Epigenetic Target Information

General Information of the Epigenetic Target (ID: EPITAR00120)
Target Name Nuclear receptor subfamily 1 group I member 2 (NR1I2)
Synonyms
ONR1; PXR; BXR; SXR; PAR2; nuclear receptor subfamily 1, group I, member 2
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Gene Name NR1I2
Sequence
MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFGITGS
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Family Nuclear hormone receptor family, NR1 subfamily
Function
Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes.
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Gene ID 8856
HGNC ID HGNC:7968
Ensembl Gene ID ENSG00000144852
KEGG ID hsa:8856
Chromosomal Location 3q13.33
RNA Modification Sequencing Data Associated with the Target (ID: EPITAR00120)
Nuclear receptor subfamily 1 group I member 2 (NR1I2)
N6-methyladenosine (m6A)
In total 13 m6A sequence/site(s) in this target gene
mod ID: M6ASITE062154 Click to Show/Hide the Full List
mod site chr3:119810130-119810131:+ [1]
Sequence CCTGCGAGATCACCCGGAAGACCCGGCGACAGTGCCAGGCC
Motif Score 2.876744048
Cell/Tissue List MM6
Seq Type List m6A-seq
Transcript ID List ENST00000640105.1; ENST00000466380.5; ENST00000638727.1; ENST00000337940.4; ENST00000474090.1; ENST00000393716.6
External Link RMBase: m6A_site_604609
mod ID: M6ASITE062155 Click to Show/Hide the Full List
mod site chr3:119811603-119811604:+ [2]
Sequence AGCGGAAGAAAAGTGAACGGACAGGGACTCAGCCACTGGGA
Motif Score 3.643047619
Cell/Tissue List HepG2; H1B; hESCs; MM6
Seq Type List m6A-seq
Transcript ID List ENST00000393716.6; ENST00000640105.1; ENST00000493757.1; ENST00000638727.1; ENST00000337940.4; ENST00000466380.5
External Link RMBase: m6A_site_604610
mod ID: M6ASITE062156 Click to Show/Hide the Full List
mod site chr3:119811609-119811610:+ [2]
Sequence AGAAAAGTGAACGGACAGGGACTCAGCCACTGGGAGTGCAG
Motif Score 4.065041667
Cell/Tissue List HepG2; H1B; hESCs; MM6
Seq Type List m6A-seq
Transcript ID List ENST00000638727.1; ENST00000493757.1; ENST00000640105.1; ENST00000337940.4; ENST00000393716.6; ENST00000466380.5
External Link RMBase: m6A_site_604611
mod ID: M6ASITE062157 Click to Show/Hide the Full List
mod site chr3:119811687-119811688:+ [2]
Sequence TGATGGACGCTCAGATGAAAACCTTTGACACTACCTTCTCC
Motif Score 2.185083333
Cell/Tissue List HepG2; H1A; H1B; hESCs; MM6
Seq Type List m6A-seq
Transcript ID List ENST00000393716.6; ENST00000640105.1; ENST00000337940.4; ENST00000466380.5; ENST00000638727.1; ENST00000493757.1
External Link RMBase: m6A_site_604612
mod ID: M6ASITE062158 Click to Show/Hide the Full List
mod site chr3:119812836-119812837:+ [3]
Sequence GGAGGATGGCAGTGTCTGGAACTACAAACCCCCAGCCGACA
Motif Score 3.373380952
Cell/Tissue List HepG2
Seq Type List m6A-seq
Transcript ID List ENST00000393716.6; ENST00000638727.1; ENST00000493757.1; ENST00000640105.1; ENST00000337940.4; ENST00000466380.5
External Link RMBase: m6A_site_604613
mod ID: M6ASITE062159 Click to Show/Hide the Full List
mod site chr3:119812843-119812844:+ [3]
Sequence GGCAGTGTCTGGAACTACAAACCCCCAGCCGACAGTGGCGG
Motif Score 2.185083333
Cell/Tissue List HepG2
Seq Type List m6A-seq
Transcript ID List ENST00000493757.1; ENST00000393716.6; ENST00000638727.1; ENST00000337940.4; ENST00000640105.1; ENST00000466380.5
External Link RMBase: m6A_site_604614
mod ID: M6ASITE062160 Click to Show/Hide the Full List
mod site chr3:119817229-119817230:+ [4]
Sequence TGAGCGGCTGCCCTTGGGTGACACCTCCGAGAGGCAGCCAG
Motif Score 2.859755952
Cell/Tissue List liver
Seq Type List m6A-REF-seq
Transcript ID List ENST00000337940.4; ENST00000393716.6; ENST00000466380.5; ENST00000493757.1
External Link RMBase: m6A_site_604615
mod ID: M6ASITE062161 Click to Show/Hide the Full List
mod site chr3:119817250-119817251:+ [2]
Sequence CACCTCCGAGAGGCAGCCAGACCCAGAGCCCTCTGAGCCGC
Motif Score 2.876744048
Cell/Tissue List HepG2; MM6
Seq Type List m6A-seq
Transcript ID List ENST00000337940.4; ENST00000393716.6; ENST00000466380.5; ENST00000493757.1
External Link RMBase: m6A_site_604616
mod ID: M6ASITE062162 Click to Show/Hide the Full List
mod site chr3:119817286-119817287:+ [2]
Sequence GCCGCCACTCCCGGGCCAAGACAGATGGACACTGCCAAGAG
Motif Score 2.897386905
Cell/Tissue List HepG2; MM6
Seq Type List m6A-seq
Transcript ID List ENST00000393716.6; ENST00000466380.5; ENST00000493757.1; ENST00000337940.4
External Link RMBase: m6A_site_604617
mod ID: M6ASITE062163 Click to Show/Hide the Full List
mod site chr3:119817294-119817295:+ [2]
Sequence TCCCGGGCCAAGACAGATGGACACTGCCAAGAGCCGACAAT
Motif Score 3.643047619
Cell/Tissue List HepG2; H1A; MM6
Seq Type List m6A-seq
Transcript ID List ENST00000493757.1; ENST00000393716.6; ENST00000466380.5; ENST00000337940.4
External Link RMBase: m6A_site_604618
mod ID: M6ASITE062164 Click to Show/Hide the Full List
mod site chr3:119817380-119817381:+ [2]
Sequence GCTAGCATTCCTCAGGAAGGACATGGGTGCCCCCCACCCCC
Motif Score 3.643047619
Cell/Tissue List HepG2; H1A; MM6
Seq Type List m6A-seq
Transcript ID List ENST00000393716.6; ENST00000337940.4; ENST00000493757.1; ENST00000466380.5
External Link RMBase: m6A_site_604619
mod ID: M6ASITE062165 Click to Show/Hide the Full List
mod site chr3:119817430-119817431:+ [2]
Sequence TGTAGGGAGTGAAGCCACAGACTCTTACGTGGAGAGTGCAC
Motif Score 3.319380952
Cell/Tissue List HepG2; H1A; MM6
Seq Type List m6A-seq
Transcript ID List ENST00000466380.5; ENST00000337940.4; ENST00000393716.6; ENST00000493757.1
External Link RMBase: m6A_site_604620
mod ID: M6ASITE062166 Click to Show/Hide the Full List
mod site chr3:119817467-119817468:+ [3]
Sequence GCACTGACCTGTAGGTCAGGACCATCAGAGAGGCAAGGTTG
Motif Score 3.622404762
Cell/Tissue List HepG2
Seq Type List m6A-seq
Transcript ID List ENST00000493757.1; ENST00000337940.4; ENST00000393716.6; ENST00000466380.5
External Link RMBase: m6A_site_604621