Epigenetic Target Information

General Information of the Epigenetic Target (ID: EPITAR00099)
Target Name POU domain, class 5, transcription factor 1 (POU5F1)
Synonyms
Octamer-binding protein 3; Oct-3; Octamer-binding protein 4; Oct-4; Octamer-binding transcription factor 3; OTF-3; OCT3; OCT4; OTF3
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Gene Name POU5F1
Sequence
MAGHLASDFAFSPPPGGGGDGPGGPEPGWVDPRTWLSFQGPPGGPGIGPGVGPGSEVWGIPPCPPPYEFCGGMAYCGPQVGVGLVPQGGLETSQPEGEAGVGVESNSDGASPEPCTVTPGAVKLEKEKLEQNPEESQDIKALQKELEQFAKLLKQKRITLGYTQADVGLTLGVLFGKVFSQTTICRFEALQLSFKNMCKLRPLLQKWVEEADNNENLQEICKAETLVQARKRKRTSIENRVRGNLENLFLQCPKPTLQQISHIAQQLGLEKDVVRVWFCNRRQKGKRSSSDYAQREDFEAAGSPFSGGPVSFPLAPGPHFGTPGYGSPHFTALYSSVPFPEGEAFPPVSVTTLGSPMHSN
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Family POU transcription factor family; Class-5 subfamily
Function
Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.
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Gene ID 5460
HGNC ID HGNC:9221
Ensembl Gene ID ENSG00000204531
KEGG ID hsa:5460
Chromosomal Location 6p21.33
RNA Modification Sequencing Data Associated with the Target (ID: EPITAR00099)
POU domain, class 5, transcription factor 1 (POU5F1)
N4-acetylcytidine (ac4C)
In total 1 m6A sequence/site(s) in this target gene
mod ID: AC4SITE000101 Click to Show/Hide the Full List
mod site chr6:31164362-31164363:- [1]
Sequence TTTTTCTTAAATAAAGAAGCCTGGGACACAGTAGATAGACA
Cell/Tissue List H1
Seq Type List ac4C-seq
Transcript ID List ENST00000606567.5; ENST00000259915.13; ENST00000441888.7; ENST00000471529.6; ENST00000513407.1; ENST00000512818.5
External Link RMBase: ac4C_site_1576
Adenosine-to-Inosine editing (A-to-I)
In total 1 m6A sequence/site(s) in this target gene
mod ID: A2ISITE001425 Click to Show/Hide the Full List
mod site chr6:31171111-31171112:- [2]
Sequence TTTCTTGAGGACAGGAATTCAAGACCAGCCTGGGTAACATA
Transcript ID List ENST00000441888.7; rmsk_1907496
External Link RMBase: RNA-editing_site_115349
2'-O-Methylation (2'-O-Me)
In total 1 m6A sequence/site(s) in this target gene
mod ID: 2OMSITE000394 Click to Show/Hide the Full List
mod site chr6:31166442-31166443:- [3]
Sequence TGGTCTTGAACTCCTGACCTCGTGATCTGCCCACCTCGGCC
Cell/Tissue List HeLa
Seq Type List Nm-seq
Transcript ID List ENST00000461401.1; ENST00000606567.5; ENST00000471529.6; ENST00000259915.13; ENST00000512818.5; ENST00000441888.7; ENST00000513407.1
External Link RMBase: Nm_site_5795
N6-methyladenosine (m6A)
In total 10 m6A sequence/site(s) in this target gene
mod ID: M6ASITE074307 Click to Show/Hide the Full List
mod site chr6:31164357-31164358:- [4]
Sequence CTTAAATAAAGAAGCCTGGGACACAGTAGATAGACACACTT
Motif Score 3.643047619
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000441888.7; ENST00000606567.5; ENST00000259915.13; ENST00000471529.6; ENST00000513407.1; ENST00000512818.5
External Link RMBase: m6A_site_711956
mod ID: M6ASITE074308 Click to Show/Hide the Full List
mod site chr6:31164397-31164398:- [4]
Sequence ATGCTCTTGATTTTAATCCCACATCATGTATCACTTTTTTC
Motif Score 2.053113095
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000259915.13; ENST00000441888.7; ENST00000512818.5; ENST00000606567.5; ENST00000471529.6; ENST00000513407.1
External Link RMBase: m6A_site_711957
mod ID: M6ASITE074309 Click to Show/Hide the Full List
mod site chr6:31164804-31164805:- [4]
Sequence CGATCAAGCAGCGACTATGCACAACGAGAGGATTTTGAGGC
Motif Score 2.830589286
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000259915.13; ENST00000620031.5; ENST00000512818.5; ENST00000441888.7; ENST00000513407.1; ENST00000606567.5; ENST00000471529.6
External Link RMBase: m6A_site_711958
mod ID: M6ASITE074310 Click to Show/Hide the Full List
mod site chr6:31165158-31165159:- [4]
Sequence CACACTGCAGCAGATCAGCCACATCGCCCAGCAGCTTGGGC
Motif Score 2.053113095
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000441888.7; ENST00000620031.5; ENST00000606567.5; ENST00000512818.5; ENST00000259915.13; ENST00000471529.6; ENST00000513407.1
External Link RMBase: m6A_site_711959
mod ID: M6ASITE074311 Click to Show/Hide the Full List
mod site chr6:31165177-31165178:- [4]
Sequence TCCTGCAGTGCCCGAAACCCACACTGCAGCAGATCAGCCAC
Motif Score 2.053113095
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000620031.5; ENST00000441888.7; ENST00000259915.13; ENST00000513407.1; ENST00000606567.5; ENST00000512818.5; ENST00000471529.6
External Link RMBase: m6A_site_711960
mod ID: M6ASITE074312 Click to Show/Hide the Full List
mod site chr6:31165589-31165590:- [4]
Sequence GTGGGTGGAGGAAGCTGACAACAATGAAAATCTTCAGGAGG
Motif Score 2.173910714
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000606567.5; ENST00000471529.6; ENST00000512818.5; ENST00000513407.1; ENST00000441888.7; ENST00000620031.5; ENST00000259915.13
External Link RMBase: m6A_site_711961
mod ID: M6ASITE074313 Click to Show/Hide the Full List
mod site chr6:31165592-31165593:- [4]
Sequence GAAGTGGGTGGAGGAAGCTGACAACAATGAAAATCTTCAGG
Motif Score 2.859755952
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000606567.5; ENST00000441888.7; ENST00000512818.5; ENST00000620031.5; ENST00000513407.1; ENST00000471529.6; ENST00000259915.13
External Link RMBase: m6A_site_711962
mod ID: M6ASITE074314 Click to Show/Hide the Full List
mod site chr6:31165640-31165641:- [4]
Sequence TCTGCAGCTTAGCTTCAAGAACATGTGTAAGCTGCGGCCCT
Motif Score 2.951386905
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000606567.5; ENST00000441888.7; ENST00000471529.6; ENST00000513407.1; ENST00000512818.5; ENST00000259915.13; ENST00000620031.5
External Link RMBase: m6A_site_711963
mod ID: M6ASITE074315 Click to Show/Hide the Full List
mod site chr6:31165965-31165966:- [4]
Sequence AGAGGATCACCCTGGGATATACACAGGCCGATGTGGGGCTC
Motif Score 2.110482143
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000513407.1; ENST00000606567.5; ENST00000471529.6; ENST00000259915.13; ENST00000512818.5; ENST00000461401.1; ENST00000441888.7
External Link RMBase: m6A_site_711964
mod ID: M6ASITE074316 Click to Show/Hide the Full List
mod site chr6:31166039-31166040:- [4]
Sequence TTTTAAAATCCAGTCCCAGGACATCAAAGCTCTGCAGAAAG
Motif Score 3.643047619
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000259915.13; ENST00000461401.1; ENST00000441888.7; ENST00000513407.1; ENST00000471529.6; ENST00000606567.5; ENST00000512818.5
External Link RMBase: m6A_site_711965