Epigenetic Target Information

General Information of the Epigenetic Target (ID: EPITAR00188)

Target Name	Insulin like growth factor binding protein 3 (IGFBP3)
Synonyms	IBP3; BP-53; insulin-like growth factor binding protein 3 Click to Show/Hide
Gene Name	IGFBP3
Sequence	MQRARPTLWAAALTLLVLLRGPPVARAGASSAGLGPVVRCEPCDARALAQCAPPPAVCAELVREPGCGCCLTCALSEGQPCGIYTERCGSGLRCQPSPDEARPLQALLDGRGLCVNASAVSRLRAYLLPAPPAPGNASESEEDRSAGSVESPSVSSTHRVSDPKFHPLHSKIIIIKKGHAKDSQRYKVDYESQSTDTQNFSSESKRETEYGPCRREMEDTLNHLKFLNVLSPRGVHIPNCDKKGFYKKKQCRPSKGRKRGFCWCVDKYGQPLPGYTTKGKEDVHCYSMQSK Click to Show/Hide
Function	IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. Inhibits the positive effect of humanin on insulin sensitivity (PubMed:19623253). Promotes testicular germ cell apoptosis (PubMed:19952275). Click to Show/Hide
Gene ID	3486
HGNC ID	HGNC:5472
Ensembl Gene ID	ENSG00000146674
KEGG ID	hsa:3486
Chromosomal Location	7p12.3

RNA Modification Sequencing Data Associated with the Target (ID: EPITAR00188)

Insulin like growth factor binding protein 3 (IGFBP3)

Adenosine-to-Inosine editing (A-to-I)

In total 18 m6A sequence/site(s) in this target gene
mod ID: A2ISITE002135		Click to Show/Hide the Full List
mod site	chr7:45913081-45913082:-		[1]
Sequence	GTGGGGTAGGAGGGACAGAGAGACAGGGAGAGTCAGCCTCC
Transcript ID List	ENST00000381083.9; ENST00000275521.10; ENST00000381086.9; ENST00000613132.4
External Link	RMBase: RNA-editing_site_122544
mod ID: A2ISITE002136		Click to Show/Hide the Full List
mod site	chr7:45913765-45913766:-		[1]
Sequence	GACATGACCAGCAGCTGGCTACAGCCTCGATTTATATTTCT
Transcript ID List	ENST00000613132.4; ENST00000275521.10; ENST00000381086.9; ENST00000381083.9
External Link	RMBase: RNA-editing_site_122545
mod ID: A2ISITE002137		Click to Show/Hide the Full List
mod site	chr7:45914922-45914923:-		[1]
Sequence	TCGCCCTTCCAAAGGCAGGAAGCGGGGCTTCTGCTGGTGTG
Transcript ID List	ENST00000615754.4; ENST00000275521.10; ENST00000460209.1; ENST00000417621.5; ENST00000613132.4; ENST00000428530.5; ENST00000381086.9; ENST00000381083.9
External Link	RMBase: RNA-editing_site_122546
mod ID: A2ISITE002138		Click to Show/Hide the Full List
mod site	chr7:45915092-45915093:-		[1]
Sequence	CTCAGCGGGCCTAGGCACGCATGGCTCTTGTGTTGCCTTAG
Transcript ID List	ENST00000615754.4; ENST00000460209.1; ENST00000428530.5; ENST00000381086.9; ENST00000381083.9; ENST00000275521.10; ENST00000417621.5; ENST00000613132.4
External Link	RMBase: RNA-editing_site_122547
mod ID: A2ISITE002139		Click to Show/Hide the Full List
mod site	chr7:45915796-45915797:-		[1]
Sequence	CGACTCACTGGCATTTCCCTAGAAAGTCCAAGTGAGAAGAA
Transcript ID List	ENST00000417621.5; ENST00000381086.9; ENST00000613132.4; ENST00000428530.5; ENST00000615754.4; ENST00000275521.10; ENST00000381083.9
External Link	RMBase: RNA-editing_site_122548
mod ID: A2ISITE002140		Click to Show/Hide the Full List
mod site	chr7:45915814-45915815:-		[1]
Sequence	GGCCATGTGGTCTTCCTCCGACTCACTGGCATTTCCCTAGA
Transcript ID List	ENST00000417621.5; ENST00000615754.4; ENST00000381086.9; ENST00000428530.5; ENST00000275521.10; ENST00000613132.4; ENST00000381083.9
External Link	RMBase: RNA-editing_site_122549
mod ID: A2ISITE002141		Click to Show/Hide the Full List
mod site	chr7:45915837-45915838:-		[2]
Sequence	GGGATGGCCAGTCTCTCCAAACTGGCCATGTGGTCTTCCTC
Transcript ID List	ENST00000615754.4; ENST00000417621.5; ENST00000613132.4; ENST00000381086.9; ENST00000428530.5; ENST00000381083.9; ENST00000275521.10
External Link	RMBase: RNA-editing_site_122550
mod ID: A2ISITE002142		Click to Show/Hide the Full List
mod site	chr7:45915848-45915849:-		[1]
Sequence	GGTCCATGCTGGGGATGGCCAGTCTCTCCAAACTGGCCATG
Transcript ID List	ENST00000275521.10; ENST00000613132.4; ENST00000381086.9; ENST00000615754.4; ENST00000381083.9; ENST00000417621.5; ENST00000428530.5
External Link	RMBase: RNA-editing_site_122551
mod ID: A2ISITE002143		Click to Show/Hide the Full List
mod site	chr7:45915936-45915937:-		[2]
Sequence	ATGGCCAGCTTGGAGAGCCCAGCCATCCCCAGCACATACCA
Transcript ID List	ENST00000381086.9; ENST00000417621.5; ENST00000615754.4; ENST00000428530.5; ENST00000275521.10; ENST00000613132.4; ENST00000381083.9
External Link	RMBase: RNA-editing_site_122552
mod ID: A2ISITE002144		Click to Show/Hide the Full List
mod site	chr7:45915985-45915986:-		[1]
Sequence	CCCTTGGGCTTTTCAAGGAAATGCTAGTGAGTGGGGGGATG
Transcript ID List	ENST00000275521.10; ENST00000417621.5; ENST00000381086.9; ENST00000381083.9; ENST00000428530.5; ENST00000613132.4; ENST00000615754.4
External Link	RMBase: RNA-editing_site_122553
mod ID: A2ISITE002145		Click to Show/Hide the Full List
mod site	chr7:45915990-45915991:-		[1]
Sequence	TGTCTCCCTTGGGCTTTTCAAGGAAATGCTAGTGAGTGGGG
Transcript ID List	ENST00000275521.10; ENST00000417621.5; ENST00000615754.4; ENST00000613132.4; ENST00000381086.9; ENST00000428530.5; ENST00000381083.9
External Link	RMBase: RNA-editing_site_122554
mod ID: A2ISITE002146		Click to Show/Hide the Full List
mod site	chr7:45915991-45915992:-		[1]
Sequence	CTGTCTCCCTTGGGCTTTTCAAGGAAATGCTAGTGAGTGGG
Transcript ID List	ENST00000381083.9; ENST00000381086.9; ENST00000428530.5; ENST00000417621.5; ENST00000275521.10; ENST00000615754.4; ENST00000613132.4
External Link	RMBase: RNA-editing_site_122555
mod ID: A2ISITE002147		Click to Show/Hide the Full List
mod site	chr7:45916045-45916046:-		[1]
Sequence	GCAATATTAAGATTTTGAAAAGGCTGTTGCTAGATGTTGGT
Transcript ID List	ENST00000381086.9; ENST00000275521.10; ENST00000613132.4; ENST00000428530.5; ENST00000417621.5; ENST00000381083.9; ENST00000615754.4
External Link	RMBase: RNA-editing_site_122556
mod ID: A2ISITE002148		Click to Show/Hide the Full List
mod site	chr7:45916046-45916047:-		[1]
Sequence	TGCAATATTAAGATTTTGAAAAGGCTGTTGCTAGATGTTGG
Transcript ID List	ENST00000381083.9; ENST00000613132.4; ENST00000428530.5; ENST00000381086.9; ENST00000615754.4; ENST00000275521.10; ENST00000417621.5
External Link	RMBase: RNA-editing_site_122557
mod ID: A2ISITE002149		Click to Show/Hide the Full List
mod site	chr7:45916047-45916048:-		[1]
Sequence	TTGCAATATTAAGATTTTGAAAAGGCTGTTGCTAGATGTTG
Transcript ID List	ENST00000275521.10; ENST00000613132.4; ENST00000381086.9; ENST00000428530.5; ENST00000615754.4; ENST00000381083.9; ENST00000417621.5
External Link	RMBase: RNA-editing_site_122558
mod ID: A2ISITE002150		Click to Show/Hide the Full List
mod site	chr7:45916054-45916055:-		[1]
Sequence	GAGCAGGTTGCAATATTAAGATTTTGAAAAGGCTGTTGCTA
Transcript ID List	ENST00000381083.9; ENST00000615754.4; ENST00000417621.5; ENST00000275521.10; ENST00000613132.4; ENST00000381086.9; ENST00000428530.5
External Link	RMBase: RNA-editing_site_122559
mod ID: A2ISITE002151		Click to Show/Hide the Full List
mod site	chr7:45916056-45916057:-		[2]
Sequence	GTGAGCAGGTTGCAATATTAAGATTTTGAAAAGGCTGTTGC
Transcript ID List	ENST00000381083.9; ENST00000428530.5; ENST00000613132.4; ENST00000615754.4; ENST00000417621.5; ENST00000275521.10; ENST00000381086.9
External Link	RMBase: RNA-editing_site_122560
mod ID: A2ISITE002152		Click to Show/Hide the Full List
mod site	chr7:45916057-45916058:-		[2]
Sequence	AGTGAGCAGGTTGCAATATTAAGATTTTGAAAAGGCTGTTG
Transcript ID List	ENST00000428530.5; ENST00000275521.10; ENST00000417621.5; ENST00000615754.4; ENST00000381083.9; ENST00000381086.9; ENST00000613132.4
External Link	RMBase: RNA-editing_site_122561

2'-O-Methylation (2'-O-Me)

In total 1 m6A sequence/site(s) in this target gene
mod ID: 2OMSITE000447		Click to Show/Hide the Full List
mod site	chr7:45912596-45912597:-		[3]
Sequence	CGCCCAGAGACTGGGCTGCTCTCCCGGAGGCCAAACCCAAG
Cell/Tissue List	HeLa
Seq Type List	Nm-seq
Transcript ID List	ENST00000381086.9; ENST00000613132.4; ENST00000381083.9
External Link	RMBase: Nm_site_6109

N1-methyladenosine (m1A)

In total 1 m6A sequence/site(s) in this target gene
mod ID: M1ASITE000112		Click to Show/Hide the Full List
mod site	chr7:45914362-45914363:-		[4]
Sequence	TGAGACAGCTGAAATAGCTCAGTTGGGAGAGCATCAGTTTG
Cell/Tissue List	cytosolic
Transcript ID List	ENST00000428530.5; ENST00000460209.1; rmsk_2223359; ENST00000275521.10; ENST00000381086.9; ENST00000381083.9; ENST00000613132.4
External Link	RMBase: m1A_site_944

5-methylcytidine (m5C)

In total 2 m6A sequence/site(s) in this target gene
mod ID: M5CSITE004131		Click to Show/Hide the Full List
mod site	chr7:45917340-45917341:-		[5]
Sequence	CTGATCCCAAGTTCCACCCCCTCCATTCAAAGATAATCATC
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000275521.10; ENST00000613132.4; ENST00000448817.1; ENST00000615754.4; ENST00000428530.5; ENST00000381086.9; ENST00000465642.1; ENST00000381083.9; ENST00000460477.1; ENST00000417621.5
External Link	RMBase: m5C_site_39346
mod ID: M5CSITE004132		Click to Show/Hide the Full List
mod site	chr7:45921257-45921258:-		[5]
Sequence	CCGCCCAGATGCGAGCACTGCGGCTGGGCGCTGAGGATCAG
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000448817.1; ENST00000381086.9; ENST00000381083.9; ENST00000275521.10
External Link	RMBase: m5C_site_39347

N6-methyladenosine (m6A)

In total 47 m6A sequence/site(s) in this target gene
mod ID: M6ASITE080118		Click to Show/Hide the Full List
mod site	chr7:45912473-45912474:-		[6]
Sequence	GAAAACAGAGGGGTCTCAAGACATTCTGCCTACCTATTAGC
Motif Score	2.897386905
Cell/Tissue List	A549; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000613132.4; ENST00000381083.9; ENST00000381086.9
External Link	RMBase: m6A_site_757145
mod ID: M6ASITE080119		Click to Show/Hide the Full List
mod site	chr7:45912489-45912490:-		[7]
Sequence	GCATAGAGCTCTCCTTGAAAACAGAGGGGTCTCAAGACATT
Motif Score	2.20572619
Cell/Tissue List	HeLa; brain; A549; endometrial; HEC-1-A
Seq Type List	m6A-seq; m6A-REF-seq
Transcript ID List	ENST00000613132.4; ENST00000381083.9; ENST00000381086.9
External Link	RMBase: m6A_site_757146
mod ID: M6ASITE080120		Click to Show/Hide the Full List
mod site	chr7:45912518-45912519:-		[7]
Sequence	TGCTGCAGACCTCGGTGTGGACACACGCTGCATAGAGCTCT
Motif Score	3.643047619
Cell/Tissue List	HeLa; fibroblasts; A549; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000613132.4; ENST00000381086.9; ENST00000381083.9
External Link	RMBase: m6A_site_757147
mod ID: M6ASITE080121		Click to Show/Hide the Full List
mod site	chr7:45912530-45912531:-		[7]
Sequence	GAGACTCTGCCCTGCTGCAGACCTCGGTGTGGACACACGCT
Motif Score	2.876744048
Cell/Tissue List	HeLa; fibroblasts; A549; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000381083.9; ENST00000613132.4; ENST00000381086.9
External Link	RMBase: m6A_site_757148
mod ID: M6ASITE080122		Click to Show/Hide the Full List
mod site	chr7:45912547-45912548:-		[7]
Sequence	GCAAAGTCAGGCTCAGGGAGACTCTGCCCTGCTGCAGACCT
Motif Score	3.319380952
Cell/Tissue List	HeLa; fibroblasts; A549; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000613132.4; ENST00000381086.9; ENST00000381083.9
External Link	RMBase: m6A_site_757149
mod ID: M6ASITE080123		Click to Show/Hide the Full List
mod site	chr7:45912582-45912583:-		[7]
Sequence	GCTGCTCTCCCGGAGGCCAAACCCAAGAAGGTCTGGCAAAG
Motif Score	2.185083333
Cell/Tissue List	HeLa; fibroblasts; A549; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000381086.9; ENST00000381083.9; ENST00000613132.4
External Link	RMBase: m6A_site_757150
mod ID: M6ASITE080124		Click to Show/Hide the Full List
mod site	chr7:45912607-45912608:-		[7]
Sequence	AAAGGAGCTCACGCCCAGAGACTGGGCTGCTCTCCCGGAGG
Motif Score	3.319380952
Cell/Tissue List	HeLa; fibroblasts; A549; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000275521.10; ENST00000381083.9; ENST00000381086.9; ENST00000613132.4
External Link	RMBase: m6A_site_757151
mod ID: M6ASITE080125		Click to Show/Hide the Full List
mod site	chr7:45912798-45912799:-		[7]
Sequence	GATTCACCCATGTTTGTTGAACTTAGAGTCATTCTCATGCT
Motif Score	3.373380952
Cell/Tissue List	HeLa; HepG2; hNPCs; hESCs; fibroblasts; A549; Huh7; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000381086.9; ENST00000275521.10; ENST00000381083.9; ENST00000613132.4
External Link	RMBase: m6A_site_757152
mod ID: M6ASITE080126		Click to Show/Hide the Full List
mod site	chr7:45912836-45912837:-		[7]
Sequence	TGCTGGGGAGCCCATCCAGGACACTGGGAGCACATAGAGAT
Motif Score	3.643047619
Cell/Tissue List	HeLa; kidney; liver; hESC-HEK293T; HepG2; hNPCs; hESCs; fibroblasts; A549; Huh7; endometrial; HEC-1-A
Seq Type List	m6A-seq; m6A-REF-seq; MAZTER-seq; m6A-CLIP/IP; MeRIP-seq
Transcript ID List	ENST00000381083.9; ENST00000381086.9; ENST00000613132.4; ENST00000275521.10
External Link	RMBase: m6A_site_757153
mod ID: M6ASITE080127		Click to Show/Hide the Full List
mod site	chr7:45912875-45912876:-		[7]
Sequence	AAAAGAATAGTAATATCAGAACAGGAAGGAGGAATGGCTTG
Motif Score	2.951386905
Cell/Tissue List	HeLa; hESC-HEK293T; HepG2; hESCs; fibroblasts; A549; endometrial; HEC-1-A
Seq Type List	m6A-seq; MAZTER-seq
Transcript ID List	ENST00000613132.4; ENST00000275521.10; ENST00000381086.9; ENST00000381083.9
External Link	RMBase: m6A_site_757154
mod ID: M6ASITE080128		Click to Show/Hide the Full List
mod site	chr7:45913079-45913080:-		[8]
Sequence	GGGGTAGGAGGGACAGAGAGACAGGGAGAGTCAGCCTCCAC
Motif Score	2.897386905
Cell/Tissue List	endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000381086.9; ENST00000275521.10; ENST00000613132.4; ENST00000381083.9
External Link	RMBase: m6A_site_757155
mod ID: M6ASITE080129		Click to Show/Hide the Full List
mod site	chr7:45913087-45913088:-		[9]
Sequence	GGCCCCGTGGGGTAGGAGGGACAGAGAGACAGGGAGAGTCA
Motif Score	3.643047619
Cell/Tissue List	liver; endometrial; HEC-1-A
Seq Type List	m6A-REF-seq; m6A-seq
Transcript ID List	ENST00000275521.10; ENST00000613132.4; ENST00000381083.9; ENST00000381086.9
External Link	RMBase: m6A_site_757156
mod ID: M6ASITE080130		Click to Show/Hide the Full List
mod site	chr7:45913145-45913146:-		[8]
Sequence	CTTCAGGAATCTTCCTGAAGACATGGCCCAGTCGAAGGCCC
Motif Score	2.897386905
Cell/Tissue List	endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000381083.9; ENST00000613132.4; ENST00000381086.9; ENST00000275521.10
External Link	RMBase: m6A_site_757157
mod ID: M6ASITE080131		Click to Show/Hide the Full List
mod site	chr7:45913196-45913197:-		[8]
Sequence	TGTTCTAGGGCACTCTGGGAACCTATAAAGGCAGGTATTTC
Motif Score	2.930744048
Cell/Tissue List	endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000381086.9; ENST00000381083.9; ENST00000613132.4; ENST00000275521.10
External Link	RMBase: m6A_site_757158
mod ID: M6ASITE080132		Click to Show/Hide the Full List
mod site	chr7:45913272-45913273:-		[10]
Sequence	GTGACCTGTACTGCTTGGGGACTATTGGAGAAAATAAGGTG
Motif Score	4.065041667
Cell/Tissue List	A549; iSLK; MSC; endometrial; HEC-1-A
Seq Type List	MeRIP-seq; m6A-CLIP/IP; m6A-seq
Transcript ID List	ENST00000381086.9; ENST00000613132.4; ENST00000275521.10; ENST00000381083.9
External Link	RMBase: m6A_site_757159
mod ID: M6ASITE080133		Click to Show/Hide the Full List
mod site	chr7:45913289-45913290:-		[11]
Sequence	AATGTTTATGTCTTCAAGTGACCTGTACTGCTTGGGGACTA
Motif Score	2.839113095
Cell/Tissue List	A549
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000381083.9; ENST00000381086.9; ENST00000613132.4; ENST00000275521.10
External Link	RMBase: m6A_site_757160
mod ID: M6ASITE080134		Click to Show/Hide the Full List
mod site	chr7:45913338-45913339:-		[10]
Sequence	TCTGTGGTGTCATTTCTGAAACAAGGGCGTGGATCCCTCAA
Motif Score	2.20572619
Cell/Tissue List	HeLa; A549; HepG2; GM12878; iSLK; MSC; HEC-1-A
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000275521.10; ENST00000613132.4; ENST00000381083.9; ENST00000381086.9
External Link	RMBase: m6A_site_757161
mod ID: M6ASITE080135		Click to Show/Hide the Full List
mod site	chr7:45913392-45913393:-		[7]
Sequence	TTTAAACCCCGGTCATCCGGACATCCCAACGCATGCTCCTG
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; liver; A549; hNPCs; fibroblasts; GM12878; MM6; Huh7; HEK293A-TOA; iSLK; MSC; endometrial; HEC-1-A
Seq Type List	m6A-seq; m6A-REF-seq; MeRIP-seq
Transcript ID List	ENST00000613132.4; ENST00000381083.9; ENST00000381086.9; ENST00000275521.10
External Link	RMBase: m6A_site_757162
mod ID: M6ASITE080136		Click to Show/Hide the Full List
mod site	chr7:45913407-45913408:-		[7]
Sequence	GAGAATAGGAAAACCTTTAAACCCCGGTCATCCGGACATCC
Motif Score	2.185083333
Cell/Tissue List	HeLa; HepG2; A549; hNPCs; fibroblasts; GM12878; MM6; Huh7; HEK293A-TOA; iSLK; MSC; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000381083.9; ENST00000613132.4; ENST00000275521.10; ENST00000381086.9
External Link	RMBase: m6A_site_757163
mod ID: M6ASITE080137		Click to Show/Hide the Full List
mod site	chr7:45913415-45913416:-		[7]
Sequence	GCTTTATCGAGAATAGGAAAACCTTTAAACCCCGGTCATCC
Motif Score	2.185083333
Cell/Tissue List	HeLa; HepG2; A549; hNPCs; hESCs; fibroblasts; GM12878; MM6; Huh7; HEK293A-TOA; iSLK; MSC; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000381086.9; ENST00000381083.9; ENST00000613132.4; ENST00000275521.10
External Link	RMBase: m6A_site_757164
mod ID: M6ASITE080138		Click to Show/Hide the Full List
mod site	chr7:45913472-45913473:-		[7]
Sequence	CTGTGTTGCCTATGTAGAGAACACGCTTCACCCCCACTCCC
Motif Score	2.951386905
Cell/Tissue List	HeLa; HepG2; A549; H1B; H1A; hNPCs; hESCs; fibroblasts; GM12878; MM6; Huh7; GSC-11; HEK293A-TOA; iSLK; MSC; endometrial; HEC-1-A; GSCs
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000381086.9; ENST00000275521.10; ENST00000381083.9; ENST00000613132.4
External Link	RMBase: m6A_site_757165
mod ID: M6ASITE080139		Click to Show/Hide the Full List
mod site	chr7:45913502-45913503:-		[11]
Sequence	GGCCGACCACTGACTTTGTGACTTAGGCGGCTGTGTTGCCT
Motif Score	3.28175
Cell/Tissue List	A549
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000613132.4; ENST00000275521.10; ENST00000381086.9; ENST00000381083.9
External Link	RMBase: m6A_site_757166
mod ID: M6ASITE080140		Click to Show/Hide the Full List
mod site	chr7:45913510-45913511:-		[11]
Sequence	GTCGAAGCGGCCGACCACTGACTTTGTGACTTAGGCGGCTG
Motif Score	3.28175
Cell/Tissue List	A549
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000275521.10; ENST00000381083.9; ENST00000613132.4; ENST00000381086.9
External Link	RMBase: m6A_site_757167
mod ID: M6ASITE080141		Click to Show/Hide the Full List
mod site	chr7:45913565-45913566:-		[7]
Sequence	GACTCGAGCACAGCACCCAGACTTCATGCGCCCGTGGAATG
Motif Score	3.319380952
Cell/Tissue List	HeLa; HepG2; A549; H1A; H1B; hNPCs; hESCs; HEK293T; fibroblasts; GM12878; MM6; Huh7; GSC-11; HEK293A-TOA; iSLK; MSC; endometrial; HEC-1-A; GSCs
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000613132.4; ENST00000275521.10; ENST00000381086.9; ENST00000381083.9
External Link	RMBase: m6A_site_757168
mod ID: M6ASITE080142		Click to Show/Hide the Full List
mod site	chr7:45913584-45913585:-		[7]
Sequence	TCCTATCAAAATATTCAGAGACTCGAGCACAGCACCCAGAC
Motif Score	3.319380952
Cell/Tissue List	HeLa; HepG2; A549; H1A; H1B; hNPCs; hESCs; HEK293T; fibroblasts; GM12878; MM6; Huh7; GSC-11; HEK293A-TOA; iSLK; MSC; endometrial; HEC-1-A; GSCs
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000613132.4; ENST00000381086.9; ENST00000381083.9; ENST00000275521.10
External Link	RMBase: m6A_site_757169
mod ID: M6ASITE080143		Click to Show/Hide the Full List
mod site	chr7:45913665-45913666:-		[7]
Sequence	ATGGTTTCTTTGAATGGTAAACTTGAGCATCTTTTCACTTT
Motif Score	2.627720238
Cell/Tissue List	HeLa; HepG2; A549; hNPCs; hESCs; fibroblasts; GM12878; Huh7; GSC-11; HEK293A-TOA; iSLK; MSC; endometrial; HEC-1-A; GSCs
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000275521.10; ENST00000613132.4; ENST00000381086.9; ENST00000381083.9
External Link	RMBase: m6A_site_757170
mod ID: M6ASITE080144		Click to Show/Hide the Full List
mod site	chr7:45913718-45913719:-		[7]
Sequence	GGTGAACTGATTTTTTTTAAACCAAAGTTTAGAAAGAGGTT
Motif Score	2.185083333
Cell/Tissue List	HeLa; A549; HepG2; hNPCs; fibroblasts; HEK293A-TOA; iSLK; MSC; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000275521.10; ENST00000381083.9; ENST00000381086.9; ENST00000613132.4
External Link	RMBase: m6A_site_757171
mod ID: M6ASITE080145		Click to Show/Hide the Full List
mod site	chr7:45913733-45913734:-		[7]
Sequence	TATATTTCTGTTTGTGGTGAACTGATTTTTTTTAAACCAAA
Motif Score	3.373380952
Cell/Tissue List	HeLa; A549; HepG2; hNPCs; fibroblasts; HEK293A-TOA; iSLK; MSC; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000381086.9; ENST00000275521.10; ENST00000613132.4; ENST00000381083.9
External Link	RMBase: m6A_site_757172
mod ID: M6ASITE080146		Click to Show/Hide the Full List
mod site	chr7:45913765-45913766:-		[9]
Sequence	GACATGACCAGCAGCTGGCTACAGCCTCGATTTATATTTCT
Motif Score	2.078666667
Cell/Tissue List	liver
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000613132.4; ENST00000381083.9; ENST00000275521.10; ENST00000381086.9
External Link	RMBase: m6A_site_757173
mod ID: M6ASITE080147		Click to Show/Hide the Full List
mod site	chr7:45913784-45913785:-		[7]
Sequence	TGCACAAAAGACTGCCAAGGACATGACCAGCAGCTGGCTAC
Motif Score	3.643047619
Cell/Tissue List	HeLa; A549; hESC-HEK293T; HepG2; hNPCs; fibroblasts; HEK293A-TOA; iSLK; MSC; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq; m6A-CLIP/IP
Transcript ID List	ENST00000275521.10; ENST00000460209.1; ENST00000381086.9; ENST00000381083.9; ENST00000613132.4
External Link	RMBase: m6A_site_757174
mod ID: M6ASITE080148		Click to Show/Hide the Full List
mod site	chr7:45913794-45913795:-		[7]
Sequence	TGCCTTATTTTGCACAAAAGACTGCCAAGGACATGACCAGC
Motif Score	3.319380952
Cell/Tissue List	HeLa; A549; HepG2; hNPCs; fibroblasts; HEK293A-TOA; iSLK; MSC; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000613132.4; ENST00000275521.10; ENST00000460209.1; ENST00000381086.9; ENST00000381083.9
External Link	RMBase: m6A_site_757175
mod ID: M6ASITE080149		Click to Show/Hide the Full List
mod site	chr7:45914124-45914125:-		[7]
Sequence	TTTTCTTTCATTTTATTAAGACAAATTTAGTAAGCAGAAGA
Motif Score	2.897386905
Cell/Tissue List	HeLa; A549; HepG2; fibroblasts; HEK293A-TOA; MSC; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000613132.4; ENST00000428530.5; ENST00000381086.9; ENST00000460209.1; ENST00000275521.10; ENST00000381083.9
External Link	RMBase: m6A_site_757176
mod ID: M6ASITE080150		Click to Show/Hide the Full List
mod site	chr7:45914170-45914171:-		[7]
Sequence	TTCTTTTAATAAATGAGGGAACTATTGGGGGAAAGGAATAA
Motif Score	3.373380952
Cell/Tissue List	HeLa; HepG2; A549; HEK293A-TOA; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000381083.9; ENST00000275521.10; ENST00000428530.5; ENST00000460209.1; ENST00000381086.9; ENST00000613132.4
External Link	RMBase: m6A_site_757177
mod ID: M6ASITE080151		Click to Show/Hide the Full List
mod site	chr7:45914657-45914658:-		[8]
Sequence	GAAAGAGCAAAGCAAATAGGACAGAGCCCTCAGAAGGGTGC
Motif Score	3.643047619
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000460209.1; ENST00000428530.5; ENST00000417621.5; ENST00000381083.9; ENST00000275521.10; ENST00000381086.9; ENST00000613132.4
External Link	RMBase: m6A_site_757178
mod ID: M6ASITE080152		Click to Show/Hide the Full List
mod site	chr7:45914752-45914753:-		[6]
Sequence	CAGGGCCTCACTGTCCTTGGACCAGCCTCAGGGGCTGGGCG
Motif Score	3.622404762
Cell/Tissue List	A549; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000428530.5; ENST00000275521.10; ENST00000460209.1; ENST00000381086.9; ENST00000613132.4; ENST00000417621.5; ENST00000381083.9
External Link	RMBase: m6A_site_757179
mod ID: M6ASITE080153		Click to Show/Hide the Full List
mod site	chr7:45914988-45914989:-		[8]
Sequence	GGCCACCGACCTGACACCAGACCCAGGAGCATTCACTTCTC
Motif Score	2.876744048
Cell/Tissue List	endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000275521.10; ENST00000381086.9; ENST00000381083.9; ENST00000428530.5; ENST00000613132.4; ENST00000460209.1; ENST00000417621.5; ENST00000615754.4
External Link	RMBase: m6A_site_757180
mod ID: M6ASITE080154		Click to Show/Hide the Full List
mod site	chr7:45916641-45916642:-		[8]
Sequence	CTGCCGTAGAGAAATGGAAGACACACTGAATCACCTGAAGT
Motif Score	2.897386905
Cell/Tissue List	HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000613132.4; ENST00000615754.4; ENST00000417621.5; ENST00000381083.9; ENST00000381086.9; ENST00000448817.1; ENST00000428530.5; ENST00000465642.1; ENST00000275521.10
External Link	RMBase: m6A_site_757181
mod ID: M6ASITE080155		Click to Show/Hide the Full List
mod site	chr7:45917220-45917221:-		[12]
Sequence	CCTCCGAGTCCAAGCGGGAGACAGAATATGTGAGAGCTTTT
Motif Score	2.897386905
Cell/Tissue List	HepG2; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000613132.4; ENST00000448817.1; ENST00000381083.9; ENST00000428530.5; ENST00000465642.1; ENST00000417621.5; ENST00000460477.1; ENST00000615754.4; ENST00000275521.10; ENST00000381086.9
External Link	RMBase: m6A_site_757182
mod ID: M6ASITE080156		Click to Show/Hide the Full List
mod site	chr7:45917246-45917247:-		[12]
Sequence	TCAGAGCACAGATACCCAGAACTTCTCCTCCGAGTCCAAGC
Motif Score	3.373380952
Cell/Tissue List	HepG2; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000613132.4; ENST00000428530.5; ENST00000275521.10; ENST00000417621.5; ENST00000448817.1; ENST00000381083.9; ENST00000615754.4; ENST00000465642.1; ENST00000381086.9; ENST00000460477.1
External Link	RMBase: m6A_site_757183
mod ID: M6ASITE080157		Click to Show/Hide the Full List
mod site	chr7:45917297-45917298:-		[12]
Sequence	CAAGAAAGGGCATGCTAAAGACAGCCAGCGCTACAAAGTTG
Motif Score	2.897386905
Cell/Tissue List	HepG2; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000460477.1; ENST00000448817.1; ENST00000613132.4; ENST00000381083.9; ENST00000381086.9; ENST00000428530.5; ENST00000615754.4; ENST00000275521.10; ENST00000465642.1; ENST00000417621.5
External Link	RMBase: m6A_site_757184
mod ID: M6ASITE080158		Click to Show/Hide the Full List
mod site	chr7:45917414-45917415:-		[7]
Sequence	TGCTAGTGAGTCGGAGGAAGACCGCAGCGCCGGCAGTGTGG
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000613132.4; ENST00000381083.9; ENST00000275521.10; ENST00000448817.1; ENST00000465642.1; ENST00000460477.1; ENST00000417621.5; ENST00000381086.9; ENST00000615754.4
External Link	RMBase: m6A_site_757185
mod ID: M6ASITE080159		Click to Show/Hide the Full List
mod site	chr7:45920037-45920038:-		[7]
Sequence	TGCACCTGCGCCGACCTCAAACAAACTTCCAGGTGCGTGGT
Motif Score	2.20572619
Cell/Tissue List	HeLa; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000381086.9; ENST00000465642.1; ENST00000615754.4; ENST00000448817.1; ENST00000613132.4; ENST00000460477.1; ENST00000275521.10; ENST00000381083.9
External Link	RMBase: m6A_site_757186
mod ID: M6ASITE080160		Click to Show/Hide the Full List
mod site	chr7:45920109-45920110:-		[7]
Sequence	ACAACAGAGTGTAGGTTTGAACTCCGCGTGCCACTTTCAGT
Motif Score	3.373380952
Cell/Tissue List	HeLa; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000381086.9; ENST00000465642.1; ENST00000381083.9; ENST00000275521.10; ENST00000448817.1; ENST00000615754.4; ENST00000613132.4; ENST00000460477.1
External Link	RMBase: m6A_site_757187
mod ID: M6ASITE080161		Click to Show/Hide the Full List
mod site	chr7:45920220-45920221:-		[13]
Sequence	TAGTCCCGGTATGTCCAAAAACAAGTAAAGTGGATTCGGGT
Motif Score	2.20572619
Cell/Tissue List	iSLK
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000615754.4; ENST00000465642.1; ENST00000613132.4; ENST00000381083.9; ENST00000448817.1; ENST00000381086.9; ENST00000460477.1; ENST00000275521.10
External Link	RMBase: m6A_site_757188
mod ID: M6ASITE080162		Click to Show/Hide the Full List
mod site	chr7:45920332-45920333:-		[7]
Sequence	GGGGATATAGGCGGATTTGGACCAAGGAAGGTGGGCAGGCA
Motif Score	3.622404762
Cell/Tissue List	HeLa; A549; HepG2; iSLK; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000381083.9; ENST00000465642.1; ENST00000615754.4; ENST00000613132.4; ENST00000381086.9; ENST00000275521.10; ENST00000460477.1; ENST00000448817.1
External Link	RMBase: m6A_site_757189
mod ID: M6ASITE080163		Click to Show/Hide the Full List
mod site	chr7:45920382-45920383:-		[7]
Sequence	CCGCACGGGGGTGCACACGGACTGCAATCCCAGGGATGCTT
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; iSLK; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000613132.4; ENST00000275521.10; ENST00000381083.9; ENST00000465642.1; ENST00000448817.1; ENST00000615754.4; ENST00000381086.9; ENST00000460477.1
External Link	RMBase: m6A_site_757190
mod ID: M6ASITE080164		Click to Show/Hide the Full List
mod site	chr7:45921648-45921649:-		[7]
Sequence	CACCGGCTCGCCGCAGGGAGACCTCACCCCGAGAGCGGAAG
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; fibroblasts; A549; GSC-11; iSLK; MSC; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000448817.1
External Link	RMBase: m6A_site_757191

Ref 1	Widespread RNA editing of embedded alu elements in the human transcriptome. Genome Res. 2004 Sep;14(9):1719-25. doi: 10.1101/gr.2855504.
Ref 2	RADAR: a rigorously annotated database of A-to-I RNA editing. Nucleic Acids Res. 2014 Jan;42(Database issue):D109-13. doi: 10.1093/nar/gkt996. Epub 2013 Oct 25.
Ref 3	Nm-seq maps 2'-O-methylation sites in human mRNA with base precision. Nat Methods. 2017 Jul;14(7):695-698. doi: 10.1038/nmeth.4294. Epub 2017 May 15.
Ref 4	MODOMICS: a database of RNA modification pathways. 2017 update. Nucleic Acids Res. 2018 Jan 4;46(D1):D303-D307. doi: 10.1093/nar/gkx1030.
Ref 5	5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m(5)C reader. Cell Res. 2017 May;27(5):606-625. doi: 10.1038/cr.2017.55. Epub 2017 Apr 18.
Ref 6	Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites. Cell Rep. 2014 Jul 10;8(1):284-96. doi: 10.1016/j.celrep.2014.05.048. Epub 2014 Jun 26.
Ref 7	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 8	m(6)A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer. Nat Cell Biol. 2018 Sep;20(9):1074-1083. doi: 10.1038/s41556-018-0174-4. Epub 2018 Aug 27.
Ref 9	Single-base mapping of m(6)A by an antibody-independent method. Sci Adv. 2019 Jul 3;5(7):eaax0250. doi: 10.1126/sciadv.aax0250. eCollection 2019 Jul.
Ref 10	Viral N(6)-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus. Nat Commun. 2019 Oct 9;10(1):4595. doi: 10.1038/s41467-019-12504-y.
Ref 11	A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation. Genes Dev. 2015 Oct 1;29(19):2037-53. doi: 10.1101/gad.269415.115. Epub 2015 Sep 24.
Ref 12	Histone H3 trimethylation at lysine 36 guides m(6)A RNA modification co-transcriptionally. Nature. 2019 Mar;567(7748):414-419. doi: 10.1038/s41586-019-1016-7. Epub 2019 Mar 13.
Ref 13	Viral and cellular N(6)-methyladenosine and N(6),2'-O-dimethyladenosine epitranscriptomes in the KSHV life cycle. Nat Microbiol. 2018 Jan;3(1):108-120. doi: 10.1038/s41564-017-0056-8. Epub 2017 Nov 6.

Epigenetic Target Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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