Epigenetic Target Information

General Information of the Epigenetic Target (ID: EPITAR00193)
Target Name Alpha tubulin acetyltransferase 1 (ATAT1)
Synonyms
FLJ13158; Em:AB023049.7; MEC17; C6orf134; chromosome 6 open reading frame 134
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Gene Name ATAT1
Sequence
MEFPFDVDALFPERITVLDQHLRPPARRPGTTTPARVDLQQQIMTIIDELGKASAKAQNLSAPITSASRMQSNRHVVYILKDSSARPAGKGAIIGFIKVGYKKLFVLDDREAHNEVEPLCILDFYIHESVQRHGHGRELFQYMLQKERVEPHQLAIDRPSQKLLKFLNKHYNLETTVPQVNNFVIFEGFFAHQHRPPAPSLRATRHSRAAAVDPTPAAPARKLPPKRAEGDIKPYSSSDREFLKVAVEPPWPLNRAPRRATPPAHPPPRSSSLGNSPERGPLRPFVPEQELLRSLRLCPPHPTARLLLAADPGGSPAQRRRTRGTPPGLVAQSCCYSRHGGVNSSSPNTGNQDSKQGEQETKNRSASEEQALSQDGSGEKPMHTAPPQAPAPPAQSWTVGGDILNARFIRNLQERRSTRPW
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Family Acetyltransferase ATAT1 family
Function
Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly.
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Gene ID 79969
HGNC ID HGNC:21186
Ensembl Gene ID ENSG00000137343
KEGG ID hsa:79969
Chromosomal Location 6p21.33
RNA Modification Sequencing Data Associated with the Target (ID: EPITAR00193)
Alpha tubulin acetyltransferase 1 (ATAT1)
Adenosine-to-Inosine editing (A-to-I)
In total 3 m6A sequence/site(s) in this target gene
mod ID: A2ISITE001390 Click to Show/Hide the Full List
mod site chr6:30629006-30629007:+ [1]
Sequence ACCTTCTGGGCTCAAGCGATACTCCTCCCTTAGCCTCCTGA
Transcript ID List ENST00000462304.5; ENST00000319027.9; ENST00000471782.5; ENST00000329992.12; ENST00000376483.8; ENST00000330083.6; ENST00000318999.11; ENST00000468713.5; ENST00000493388.5; ENST00000376485.8
External Link RMBase: RNA-editing_site_115299
mod ID: A2ISITE001391 Click to Show/Hide the Full List
mod site chr6:30632675-30632676:+ [1]
Sequence AGCCGGGCACAGTGGCTCACACCTGTAATCCTAGCACTTTG
Transcript ID List ENST00000468713.5; ENST00000329992.12; ENST00000462304.5; ENST00000493388.5; ENST00000471782.5; ENST00000318999.11; ENST00000376483.8; ENST00000376485.8; ENST00000319027.9; rmsk_1906252; ENST00000330083.6
External Link RMBase: RNA-editing_site_115300
mod ID: A2ISITE001392 Click to Show/Hide the Full List
mod site chr6:30637799-30637800:+ [1]
Sequence ATCCTGGCCAACATGGTGAAACCCTGTCTCTACTGAAAATA
Transcript ID List ENST00000376485.8; ENST00000462304.5; rmsk_1906269; ENST00000319027.9; ENST00000471782.5; ENST00000329992.12; ENST00000493388.5; ENST00000376483.8; ENST00000468713.5; ENST00000330083.6; ENST00000318999.11
External Link RMBase: RNA-editing_site_115301
5-methylcytidine (m5C)
In total 1 m6A sequence/site(s) in this target gene
mod ID: M5CSITE003801 Click to Show/Hide the Full List
mod site chr6:30642822-30642823:+ [2]
Sequence AACAGGGCCCCTCGCCGCGCCACACCTCCAGCCCACCCACC
Seq Type List Bisulfite-seq
Transcript ID List ENST00000318999.11; ENST00000319027.9; ENST00000471782.5; ENST00000330083.6; ENST00000376485.8; ENST00000462304.5; ENST00000479562.1; ENST00000329992.12; ENST00000468713.5; ENST00000376483.8
External Link RMBase: m5C_site_37348
N6-methyladenosine (m6A)
In total 10 m6A sequence/site(s) in this target gene
mod ID: M6ASITE074283 Click to Show/Hide the Full List
mod site chr6:30627484-30627485:+ [3]
Sequence ATCTACAGCAGCAAATTATGACCATTATAGATGAACTGGGC
Motif Score 2.839113095
Cell/Tissue List HEK293T
Seq Type List DART-seq
Transcript ID List ENST00000468713.5; ENST00000329992.12; ENST00000376483.8; ENST00000319027.9; ENST00000471782.5; ENST00000330083.6; ENST00000493388.5; ENST00000376485.8; ENST00000318999.11
External Link RMBase: m6A_site_711590
mod ID: M6ASITE074284 Click to Show/Hide the Full List
mod site chr6:30627711-30627712:+ [3]
Sequence TGTTGTTTATATTCTCAAAGACAGTTCAGCCCGACCGTGAG
Motif Score 2.897386905
Cell/Tissue List HEK293T
Seq Type List DART-seq
Transcript ID List ENST00000318999.11; ENST00000376483.8; ENST00000468713.5; ENST00000471782.5; ENST00000329992.12; ENST00000330083.6; ENST00000493388.5; ENST00000376485.8; ENST00000319027.9
External Link RMBase: m6A_site_711591
mod ID: M6ASITE074285 Click to Show/Hide the Full List
mod site chr6:30627891-30627892:+ [4]
Sequence TGGTTTCATCAAAGTTGGATACAAGAAGCTCTTTGTACTGG
Motif Score 2.110482143
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000376485.8; ENST00000376483.8; ENST00000493388.5; ENST00000329992.12; ENST00000330083.6; ENST00000318999.11; ENST00000319027.9; ENST00000468713.5; ENST00000471782.5
External Link RMBase: m6A_site_711592
mod ID: M6ASITE074286 Click to Show/Hide the Full List
mod site chr6:30628083-30628084:+ [4]
Sequence ACTTTGCATCCTGGACTTTTACATCCATGAGTCTGTGCAAC
Motif Score 2.07285119
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000493388.5; ENST00000376483.8; ENST00000329992.12; ENST00000471782.5; ENST00000318999.11; ENST00000376485.8; ENST00000330083.6; ENST00000468713.5; ENST00000319027.9
External Link RMBase: m6A_site_711593
mod ID: M6ASITE074287 Click to Show/Hide the Full List
mod site chr6:30640565-30640566:+ [4]
Sequence CCCTCTCTGAGGGCAACTCGACACTCTCGTGCTGCTGCAGT
Motif Score 2.865571429
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000468713.5; ENST00000318999.11; ENST00000376483.8; ENST00000462304.5; ENST00000330083.6; ENST00000376485.8; ENST00000493388.5; ENST00000329992.12; ENST00000471782.5; ENST00000319027.9
External Link RMBase: m6A_site_711594
mod ID: M6ASITE074288 Click to Show/Hide the Full List
mod site chr6:30642214-30642215:+ [4]
Sequence ACCCAAGAGAGCAGAGGGAGACATCAAGCCATACTCCTCTA
Motif Score 2.897386905
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000376483.8; ENST00000330083.6; ENST00000471782.5; ENST00000479562.1; ENST00000462304.5; ENST00000318999.11; ENST00000329992.12; ENST00000468713.5; ENST00000376485.8; ENST00000319027.9
External Link RMBase: m6A_site_711595
mod ID: M6ASITE074289 Click to Show/Hide the Full List
mod site chr6:30644441-30644442:+ [3]
Sequence TCCTTTCCTCCATAGCAAGGACGACCTTCCCTGCTCCATGC
Motif Score 3.616982143
Cell/Tissue List HEK293T
Seq Type List DART-seq
Transcript ID List ENST00000376483.8; ENST00000468713.5; ENST00000376485.8; ENST00000462304.5; ENST00000479562.1; ENST00000471782.5; ENST00000319027.9; ENST00000330083.6; ENST00000318999.11; ENST00000329992.12
External Link RMBase: m6A_site_711596
mod ID: M6ASITE074290 Click to Show/Hide the Full List
mod site chr6:30646524-30646525:+ [3]
Sequence GTCTGGGGAGAAGCCCATGCACACAGCTCCTCCACAGGCCC
Motif Score 2.830589286
Cell/Tissue List HEK293T
Seq Type List DART-seq
Transcript ID List ENST00000376485.8; ENST00000468713.5; ENST00000479562.1; ENST00000471782.5; ENST00000330083.6
External Link RMBase: m6A_site_711597
mod ID: M6ASITE074291 Click to Show/Hide the Full List
mod site chr6:30646685-30646686:+ [3]
Sequence CAAAGTATTATTTCTCCCTCACTACAGGAAAGAGCCAAAGC
Motif Score 2.469291667
Cell/Tissue List HEK293T
Seq Type List DART-seq
Transcript ID List ENST00000468713.5; ENST00000471782.5; ENST00000376485.8; ENST00000479562.1; ENST00000330083.6
External Link RMBase: m6A_site_711598
mod ID: M6ASITE074292 Click to Show/Hide the Full List
mod site chr6:30646728-30646729:+ [4]
Sequence AACCCTCATAATAGATGGATACATTCATTCATTCATTCATT
Motif Score 2.110482143
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000471782.5; ENST00000479562.1; ENST00000376485.8; rmsk_1906287; ENST00000330083.6; ENST00000468713.5
External Link RMBase: m6A_site_711599
Pseudouridine (Pseudo)
In total 1 m6A sequence/site(s) in this target gene
mod ID: PSESITE000229 Click to Show/Hide the Full List
mod site chr6:30627702-30627703:+ [5]
Sequence TAACCGCCATGTTGTTTATATTCTCAAAGACAGTTCAGCCC
Transcript ID List ENST00000376483.8; ENST00000319027.9; ENST00000471782.5; ENST00000468713.5; ENST00000318999.11; ENST00000330083.6; ENST00000329992.12; ENST00000376485.8; ENST00000493388.5
External Link RMBase: Pseudo_site_4214