2.185083333
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000606017.2; ENST00000619133.4
External Link	RMBase: m6A_site_729097
mod ID: M6ASITE076436		Click to Show/Hide the Full List
mod site	chr6:106970235-106970236:-		[2]
Sequence	AATATTTTTAGATAGTTAGAACCTGGTCCTAAGCCTAAAAG
Motif Score	2.930744048
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000619133.4; ENST00000606017.2
External Link	RMBase: m6A_site_729098
mod ID: M6ASITE076437		Click to Show/Hide the Full List
mod site	chr6:106970348-106970349:-		[2]
Sequence	AATTTGCATTAAATTCACAAACTTTTATACTCTTTCTGTAT
Motif Score	2.627720238
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000606017.2; ENST00000619133.4
External Link	RMBase: m6A_site_729099
mod ID: M6ASITE076440		Click to Show/Hide the Full List
mod site	chr6:106970805-106970806:-		[3]
Sequence	TTATTATTATTATTTTTTAGACAGTCTCACTTTGTCGCCCA
Motif Score	2.897386905
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000619133.4; ENST00000606017.2
External Link	RMBase: m6A_site_729100
mod ID: M6ASITE076441		Click to Show/Hide the Full List
mod site	chr6:106971084-106971085:-		[2]
Sequence	GCTGTTCTCTTGGGAACTGAACTCACTTTCCTCCTGAGGCT
Motif Score	3.373380952
Cell/Tissue List	HeLa; H1B; hESCs; fibroblasts; A549; Huh7; iSLK; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000606017.2; ENST00000615659.1; ENST00000619133.4
External Link	RMBase: m6A_site_729101
mod ID: M6ASITE076442		Click to Show/Hide the Full List
mod site	chr6:106971089-106971090:-		[2]
Sequence	CTATTGCTGTTCTCTTGGGAACTGAACTCACTTTCCTCCTG
Motif Score	3.373380952
Cell/Tissue List	HeLa; H1B; hESCs; fibroblasts; A549; Huh7; iSLK; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000615659.1; ENST00000619133.4; ENST00000606017.2
External Link	RMBase: m6A_site_729102
mod ID: M6ASITE076443		Click to Show/Hide the Full List
mod site	chr6:106971201-106971202:-		[2]
Sequence	TTATATGTACATGAGAAGGAACTTCCAGGTGTTACTGTAAT
Motif Score	3.373380952
Cell/Tissue List	HeLa; HepG2; HEK293T; hNPCs; hESCs; fibroblasts; A549; Huh7; iSLK
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000619133.4; ENST00000615659.1; ENST00000620405.1; ENST00000606017.2
External Link	RMBase: m6A_site_729103
mod ID: M6ASITE076444		Click to Show/Hide the Full List
mod site	chr6:106971253-106971254:-		[2]
Sequence	TAATTCTATAAGGCCATAAAACAGGTAATATAAAAAGCTTC
Motif Score	2.20572619
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; hNPCs; hESCs; fibroblasts; Huh7; iSLK; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000619133.4; ENST00000606017.2; ENST00000615659.1; ENST00000620405.1
External Link	RMBase: m6A_site_729104
mod ID: M6ASITE076445		Click to Show/Hide the Full List
mod site	chr6:106971354-106971355:-		[2]
Sequence	ATGTGGCTTGAGAAATATGGACACTTAATACTACCTTGAAA
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; hNPCs; hESCs; fibroblasts; Huh7; HEK293A-TOA; iSLK; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000606017.2; ENST00000619133.4; ENST00000615659.1; ENST00000620405.1
External Link	RMBase: m6A_site_729105
mod ID: M6ASITE076446		Click to Show/Hide the Full List
mod site	chr6:106971389-106971390:-		[2]
Sequence	CAACATCCAAAATAGTTAAGACATGATTTCCTTGAATGTGG
Motif Score	2.897386905
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; hNPCs; hESCs; fibroblasts; Huh7; HEK293A-TOA; iSLK; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000615659.1; ENST00000622315.1; ENST00000619869.1; ENST00000619133.4; ENST00000606017.2; ENST00000620405.1
External Link	RMBase: m6A_site_729106
mod ID: M6ASITE076447		Click to Show/Hide the Full List
mod site	chr6:106971486-106971487:-		[2]
Sequence	AAATTTGATTGATTTGAAGAACATGTGAGAGGTTTGACTAG
Motif Score	2.951386905
Cell/Tissue List	HeLa; HepG2; HEK293T; H1A; H1B; hNPCs; hESCs; fibroblasts; A549; Huh7; HEK293A-TOA; iSLK
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000615659.1; ENST00000610952.1; ENST00000619133.4; ENST00000619869.1; ENST00000622315.1; ENST00000606017.2; ENST00000620405.1
External Link	RMBase: m6A_site_729107
mod ID: M6ASITE076448		Click to Show/Hide the Full List
mod site	chr6:106971570-106971571:-		[2]
Sequence	GTCCAATGTGGCAAGGAAAAACAGGTCTTCATCGAATCTAC
Motif Score	2.20572619
Cell/Tissue List	HeLa; HEK293T; HepG2; hNPCs; hESCs; fibroblasts; A549; Huh7; HEK293A-TOA; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000619869.1; ENST00000620405.1; ENST00000615659.1; ENST00000619133.4; ENST00000610952.1; ENST00000606017.2; ENST00000622315.1
External Link	RMBase: m6A_site_729108
mod ID: M6ASITE076449		Click to Show/Hide the Full List
mod site	chr6:106971614-106971615:-		[2]
Sequence	TAAATTTCCCCATCTTCTAAACCCAATCCAAATGGCGTCTG
Motif Score	2.185083333
Cell/Tissue List	HeLa; HEK293T; HepG2; hNPCs; hESCs; fibroblasts; A549; Huh7; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000610952.1; ENST00000619869.1; ENST00000619133.4; ENST00000620405.1; ENST00000606017.2; ENST00000615659.1; ENST00000622315.1
External Link	RMBase: m6A_site_729109
mod ID: M6ASITE076451		Click to Show/Hide the Full List
mod site	chr6:106971656-106971657:-		[2]
Sequence	TGCATCTCTACTCTTAAGAGACTCAGGCCAAGAAACGTCTT
Motif Score	3.319380952
Cell/Tissue List	HeLa; HepG2; hNPCs; hESCs; fibroblasts; A549; Huh7; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000610952.1; ENST00000620405.1; ENST00000606017.2; ENST00000619869.1; ENST00000622315.1; ENST00000615659.1; ENST00000619133.4
External Link	RMBase: m6A_site_729110
mod ID: M6ASITE076452		Click to Show/Hide the Full List
mod site	chr6:106971806-106971807:-		[4]
Sequence	CCAGTGAAACAACAACTGGAACTTCAAGTAACTCCTCCCAG
Motif Score	3.373380952
Cell/Tissue List	HeLa; A549; HepG2; Huh7; iSLK; HEC-1-A
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000606017.2; ENST00000610952.1; ENST00000620405.1; ENST00000619133.4; ENST00000619869.1; ENST00000622315.1; ENST00000615659.1
External Link	RMBase: m6A_site_729111
mod ID: M6ASITE076453		Click to Show/Hide the Full List
mod site	chr6:106971818-106971819:-		[4]
Sequence	TTTAGATTTATTCCAGTGAAACAACAACTGGAACTTCAAGT
Motif Score	2.20572619
Cell/Tissue List	HeLa; A549; HepG2; Huh7; iSLK; HEC-1-A
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000622315.1; ENST00000619133.4; ENST00000620405.1; ENST00000606017.2; ENST00000610952.1; ENST00000615659.1; ENST00000619869.1
External Link	RMBase: m6A_site_729112
mod ID: M6ASITE076454		Click to Show/Hide the Full List
mod site	chr6:106973695-106973696:-		[4]
Sequence	CCGGGGGCTGGGCCTGGGAGACCCTAGCGGGGGCGGGGGCG
Motif Score	2.876744048
Cell/Tissue List	HeLa; A549; iSLK; HEC-1-A
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000622315.1; ENST00000606017.2; ENST00000621311.1; ENST00000619133.4; ENST00000615659.1; ENST00000610952.1; ENST00000620405.1; ENST00000619869.1
External Link	RMBase: m6A_site_729113
mod ID: M6ASITE076455		Click to Show/Hide the Full List
mod site	chr6:106973716-106973717:-		[4]
Sequence	GCACCGCGCCGGCGAGAGAGACCGGGGGCTGGGCCTGGGAG
Motif Score	2.876744048
Cell/Tissue List	A549; iSLK; HEC-1-A
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000619869.1; ENST00000610952.1; ENST00000620405.1; ENST00000622315.1; ENST00000619133.4; ENST00000615659.1; ENST00000606017.2; ENST00000621311.1
External Link	RMBase: m6A_site_729114
mod ID: M6ASITE076456		Click to Show/Hide the Full List
mod site	chr6:106974030-106974031:-		[2]
Sequence	GGCTATCTGGCCCTTTTTAAACAAACCCCGGTTCCGGGCTG
Motif Score	2.20572619
Cell/Tissue List	HeLa; HepG2; A549; H1A; H1B; iSLK; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000620405.1; ENST00000610952.1; ENST00000622315.1; ENST00000621311.1; ENST00000619869.1; ENST00000619133.4; ENST00000615659.1; ENST00000606017.2
External Link	RMBase: m6A_site_729115
mod ID: M6ASITE076457		Click to Show/Hide the Full List
mod site	chr6:106974647-106974648:-		[2]
Sequence	GCCGCGCACCGACGGAGGGGACATGGGCAGAGCAATGGTGG
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; A549; H1A; H1B; iSLK; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000620405.1; ENST00000619133.4; ENST00000610952.1; ENST00000619869.1; ENST00000621311.1; ENST00000615659.1; ENST00000606017.2
External Link	RMBase: m6A_site_729116
mod ID: M6ASITE076458		Click to Show/Hide the Full List
mod site	chr6:106975148-106975149:-		[2]
Sequence	CCGCCGCAGCGGAGGCGCGGACTTTTCTTTTGGGGGGTAAG
Motif Score	4.065041667
Cell/Tissue List	HeLa; H1A; H1B; A549; iSLK; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000615659.1; ENST00000621311.1; ENST00000619133.4; ENST00000619869.1; ENST00000610952.1
External Link	RMBase: m6A_site_729117
mod ID: M6ASITE076459		Click to Show/Hide the Full List
mod site	chr6:106975181-106975182:-		[2]
Sequence	GGCAATGCACTTGCTCCAGGACAGGCGGCTACCCCGCCGCA
Motif Score	3.643047619
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000619869.1; ENST00000610952.1; ENST00000619133.4; ENST00000615659.1
External Link	RMBase: m6A_site_729118

Ref 1	NAT10-mediated N4-acetylcytidine mRNA modification regulates self-renewal in human embryonic stem cells. Nucleic Acids Res. 2023 Sep 8;51(16):8514-8531. doi: 10.1093/nar/gkad628.
Ref 2	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 3	N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection. Cell Host Microbe. 2016 Nov 9;20(5):654-665. doi: 10.1016/j.chom.2016.09.015. Epub 2016 Oct 20.
Ref 4	Viral N(6)-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus. Nat Commun. 2019 Oct 9;10(1):4595. doi: 10.1038/s41467-019-12504-y.

Epigenetic Target Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

Visitor Map