Epigenetic Target Information

General Information of the Epigenetic Target (ID: EPITAR00107)

Target Name	Interferon induced protein with tetratricopeptide repeats 3 (IFIT3)
Synonyms	ISG60; RIG-G; CIG-49; IFI60; GARG-49; IRG2; IFIT4; interferon-induced protein with tetratricopeptide repeats 4; interferon-induced protein with tetratricopeptide repeats 3 Click to Show/Hide
Gene Name	IFIT3
Sequence	MSEVTKNSLEKILPQLKCHFTWNLFKEDSVSRDLEDRVCNQIEFLNTEFKATMYNLLAYIKHLDGNNEAALECLRQAEELIQQEHADQAEIRSLVTWGNYAWVYYHLGRLSDAQIYVDKVKQTCKKFSNPYSIEYSELDCEEGWTQLKCGRNERAKVCFEKALEEKPNNPEFSSGLAIAMYHLDNHPEKQFSTDVLKQAIELSPDNQYVKVLLGLKLQKMNKEAEGEQFVEEALEKSPCQTDVLRSAAKFYRRKGDLDKAIELFQRVLESTPNNGYLYHQIGCCYKAKVRQMQNTGESEASGNKEMIEALKQYAMDYSNKALEKGLNPLNAYSDLAEFLETECYQTPFNKEVPDAEKQQSHQRYCNLQKYNGKSEDTAVQHGLEGLSISKKSTDKEEIKDQPQNVSENLLPQNAPNYWYLQGLIHKQNGDLLQAAKCYEKELGRLLRDAPSGIGSIFLSASELEDGSEEMGQGAVSSSPRELLSNSEQLN Click to Show/Hide
Family	IFIT family
Function	IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exhibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Up-regulates CDKN1A/p21 by down-regulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2. Click to Show/Hide
Gene ID	3437
HGNC ID	HGNC:5411
Ensembl Gene ID	ENSG00000119917
KEGG ID	hsa:3437
Chromosomal Location	10q23.31

RNA Modification Sequencing Data Associated with the Target (ID: EPITAR00107)

Interferon induced protein with tetratricopeptide repeats 3 (IFIT3)

5-methylcytidine (m5C)

In total 1 m6A sequence/site(s) in this target gene
mod ID: M5CSITE004734		Click to Show/Hide the Full List
mod site	chr10:89340456-89340457:+
Sequence	AGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATGGCGTG
Cell/Tissue List	testis
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000371811.4; ENST00000371818.9; rmsk_3375215
External Link	RMBase: m5C_site_5624

N6-methyladenosine (m6A)

In total 46 m6A sequence/site(s) in this target gene
mod ID: M6ASITE001409		Click to Show/Hide the Full List
mod site	chr10:89328000-89328001:+		[1]
Sequence	TCAGTATTTACTTGAGGCAGACAGGAAGACTTCTGAAGAAC
Motif Score	2.897386905
Cell/Tissue List	HeLa; A549; CD4T; iSLK; TIME; HEC-1-A; GSCs; NB4
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000371818.9
External Link	RMBase: m6A_site_109679
mod ID: M6ASITE001410		Click to Show/Hide the Full List
mod site	chr10:89328008-89328009:+		[1]
Sequence	TACTTGAGGCAGACAGGAAGACTTCTGAAGAACAAATCAGC
Motif Score	3.319380952
Cell/Tissue List	HeLa; A549; CD4T; iSLK; TIME; HEC-1-A; GSCs; NB4
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000371818.9
External Link	RMBase: m6A_site_109680
mod ID: M6ASITE001411		Click to Show/Hide the Full List
mod site	chr10:89328019-89328020:+		[1]
Sequence	GACAGGAAGACTTCTGAAGAACAAATCAGCCTGGTCACCAG
Motif Score	2.951386905
Cell/Tissue List	HeLa; A549; CD4T; iSLK; TIME; HEC-1-A; GSCs; NB4
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000371818.9
External Link	RMBase: m6A_site_109681
mod ID: M6ASITE001412		Click to Show/Hide the Full List
mod site	chr10:89328049-89328050:+		[1]
Sequence	CTGGTCACCAGCTTTTCGGAACAGCAGAGACACAGAGGGCA
Motif Score	2.951386905
Cell/Tissue List	HeLa; A549; CD4T; iSLK; TIME; HEC-1-A; GSCs; NB4
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000371818.9
External Link	RMBase: m6A_site_109682
mod ID: M6ASITE001413		Click to Show/Hide the Full List
mod site	chr10:89328058-89328059:+		[1]
Sequence	AGCTTTTCGGAACAGCAGAGACACAGAGGGCAGTCATGAGG
Motif Score	2.897386905
Cell/Tissue List	HeLa; A549; CD4T; iSLK; MSC; TIME; HEC-1-A; GSCs; NB4
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000371818.9
External Link	RMBase: m6A_site_109683
mod ID: M6ASITE001414		Click to Show/Hide the Full List
mod site	chr10:89332511-89332512:+		[1]
Sequence	CCCCTTTCATAAAAGCACAGACCTAACAGCACCCTGGGTGG
Motif Score	2.876744048
Cell/Tissue List	HeLa; A549; MM6; CD4T; iSLK; MSC; TIME; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000371818.9; ENST00000371811.4
External Link	RMBase: m6A_site_109684
mod ID: M6ASITE001415		Click to Show/Hide the Full List
mod site	chr10:89332534-89332535:+		[1]
Sequence	TAACAGCACCCTGGGTGGAAACCTCTTCAGCATTTGCTTGG
Motif Score	2.185083333
Cell/Tissue List	HeLa; A549; MM6; CD4T; iSLK; MSC; endometrial; HEC-1-A; NB4
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000371811.4; ENST00000371818.9
External Link	RMBase: m6A_site_109685
mod ID: M6ASITE001416		Click to Show/Hide the Full List
mod site	chr10:89332571-89332572:+		[1]
Sequence	TTGGAATCAGTAAGCTAAAAACAAAATCAACCGGGACCCCA
Motif Score	2.20572619
Cell/Tissue List	HeLa; A549; CD4T; endometrial; HEC-1-A; NB4
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000371811.4; ENST00000371818.9
External Link	RMBase: m6A_site_109686
mod ID: M6ASITE001417		Click to Show/Hide the Full List
mod site	chr10:89332586-89332587:+		[1]
Sequence	TAAAAACAAAATCAACCGGGACCCCAGCTTTTCAGAACTGC
Motif Score	3.622404762
Cell/Tissue List	A549; CD4T; endometrial; HEC-1-A; NB4
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000371811.4; ENST00000371818.9
External Link	RMBase: m6A_site_109687
mod ID: M6ASITE001418		Click to Show/Hide the Full List
mod site	chr10:89332602-89332603:+		[1]
Sequence	CGGGACCCCAGCTTTTCAGAACTGCAGGGAAACAGCCATCA
Motif Score	3.373380952
Cell/Tissue List	A549; CD4T; endometrial; HEC-1-A; NB4
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000371811.4; ENST00000371818.9
External Link	RMBase: m6A_site_109688
mod ID: M6ASITE001419		Click to Show/Hide the Full List
mod site	chr10:89332613-89332614:+		[1]
Sequence	CTTTTCAGAACTGCAGGGAAACAGCCATCATGAGGTAAATA
Motif Score	2.20572619
Cell/Tissue List	A549; CD4T; HEC-1-A; NB4
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000371818.9; ENST00000371811.4
External Link	RMBase: m6A_site_109689
mod ID: M6ASITE001420		Click to Show/Hide the Full List
mod site	chr10:89338722-89338723:+		[2]
Sequence	GAAATGCCATTTCACCTGGAACTTATTCAAGGAAGACAGTG
Motif Score	3.373380952
Cell/Tissue List	HeLa; A549; CD4T; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000371811.4; ENST00000371818.9
External Link	RMBase: m6A_site_109690
mod ID: M6ASITE001421		Click to Show/Hide the Full List
mod site	chr10:89338737-89338738:+		[2]
Sequence	CTGGAACTTATTCAAGGAAGACAGTGTCTCAAGGGATCTAG
Motif Score	2.897386905
Cell/Tissue List	HeLa; kidney; A549; CD4T; iSLK; HEC-1-A; NB4
Seq Type List	m6A-seq; m6A-REF-seq; MeRIP-seq
Transcript ID List	ENST00000371818.9; ENST00000371811.4
External Link	RMBase: m6A_site_109691
mod ID: M6ASITE001422		Click to Show/Hide the Full List
mod site	chr10:89338791-89338792:+		[3]
Sequence	TAACCAGATTGAATTTTTAAACACTGAGTTCAAAGCTACAA
Motif Score	2.20572619
Cell/Tissue List	iSLK; HEC-1-A
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000371818.9; ENST00000371811.4
External Link	RMBase: m6A_site_109692
mod ID: M6ASITE001423		Click to Show/Hide the Full List
mod site	chr10:89338837-89338838:+		[4]
Sequence	AACTTGTTGGCCTACATAAAACACCTAGATGGTAACAACGA
Motif Score	2.20572619
Cell/Tissue List	HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000371818.9; ENST00000371811.4
External Link	RMBase: m6A_site_109693
mod ID: M6ASITE001424		Click to Show/Hide the Full List
mod site	chr10:89338906-89338907:+		[5]
Sequence	GAAGAGTTAATCCAGCAAGAACATGCTGACCAAGCAGAAAT
Motif Score	2.951386905
Cell/Tissue List	HepG2; fibroblasts; GM12878; LCLs; Huh7; iSLK; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000371818.9; ENST00000371811.4
External Link	RMBase: m6A_site_109694
mod ID: M6ASITE001425		Click to Show/Hide the Full List
mod site	chr10:89338950-89338951:+		[1]
Sequence	AAGTCTAGTCACTTGGGGAAACTACGCCTGGGTCTACTATC
Motif Score	2.627720238
Cell/Tissue List	HEK293T; HeLa; A549; HepG2; fibroblasts; GM12878; LCLs; Huh7; HEK293A-TOA; iSLK; MSC; TIME; HEC-1-A; NB4
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000371811.4; ENST00000371818.9
External Link	RMBase: m6A_site_109695
mod ID: M6ASITE001426		Click to Show/Hide the Full List
mod site	chr10:89338981-89338982:+		[2]
Sequence	GTCTACTATCACTTGGGCAGACTCTCAGATGCTCAGATTTA
Motif Score	3.319380952
Cell/Tissue List	HeLa; HEK293T; A549; HepG2; U2OS; fibroblasts; GM12878; LCLs; MM6; Huh7; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000371818.9; ENST00000371811.4
External Link	RMBase: m6A_site_109696
mod ID: M6ASITE001427		Click to Show/Hide the Full List
mod site	chr10:89339017-89339018:+		[2]
Sequence	ATTTATGTAGATAAGGTGAAACAAACCTGCAAGAAATTTTC
Motif Score	2.20572619
Cell/Tissue List	HeLa; HEK293T; A549; HepG2; fibroblasts; GM12878; LCLs; MM6; Huh7; CD4T; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000371811.4; ENST00000371818.9
External Link	RMBase: m6A_site_109697
mod ID: M6ASITE001428		Click to Show/Hide the Full List
mod site	chr10:89339065-89339066:+		[2]
Sequence	TACAGTATTGAGTATTCTGAACTTGACTGTGAGGAAGGGTG
Motif Score	3.373380952
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; fibroblasts; GM12878; LCLs; MM6; Huh7; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000371818.9; ENST00000371811.4
External Link	RMBase: m6A_site_109698
mod ID: M6ASITE001429		Click to Show/Hide the Full List
mod site	chr10:89339087-89339088:+		[2]
Sequence	TTGACTGTGAGGAAGGGTGGACACAACTGAAGTGTGGAAGA
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; fibroblasts; GM12878; LCLs; MM6; Huh7; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000371818.9; ENST00000371811.4
External Link	RMBase: m6A_site_109699
mod ID: M6ASITE001430		Click to Show/Hide the Full List
mod site	chr10:89339179-89339180:+		[2]
Sequence	AACCCAGAATTCTCCTCTGGACTGGCAATTGCGATGTACCA
Motif Score	4.065041667
Cell/Tissue List	HeLa; A549; HepG2; fibroblasts; GM12878; LCLs; MM6; Huh7; CD4T; peripheral-blood; GSC-11; iSLK; MSC; TIME; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000371811.4; ENST00000371818.9
External Link	RMBase: m6A_site_109700
mod ID: M6ASITE001431		Click to Show/Hide the Full List
mod site	chr10:89339221-89339222:+		[2]
Sequence	CTGGATAATCACCCAGAGAAACAGTTCTCTACTGATGTTTT
Motif Score	2.20572619
Cell/Tissue List	HeLa; A549; HepG2; fibroblasts; GM12878; LCLs; MM6; Huh7; CD4T; peripheral-blood; GSC-11; iSLK; MSC; TIME; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000371818.9; ENST00000371811.4
External Link	RMBase: m6A_site_109701
mod ID: M6ASITE001432		Click to Show/Hide the Full List
mod site	chr10:89339302-89339303:+		[6]
Sequence	AAGGTTCTCTTGGGCCTGAAACTGCAGAAGATGAATAAAGA
Motif Score	2.627720238
Cell/Tissue List	Huh7; HEC-1-A; NB4; MM6
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000371811.4; ENST00000371818.9
External Link	RMBase: m6A_site_109702
mod ID: M6ASITE001433		Click to Show/Hide the Full List
mod site	chr10:89339375-89339376:+		[5]
Sequence	TGGAAAAGTCTCCTTGCCAAACAGATGTCCTCCGCAGTGCA
Motif Score	2.20572619
Cell/Tissue List	HepG2; fibroblasts; A549; HEC-1-A; NB4
Seq Type List	m6A-seq
Transcript ID List	ENST00000371811.4; ENST00000371818.9
External Link	RMBase: m6A_site_109703
mod ID: M6ASITE001434		Click to Show/Hide the Full List
mod site	chr10:89339427-89339428:+		[5]
Sequence	CAGAAGAAAAGGTGACCTAGACAAAGCTATTGAACTGTTTC
Motif Score	2.897386905
Cell/Tissue List	HepG2; fibroblasts; A549; LCLs; MM6; iSLK; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000371811.4; ENST00000371818.9
External Link	RMBase: m6A_site_109704
mod ID: M6ASITE001435		Click to Show/Hide the Full List
mod site	chr10:89339440-89339441:+		[5]
Sequence	GACCTAGACAAAGCTATTGAACTGTTTCAACGGGTGTTGGA
Motif Score	3.373380952
Cell/Tissue List	HepG2; fibroblasts; A549; LCLs; MM6; iSLK; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000371818.9; ENST00000371811.4
External Link	RMBase: m6A_site_109705
mod ID: M6ASITE001436		Click to Show/Hide the Full List
mod site	chr10:89339472-89339473:+		[1]
Sequence	GGTGTTGGAATCCACACCAAACAATGGCTACCTCTATCACC
Motif Score	2.20572619
Cell/Tissue List	HEK293T; HeLa; HepG2; fibroblasts; A549; GM12878; LCLs; MM6; Huh7; iSLK; endometrial; HEC-1-A; NB4
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000371818.9; ENST00000371811.4
External Link	RMBase: m6A_site_109706
mod ID: M6ASITE001437		Click to Show/Hide the Full List
mod site	chr10:89339524-89339525:+		[2]
Sequence	TGCTACAAGGCAAAAGTAAGACAAATGCAGAATACAGGAGA
Motif Score	2.897386905
Cell/Tissue List	HeLa; HEK293T; A549; HepG2; fibroblasts; GM12878; LCLs; MM6; Huh7; iSLK; MSC; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000371818.9; ENST00000371811.4
External Link	RMBase: m6A_site_109707
mod ID: M6ASITE001438		Click to Show/Hide the Full List
mod site	chr10:89339601-89339602:+		[2]
Sequence	ACTAAAGCAATATGCTATGGACTATTCGAATAAAGCTCTTG
Motif Score	4.065041667
Cell/Tissue List	HeLa; HEK293T; A549; HepG2; fibroblasts; GM12878; LCLs; CD8T; MM6; Huh7; HEK293A-TOA; iSLK; MSC; TIME; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000371811.4; ENST00000371818.9
External Link	RMBase: m6A_site_109708
mod ID: M6ASITE001439		Click to Show/Hide the Full List
mod site	chr10:89339629-89339630:+		[2]
Sequence	AATAAAGCTCTTGAGAAGGGACTGAATCCTCTGAATGCATA
Motif Score	4.065041667
Cell/Tissue List	HeLa; HEK293T; A549; HepG2; fibroblasts; GM12878; LCLs; MM6; Huh7; HEK293A-TOA; iSLK; MSC; TIME; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000371811.4; ENST00000371818.9
External Link	RMBase: m6A_site_109709
mod ID: M6ASITE001440		Click to Show/Hide the Full List
mod site	chr10:89339690-89339691:+		[1]
Sequence	TGGAGACGGAATGTTATCAGACACCATTCAATAAGGAAGTC
Motif Score	2.897386905
Cell/Tissue List	HEK293T; HeLa; A549; HepG2; fibroblasts; GM12878; LCLs; MM6; Huh7; iSLK; MSC; TIME; HEC-1-A; NB4
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000371818.9; ENST00000371811.4
External Link	RMBase: m6A_site_109710
mod ID: M6ASITE001441		Click to Show/Hide the Full List
mod site	chr10:89339781-89339782:+		[7]
Sequence	ATATAATGGGAAGTCTGAAGACACTGCTGTGCAACATGGTT
Motif Score	2.897386905
Cell/Tissue List	brain; A549; fibroblasts; LCLs; Huh7; iSLK; HEC-1-A
Seq Type List	m6A-REF-seq; MeRIP-seq; m6A-seq
Transcript ID List	ENST00000371818.9; ENST00000371811.4
External Link	RMBase: m6A_site_109711
mod ID: M6ASITE001442		Click to Show/Hide the Full List
mod site	chr10:89339835-89339836:+		[7]
Sequence	CATAAGCAAAAAATCAACTGACAAGGAAGAGATCAAAGACC
Motif Score	2.859755952
Cell/Tissue List	brain
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000371818.9; ENST00000371811.4
External Link	RMBase: m6A_site_109712
mod ID: M6ASITE001443		Click to Show/Hide the Full List
mod site	chr10:89339853-89339854:+		[8]
Sequence	TGACAAGGAAGAGATCAAAGACCAACCACAGAATGTATCTG
Motif Score	2.876744048
Cell/Tissue List	fibroblasts; LCLs; Huh7; iSLK; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000371811.4; ENST00000371818.9
External Link	RMBase: m6A_site_109713
mod ID: M6ASITE001444		Click to Show/Hide the Full List
mod site	chr10:89339977-89339978:+		[1]
Sequence	GCCAAATGTTATGAGAAGGAACTGGGCCGCCTGCTAAGGGA
Motif Score	3.373380952
Cell/Tissue List	HEK293T; HeLa; fibroblasts; A549; GM12878; LCLs; Huh7; iSLK; HEC-1-A
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000371818.9; ENST00000371811.4
External Link	RMBase: m6A_site_109714
mod ID: M6ASITE001445		Click to Show/Hide the Full List
mod site	chr10:89340123-89340124:+		[2]
Sequence	CTCTAACTCAGAGCAACTGAACTGAGACAGAGGAGGAAAAC
Motif Score	3.373380952
Cell/Tissue List	HeLa; HepG2; A549; U2OS; fibroblasts; GM12878; LCLs; MM6; Huh7; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000371811.4; ENST00000371818.9
External Link	RMBase: m6A_site_109715
mod ID: M6ASITE001446		Click to Show/Hide the Full List
mod site	chr10:89340129-89340130:+		[2]
Sequence	CTCAGAGCAACTGAACTGAGACAGAGGAGGAAAACAGAGCA
Motif Score	2.897386905
Cell/Tissue List	HeLa; HepG2; A549; U2OS; fibroblasts; GM12878; LCLs; MM6; Huh7; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000371811.4; ENST00000371818.9
External Link	RMBase: m6A_site_109716
mod ID: M6ASITE001447		Click to Show/Hide the Full List
mod site	chr10:89340142-89340143:+		[2]
Sequence	AACTGAGACAGAGGAGGAAAACAGAGCATCAGAAGCCTGCA
Motif Score	2.20572619
Cell/Tissue List	HeLa; HepG2; A549; U2OS; fibroblasts; GM12878; LCLs; MM6; Huh7; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000371811.4; ENST00000371818.9
External Link	RMBase: m6A_site_109717
mod ID: M6ASITE001448		Click to Show/Hide the Full List
mod site	chr10:89340195-89340196:+		[2]
Sequence	ACGGGTAGGACGATAGGAAGACAGGGGGCCCCAACCTGGGA
Motif Score	2.897386905
Cell/Tissue List	HeLa; HepG2; A549; U2OS; fibroblasts; GM12878; LCLs; MM6; Huh7; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000371811.4; ENST00000371818.9
External Link	RMBase: m6A_site_109718
mod ID: M6ASITE001449		Click to Show/Hide the Full List
mod site	chr10:89340357-89340358:+		[1]
Sequence	CACGAGGTCTGGAGTTTGAGACCATCCTGGCTAACACAGTG
Motif Score	2.876744048
Cell/Tissue List	HeLa; A549; fibroblasts; GM12878; Huh7; HEK293A-TOA; iSLK; HEC-1-A; NB4
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000371811.4; ENST00000371818.9; rmsk_3375215
External Link	RMBase: m6A_site_109719
mod ID: M6ASITE001450		Click to Show/Hide the Full List
mod site	chr10:89340478-89340479:+		[4]
Sequence	GAGGCAGGAGAATGGCGTGAACCTGGAAGGAAGAGGTTGCA
Motif Score	2.930744048
Cell/Tissue List	HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	rmsk_3375215; ENST00000371811.4; ENST00000371818.9
External Link	RMBase: m6A_site_109720
mod ID: M6ASITE001451		Click to Show/Hide the Full List
mod site	chr10:89340547-89340548:+		[6]
Sequence	AGCCTGGGCAACAGAGCAAGACTCCATCTCAAAAAAAAAAA
Motif Score	3.319380952
Cell/Tissue List	Huh7; HEC-1-A
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	rmsk_3375215; ENST00000371818.9; ENST00000371811.4
External Link	RMBase: m6A_site_109721
mod ID: M6ASITE001452		Click to Show/Hide the Full List
mod site	chr10:89340805-89340806:+		[2]
Sequence	CTCATCTCATTTTCATCCAGACTTCTGGAACTCAAAGATTA
Motif Score	3.319380952
Cell/Tissue List	HeLa; HEK293T; GM12878; LCLs; Huh7; iSLK
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000371818.9; ENST00000371811.4
External Link	RMBase: m6A_site_109722
mod ID: M6ASITE001453		Click to Show/Hide the Full List
mod site	chr10:89340814-89340815:+		[2]
Sequence	TTTTCATCCAGACTTCTGGAACTCAAAGATTAACTTTTGAC
Motif Score	3.373380952
Cell/Tissue List	HeLa; HEK293T; GM12878; LCLs; Huh7; iSLK
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000371811.4; ENST00000371818.9
External Link	RMBase: m6A_site_109723
mod ID: M6ASITE001454		Click to Show/Hide the Full List
mod site	chr10:89340951-89340952:+		[7]
Sequence	TAATGCTACAATAAATCCAAACATTTCAACTCTGTTAGAAT
Motif Score	2.20572619
Cell/Tissue List	brain; Huh7
Seq Type List	m6A-REF-seq; MeRIP-seq
Transcript ID List	ENST00000371818.9; ENST00000371811.4
External Link	RMBase: m6A_site_109724

Ref 1	Viral N(6)-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus. Nat Commun. 2019 Oct 9;10(1):4595. doi: 10.1038/s41467-019-12504-y.
Ref 2	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 3	Viral and cellular N(6)-methyladenosine and N(6),2'-O-dimethyladenosine epitranscriptomes in the KSHV life cycle. Nat Microbiol. 2018 Jan;3(1):108-120. doi: 10.1038/s41564-017-0056-8. Epub 2017 Nov 6.
Ref 4	m(6)A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer. Nat Cell Biol. 2018 Sep;20(9):1074-1083. doi: 10.1038/s41556-018-0174-4. Epub 2018 Aug 27.
Ref 5	Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Nature. 2012 Apr 29;485(7397):201-6. doi: 10.1038/nature11112.
Ref 6	N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection. Cell Host Microbe. 2016 Nov 9;20(5):654-665. doi: 10.1016/j.chom.2016.09.015. Epub 2016 Oct 20.
Ref 7	Single-base mapping of m(6)A by an antibody-independent method. Sci Adv. 2019 Jul 3;5(7):eaax0250. doi: 10.1126/sciadv.aax0250. eCollection 2019 Jul.
Ref 8	Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites. Cell Rep. 2014 Jul 10;8(1):284-96. doi: 10.1016/j.celrep.2014.05.048. Epub 2014 Jun 26.

Epigenetic Target Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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