Epigenetic Target Information

General Information of the Epigenetic Target (ID: EPITAR00091)

Target Name	Hepatocyte nuclear factor 4 alpha (HNF4A)
Synonyms	NR2A1; HNF4; TCF14; MODY; MODY1 Click to Show/Hide
Gene Name	HNF4A
Sequence	MRLSKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMCEWPRPRGQAATPETPQPSPPGGSGSEPYKLLPGAVATIVKPLSAIPQPTITKQEVI Click to Show/Hide
Family	Nuclear hormone receptor family, NR2 subfamily
Function	Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes (PubMed:30597922). Activates the transcription of CYP2C38 (By similarity). Represses the CLOCK-BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells (PubMed:30530698). Click to Show/Hide
Gene ID	3172
HGNC ID	HGNC:5024
Ensembl Gene ID	ENSG00000101076
KEGG ID	hsa:3172
Chromosomal Location	20q13.12

RNA Modification Sequencing Data Associated with the Target (ID: EPITAR00091)

Hepatocyte nuclear factor 4 alpha (HNF4A)

N6-methyladenosine (m6A)

In total 70 m6A sequence/site(s) in this target gene
mod ID: M6ASITE052993		Click to Show/Hide the Full List
mod site	chr20:44401229-44401230:+		[1]
Sequence	TTCACAGAGGCTAGGCCAAGACTCCCAGCAGATCTTCCCAG
Motif Score	3.319380952
Cell/Tissue List	A549
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000609795.5; ENST00000457232.5; ENST00000619550.4; ENST00000316673.8; ENST00000609262.5
External Link	RMBase: m6A_site_532810
mod ID: M6ASITE052994		Click to Show/Hide the Full List
mod site	chr20:44401387-44401388:+		[2]
Sequence	GGAGAATGCGACTCTCCAAAACCCTCGTCGACATGGACATG
Motif Score	2.185083333
Cell/Tissue List	HepG2; A549
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000609795.5; ENST00000443598.6; ENST00000457232.5; ENST00000609262.5; ENST00000316673.8; ENST00000316099.8; ENST00000372920.1; ENST00000619550.4; ENST00000415691.2
External Link	RMBase: m6A_site_532811
mod ID: M6ASITE052995		Click to Show/Hide the Full List
mod site	chr20:44401403-44401404:+		[2]
Sequence	CAAAACCCTCGTCGACATGGACATGGCCGACTACAGTGCTG
Motif Score	3.643047619
Cell/Tissue List	HepG2; A549
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000372920.1; ENST00000457232.5; ENST00000316099.8; ENST00000316673.8; ENST00000609795.5; ENST00000443598.6; ENST00000609262.5; ENST00000415691.2; ENST00000619550.4
External Link	RMBase: m6A_site_532812
mod ID: M6ASITE052996		Click to Show/Hide the Full List
mod site	chr20:44401430-44401431:+		[2]
Sequence	CGACTACAGTGCTGCACTGGACCCAGCCTACACCACCCTGG
Motif Score	3.622404762
Cell/Tissue List	HepG2; A549
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000457232.5; ENST00000372920.1; ENST00000316099.8; ENST00000619550.4; ENST00000316673.8; ENST00000415691.2; ENST00000443598.6; ENST00000609262.5; ENST00000609795.5
External Link	RMBase: m6A_site_532813
mod ID: M6ASITE052997		Click to Show/Hide the Full List
mod site	chr20:44402626-44402627:+		[3]
Sequence	GAGCATATCTGGAGGGGTGGACAGTTCTCCACAGGGAGGTA
Motif Score	3.643047619
Cell/Tissue List	HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000609795.5; ENST00000415691.2; ENST00000443598.6; ENST00000316673.8; ENST00000457232.5; ENST00000609262.5; ENST00000316099.8; ENST00000372920.1; ENST00000619550.4
External Link	RMBase: m6A_site_532814
mod ID: M6ASITE052998		Click to Show/Hide the Full List
mod site	chr20:44406135-44406136:+		[3]
Sequence	CCTGTGTGCCATCTGCGGGGACCGGGCCACGGGCAAACACT
Motif Score	3.622404762
Cell/Tissue List	HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000609262.5; ENST00000609795.5; ENST00000619550.4; ENST00000457232.5; ENST00000316099.8; ENST00000415691.2; ENST00000316673.8; ENST00000372920.1; ENST00000443598.6
External Link	RMBase: m6A_site_532815
mod ID: M6ASITE052999		Click to Show/Hide the Full List
mod site	chr20:44406151-44406152:+		[3]
Sequence	GGGGACCGGGCCACGGGCAAACACTACGGTGCCTCGAGCTG
Motif Score	2.20572619
Cell/Tissue List	HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000609795.5; ENST00000457232.5; ENST00000609262.5; ENST00000415691.2; ENST00000372920.1; ENST00000316099.8; ENST00000619550.4; ENST00000316673.8; ENST00000443598.6
External Link	RMBase: m6A_site_532816
mod ID: M6ASITE053000		Click to Show/Hide the Full List
mod site	chr20:44406213-44406214:+		[3]
Sequence	CCGGAGGAGCGTGCGGAAGAACCACATGTACTCCTGCAGGT
Motif Score	2.930744048
Cell/Tissue List	HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000415691.2; ENST00000609795.5; ENST00000609262.5; ENST00000316099.8; ENST00000372920.1; ENST00000316673.8; ENST00000457232.5; ENST00000443598.6; ENST00000619550.4
External Link	RMBase: m6A_site_532817
mod ID: M6ASITE053001		Click to Show/Hide the Full List
mod site	chr20:44407403-44407404:+		[3]
Sequence	TAGCCGGCAGTGCGTGGTGGACAAAGACAAGAGGAACCAGT
Motif Score	3.643047619
Cell/Tissue List	HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000316099.8; ENST00000619550.4; ENST00000457232.5; ENST00000609795.5; ENST00000443598.6; ENST00000415691.2; ENST00000316673.8; ENST00000372920.1; ENST00000609262.5
External Link	RMBase: m6A_site_532818
mod ID: M6ASITE053002		Click to Show/Hide the Full List
mod site	chr20:44407409-44407410:+		[3]
Sequence	GCAGTGCGTGGTGGACAAAGACAAGAGGAACCAGTGCCGCT
Motif Score	2.897386905
Cell/Tissue List	HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000415691.2; ENST00000609262.5; ENST00000609795.5; ENST00000457232.5; ENST00000316099.8; ENST00000619550.4; ENST00000316673.8; ENST00000443598.6; ENST00000372920.1
External Link	RMBase: m6A_site_532819
mod ID: M6ASITE053003		Click to Show/Hide the Full List
mod site	chr20:44407418-44407419:+		[3]
Sequence	GGTGGACAAAGACAAGAGGAACCAGTGCCGCTACTGCAGGC
Motif Score	2.930744048
Cell/Tissue List	HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000415691.2; ENST00000619550.4; ENST00000609262.5; ENST00000457232.5; ENST00000316099.8; ENST00000443598.6; ENST00000372920.1; ENST00000609795.5; ENST00000316673.8
External Link	RMBase: m6A_site_532820
mod ID: M6ASITE053004		Click to Show/Hide the Full List
mod site	chr20:44413711-44413712:+		[3]
Sequence	AGCCGTCCAGAATGAGCGGGACCGGATCAGCACTCGAAGGT
Motif Score	3.622404762
Cell/Tissue List	HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000457232.5; ENST00000316099.8; ENST00000372920.1; ENST00000443598.6; ENST00000619550.4; ENST00000609795.5; ENST00000316673.8; ENST00000415691.2
External Link	RMBase: m6A_site_532821
mod ID: M6ASITE053005		Click to Show/Hide the Full List
mod site	chr20:44413744-44413745:+		[3]
Sequence	TCGAAGGTCAAGCTATGAGGACAGCAGCCTGCCCTCCATCA
Motif Score	3.643047619
Cell/Tissue List	HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000619550.4; ENST00000457232.5; ENST00000316099.8; ENST00000372920.1; ENST00000609795.5; ENST00000316673.8; ENST00000415691.2; ENST00000443598.6
External Link	RMBase: m6A_site_532822
mod ID: M6ASITE053006		Click to Show/Hide the Full List
mod site	chr20:44413796-44413797:+		[4]
Sequence	CAGGCGGAGGTCCTGTCCCGACAGGTACCGGGGTGATCCTG
Motif Score	2.865571429
Cell/Tissue List	kidney
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000457232.5; ENST00000316673.8; ENST00000619550.4; ENST00000443598.6; ENST00000316099.8; ENST00000415691.2; ENST00000372920.1; ENST00000609795.5
External Link	RMBase: m6A_site_532823
mod ID: M6ASITE053007		Click to Show/Hide the Full List
mod site	chr20:44419729-44419730:+		[4]
Sequence	AACCCTTCCAGGCAATGACTACATTGTCCCTCGGCACTGCC
Motif Score	2.078666667
Cell/Tissue List	liver
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000619550.4; ENST00000443598.6; ENST00000415691.2; ENST00000316673.8; ENST00000372920.1; ENST00000316099.8; ENST00000457232.5; ENST00000609795.5
External Link	RMBase: m6A_site_532824
mod ID: M6ASITE053008		Click to Show/Hide the Full List
mod site	chr20:44424086-44424087:+		[3]
Sequence	GGTGCAGGTGAGCTTGGAGGACTACATCAACGACCGCCAGT
Motif Score	4.065041667
Cell/Tissue List	HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000609795.5; ENST00000415691.2; ENST00000443598.6; ENST00000619550.4; ENST00000372920.1; ENST00000457232.5; ENST00000316099.8; ENST00000316673.8
External Link	RMBase: m6A_site_532825
mod ID: M6ASITE053009		Click to Show/Hide the Full List
mod site	chr20:44424089-44424090:+		[4]
Sequence	GCAGGTGAGCTTGGAGGACTACATCAACGACCGCCAGTATG
Motif Score	2.078666667
Cell/Tissue List	liver
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000316099.8; ENST00000609795.5; ENST00000619550.4; ENST00000415691.2; ENST00000443598.6; ENST00000316673.8; ENST00000372920.1; ENST00000457232.5
External Link	RMBase: m6A_site_532826
mod ID: M6ASITE053010		Click to Show/Hide the Full List
mod site	chr20:44424293-44424294:+		[5]
Sequence	GGGGCGGGGTTGGAGTGGGGACTCCCCAGGAGACAGGCCTC
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000316099.8; ENST00000316673.8; ENST00000457232.5; ENST00000372920.1; ENST00000443598.6; ENST00000609795.5; ENST00000619550.4; ENST00000415691.2
External Link	RMBase: m6A_site_532827
mod ID: M6ASITE053011		Click to Show/Hide the Full List
mod site	chr20:44424305-44424306:+		[5]
Sequence	GAGTGGGGACTCCCCAGGAGACAGGCCTCACACAGTGAGCT
Motif Score	2.897386905
Cell/Tissue List	HeLa; HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000316673.8; ENST00000415691.2; ENST00000609795.5; ENST00000619550.4; ENST00000372920.1; ENST00000316099.8; ENST00000443598.6; ENST00000457232.5
External Link	RMBase: m6A_site_532828
mod ID: M6ASITE053012		Click to Show/Hide the Full List
mod site	chr20:44428392-44428393:+		[6]
Sequence	CACCCTCACCTGATGCAGGAACATATGGGAACCAACGTCAT
Motif Score	2.951386905
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000372920.1; ENST00000619550.4; ENST00000316099.8; ENST00000316673.8; ENST00000457232.5; ENST00000415691.2
External Link	RMBase: m6A_site_532829
mod ID: M6ASITE053013		Click to Show/Hide the Full List
mod site	chr20:44428402-44428403:+		[6]
Sequence	TGATGCAGGAACATATGGGAACCAACGTCATCGTTGCCAAC
Motif Score	2.930744048
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000457232.5; ENST00000316099.8; ENST00000372920.1; ENST00000415691.2; ENST00000619550.4; ENST00000316673.8
External Link	RMBase: m6A_site_532830
mod ID: M6ASITE053014		Click to Show/Hide the Full List
mod site	chr20:44428449-44428450:+		[2]
Sequence	CCCACTCACCTCAGCAACGGACAGATGTGTGAGTGGCCCCG
Motif Score	3.643047619
Cell/Tissue List	HepG2; kidney; Huh7
Seq Type List	m6A-seq; m6A-REF-seq; MeRIP-seq
Transcript ID List	ENST00000316099.8; ENST00000316673.8; ENST00000619550.4; ENST00000372920.1; ENST00000415691.2; ENST00000457232.5
External Link	RMBase: m6A_site_532831
mod ID: M6ASITE053015		Click to Show/Hide the Full List
mod site	chr20:44428479-44428480:+		[7]
Sequence	GAGTGGCCCCGACCCAGGGGACAGGCAGGTGGGCAAACTCT
Motif Score	3.643047619
Cell/Tissue List	HepG2; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000457232.5; ENST00000372920.1; ENST00000415691.2; ENST00000316099.8; ENST00000316673.8; ENST00000619550.4
External Link	RMBase: m6A_site_532832
mod ID: M6ASITE053016		Click to Show/Hide the Full List
mod site	chr20:44429533-44429534:+		[7]
Sequence	TCCTTCCAGCCACCCCTGAGACCCCACAGCCCTCACCGCCA
Motif Score	2.876744048
Cell/Tissue List	HepG2; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000457232.5; ENST00000372920.1; ENST00000316099.8; ENST00000316673.8; ENST00000619550.4; ENST00000415691.2
External Link	RMBase: m6A_site_532833
mod ID: M6ASITE053017		Click to Show/Hide the Full List
mod site	chr20:44429764-44429765:+		[5]
Sequence	AAGGAAGACGTGATGCCAGGACCAGTCCCAGAGCAGGAATG
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; A549; Huh7; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000372920.1; ENST00000316099.8; ENST00000415691.2; ENST00000619550.4
External Link	RMBase: m6A_site_532834
mod ID: M6ASITE053018		Click to Show/Hide the Full List
mod site	chr20:44429806-44429807:+		[5]
Sequence	GAAGGATGAAGGGCCCGAGAACATGGCCTAAGGGCCACATC
Motif Score	2.951386905
Cell/Tissue List	HeLa; HepG2; liver; A549; Huh7; HEC-1-A
Seq Type List	m6A-seq; m6A-REF-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000619550.4; ENST00000372920.1; ENST00000415691.2; ENST00000316099.8
External Link	RMBase: m6A_site_532835
mod ID: M6ASITE053019		Click to Show/Hide the Full List
mod site	chr20:44429842-44429843:+		[1]
Sequence	ACATCCCACTGCCACCCTTGACGCCCTGCTCTGGATAACAA
Motif Score	2.833690476
Cell/Tissue List	A549
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000415691.2; ENST00000619550.4; ENST00000316099.8; ENST00000372920.1
External Link	RMBase: m6A_site_532836
mod ID: M6ASITE053020		Click to Show/Hide the Full List
mod site	chr20:44429864-44429865:+		[5]
Sequence	GCCCTGCTCTGGATAACAAGACTTTGACTTGGGGAGACCTC
Motif Score	3.319380952
Cell/Tissue List	HeLa; HepG2; A549; H1B; Huh7; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000372920.1; ENST00000619550.4; ENST00000316099.8; ENST00000415691.2
External Link	RMBase: m6A_site_532837
mod ID: M6ASITE053021		Click to Show/Hide the Full List
mod site	chr20:44429870-44429871:+		[1]
Sequence	CTCTGGATAACAAGACTTTGACTTGGGGAGACCTCTACTGC
Motif Score	3.28175
Cell/Tissue List	A549
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000619550.4; ENST00000316099.8; ENST00000415691.2; ENST00000372920.1
External Link	RMBase: m6A_site_532838
mod ID: M6ASITE053022		Click to Show/Hide the Full List
mod site	chr20:44429880-44429881:+		[5]
Sequence	CAAGACTTTGACTTGGGGAGACCTCTACTGCCTTGGACAAC
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; A549; H1B; Huh7; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000619550.4; ENST00000372920.1; ENST00000316099.8; ENST00000415691.2
External Link	RMBase: m6A_site_532839
mod ID: M6ASITE053023		Click to Show/Hide the Full List
mod site	chr20:44429896-44429897:+		[5]
Sequence	GGAGACCTCTACTGCCTTGGACAACTTTTCTCATGTTGAAG
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; A549; H1B; Huh7; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000415691.2; ENST00000372920.1; ENST00000619550.4; ENST00000316099.8
External Link	RMBase: m6A_site_532840
mod ID: M6ASITE053024		Click to Show/Hide the Full List
mod site	chr20:44429899-44429900:+		[1]
Sequence	GACCTCTACTGCCTTGGACAACTTTTCTCATGTTGAAGCCA
Motif Score	2.595904762
Cell/Tissue List	A549
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000415691.2; ENST00000316099.8; ENST00000372920.1; ENST00000619550.4
External Link	RMBase: m6A_site_532841
mod ID: M6ASITE053025		Click to Show/Hide the Full List
mod site	chr20:44429973-44429974:+		[5]
Sequence	CCCCGACTTCATCCCAAAGGACAGCCGCCTGGAGATGACTT
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; A549; Huh7; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000372920.1; ENST00000316099.8; ENST00000619550.4; ENST00000415691.2
External Link	RMBase: m6A_site_532842
mod ID: M6ASITE053026		Click to Show/Hide the Full List
mod site	chr20:44430008-44430009:+		[5]
Sequence	TGACTTGAGGCCTTACTTAAACCCAGCTCCCTTCTTCCCTA
Motif Score	2.185083333
Cell/Tissue List	HeLa; HepG2; A549; Huh7; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000316099.8; ENST00000415691.2; ENST00000619550.4; ENST00000372920.1
External Link	RMBase: m6A_site_532843
mod ID: M6ASITE053027		Click to Show/Hide the Full List
mod site	chr20:44430071-44430072:+		[2]
Sequence	GCCCCTGTCATGGTGTCCAGACAGAGCCCTGTGAGGCTGGG
Motif Score	2.897386905
Cell/Tissue List	HepG2; A549; Huh7; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000316099.8; ENST00000372920.1; ENST00000415691.2; ENST00000619550.4
External Link	RMBase: m6A_site_532844
mod ID: M6ASITE053028		Click to Show/Hide the Full List
mod site	chr20:44430254-44430255:+		[2]
Sequence	TTCCCCCAGTCATTCTGGGAACATGTTGTAAGCACTGACTG
Motif Score	2.951386905
Cell/Tissue List	HepG2; A549; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000316099.8; ENST00000415691.2; ENST00000372920.1; ENST00000619550.4
External Link	RMBase: m6A_site_532845
mod ID: M6ASITE053029		Click to Show/Hide the Full List
mod site	chr20:44430271-44430272:+		[1]
Sequence	GGAACATGTTGTAAGCACTGACTGGGACCAGGCACCAGGCA
Motif Score	3.28175
Cell/Tissue List	A549
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000372920.1; ENST00000619550.4; ENST00000415691.2; ENST00000316099.8
External Link	RMBase: m6A_site_532846
mod ID: M6ASITE053030		Click to Show/Hide the Full List
mod site	chr20:44430277-44430278:+		[2]
Sequence	TGTTGTAAGCACTGACTGGGACCAGGCACCAGGCAGGGTCT
Motif Score	3.622404762
Cell/Tissue List	HepG2; A549; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000372920.1; ENST00000316099.8; ENST00000619550.4; ENST00000415691.2
External Link	RMBase: m6A_site_532847
mod ID: M6ASITE053031		Click to Show/Hide the Full List
mod site	chr20:44430362-44430363:+		[2]
Sequence	CTCATCCTCCTTCTTCAGGGACTTGGGTGGGTACTTGGGTG
Motif Score	4.065041667
Cell/Tissue List	HepG2; A549; Huh7; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000415691.2; ENST00000316099.8; ENST00000619550.4; ENST00000372920.1
External Link	RMBase: m6A_site_532848
mod ID: M6ASITE053032		Click to Show/Hide the Full List
mod site	chr20:44430413-44430414:+		[2]
Sequence	AAGGCCTTCAACCCGAGAAAACAAACCCAGGTTGGCGACTG
Motif Score	2.20572619
Cell/Tissue List	HepG2; A549; H1B; Huh7; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000316099.8; ENST00000415691.2; ENST00000372920.1; ENST00000619550.4
External Link	RMBase: m6A_site_532849
mod ID: M6ASITE053033		Click to Show/Hide the Full List
mod site	chr20:44430430-44430431:+		[1]
Sequence	AAAACAAACCCAGGTTGGCGACTGCAACAGGAACTTGGAGT
Motif Score	3.287565476
Cell/Tissue List	A549
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000619550.4; ENST00000372920.1; ENST00000316099.8; ENST00000415691.2
External Link	RMBase: m6A_site_532850
mod ID: M6ASITE053034		Click to Show/Hide the Full List
mod site	chr20:44430442-44430443:+		[2]
Sequence	GGTTGGCGACTGCAACAGGAACTTGGAGTGGAGAGGAAAAG
Motif Score	3.373380952
Cell/Tissue List	HepG2; A549; H1B; Huh7; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000316099.8; ENST00000415691.2; ENST00000619550.4; ENST00000372920.1
External Link	RMBase: m6A_site_532851
mod ID: M6ASITE053035		Click to Show/Hide the Full List
mod site	chr20:44430479-44430480:+		[2]
Sequence	AAAGCATCAGAAAGAGGCAGACCATCCACCAGGCCTTTGAG
Motif Score	2.876744048
Cell/Tissue List	HepG2; A549; H1B; Huh7; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000372920.1; ENST00000619550.4; ENST00000415691.2; ENST00000316099.8
External Link	RMBase: m6A_site_532852
mod ID: M6ASITE053036		Click to Show/Hide the Full List
mod site	chr20:44430539-44430540:+		[2]
Sequence	GGTAGAGCAGGTGAGATGGGACATTCCAAAGAACAGCCTGA
Motif Score	3.643047619
Cell/Tissue List	HepG2; kidney; liver; A549; Huh7; endometrial; HEC-1-A
Seq Type List	m6A-seq; m6A-REF-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000372920.1; ENST00000316099.8; ENST00000619550.4
External Link	RMBase: m6A_site_532853
mod ID: M6ASITE053037		Click to Show/Hide the Full List
mod site	chr20:44430551-44430552:+		[2]
Sequence	GAGATGGGACATTCCAAAGAACAGCCTGAGCCAAGGCCTAG
Motif Score	2.951386905
Cell/Tissue List	HepG2; A549; Huh7; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000619550.4; ENST00000372920.1; ENST00000316099.8
External Link	RMBase: m6A_site_532854
mod ID: M6ASITE053038		Click to Show/Hide the Full List
mod site	chr20:44430665-44430666:+		[7]
Sequence	TGGAGAGCATAGGGTCTGGAACACCAGGCTGAGGTCCTGAT
Motif Score	2.951386905
Cell/Tissue List	HepG2; A549; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000316099.8; ENST00000372920.1; ENST00000619550.4
External Link	RMBase: m6A_site_532855
mod ID: M6ASITE053039		Click to Show/Hide the Full List
mod site	chr20:44430729-44430730:+		[7]
Sequence	GCTGGGCTTCCAGAAAATGAACACAGCAGTTCTGCAGAGGA
Motif Score	2.951386905
Cell/Tissue List	HepG2; A549; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000619550.4; ENST00000372920.1; ENST00000316099.8
External Link	RMBase: m6A_site_532856
mod ID: M6ASITE053040		Click to Show/Hide the Full List
mod site	chr20:44430830-44430831:+		[7]
Sequence	GAGGCTTGGGGCTGGAGAGGACAAGATGGGTAAACCCTCAC
Motif Score	3.643047619
Cell/Tissue List	HepG2; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000372920.1; ENST00000316099.8; ENST00000619550.4
External Link	RMBase: m6A_site_532857
mod ID: M6ASITE053041		Click to Show/Hide the Full List
mod site	chr20:44430843-44430844:+		[7]
Sequence	GGAGAGGACAAGATGGGTAAACCCTCACATCAGAGTGACAT
Motif Score	2.185083333
Cell/Tissue List	HepG2; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000619550.4; ENST00000316099.8; ENST00000372920.1
External Link	RMBase: m6A_site_532858
mod ID: M6ASITE053042		Click to Show/Hide the Full List
mod site	chr20:44431058-44431059:+		[4]
Sequence	CTCCTAACCTAGAGATTGTTACAGAAGCTGAAATTGCGTTC
Motif Score	2.07285119
Cell/Tissue List	liver
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000372920.1; ENST00000619550.4; ENST00000316099.8
External Link	RMBase: m6A_site_532859
mod ID: M6ASITE053043		Click to Show/Hide the Full List
mod site	chr20:44431107-44431108:+		[8]
Sequence	GAAGTGATTTTTTTTCTGAAACTCACACAACTAGGAAGTGG
Motif Score	2.627720238
Cell/Tissue List	A549; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000316099.8; ENST00000619550.4; ENST00000372920.1
External Link	RMBase: m6A_site_532860
mod ID: M6ASITE053044		Click to Show/Hide the Full List
mod site	chr20:44431138-44431139:+		[8]
Sequence	TAGGAAGTGGCTGAGTCAGGACTTGAACCCAGGTCTCCCTG
Motif Score	4.065041667
Cell/Tissue List	A549; Huh7
Seq Type List	m6A-seq; m6A-CLIP/IP; MeRIP-seq
Transcript ID List	ENST00000372920.1; ENST00000316099.8; ENST00000619550.4
External Link	RMBase: m6A_site_532861
mod ID: M6ASITE053045		Click to Show/Hide the Full List
mod site	chr20:44431144-44431145:+		[8]
Sequence	GTGGCTGAGTCAGGACTTGAACCCAGGTCTCCCTGGATCAG
Motif Score	2.930744048
Cell/Tissue List	A549; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000372920.1; ENST00000619550.4; ENST00000316099.8
External Link	RMBase: m6A_site_532862
mod ID: M6ASITE053046		Click to Show/Hide the Full List
mod site	chr20:44431166-44431167:+		[4]
Sequence	CCAGGTCTCCCTGGATCAGAACAGGAGCTCTTAACTACAGT
Motif Score	2.951386905
Cell/Tissue List	kidney; A549; Huh7
Seq Type List	m6A-REF-seq; MeRIP-seq; m6A-seq
Transcript ID List	ENST00000316099.8; ENST00000619550.4; ENST00000372920.1
External Link	RMBase: m6A_site_532863
mod ID: M6ASITE053047		Click to Show/Hide the Full List
mod site	chr20:44431271-44431272:+		[9]
Sequence	TCCCTTCTACAGCCTCAGAAACCAGACTCGTTCTTCTGGGA
Motif Score	2.185083333
Cell/Tissue List	A549; Huh7
Seq Type List	MeRIP-seq; m6A-seq; m6A-CLIP/IP
Transcript ID List	ENST00000316099.8; ENST00000619550.4; ENST00000372920.1
External Link	RMBase: m6A_site_532864
mod ID: M6ASITE053048		Click to Show/Hide the Full List
mod site	chr20:44431276-44431277:+		[9]
Sequence	TCTACAGCCTCAGAAACCAGACTCGTTCTTCTGGGAACCCT
Motif Score	3.319380952
Cell/Tissue List	A549; Huh7
Seq Type List	MeRIP-seq; m6A-seq; m6A-CLIP/IP
Transcript ID List	ENST00000316099.8; ENST00000372920.1; ENST00000619550.4
External Link	RMBase: m6A_site_532865
mod ID: M6ASITE053049		Click to Show/Hide the Full List
mod site	chr20:44431292-44431293:+		[9]
Sequence	CCAGACTCGTTCTTCTGGGAACCCTGCCCACTCCCAGGACC
Motif Score	2.930744048
Cell/Tissue List	A549; Huh7
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000619550.4; ENST00000316099.8; ENST00000372920.1
External Link	RMBase: m6A_site_532866
mod ID: M6ASITE053050		Click to Show/Hide the Full List
mod site	chr20:44431310-44431311:+		[9]
Sequence	GAACCCTGCCCACTCCCAGGACCAAGATTGGCCTGAGGCTG
Motif Score	3.622404762
Cell/Tissue List	A549; Huh7
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000316099.8; ENST00000619550.4; ENST00000372920.1
External Link	RMBase: m6A_site_532867
mod ID: M6ASITE053051		Click to Show/Hide the Full List
mod site	chr20:44431392-44431393:+		[1]
Sequence	AATATTAAGGAGAATTCATGACTCTTGACAGCTTTTCTCTC
Motif Score	3.28175
Cell/Tissue List	A549
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000316099.8; ENST00000619550.4
External Link	RMBase: m6A_site_532868
mod ID: M6ASITE053052		Click to Show/Hide the Full List
mod site	chr20:44431497-44431498:+		[9]
Sequence	CCTGTTGGCATGGGGGTGGGACAGTGTGCACAGTGTGGGGG
Motif Score	3.643047619
Cell/Tissue List	A549; Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000619550.4; ENST00000316099.8
External Link	RMBase: m6A_site_532869
mod ID: M6ASITE053053		Click to Show/Hide the Full List
mod site	chr20:44431562-44431563:+		[2]
Sequence	GTTTGAGGGCTGCTCCGGAGACCGTCACTCCAGGTGCATTC
Motif Score	2.876744048
Cell/Tissue List	HepG2; A549; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000619550.4; ENST00000316099.8
External Link	RMBase: m6A_site_532870
mod ID: M6ASITE053054		Click to Show/Hide the Full List
mod site	chr20:44431595-44431596:+		[2]
Sequence	GTGCATTCTGGAAGCATTAGACCCCAGGATGGAGCGACCAG
Motif Score	2.876744048
Cell/Tissue List	HepG2; A549; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000316099.8; ENST00000619550.4
External Link	RMBase: m6A_site_532871
mod ID: M6ASITE053055		Click to Show/Hide the Full List
mod site	chr20:44431651-44431652:+		[2]
Sequence	GAATCTTGGTGGCTTTGAGGACATTCTGGAAAATGCCACTG
Motif Score	3.643047619
Cell/Tissue List	HepG2; A549; Huh7; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000619550.4; ENST00000316099.8
External Link	RMBase: m6A_site_532872
mod ID: M6ASITE053056		Click to Show/Hide the Full List
mod site	chr20:44431672-44431673:+		[1]
Sequence	CATTCTGGAAAATGCCACTGACCAGTGTGAACAAAAGGGAT
Motif Score	2.839113095
Cell/Tissue List	A549
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000316099.8; ENST00000619550.4
External Link	RMBase: m6A_site_532873
mod ID: M6ASITE053057		Click to Show/Hide the Full List
mod site	chr20:44431682-44431683:+		[2]
Sequence	AATGCCACTGACCAGTGTGAACAAAAGGGATGTGTTATGGG
Motif Score	2.951386905
Cell/Tissue List	HepG2; A549; Huh7; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000619550.4; ENST00000316099.8
External Link	RMBase: m6A_site_532874
mod ID: M6ASITE053058		Click to Show/Hide the Full List
mod site	chr20:44431731-44431732:+		[2]
Sequence	TGTGATTAGGTAGGAGGGAAACTGTTGGACCGACTCCTGCC
Motif Score	2.627720238
Cell/Tissue List	HepG2; A549; Huh7; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000619550.4; ENST00000316099.8
External Link	RMBase: m6A_site_532875
mod ID: M6ASITE053059		Click to Show/Hide the Full List
mod site	chr20:44431739-44431740:+		[2]
Sequence	GGTAGGAGGGAAACTGTTGGACCGACTCCTGCCCCCTGCTC
Motif Score	3.622404762
Cell/Tissue List	HepG2; A549; Huh7; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000316099.8; ENST00000619550.4
External Link	RMBase: m6A_site_532876
mod ID: M6ASITE053060		Click to Show/Hide the Full List
mod site	chr20:44431930-44431931:+		[6]
Sequence	AGCCCCCAATCCCAGCGGAGACTGTGCCCTGCTCAGAGCTC
Motif Score	3.319380952
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000619550.4; ENST00000316099.8
External Link	RMBase: m6A_site_532877
mod ID: M6ASITE053061		Click to Show/Hide the Full List
mod site	chr20:44432408-44432409:+		[1]
Sequence	TAAAACATAAAATCTGATGGACAAACAGAGGGTTGCTGGGG
Motif Score	3.643047619
Cell/Tissue List	A549
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000619550.4; ENST00000316099.8
External Link	RMBase: m6A_site_532878
mod ID: M6ASITE053062		Click to Show/Hide the Full List
mod site	chr20:44432460-44432461:+		[8]
Sequence	GGCACAATTTCCCCACCAAGACACCCTGATCTTCAGGCGGG
Motif Score	2.897386905
Cell/Tissue List	A549
Seq Type List	m6A-seq
Transcript ID List	ENST00000619550.4; ENST00000316099.8
External Link	RMBase: m6A_site_532879

2'-O-Methylation (2'-O-Me)

In total 1 m6A sequence/site(s) in this target gene
mod ID: 2OMSITE000260		Click to Show/Hide the Full List
mod site	chr20:44432710-44432711:+		[10]
Sequence	TCTTTCTGTGGGTGTGAATGTCATTAGGTCTTGCGCTGACC
Cell/Tissue List	HeLa
Seq Type List	Nm-seq
Transcript ID List	ENST00000316099.8; ENST00000619550.4
External Link	RMBase: Nm_site_3532

Ref 1	A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation. Genes Dev. 2015 Oct 1;29(19):2037-53. doi: 10.1101/gad.269415.115. Epub 2015 Sep 24.
Ref 2	Histone H3 trimethylation at lysine 36 guides m(6)A RNA modification co-transcriptionally. Nature. 2019 Mar;567(7748):414-419. doi: 10.1038/s41586-019-1016-7. Epub 2019 Mar 13.
Ref 3	[Action myoclonias and paranoid alternative psychosis in progressive myoclonic epilepsy (late form of the Lafora type)]. Nervenarzt. 1986 Apr;57(4):233-7.
Ref 4	Single-base mapping of m(6)A by an antibody-independent method. Sci Adv. 2019 Jul 3;5(7):eaax0250. doi: 10.1126/sciadv.aax0250. eCollection 2019 Jul.
Ref 5	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 6	N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection. Cell Host Microbe. 2016 Nov 9;20(5):654-665. doi: 10.1016/j.chom.2016.09.015. Epub 2016 Oct 20.
Ref 7	Efficacy of MEK inhibition in patients with histiocytic neoplasms. Nature. 2019 Mar;567(7749):521-524. doi: 10.1038/s41586-019-1012-y. Epub 2019 Mar 13.
Ref 8	Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites. Cell Rep. 2014 Jul 10;8(1):284-96. doi: 10.1016/j.celrep.2014.05.048. Epub 2014 Jun 26.
Ref 9	Viral N(6)-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus. Nat Commun. 2019 Oct 9;10(1):4595. doi: 10.1038/s41467-019-12504-y.
Ref 10	Nm-seq maps 2'-O-methylation sites in human mRNA with base precision. Nat Methods. 2017 Jul;14(7):695-698. doi: 10.1038/nmeth.4294. Epub 2017 May 15.

Epigenetic Target Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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