Epigenetic Target Information

General Information of the Epigenetic Target (ID: EPITAR00157)
Target Name N-myc proto-oncogene protein (MYCN)
Synonyms
Class E basic helix-loop-helix protein 37; bHLHe37
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Gene Name MYCN
Sequence
MPSCSTSTMPGMICKNPDLEFDSLQPCFYPDEDDFYFGGPDSTPPGEDIWKKFELLPTPPLSPSRGFAEHSSEPPSWVTEMLLENELWGSPAEEDAFGLGGLGGLTPNPVILQDCMWSGFSAREKLERAVSEKLQHGRGPPTAGSTAQSPGAGAASPAGRGHGGAAGAGRAGAALPAELAHPAAECVDPAVVFPFPVNKREPAPVPAAPASAPAAGPAVASGAGIAAPAGAPGVAPPRPGGRQTSGGDHKALSTSGEDTLSDSDDEDDEEEDEEEEIDVVTVEKRRSSSNTKAVTTFTITVRPKNAALGPGRAQSSELILKRCLPIHQQHNYAAPSPYVESEDAPPQKKIKSEASPRPLKSVIPPKAKSLSPRNSDSEDSERRRNHNILERQRRNDLRSSFLTLRDHVPELVKNEKAAKVVILKKATEYVHSLQAEEHQLLLEKEKLQARQQQLLKKIEHARTC
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Function
Positively regulates the transcription of MYCNOS in neuroblastoma cells.
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Gene ID 4613
HGNC ID HGNC:7559
Ensembl Gene ID ENSG00000134323
KEGG ID hsa:4613
Chromosomal Location 2p24.3
RNA Modification Sequencing Data Associated with the Target (ID: EPITAR00157)
N-myc proto-oncogene protein (MYCN)
N6-methyladenosine (m6A)
In total 29 m6A sequence/site(s) in this target gene
mod ID: M6ASITE043169 Click to Show/Hide the Full List
mod site chr2:15940605-15940606:+ [1]
Sequence GATGCGGGGGGCTCCTGGGAACTGTGTTGGAGCCGAGCAAG
Motif Score 3.373380952
Cell/Tissue List H1A; H1B; hESCs; Jurkat
Seq Type List m6A-seq
Transcript ID List ENST00000638417.1; ENST00000281043.4
External Link RMBase: m6A_site_461666
mod ID: M6ASITE043170 Click to Show/Hide the Full List
mod site chr2:15940652-15940653:+ [1]
Sequence CCAGGCGCAAGCGCGCACAGACTGTAGCCATCCGAGGACAC
Motif Score 3.319380952
Cell/Tissue List H1A; H1B; hESCs; Jurkat
Seq Type List m6A-seq
Transcript ID List ENST00000638417.1; ENST00000281043.4
External Link RMBase: m6A_site_461667
mod ID: M6ASITE043171 Click to Show/Hide the Full List
mod site chr2:15940669-15940670:+ [1]
Sequence CAGACTGTAGCCATCCGAGGACACCCCCGCCCCCCCGGCCC
Motif Score 3.643047619
Cell/Tissue List H1A; H1B; hESCs; Jurkat
Seq Type List m6A-seq
Transcript ID List ENST00000281043.4; ENST00000638417.1
External Link RMBase: m6A_site_461668
mod ID: M6ASITE043172 Click to Show/Hide the Full List
mod site chr2:15940698-15940699:+ [1]
Sequence CCCCCCCGGCCCACCCGGAGACACCCGCGCAGAATCGCCTC
Motif Score 2.897386905
Cell/Tissue List H1A; H1B; hESCs; Jurkat
Seq Type List m6A-seq
Transcript ID List ENST00000281043.4; ENST00000638417.1
External Link RMBase: m6A_site_461669
mod ID: M6ASITE043173 Click to Show/Hide the Full List
mod site chr2:15942110-15942111:+ [2]
Sequence GCCGGGCATGATCTGCAAGAACCCAGACCTCGAGTTTGACT
Motif Score 2.930744048
Cell/Tissue List Huh7; Jurkat
Seq Type List MeRIP-seq; m6A-seq
Transcript ID List ENST00000638417.1; ENST00000281043.4
External Link RMBase: m6A_site_461670
mod ID: M6ASITE043174 Click to Show/Hide the Full List
mod site chr2:15942116-15942117:+ [3]
Sequence CATGATCTGCAAGAACCCAGACCTCGAGTTTGACTCGCTAC
Motif Score 2.876744048
Cell/Tissue List hNPCs; Huh7; Jurkat; endometrial
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000281043.4; ENST00000638417.1
External Link RMBase: m6A_site_461671
mod ID: M6ASITE043175 Click to Show/Hide the Full List
mod site chr2:15942206-15942207:+ [4]
Sequence CTCGACCCCCCCGGGGGAGGACATCTGGAAGAAGTTTGAGC
Motif Score 3.643047619
Cell/Tissue List HeLa; H1A; H1B; hNPCs; hESCs; fibroblasts; Huh7; Jurkat; endometrial; GSCs
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000281043.4; ENST00000638417.1
External Link RMBase: m6A_site_461672
mod ID: M6ASITE043176 Click to Show/Hide the Full List
mod site chr2:15942366-15942367:+ [4]
Sequence GACGCGTTCGGCCTGGGGGGACTGGGTGGCCTCACCCCCAA
Motif Score 4.065041667
Cell/Tissue List HeLa; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; Jurkat; GSC-11; HEK293T; HEK293A-TOA; endometrial; GSCs
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000638417.1; ENST00000281043.4
External Link RMBase: m6A_site_461674
mod ID: M6ASITE043177 Click to Show/Hide the Full List
mod site chr2:15942404-15942405:+ [4]
Sequence CAACCCGGTCATCCTCCAGGACTGCATGTGGAGCGGCTTCT
Motif Score 4.065041667
Cell/Tissue List HeLa; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; Jurkat; GSC-11; HEK293T; HEK293A-TOA; endometrial; GSCs
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000281043.4; ENST00000638417.1
External Link RMBase: m6A_site_461675
mod ID: M6ASITE043178 Click to Show/Hide the Full List
mod site chr2:15942656-15942657:+ [5]
Sequence GGTCTTCCCCTTTCCCGTGAACAAGCGCGAGCCAGCGCCCG
Motif Score 2.951386905
Cell/Tissue List CD34
Seq Type List m6A-seq
Transcript ID List ENST00000281043.4; ENST00000638417.1
External Link RMBase: m6A_site_461676
mod ID: M6ASITE043179 Click to Show/Hide the Full List
mod site chr2:15942793-15942794:+ [5]
Sequence CGCGCCCAGGCGGCCGCCAGACCAGCGGCGGCGACCACAAG
Motif Score 2.876744048
Cell/Tissue List CD34
Seq Type List m6A-seq
Transcript ID List ENST00000638417.1; ENST00000281043.4
External Link RMBase: m6A_site_461677
mod ID: M6ASITE043180 Click to Show/Hide the Full List
mod site chr2:15942836-15942837:+ [5]
Sequence CCTCAGTACCTCCGGAGAGGACACCCTGAGCGATTCAGGTA
Motif Score 3.643047619
Cell/Tissue List CD34; Huh7
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000638417.1; ENST00000281043.4
External Link RMBase: m6A_site_461678
mod ID: M6ASITE043181 Click to Show/Hide the Full List
mod site chr2:15945822-15945823:+ [4]
Sequence TAAGAGCTTGAGCCCCCGAAACTCTGACTCGGAGGACAGTG
Motif Score 2.627720238
Cell/Tissue List HeLa; CD34; H1A; H1B; hNPCs; hESCs; fibroblasts; MT4; Huh7; Jurkat; HEK293A-TOA; endometrial
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000638417.1; ENST00000281043.4
External Link RMBase: m6A_site_461679
mod ID: M6ASITE043182 Click to Show/Hide the Full List
mod site chr2:15945837-15945838:+ [4]
Sequence CCGAAACTCTGACTCGGAGGACAGTGAGCGTCGCAGAAACC
Motif Score 3.643047619
Cell/Tissue List HeLa; CD34; H1A; H1B; hNPCs; hESCs; fibroblasts; MT4; Huh7; Jurkat; HEK293A-TOA; endometrial
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000281043.4; ENST00000638417.1
External Link RMBase: m6A_site_461680
mod ID: M6ASITE043183 Click to Show/Hide the Full List
mod site chr2:15945855-15945856:+ [4]
Sequence GGACAGTGAGCGTCGCAGAAACCACAACATCCTGGAGCGCC
Motif Score 2.185083333
Cell/Tissue List HeLa; CD34; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; MT4; Huh7; Jurkat; HEK293A-TOA; endometrial
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000281043.4; ENST00000638417.1
External Link RMBase: m6A_site_461681
mod ID: M6ASITE043184 Click to Show/Hide the Full List
mod site chr2:15945918-15945919:+ [4]
Sequence CAGCTTTCTCACGCTCAGGGACCACGTGCCGGAGTTGGTAA
Motif Score 3.622404762
Cell/Tissue List HeLa; CD34; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; MT4; Huh7; Jurkat; HEK293A-TOA; endometrial
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000281043.4; ENST00000638417.1
External Link RMBase: m6A_site_461682
mod ID: M6ASITE043185 Click to Show/Hide the Full List
mod site chr2:15946051-15946052:+ [4]
Sequence AAGGAAAAATTGCAGGCAAGACAGCAGCAGTTGCTAAAGAA
Motif Score 2.897386905
Cell/Tissue List HeLa; CD34; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; Huh7; Jurkat; HEK293A-TOA
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000638417.1; ENST00000281043.4
External Link RMBase: m6A_site_461683
mod ID: M6ASITE043186 Click to Show/Hide the Full List
mod site chr2:15946078-15946079:+ [4]
Sequence CAGTTGCTAAAGAAAATTGAACACGCTCGGACTTGCTAGAC
Motif Score 2.951386905
Cell/Tissue List HeLa; CD34; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; Huh7; Jurkat; HEK293A-TOA
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000638417.1; ENST00000281043.4
External Link RMBase: m6A_site_461684
mod ID: M6ASITE043187 Click to Show/Hide the Full List
mod site chr2:15946088-15946089:+ [4]
Sequence AGAAAATTGAACACGCTCGGACTTGCTAGACGCTTCTCAAA
Motif Score 4.065041667
Cell/Tissue List HeLa; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; Huh7; Jurkat; HEK293A-TOA
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000281043.4; ENST00000638417.1
External Link RMBase: m6A_site_461685
mod ID: M6ASITE043188 Click to Show/Hide the Full List
mod site chr2:15946109-15946110:+ [4]
Sequence CTTGCTAGACGCTTCTCAAAACTGGACAGTCACTGCCACTT
Motif Score 2.627720238
Cell/Tissue List HeLa; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; Huh7; Jurkat; HEK293A-TOA
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000281043.4; ENST00000638417.1
External Link RMBase: m6A_site_461686
mod ID: M6ASITE043189 Click to Show/Hide the Full List
mod site chr2:15946114-15946115:+ [4]
Sequence TAGACGCTTCTCAAAACTGGACAGTCACTGCCACTTTGCAC
Motif Score 3.643047619
Cell/Tissue List HeLa; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; Huh7; Jurkat; HEK293A-TOA
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000638417.1; ENST00000281043.4
External Link RMBase: m6A_site_461687
mod ID: M6ASITE043190 Click to Show/Hide the Full List
mod site chr2:15946154-15946155:+ [4]
Sequence CATTTTGATTTTTTTTTTAAACAAACATTGTGTTGACATTA
Motif Score 2.20572619
Cell/Tissue List HeLa; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; Huh7; Jurkat; HEK293A-TOA; GSCs
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000281043.4; ENST00000638417.1
External Link RMBase: m6A_site_461688
mod ID: M6ASITE043191 Click to Show/Hide the Full List
mod site chr2:15946236-15946237:+ [1]
Sequence GGCTCTGGGTGGGCAGTAGGACCACCAGTGTGGGGTTCTGC
Motif Score 3.622404762
Cell/Tissue List H1A; H1B; hNPCs; hESCs; fibroblasts; Huh7; Jurkat; endometrial
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000638417.1; ENST00000281043.4
External Link RMBase: m6A_site_461689
mod ID: M6ASITE043192 Click to Show/Hide the Full List
mod site chr2:15946261-15946262:+ [1]
Sequence CAGTGTGGGGTTCTGCTGGGACCTTGGAGAGCCTGCATCCC
Motif Score 3.622404762
Cell/Tissue List H1A; H1B; hNPCs; hESCs; fibroblasts; Huh7; Jurkat; endometrial
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000638417.1; ENST00000281043.4
External Link RMBase: m6A_site_461690
mod ID: M6ASITE043193 Click to Show/Hide the Full List
mod site chr2:15946400-15946401:+ [1]
Sequence TGTGTGTTCCAAGTTTCCAAACAACAGAAAGTCATTCCTTC
Motif Score 2.20572619
Cell/Tissue List H1A; H1B; hESCs; fibroblasts; Huh7
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000281043.4; ENST00000638417.1
External Link RMBase: m6A_site_461691
mod ID: M6ASITE043194 Click to Show/Hide the Full List
mod site chr2:15946489-15946490:+ [3]
Sequence CCATTTGATACCCCTGGGGAACATTTCTGTAAATACCATTG
Motif Score 2.951386905
Cell/Tissue List hNPCs; hESCs; fibroblasts; Huh7
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000638417.1; ENST00000281043.4
External Link RMBase: m6A_site_461692
mod ID: M6ASITE043195 Click to Show/Hide the Full List
mod site chr2:15946571-15946572:+ [3]
Sequence GCTTTTGCGGCCAGTATTAGACTGGAAGTTCATACCTAAGT
Motif Score 3.319380952
Cell/Tissue List hNPCs; hESCs; fibroblasts; Huh7
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000638417.1; ENST00000281043.4
External Link RMBase: m6A_site_461693
mod ID: M6ASITE043196 Click to Show/Hide the Full List
mod site chr2:15946633-15946634:+ [6]
Sequence TTGAGGAGCATGTTTTGTATACAAATATATTGTTAATCTCT
Motif Score 2.110482143
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000281043.4; ENST00000638417.1
External Link RMBase: m6A_site_461694
mod ID: M6ASITE043197 Click to Show/Hide the Full List
mod site chr2:15946676-15946677:+ [6]
Sequence TATGTACTGTACTAATTCTTACACTGCCTGTATACTTTAGT
Motif Score 2.07285119
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000638417.1; ENST00000281043.4
External Link RMBase: m6A_site_461695