Epigenetic Target Information

General Information of the Epigenetic Target (ID: EPITAR00146)
Target Name Cyclin-dependent kinase inhibitor 1C (CDKN1C)
Synonyms
Cyclin-dependent kinase inhibitor p57; p57Kip2
    Click to Show/Hide
Gene Name CDKN1C
Sequence
MSDASLRSTSTMERLVARGTFPVLVRTSACRSLFGPVDHEELSRELQARLAELNAEDQNRWDYDFQQDMPLRGPGRLQWTEVDSDSVPAFYRETVQVGRCRLLLAPRPVAVAVAVSPPLEPAAESLDGLEEAPEQLPSVPVPAPASTPPPVPVLAPAPAPAPAPVAAPVAAPVAVAVLAPAPAPAPAPAPAPAPVAAPAPAPAPAPAPAPAPAPAPDAAPQESAEQGANQGQRGQEPLADQLHSGISGRPAAGTAAASANGAAIKKLSGPLISDFFAKRKRSAPEKSSGDVPAPCPSPSAAPGVGSVEQTPRKRLR
    Click to Show/Hide
Family CDI family
Function
Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life.
    Click to Show/Hide
Gene ID 1028
HGNC ID HGNC:1786
Ensembl Gene ID ENSG00000129757
KEGG ID hsa:1028
Chromosomal Location 11p15.4
RNA Modification Sequencing Data Associated with the Target (ID: EPITAR00146)
Cyclin-dependent kinase inhibitor 1C (CDKN1C)
5-methylcytidine (m5C)
In total 2 m6A sequence/site(s) in this target gene
mod ID: M5CSITE005044 Click to Show/Hide the Full List
mod site chr11:2884064-2884065:- [1]
Sequence TGTCCCCGCGCCGTGTCCCTCTCCAAGCGCCGCCCCTGGCG
Seq Type List Bisulfite-seq
Transcript ID List ENST00000430149.3; ENST00000471157.2; ENST00000414822.8; ENST00000647251.1; ENST00000380725.2; ENST00000440480.7
External Link RMBase: m5C_site_6773
mod ID: M5CSITE005045 Click to Show/Hide the Full List
mod site chr11:2885104-2885105:-
Sequence CCGCTGAGTCCCTCGACGGCCTCGAGGAGGCGCCGGAGCAG
Cell/Tissue List T24
Seq Type List Bisulfite-seq
Transcript ID List ENST00000380725.2; ENST00000647251.1; ENST00000414822.8; ENST00000440480.7; ENST00000430149.3
External Link RMBase: m5C_site_6774
N6-methyladenosine (m6A)
In total 11 m6A sequence/site(s) in this target gene
mod ID: M6ASITE003498 Click to Show/Hide the Full List
mod site chr11:2883310-2883311:- [2]
Sequence TGTTTATCTGAAACTTGAAGACAAGTCTGTTAAAATGGTTC
Motif Score 2.897386905
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000440480.7; ENST00000414822.8; ENST00000380725.2; ENST00000430149.3
External Link RMBase: m6A_site_127636
mod ID: M6ASITE003499 Click to Show/Hide the Full List
mod site chr11:2883388-2883389:- [2]
Sequence TCACAAGCTGTAGCTGCCATACATGCCCATCTAGCTTGCAG
Motif Score 2.110482143
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000380725.2; ENST00000430149.3; ENST00000414822.8; ENST00000440480.7
External Link RMBase: m6A_site_127637
mod ID: M6ASITE003500 Click to Show/Hide the Full List
mod site chr11:2883584-2883585:- [2]
Sequence AAAAAACCATGTATATTTGTACAAAAAGTTTTTAAAGTTAT
Motif Score 2.856142857
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000380725.2; ENST00000440480.7; ENST00000430149.3; ENST00000414822.8
External Link RMBase: m6A_site_127638
mod ID: M6ASITE003501 Click to Show/Hide the Full List
mod site chr11:2883712-2883713:- [2]
Sequence TGTATTCTGCACGAGAAGGTACACTGGTCCCAAGGTGTAAA
Motif Score 2.856142857
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000430149.3; ENST00000440480.7; ENST00000471157.2; ENST00000647251.1; ENST00000380725.2; ENST00000414822.8
External Link RMBase: m6A_site_127639
mod ID: M6ASITE003502 Click to Show/Hide the Full List
mod site chr11:2885241-2885242:- [3]
Sequence CCTGCAGTGGACCGAAGTGGACAGCGACTCGGTGCCCGCGT
Motif Score 3.643047619
Cell/Tissue List kidney
Seq Type List m6A-REF-seq
Transcript ID List ENST00000440480.7; ENST00000430149.3; ENST00000380725.2; ENST00000647251.1; ENST00000414822.8
External Link RMBase: m6A_site_127640
mod ID: M6ASITE003503 Click to Show/Hide the Full List
mod site chr11:2885464-2885465:- [2]
Sequence CCGACGCGTCCCTCCGCAGCACATCCACGATGGAGCGTCTT
Motif Score 2.830589286
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000430149.3; ENST00000440480.7; ENST00000647251.1; ENST00000380725.2; ENST00000414822.8
External Link RMBase: m6A_site_127641
mod ID: M6ASITE094588 Click to Show/Hide the Full List
mod site KI270831.1:117586-117587:- [4]
Sequence CAGCCTCTTCGGGCCGGTGGACCACGAGGAGCTGAGCCGCG
Motif Score 3.622404762
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000313407.10; ENST00000633020.1; ENST00000616138.2; ENST00000631604.1
External Link RMBase: m6A_site_880931
mod ID: M6ASITE094589 Click to Show/Hide the Full List
mod site KI270831.1:117641-117642:- [4]
Sequence AGCGTCTTGTCGCCCGTGGGACCTTCCCAGTACTAGTGCGC
Motif Score 3.622404762
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000313407.10; ENST00000631604.1; ENST00000633020.1; ENST00000616138.2
External Link RMBase: m6A_site_880932
mod ID: M6ASITE094590 Click to Show/Hide the Full List
mod site KI270831.1:117850-117851:- [4]
Sequence GCAGAAGAGTCCACCACCGGACAGCCAGGTAGCCGCCGCGT
Motif Score 3.643047619
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000631604.1; ENST00000633020.1; ENST00000313407.10; ENST00000616138.2
External Link RMBase: m6A_site_880933
mod ID: M6ASITE094591 Click to Show/Hide the Full List
mod site KI270831.1:117877-117878:- [4]
Sequence CGTCCGGACGAGACAGGCGAACCCGACGCAGAAGAGTCCAC
Motif Score 2.930744048
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000616138.2; ENST00000633020.1; ENST00000313407.10; ENST00000631604.1
External Link RMBase: m6A_site_880934
mod ID: M6ASITE094592 Click to Show/Hide the Full List
mod site KI270831.1:117885-117886:- [4]
Sequence GCGGCTGCCGTCCGGACGAGACAGGCGAACCCGACGCAGAA
Motif Score 2.897386905
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000313407.10; ENST00000631604.1; ENST00000616138.2; ENST00000633020.1
External Link RMBase: m6A_site_880935