Epigenetic Target Information

General Information of the Epigenetic Target (ID: EPITAR00173)
Target Name Krueppel-like factor 4 (KLF4)
Synonyms
Epithelial zinc finger protein EZF; Gut-enriched krueppel-like factor; EZF; GKLF
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Gene Name KLF4
Sequence
MRQPPGESDMAVSDALLPSFSTFASGPAGREKTLRQAGAPNNRWREELSHMKRLPPVLPGRPYDLAAATVATDLESGGAGAACGGSNLAPLPRRETEEFNDLLDLDFILSNSLTHPPESVAATVSSSASASSSSSPSSSGPASAPSTCSFTYPIRAGNDPGVAPGGTGGGLLYGRESAPPPTAPFNLADINDVSPSGGFVAELLRPELDPVYIPPQQPQPPGGGLMGKFVLKASLSAPGSEYGSPSVISVSKGSPDGSHPVVVAPYNGGPPRTCPKIKQEAVSSCTHLGAGPPLSNGHRPAAHDFPLGRQLPSRTTPTLGLEEVLSSRDCHPALPLPPGFHPHPGPNYPSFLPDQMQPQVPPLHYQGQSRGFVARAGEPCVCWPHFGTHGMMLTPPSSPLELMPPGSCMPEEPKPKRGRRSWPRKRTATHTCDYAGCGKTYTKSSHLKAHLRTHTGEKPYHCDWDGCGWKFARSDELTRHYRKHTGHRPFQCQKCDRAFSRSDHLALHMKRHF
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Family Krueppel C2H2-type zinc-finger protein family
Function
Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription.
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Gene ID 9314
HGNC ID HGNC:6348
Ensembl Gene ID ENSG00000136826
KEGG ID hsa:9314
Chromosomal Location 9q31.2
RNA Modification Sequencing Data Associated with the Target (ID: EPITAR00173)
Krueppel-like factor 4 (KLF4)
N6-methyladenosine (m6A)
In total 34 m6A sequence/site(s) in this target gene
mod ID: M6ASITE088979 Click to Show/Hide the Full List
mod site chr9:107485233-107485234:- [1]
Sequence CTTGGTTCTAAAGGTACCAAACAAGGAAGCCAAAGTTTTCA
Motif Score 2.20572619
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000374672.5; ENST00000610832.1; ENST00000493306.1; ENST00000497048.5
External Link RMBase: m6A_site_832383
mod ID: M6ASITE088980 Click to Show/Hide the Full List
mod site chr9:107485416-107485417:- [2]
Sequence CGTGAGTTGGGGGAGGGAAGACCAGAATTCCCTTGAATTGT
Motif Score 2.876744048
Cell/Tissue List HeLa; HEK293T; A549; HepG2; MM6; Huh7; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; endometrial; HEC-1-A; NB4
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000493306.1; ENST00000374672.5; ENST00000497048.5; ENST00000610832.1
External Link RMBase: m6A_site_832384
mod ID: M6ASITE088981 Click to Show/Hide the Full List
mod site chr9:107485495-107485496:- [2]
Sequence TCCGACTTGAATATTCCTGGACTTACAAAATGCCAAGGGGG
Motif Score 4.065041667
Cell/Tissue List HeLa; HepG2; HEK293T; A549; H1A; H1B; MM6; Huh7; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; endometrial; HEC-1-A; NB4
Seq Type List m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List ENST00000374672.5; ENST00000493306.1; ENST00000610832.1; ENST00000497048.5
External Link RMBase: m6A_site_832385
mod ID: M6ASITE088982 Click to Show/Hide the Full List
mod site chr9:107485511-107485512:- [3]
Sequence TCATTCCAATTCTAAATCCGACTTGAATATTCCTGGACTTA
Motif Score 3.287565476
Cell/Tissue List A549
Seq Type List m6A-CLIP/IP
Transcript ID List ENST00000374672.5; ENST00000610832.1; ENST00000497048.5; ENST00000493306.1
External Link RMBase: m6A_site_832386
mod ID: M6ASITE088983 Click to Show/Hide the Full List
mod site chr9:107485560-107485561:- [2]
Sequence CAAAAGACAAAAATCAAAGAACAGATGGGGTCTGTGACTGG
Motif Score 2.951386905
Cell/Tissue List HeLa; HepG2; HEK293T; A549; H1A; MM6; Huh7; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; endometrial; HEC-1-A; NB4
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000497048.5; ENST00000493306.1; ENST00000610832.1; ENST00000374672.5
External Link RMBase: m6A_site_832387
mod ID: M6ASITE088984 Click to Show/Hide the Full List
mod site chr9:107485574-107485575:- [2]
Sequence AAAAATGAGGAATCCAAAAGACAAAAATCAAAGAACAGATG
Motif Score 2.897386905
Cell/Tissue List HeLa; HepG2; HEK293T; A549; hESC-HEK293T; MM6; Huh7; Jurkat; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; endometrial; HEC-1-A; NB4
Seq Type List m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List ENST00000493306.1; ENST00000610832.1; ENST00000497048.5; ENST00000374672.5
External Link RMBase: m6A_site_832388
mod ID: M6ASITE088985 Click to Show/Hide the Full List
mod site chr9:107485742-107485743:- [2]
Sequence GAGGCATTTTTAAATCCCAGACAGTGGATATGACCCACACT
Motif Score 2.897386905
Cell/Tissue List HeLa; HEK293T; A549; HepG2; fibroblasts; H1299; Huh7; HEK293A-TOA; iSLK; MSC; TIME; HEC-1-A
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000374672.5; ENST00000497048.5; ENST00000610832.1; ENST00000493306.1
External Link RMBase: m6A_site_832389
mod ID: M6ASITE088986 Click to Show/Hide the Full List
mod site chr9:107485784-107485785:- [2]
Sequence CCGAGCATTTTCCAGGTCGGACCACCTCGCCTTACACATGA
Motif Score 3.622404762
Cell/Tissue List HeLa; HEK293T; A549; HepG2; hESCs; fibroblasts; H1299; MM6; Huh7; HEK293A-TOA; iSLK; MSC; TIME; endometrial; HEC-1-A
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000493306.1; ENST00000374672.5; ENST00000497048.5; ENST00000610832.1
External Link RMBase: m6A_site_832390
mod ID: M6ASITE088987 Click to Show/Hide the Full List
mod site chr9:107485843-107485844:- [2]
Sequence CTGACCAGGCACTACCGTAAACACACGGGGCACCGCCCGTT
Motif Score 2.20572619
Cell/Tissue List HeLa; HEK293T; A549; HepG2; fibroblasts; H1299; MM6; Huh7; Jurkat; HEK293A-TOA; iSLK; MSC; TIME; endometrial; HEC-1-A
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000493306.1; ENST00000374672.5; ENST00000610832.1; ENST00000497048.5
External Link RMBase: m6A_site_832391
mod ID: M6ASITE088988 Click to Show/Hide the Full List
mod site chr9:107485864-107485865:- [2]
Sequence AAATTCGCCCGCTCAGATGAACTGACCAGGCACTACCGTAA
Motif Score 3.373380952
Cell/Tissue List HeLa; HEK293T; A549; HepG2; fibroblasts; H1299; MM6; Huh7; HEK293A-TOA; iSLK; MSC; TIME; endometrial; HEC-1-A
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000497048.5; ENST00000493306.1; ENST00000610832.1; ENST00000374672.5
External Link RMBase: m6A_site_832392
mod ID: M6ASITE088989 Click to Show/Hide the Full List
mod site chr9:107485898-107485899:- [3]
Sequence ACCTTACCACTGTGACTGGGACGGCTGTGGATGGAAATTCG
Motif Score 3.616982143
Cell/Tissue List A549
Seq Type List m6A-CLIP/IP
Transcript ID List ENST00000610832.1; ENST00000497048.5; ENST00000374672.5; ENST00000493306.1
External Link RMBase: m6A_site_832393
mod ID: M6ASITE088990 Click to Show/Hide the Full List
mod site chr9:107485918-107485919:- [2]
Sequence TTTACCTTTACAGGTGAGAAACCTTACCACTGTGACTGGGA
Motif Score 2.185083333
Cell/Tissue List HeLa; HEK293T; A549; HepG2; fibroblasts; MM6; Huh7; HEK293A-TOA; iSLK; MSC; TIME; endometrial; HEC-1-A
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000610832.1; ENST00000493306.1; ENST00000374672.5; ENST00000497048.5
External Link RMBase: m6A_site_832394
mod ID: M6ASITE088991 Click to Show/Hide the Full List
mod site chr9:107487036-107487037:- [2]
Sequence ATCTCAAGGCACACCTGCGAACCCACACAGGTAGGGGGACA
Motif Score 2.930744048
Cell/Tissue List HeLa; HEK293T; A549; HepG2; fibroblasts; MM6; Huh7; HEK293A-TOA; iSLK; MSC; TIME; endometrial; HEC-1-A
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000610832.1; ENST00000497048.5; ENST00000374672.5; ENST00000493306.1
External Link RMBase: m6A_site_832395
mod ID: M6ASITE088992 Click to Show/Hide the Full List
mod site chr9:107487075-107487076:- [2]
Sequence ATTACGCGGGCTGCGGCAAAACCTACACAAAGAGTTCCCAT
Motif Score 2.185083333
Cell/Tissue List HeLa; HEK293T; HepG2; fibroblasts; A549; MM6; Huh7; HEK293A-TOA; iSLK; MSC; TIME; endometrial; HEC-1-A
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000610832.1; ENST00000497048.5; ENST00000493306.1; ENST00000374672.5
External Link RMBase: m6A_site_832396
mod ID: M6ASITE088993 Click to Show/Hide the Full List
mod site chr9:107487114-107487115:- [2]
Sequence GATCGTGGCCCCGGAAAAGGACCGCCACCCACACTTGTGAT
Motif Score 3.622404762
Cell/Tissue List HeLa; HEK293T; fibroblasts; MM6; Huh7; iSLK; MSC; endometrial; HEC-1-A
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000610832.1; ENST00000497048.5; ENST00000493306.1; ENST00000374672.5
External Link RMBase: m6A_site_832397
mod ID: M6ASITE088994 Click to Show/Hide the Full List
mod site chr9:107487231-107487232:- [2]
Sequence TGTGCTGGCCCCACTTCGGGACACACGGGATGATGCTCACC
Motif Score 3.643047619
Cell/Tissue List HeLa; HEK293T; A549; fibroblasts; Huh7; iSLK; MSC; TIME; HEC-1-A
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000610832.1; ENST00000493306.1; ENST00000374672.5; ENST00000497048.5
External Link RMBase: m6A_site_832398
mod ID: M6ASITE088995 Click to Show/Hide the Full List
mod site chr9:107487407-107487408:- [2]
Sequence GGAAGTGCTGAGCAGCAGGGACTGTCACCCTGCCCTGCCGC
Motif Score 4.065041667
Cell/Tissue List HeLa; HepG2; HEK293T; A549; H1A; H1B; fibroblasts; MM6; Huh7; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; endometrial; HEC-1-A; NB4
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000497048.5; ENST00000374672.5; ENST00000610832.1; ENST00000493306.1
External Link RMBase: m6A_site_832399
mod ID: M6ASITE088996 Click to Show/Hide the Full List
mod site chr9:107487450-107487451:- [2]
Sequence GGCGGCAGCTCCCCAGCAGGACTACCCCGACCCTGGGTCTT
Motif Score 4.065041667
Cell/Tissue List HeLa; HEK293T; A549; HepG2; H1A; H1B; fibroblasts; MM6; GSC-11; HEK293A-TOA; MSC; TIME; iSLK; endometrial; HEC-1-A; NB4
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000497048.5; ENST00000610832.1; ENST00000374672.5; ENST00000493306.1
External Link RMBase: m6A_site_832400
mod ID: M6ASITE088997 Click to Show/Hide the Full List
mod site chr9:107487520-107487521:- [2]
Sequence TGCACCCACTTGGGCGCTGGACCCCCTCTCAGCAATGGCCA
Motif Score 3.622404762
Cell/Tissue List HeLa; HEK293T; A549; HepG2; fibroblasts; MM6; GSC-11; HEK293A-TOA; MSC; iSLK; TIME; endometrial; HEC-1-A; NB4
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000374672.5; ENST00000610832.1; ENST00000493306.1; ENST00000497048.5
External Link RMBase: m6A_site_832401
mod ID: M6ASITE088998 Click to Show/Hide the Full List
mod site chr9:107487767-107487768:- [2]
Sequence GCTCCTGCGGCCAGAATTGGACCCGGTGTACATTCCGCCGC
Motif Score 3.622404762
Cell/Tissue List HeLa; CD34; HepG2; HEK293T; A549; H1A; H1B; fibroblasts; MM6; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; endometrial; HEC-1-A; NB4
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000497048.5; ENST00000493306.1; ENST00000610832.1; ENST00000374672.5; ENST00000411706.1
External Link RMBase: m6A_site_832402
mod ID: M6ASITE088999 Click to Show/Hide the Full List
mod site chr9:107487827-107487828:- [2]
Sequence GGCTCCCTTCAACCTGGCGGACATCAACGACGTGAGCCCCT
Motif Score 3.643047619
Cell/Tissue List HeLa; CD34; HEK293T; A549; HepG2; fibroblasts; MM6; CD4T; GSC-11; HEK293A-TOA; MSC; iSLK; TIME; endometrial; HEC-1-A; NB4
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000497048.5; ENST00000374672.5; ENST00000411706.1; ENST00000493306.1; ENST00000610832.1
External Link RMBase: m6A_site_832403
mod ID: M6ASITE089000 Click to Show/Hide the Full List
mod site chr9:107488076-107488077:- [2]
Sequence CAACGATCTCCTGGACCTGGACTTTATTCTCTCCAATTCGC
Motif Score 4.065041667
Cell/Tissue List HeLa; HEK293T; A549; fibroblasts; MM6; HEK293A-TOA; iSLK; MSC; endometrial; HEC-1-A
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000610832.1; ENST00000497048.5; ENST00000411706.1; ENST00000493306.1; ENST00000374672.5
External Link RMBase: m6A_site_832404
mod ID: M6ASITE089001 Click to Show/Hide the Full List
mod site chr9:107488082-107488083:- [2]
Sequence GGAGTTCAACGATCTCCTGGACCTGGACTTTATTCTCTCCA
Motif Score 3.622404762
Cell/Tissue List HeLa; HEK293T; A549; fibroblasts; MM6; HEK293A-TOA; iSLK; MSC; endometrial; HEC-1-A
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000497048.5; ENST00000493306.1; ENST00000411706.1; ENST00000374672.5; ENST00000610832.1
External Link RMBase: m6A_site_832405
mod ID: M6ASITE089002 Click to Show/Hide the Full List
mod site chr9:107488107-107488108:- [2]
Sequence CGCCCCTACCTCGGAGAGAGACCGAGGAGTTCAACGATCTC
Motif Score 2.876744048
Cell/Tissue List HeLa; HEK293T; A549; fibroblasts; MM6; HEK293A-TOA; iSLK; MSC; endometrial; HEC-1-A
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000610832.1; ENST00000497048.5; ENST00000493306.1; ENST00000411706.1; ENST00000374672.5
External Link RMBase: m6A_site_832406
mod ID: M6ASITE089003 Click to Show/Hide the Full List
mod site chr9:107488175-107488176:- [2]
Sequence GGCGGCGACCGTGGCCACAGACCTGGAGAGCGGCGGAGCCG
Motif Score 2.876744048
Cell/Tissue List HeLa; HEK293T; fibroblasts; A549; MM6; HEK293A-TOA; iSLK; MSC; endometrial; HEC-1-A
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000374672.5; ENST00000497048.5; ENST00000411706.1; ENST00000610832.1; ENST00000493306.1
External Link RMBase: m6A_site_832407
mod ID: M6ASITE089004 Click to Show/Hide the Full List
mod site chr9:107488304-107488305:- [2]
Sequence ATGTCGGGTGGCAACAGGGGACCACCACTGACAGGTCTCTC
Motif Score 3.622404762
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000497048.5; ENST00000493306.1; ENST00000610832.1; ENST00000411706.1; ENST00000374672.5
External Link RMBase: m6A_site_832408
mod ID: M6ASITE089005 Click to Show/Hide the Full List
mod site chr9:107488958-107488959:- [4]
Sequence GCCCGGCGGGAAGGGAGAAGACACTGCGTCAAGCAGGTGCC
Motif Score 2.897386905
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000610832.1; ENST00000411706.1; ENST00000493306.1; ENST00000374672.5
External Link RMBase: m6A_site_832409
mod ID: M6ASITE089006 Click to Show/Hide the Full List
mod site chr9:107489125-107489126:- [5]
Sequence GGGAGCAGGGAGGGGTGAGGACCGGTGGGACGCGCCGGAAC
Motif Score 3.622404762
Cell/Tissue List A549
Seq Type List MeRIP-seq
Transcript ID List ENST00000374672.5; ENST00000610832.1; ENST00000420475.1; ENST00000493306.1; ENST00000411706.1
External Link RMBase: m6A_site_832410
mod ID: M6ASITE089007 Click to Show/Hide the Full List
mod site chr9:107489192-107489193:- [2]
Sequence GCTGCTTCGGGCTGCCGAGGACCTTCTGGGCCCCCACATTA
Motif Score 3.622404762
Cell/Tissue List HeLa; HEK293T; A549; HEK293A-TOA
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000610832.1; ENST00000374672.5; ENST00000420475.1; ENST00000493306.1
External Link RMBase: m6A_site_832411
mod ID: M6ASITE089008 Click to Show/Hide the Full List
mod site chr9:107489335-107489336:- [2]
Sequence GAACTTTTGTATACAAAGGAACTTTTTAAAAAAGACGCTTC
Motif Score 3.373380952
Cell/Tissue List HeLa; HEK293T; A549; HEK293A-TOA
Seq Type List m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List ENST00000420475.1; ENST00000374672.5; ENST00000610832.1; ENST00000493306.1
External Link RMBase: m6A_site_832412
mod ID: M6ASITE089009 Click to Show/Hide the Full List
mod site chr9:107489353-107489354:- [2]
Sequence CGTTTACAACTTTTCTAAGAACTTTTGTATACAAAGGAACT
Motif Score 3.373380952
Cell/Tissue List HeLa; HEK293T; A549; HEK293A-TOA
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000420475.1; ENST00000374672.5; ENST00000493306.1; ENST00000610832.1
External Link RMBase: m6A_site_832413
mod ID: M6ASITE089010 Click to Show/Hide the Full List
mod site chr9:107489408-107489409:- [2]
Sequence GAGCGCAGCCCGGCCACCGGACCTACTTACTCGCCTTGCTG
Motif Score 3.622404762
Cell/Tissue List HeLa; HEK293T; A549; HEK293A-TOA; MSC
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000374672.5; ENST00000610832.1; ENST00000420475.1; ENST00000493306.1
External Link RMBase: m6A_site_832414
mod ID: M6ASITE089011 Click to Show/Hide the Full List
mod site chr9:107490139-107490140:- [2]
Sequence CCAGTCTTCGCGGGCTTCGAACCCAGGGAGCCGACAATGGC
Motif Score 2.930744048
Cell/Tissue List HeLa; A549; HEK293A-TOA
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000420475.1
External Link RMBase: m6A_site_832415
mod ID: M6ASITE089012 Click to Show/Hide the Full List
mod site chr9:107490224-107490225:- [2]
Sequence CGCTCTTCTCCAGCGCGCAGACAGCGCGGCAAGCGCGTATG
Motif Score 2.897386905
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000420475.1
External Link RMBase: m6A_site_832416
N7-methylguanosine (m7G)
In total 1 m6A sequence/site(s) in this target gene
mod ID: m7GSITE000119 Click to Show/Hide the Full List
mod site chr9:107489438-107489439:- [6]
Sequence CAGTGGTGGGGGACGCTGCTGAGTGGAAGAGAGCGCAGCCC
Cell/Tissue List A549; HeLa; HepG2
Seq Type List BoRed-seq&m7G-RIP-seq; m7G-seq
Transcript ID List ENST00000374672.5; ENST00000610832.1; ENST00000420475.1
External Link RMBase: m7G_site_867