Epigenetic Target Information

General Information of the Epigenetic Target (ID: EPITAR00088)
Target Name Cytochrome P450 2B6 (CYP2B6)
Synonyms
EC 1.14.13.-; 1,4-cineole 2-exo-monooxygenase; CYPIIB6; Cytochrome P450 IIB1
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Gene Name CYP2B6
Sequence
MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR
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Family Cytochrome P450 family
Function
A cytochrome P450 monooxygenase involved in the metabolism of endocannabinoids and steroids (PubMed:21289075, PubMed:12865317). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the epoxidation of double bonds of arachidonoylethanolamide (anandamide) to 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling (PubMed:21289075). Hydroxylates steroid hormones, including testosterone at C-16 and estrogens at C-2 (PubMed:21289075, PubMed:12865317). Plays a role in the oxidative metabolism of xenobiotics, including plant lipids and drugs (PubMed:11695850, PubMed:22909231). Acts as a 1,4-cineole 2-exo-monooxygenase (PubMed:11695850).
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Gene ID 1555
HGNC ID HGNC:2615
Ensembl Gene ID ENSG00000197408
KEGG ID hsa:1555
Chromosomal Location 19q13.2
RNA Modification Sequencing Data Associated with the Target (ID: EPITAR00088)
Cytochrome P450 2B6 (CYP2B6)
N6-methyladenosine (m6A)
In total 28 m6A sequence/site(s) in this target gene
mod ID: M6ASITE041259 Click to Show/Hide the Full List
mod site chr19:40991341-40991342:+ [1]
Sequence TCCTCTTCCTTGCACTCCTCACAGGACTCTTGCTACTCCTG
Motif Score 2.047297619
Cell/Tissue List liver
Seq Type List m6A-REF-seq
Transcript ID List ENST00000324071.10
External Link RMBase: m6A_site_439997
mod ID: M6ASITE041260 Click to Show/Hide the Full List
mod site chr19:41009335-41009336:+ [2]
Sequence GTGTGGAGAAGCACCGTGAAACCCTGGACCCCAGCGCCCCC
Motif Score 2.185083333
Cell/Tissue List Huh7
Seq Type List MeRIP-seq
Transcript ID List ENST00000324071.10; ENST00000593831.1; ENST00000598834.2
External Link RMBase: m6A_site_439998
mod ID: M6ASITE041261 Click to Show/Hide the Full List
mod site chr19:41009342-41009343:+ [2]
Sequence GAAGCACCGTGAAACCCTGGACCCCAGCGCCCCCAAGGACC
Motif Score 3.622404762
Cell/Tissue List Huh7
Seq Type List MeRIP-seq
Transcript ID List ENST00000593831.1; ENST00000598834.2; ENST00000324071.10
External Link RMBase: m6A_site_439999
mod ID: M6ASITE041262 Click to Show/Hide the Full List
mod site chr19:41009360-41009361:+ [2]
Sequence GGACCCCAGCGCCCCCAAGGACCTCATCGACACCTACCTGC
Motif Score 3.622404762
Cell/Tissue List Huh7
Seq Type List MeRIP-seq
Transcript ID List ENST00000593831.1; ENST00000598834.2; ENST00000324071.10
External Link RMBase: m6A_site_440000
mod ID: M6ASITE041263 Click to Show/Hide the Full List
mod site chr19:41009692-41009693:+ [2]
Sequence GAAGGAATTCGGGGCAAGGGACAAAAATACAGCAACAAGAG
Motif Score 3.643047619
Cell/Tissue List Huh7
Seq Type List MeRIP-seq
Transcript ID List ENST00000598834.2; ENST00000597612.1; ENST00000324071.10; ENST00000593831.1
External Link RMBase: m6A_site_440001
mod ID: M6ASITE041264 Click to Show/Hide the Full List
mod site chr19:41009718-41009719:+ [2]
Sequence ATACAGCAACAAGAGAAAAAACTCACAGAGGCAGAAAGAGA
Motif Score 2.627720238
Cell/Tissue List Huh7
Seq Type List MeRIP-seq
Transcript ID List ENST00000598834.2; ENST00000593831.1; ENST00000324071.10; ENST00000597612.1
External Link RMBase: m6A_site_440002
mod ID: M6ASITE041265 Click to Show/Hide the Full List
mod site chr19:41009744-41009745:+ [2]
Sequence AGAGGCAGAAAGAGACGGGGACAAAAAGAGAGAAACACATC
Motif Score 3.643047619
Cell/Tissue List Huh7
Seq Type List MeRIP-seq
Transcript ID List ENST00000598834.2; ENST00000597612.1; ENST00000593831.1; ENST00000324071.10
External Link RMBase: m6A_site_440003
mod ID: M6ASITE041266 Click to Show/Hide the Full List
mod site chr19:41009758-41009759:+ [2]
Sequence ACGGGGACAAAAAGAGAGAAACACATCAAAGAGATGTGGAG
Motif Score 2.20572619
Cell/Tissue List Huh7
Seq Type List MeRIP-seq
Transcript ID List ENST00000593831.1; ENST00000324071.10; ENST00000598834.2; ENST00000597612.1
External Link RMBase: m6A_site_440004
mod ID: M6ASITE041267 Click to Show/Hide the Full List
mod site chr19:41009789-41009790:+ [2]
Sequence AGATGTGGAGAGAGATAGAAACAGAGTTAGGAAGACTAAAG
Motif Score 2.20572619
Cell/Tissue List Huh7
Seq Type List MeRIP-seq
Transcript ID List ENST00000597612.1; ENST00000593831.1; ENST00000598834.2; ENST00000324071.10
External Link RMBase: m6A_site_440005
mod ID: M6ASITE041268 Click to Show/Hide the Full List
mod site chr19:41009803-41009804:+ [2]
Sequence ATAGAAACAGAGTTAGGAAGACTAAAGAGAGGCTGAGAGAG
Motif Score 3.319380952
Cell/Tissue List Huh7
Seq Type List MeRIP-seq
Transcript ID List ENST00000598834.2; ENST00000593831.1; ENST00000324071.10; ENST00000597612.1
External Link RMBase: m6A_site_440006
mod ID: M6ASITE041269 Click to Show/Hide the Full List
mod site chr19:41009858-41009859:+ [2]
Sequence CGCGGTTGGATGTGTAGAGGACAGAGAAAAGCAAACTGGGC
Motif Score 3.643047619
Cell/Tissue List Huh7
Seq Type List MeRIP-seq
Transcript ID List ENST00000593831.1; ENST00000324071.10; ENST00000598834.2; ENST00000597612.1
External Link RMBase: m6A_site_440007
mod ID: M6ASITE041270 Click to Show/Hide the Full List
mod site chr19:41009872-41009873:+ [2]
Sequence TAGAGGACAGAGAAAAGCAAACTGGGCCAGATAGTGTCAAA
Motif Score 2.627720238
Cell/Tissue List Huh7
Seq Type List MeRIP-seq
Transcript ID List ENST00000598834.2; ENST00000597612.1; ENST00000593831.1; ENST00000324071.10
External Link RMBase: m6A_site_440008
mod ID: M6ASITE041271 Click to Show/Hide the Full List
mod site chr19:41009894-41009895:+ [2]
Sequence TGGGCCAGATAGTGTCAAAGACCTTTAGGCCAACGGAGGGC
Motif Score 2.876744048
Cell/Tissue List Huh7
Seq Type List MeRIP-seq
Transcript ID List ENST00000598834.2; ENST00000324071.10; ENST00000597612.1; ENST00000593831.1
External Link RMBase: m6A_site_440009
mod ID: M6ASITE041272 Click to Show/Hide the Full List
mod site chr19:41012306-41012307:+ [1]
Sequence TTTCTGTACAGAGAGAGTCTACAGGGAGATTGAACAGGTGA
Motif Score 2.078666667
Cell/Tissue List liver
Seq Type List m6A-REF-seq
Transcript ID List ENST00000598834.2; ENST00000324071.10; ENST00000593831.1; ENST00000597612.1
External Link RMBase: m6A_site_440010
mod ID: M6ASITE041273 Click to Show/Hide the Full List
mod site chr19:41012319-41012320:+ [2]
Sequence AGAGTCTACAGGGAGATTGAACAGGTGATTGGCCCACATCG
Motif Score 2.951386905
Cell/Tissue List Huh7
Seq Type List MeRIP-seq
Transcript ID List ENST00000324071.10; ENST00000593831.1; ENST00000597612.1; ENST00000598834.2
External Link RMBase: m6A_site_440011
mod ID: M6ASITE041274 Click to Show/Hide the Full List
mod site chr19:41012732-41012733:+ [2]
Sequence GACCCACACTACTTTGAAAAACCAGACGCCTTCAATCCTGA
Motif Score 2.185083333
Cell/Tissue List Huh7
Seq Type List MeRIP-seq
Transcript ID List ENST00000593831.1; ENST00000598834.2; ENST00000324071.10; ENST00000597612.1
External Link RMBase: m6A_site_440012
mod ID: M6ASITE041275 Click to Show/Hide the Full List
mod site chr19:41012787-41012788:+ [2]
Sequence CCAATGGGGCACTGAAAAAGACTGAAGCTTTTATCCCCTTC
Motif Score 3.319380952
Cell/Tissue List Huh7
Seq Type List MeRIP-seq
Transcript ID List ENST00000598834.2; ENST00000593831.1; ENST00000324071.10; ENST00000597612.1
External Link RMBase: m6A_site_440013
mod ID: M6ASITE041276 Click to Show/Hide the Full List
mod site chr19:41013023-41013024:+ [2]
Sequence GGCACATCTTGGCAAGCAGGACCTTGGGCAAGTATTTTAAC
Motif Score 3.622404762
Cell/Tissue List Huh7
Seq Type List MeRIP-seq
Transcript ID List ENST00000324071.10; ENST00000593831.1; ENST00000597612.1; ENST00000598834.2; rmsk_5000070
External Link RMBase: m6A_site_440014
mod ID: M6ASITE041277 Click to Show/Hide the Full List
mod site chr19:41016717-41016718:+ [2]
Sequence CTTCACCACCATCCTCCAGAACTTCTCCATGGCCAGCCCCG
Motif Score 3.373380952
Cell/Tissue List Huh7
Seq Type List MeRIP-seq
Transcript ID List ENST00000598834.2; ENST00000593831.1; ENST00000597612.1; ENST00000324071.10
External Link RMBase: m6A_site_440015
mod ID: M6ASITE041278 Click to Show/Hide the Full List
mod site chr19:41016750-41016751:+ [2]
Sequence CAGCCCCGTGGCCCCAGAAGACATCGATCTGACACCCCAGG
Motif Score 2.897386905
Cell/Tissue List Huh7
Seq Type List MeRIP-seq
Transcript ID List ENST00000593831.1; ENST00000597612.1; ENST00000324071.10; ENST00000598834.2
External Link RMBase: m6A_site_440016
mod ID: M6ASITE041279 Click to Show/Hide the Full List
mod site chr19:41016887-41016888:+ [3]
Sequence CAGTGTCCCCGCCTCTGTAGACAATGGCTCTGACTCCCCGC
Motif Score 2.897386905
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000597612.1; ENST00000324071.10; ENST00000593831.1; ENST00000598834.2
External Link RMBase: m6A_site_440017
mod ID: M6ASITE041280 Click to Show/Hide the Full List
mod site chr19:41016927-41016928:+ [3]
Sequence CAACTTCCTGCCTCTGAGAGACCTGCTACAAGCCAGCTTCC
Motif Score 2.876744048
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000598834.2; ENST00000593831.1; ENST00000597612.1; ENST00000324071.10
External Link RMBase: m6A_site_440018
mod ID: M6ASITE041281 Click to Show/Hide the Full List
mod site chr19:41016979-41016980:+ [1]
Sequence GGCACCAGTTGTCTGAGGTCACATTGCAAGTGAGTGCAGGA
Motif Score 2.047297619
Cell/Tissue List liver
Seq Type List m6A-REF-seq
Transcript ID List ENST00000324071.10; ENST00000598834.2; ENST00000593831.1; ENST00000597612.1
External Link RMBase: m6A_site_440019
mod ID: M6ASITE041282 Click to Show/Hide the Full List
mod site chr19:41017661-41017662:+ [2]
Sequence GTATTTTTAGGTGGTCTTGAACTCCTGATGTCAGGTGATTC
Motif Score 3.373380952
Cell/Tissue List Huh7
Seq Type List MeRIP-seq
Transcript ID List ENST00000324071.10; ENST00000597612.1
External Link RMBase: m6A_site_440020
mod ID: M6ASITE041283 Click to Show/Hide the Full List
mod site chr19:41017722-41017723:+ [2]
Sequence ATTATCTCTCCCCCAACAAAACCCATACCTATCAAGCTGTC
Motif Score 2.185083333
Cell/Tissue List Huh7
Seq Type List MeRIP-seq
Transcript ID List ENST00000597612.1; ENST00000324071.10
External Link RMBase: m6A_site_440021
mod ID: M6ASITE041284 Click to Show/Hide the Full List
mod site chr19:41017806-41017807:+ [2]
Sequence TCTGGTTTTTGTCACTATGGACTTACCAATTCTGAATATTT
Motif Score 4.065041667
Cell/Tissue List Huh7
Seq Type List MeRIP-seq
Transcript ID List ENST00000597612.1; ENST00000324071.10
External Link RMBase: m6A_site_440022
mod ID: M6ASITE041285 Click to Show/Hide the Full List
mod site chr19:41017834-41017835:+ [2]
Sequence ATTCTGAATATTTCCCATAAACAGAATCATACAATATTTGA
Motif Score 2.20572619
Cell/Tissue List Huh7
Seq Type List MeRIP-seq
Transcript ID List ENST00000324071.10; ENST00000597612.1
External Link RMBase: m6A_site_440023
mod ID: M6ASITE041286 Click to Show/Hide the Full List
mod site chr19:41017874-41017875:+ [2]
Sequence ATTTTTTTTTTTTTTTTGAAACTAAGCCTTGCTCTGTCTCC
Motif Score 2.627720238
Cell/Tissue List Huh7
Seq Type List MeRIP-seq
Transcript ID List ENST00000324071.10
External Link RMBase: m6A_site_440024