Epigenetic Target Information

General Information of the Epigenetic Target (ID: EPITAR00086)
Target Name Integrin subunit alpha 2 (ITGA2)
Synonyms
GPIa; VLAA2; HPA-5; CD49B; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
    Click to Show/Hide
Gene Name ITGA2
Sequence
MGPERTGAAPLPLLLVLALSQGILNCCLAYNVGLPEAKIFSGPSSEQFGYAVQQFINPKGNWLLVGSPWSGFPENRMGDVYKCPVDLSTATCEKLNLQTSTSIPNVTEMKTNMSLGLILTRNMGTGGFLTCGPLWAQQCGNQYYTTGVCSDISPDFQLSASFSPATQPCPSLIDVVVVCDESNSIYPWDAVKNFLEKFVQGLDIGPTKTQVGLIQYANNPRVVFNLNTYKTKEEMIVATSQTSQYGGDLTNTFGAIQYARKYAYSAASGGRRSATKVMVVVTDGESHDGSMLKAVIDQCNHDNILRFGIAVLGYLNRNALDTKNLIKEIKAIASIPTERYFFNVSDEAALLEKAGTLGEQIFSIEGTVQGGDNFQMEMSQVGFSADYSSQNDILMLGAVGAFGWSGTIVQKTSHGHLIFPKQAFDQILQDRNHSSYLGYSVAAISTGESTHFVAGAPRANYTGQIVLYSVNENGNITVIQAHRGDQIGSYFGSVLCSVDVDKDTITDVLLVGAPMYMSDLKKEEGRVYLFTIKEGILGQHQFLEGPEGIENTRFGSAIAALSDINMDGFNDVIVGSPLENQNSGAVYIYNGHQGTIRTKYSQKILGSDGAFRSHLQYFGRSLDGYGDLNGDSITDVSIGAFGQVVQLWSQSIADVAIEASFTPEKITLVNKNAQIILKLCFSAKFRPTKQNNQVAIVYNITLDADGFSSRVTSRGLFKENNERCLQKNMVVNQAQSCPEHIIYIQEPSDVVNSLDLRVDISLENPGTSPALEAYSETAKVFSIPFHKDCGEDGLCISDLVLDVRQIPAAQEQPFIVSNQNKRLTFSVTLKNKRESAYNTGIVVDFSENLFFASFSLPVDGTEVTCQVAASQKSVACDVGYPALKREQQVTFTINFDFNLQNLQNQASLSFQALSESQEENKADNLVNLKIPLLYDAEIHLTRSTNINFYEISSDGNVPSIVHSFEDVGPKFIFSLKVTTGSVPVSMATVIIHIPQYTKEKNPLMYLTGVQTDKAGDISCNADINPLKIGQTSSSVSFKSENFRHTKELNCRTASCSNVTCWLKDVHMKGEYFVNVTTRIWNGTFASSTFQTVQLTAAAEINTYNPEIYVIEDNTVTIPLMIMKPDEKAEVPTGVIIGSIIAGILLLLALVAILWKLGFFKRKYEKMTKNPDEIDETTELSS
    Click to Show/Hide
Family Integrin alpha chain family
Function
Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.
    Click to Show/Hide
Gene ID 3673
HGNC ID HGNC:6137
Ensembl Gene ID ENSG00000164171
KEGG ID hsa:3673
Chromosomal Location 5q11.2
RNA Modification Sequencing Data Associated with the Target (ID: EPITAR00086)
Integrin subunit alpha 2 (ITGA2)
Adenosine-to-Inosine editing (A-to-I)
In total 2 m6A sequence/site(s) in this target gene
mod ID: A2ISITE000654 Click to Show/Hide the Full List
mod site chr5:53093476-53093477:+ [1]
Sequence TAGGACAGCAGCCCTGTCCTAGAAGGTATGTTTAGCAGCAT
Transcript ID List ENST00000296585.10
External Link RMBase: RNA-editing_site_108926
mod ID: A2ISITE000655 Click to Show/Hide the Full List
mod site chr5:53093984-53093985:+ [1]
Sequence TTAAAACTGTGAAGAGTAAAACTAAAGCCAATTTATTATAG
Transcript ID List ENST00000296585.10
External Link RMBase: RNA-editing_site_108927
N6-methyladenosine (m6A)
In total 32 m6A sequence/site(s) in this target gene
mod ID: M6ASITE069136 Click to Show/Hide the Full List
mod site chr5:52989366-52989367:+ [2]
Sequence GGGGGAGAGAAGCCCTCTGGACAGCTTCTAGAGTGTGCAGG
Motif Score 3.643047619
Cell/Tissue List MSC; TIME
Seq Type List MeRIP-seq
Transcript ID List ENST00000503810.6; ENST00000296585.10
External Link RMBase: m6A_site_668280
mod ID: M6ASITE069137 Click to Show/Hide the Full List
mod site chr5:52989422-52989423:+ [3]
Sequence GCCAAGGGTATCCTCTGCAAACCTCTGCAAACCCAGCGCAA
Motif Score 2.185083333
Cell/Tissue List HeLa; MSC; TIME
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000503810.6; ENST00000296585.10
External Link RMBase: m6A_site_668281
mod ID: M6ASITE069138 Click to Show/Hide the Full List
mod site chr5:52989432-52989433:+ [3]
Sequence TCCTCTGCAAACCTCTGCAAACCCAGCGCAACTACGGTCCC
Motif Score 2.185083333
Cell/Tissue List HeLa; MSC; TIME
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000296585.10; ENST00000503810.6
External Link RMBase: m6A_site_668282
mod ID: M6ASITE069139 Click to Show/Hide the Full List
mod site chr5:52989461-52989462:+ [3]
Sequence AACTACGGTCCCCCGGTCAGACCCAGGATGGGGCCAGAACG
Motif Score 2.876744048
Cell/Tissue List HeLa; TIME
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000510722.1; ENST00000509960.5; ENST00000513685.5; ENST00000296585.10; ENST00000509814.5; ENST00000503810.6
External Link RMBase: m6A_site_668283
mod ID: M6ASITE069140 Click to Show/Hide the Full List
mod site chr5:52989483-52989484:+ [3]
Sequence CCAGGATGGGGCCAGAACGGACAGGGGCCGCGCCGCTGCCG
Motif Score 3.643047619
Cell/Tissue List HeLa; TIME
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000513685.5; ENST00000509814.5; ENST00000510722.1; ENST00000509960.5; ENST00000296585.10; ENST00000503810.6
External Link RMBase: m6A_site_668284
mod ID: M6ASITE069141 Click to Show/Hide the Full List
mod site chr5:53045035-53045036:+ [3]
Sequence CAAATGTTACTGAGATGAAAACCAACATGAGCCTCGGCTTG
Motif Score 2.185083333
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000509814.5; ENST00000503810.6; ENST00000509960.5; ENST00000513685.5; ENST00000510722.1; ENST00000296585.10
External Link RMBase: m6A_site_668285
mod ID: M6ASITE069142 Click to Show/Hide the Full List
mod site chr5:53045069-53045070:+ [3]
Sequence CGGCTTGATCCTCACCAGGAACATGGGAACTGGAGGTTTTC
Motif Score 2.951386905
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000510722.1; ENST00000509960.5; ENST00000296585.10; ENST00000513685.5; ENST00000509814.5; ENST00000503810.6
External Link RMBase: m6A_site_668286
mod ID: M6ASITE069143 Click to Show/Hide the Full List
mod site chr5:53045077-53045078:+ [3]
Sequence TCCTCACCAGGAACATGGGAACTGGAGGTTTTCTCGTGAGT
Motif Score 3.373380952
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000510722.1; ENST00000509960.5; ENST00000509814.5; ENST00000296585.10; ENST00000503810.6; ENST00000513685.5
External Link RMBase: m6A_site_668287
mod ID: M6ASITE069144 Click to Show/Hide the Full List
mod site chr5:53055999-53056000:+ [3]
Sequence CAAGGTTCTTGGGTACTTAAACAGAAACGCCCTTGATACTA
Motif Score 2.20572619
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000510722.1; ENST00000509814.5; ENST00000296585.10; ENST00000509960.5; ENST00000503810.6; ENST00000513685.5
External Link RMBase: m6A_site_668288
mod ID: M6ASITE069145 Click to Show/Hide the Full List
mod site chr5:53056118-53056119:+ [3]
Sequence CTCTACTAGAAAAGGCTGGGACATTAGGAGAACAAATTTTC
Motif Score 3.643047619
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000296585.10; ENST00000503810.6; ENST00000509814.5; ENST00000513685.5; ENST00000509960.5; ENST00000510722.1
External Link RMBase: m6A_site_668289
mod ID: M6ASITE069146 Click to Show/Hide the Full List
mod site chr5:53056129-53056130:+ [3]
Sequence AAGGCTGGGACATTAGGAGAACAAATTTTCAGCATTGAAGG
Motif Score 2.951386905
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000509814.5; ENST00000510722.1; ENST00000509960.5; ENST00000296585.10; ENST00000503810.6; ENST00000513685.5
External Link RMBase: m6A_site_668290
mod ID: M6ASITE069147 Click to Show/Hide the Full List
mod site chr5:53058042-53058043:+ [3]
Sequence AGGTACTGTTCAAGGAGGAGACAACTTTCAGATGGAAATGT
Motif Score 2.897386905
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000503810.6; ENST00000509814.5; ENST00000296585.10; ENST00000510722.1; ENST00000513685.5; ENST00000509960.5
External Link RMBase: m6A_site_668291
mod ID: M6ASITE069148 Click to Show/Hide the Full List
mod site chr5:53062834-53062835:+ [3]
Sequence TTCAGTTGATGTGGATAAAGACACCATTACAGACGTGCTCT
Motif Score 2.897386905
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000503810.6; ENST00000509960.5; ENST00000509814.5; ENST00000513685.5; ENST00000296585.10; ENST00000510722.1
External Link RMBase: m6A_site_668292
mod ID: M6ASITE069149 Click to Show/Hide the Full List
mod site chr5:53065826-53065827:+ [3]
Sequence GTACTATAATTTCGTGTCAAACCTGCTCTTTTAGAAAATCT
Motif Score 2.185083333
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000509960.5; ENST00000503810.6; ENST00000510722.1; ENST00000513685.5; ENST00000296585.10; ENST00000509814.5
External Link RMBase: m6A_site_668293
mod ID: M6ASITE069150 Click to Show/Hide the Full List
mod site chr5:53070183-53070184:+ [3]
Sequence CAGGGGGTTATTTAAAGAAAACAATGAAAGGTGCCTGCAGA
Motif Score 2.20572619
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000503810.6; ENST00000509960.5; ENST00000509814.5; ENST00000510722.1; ENST00000513685.5; ENST00000296585.10
External Link RMBase: m6A_site_668294
mod ID: M6ASITE069151 Click to Show/Hide the Full List
mod site chr5:53071977-53071978:+ [3]
Sequence CTCTTTGGATTTGCGTGTGGACATCAGTCTGGAAAACCCTG
Motif Score 3.643047619
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000513685.5; ENST00000503810.6; ENST00000509814.5; ENST00000510722.1; ENST00000509960.5; ENST00000296585.10
External Link RMBase: m6A_site_668295
mod ID: M6ASITE069152 Click to Show/Hide the Full List
mod site chr5:53071992-53071993:+ [3]
Sequence TGTGGACATCAGTCTGGAAAACCCTGGCACTAGCCCTGCCC
Motif Score 2.185083333
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000509960.5; ENST00000510722.1; ENST00000296585.10; ENST00000503810.6; ENST00000509814.5; ENST00000513685.5
External Link RMBase: m6A_site_668296
mod ID: M6ASITE069153 Click to Show/Hide the Full List
mod site chr5:53073230-53073231:+ [3]
Sequence TGTTGTTGATTTTTCAGAAAACTTGTTTTTTGCATCATTCT
Motif Score 2.627720238
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000509960.5; ENST00000503810.6; ENST00000510722.1; ENST00000513685.5; ENST00000509814.5; ENST00000296585.10
External Link RMBase: m6A_site_668297
mod ID: M6ASITE069154 Click to Show/Hide the Full List
mod site chr5:53074393-53074394:+ [3]
Sequence GTCTTGTTCAGGTTGATGGGACAGAAGTAACATGCCAGGTG
Motif Score 3.643047619
Cell/Tissue List HeLa; kidney
Seq Type List m6A-seq; m6A-REF-seq
Transcript ID List ENST00000296585.10; ENST00000509814.5; ENST00000513685.5; ENST00000503810.6; ENST00000510722.1; ENST00000509960.5
External Link RMBase: m6A_site_668298
mod ID: M6ASITE069155 Click to Show/Hide the Full List
mod site chr5:53074470-53074471:+ [3]
Sequence TACCCTGCTTTAAAGAGAGAACAACAGGTACAACTTGCATT
Motif Score 2.951386905
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000509960.5; ENST00000509814.5; ENST00000513685.5; ENST00000296585.10; ENST00000510722.1; ENST00000503810.6
External Link RMBase: m6A_site_668299
mod ID: M6ASITE069156 Click to Show/Hide the Full List
mod site chr5:53075097-53075098:+ [3]
Sequence CTTTGACTTCAATCTTCAAAACCTTCAGAATCAGGCGTCTC
Motif Score 2.185083333
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000510722.1; ENST00000509960.5; ENST00000513685.5; ENST00000509814.5; ENST00000296585.10; ENST00000503810.6
External Link RMBase: m6A_site_668300
mod ID: M6ASITE069157 Click to Show/Hide the Full List
mod site chr5:53075237-53075238:+ [3]
Sequence TAGTGAAAGCCAAGAAGAAAACAAGGCTGATAATTTGGTCA
Motif Score 2.20572619
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000509960.5; ENST00000509814.5; ENST00000503810.6; ENST00000510722.1; ENST00000513685.5; ENST00000296585.10
External Link RMBase: m6A_site_668301
mod ID: M6ASITE069158 Click to Show/Hide the Full List
mod site chr5:53083348-53083349:+ [3]
Sequence AATACTATAAGAACTGCAGAACTGCTTCCTGTAGTAATGTT
Motif Score 3.373380952
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000509814.5; ENST00000510722.1; ENST00000513685.5; ENST00000509960.5; ENST00000296585.10; ENST00000503810.6
External Link RMBase: m6A_site_668302
mod ID: M6ASITE069159 Click to Show/Hide the Full List
mod site chr5:53083441-53083442:+ [3]
Sequence CTACCAGAATTTGGAACGGGACTTTCGCATCAGTAAGTATC
Motif Score 4.065041667
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000509960.5; ENST00000503810.6; ENST00000296585.10; ENST00000513685.5; ENST00000509814.5; ENST00000510722.1
External Link RMBase: m6A_site_668303
mod ID: M6ASITE069160 Click to Show/Hide the Full List
mod site chr5:53086963-53086964:+ [3]
Sequence TGTTCCAGTCAACGTTCCAGACAGTACAGCTAACGGCAGCT
Motif Score 2.897386905
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000513685.5; ENST00000510722.1; ENST00000503810.6; ENST00000509814.5; ENST00000509960.5; ENST00000296585.10
External Link RMBase: m6A_site_668304
mod ID: M6ASITE069161 Click to Show/Hide the Full List
mod site chr5:53089965-53089966:+ [3]
Sequence ATTCCCCTGATGATAATGAAACCTGATGAGAAAGCCGAAGT
Motif Score 2.185083333
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000510722.1; ENST00000503810.6; ENST00000509960.5; ENST00000509814.5; ENST00000296585.10; ENST00000513685.5
External Link RMBase: m6A_site_668305
mod ID: M6ASITE069162 Click to Show/Hide the Full List
mod site chr5:53091539-53091540:+ [3]
Sequence CCTTCCTCCTCCCTTACTGAACCACTCTCCCACCTCCTGGT
Motif Score 2.930744048
Cell/Tissue List HeLa; Huh7
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000296585.10
External Link RMBase: m6A_site_668306
mod ID: M6ASITE069163 Click to Show/Hide the Full List
mod site chr5:53091661-53091662:+ [4]
Sequence AAAGTTCCCACTCCTTCAGGACAGCTGCTGTGCATTAGATA
Motif Score 3.643047619
Cell/Tissue List Huh7
Seq Type List MeRIP-seq
Transcript ID List ENST00000296585.10
External Link RMBase: m6A_site_668307
mod ID: M6ASITE069164 Click to Show/Hide the Full List
mod site chr5:53092080-53092081:+ [3]
Sequence AGTCACTAGGATGCAGATGGACCACACTTTGAGAAACACCA
Motif Score 3.622404762
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000296585.10
External Link RMBase: m6A_site_668308
mod ID: M6ASITE069165 Click to Show/Hide the Full List
mod site chr5:53092095-53092096:+ [3]
Sequence GATGGACCACACTTTGAGAAACACCACCCATTTCTACTTTT
Motif Score 2.20572619
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000296585.10
External Link RMBase: m6A_site_668309
mod ID: M6ASITE069166 Click to Show/Hide the Full List
mod site chr5:53093259-53093260:+ [3]
Sequence GCTAAACATACATATACGGAACTTGAAAGCTTTGGTTAGCC
Motif Score 3.373380952
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000296585.10
External Link RMBase: m6A_site_668310
mod ID: M6ASITE069167 Click to Show/Hide the Full List
mod site chr5:53093795-53093796:+ [3]
Sequence GTCTATAGAATGTGGTAAAAACTTGACTGCAACACAAGGCT
Motif Score 2.627720238
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000296585.10
External Link RMBase: m6A_site_668311