Epigenetic Target Information

General Information of the Epigenetic Target (ID: EPITAR00075)

Target Name	Thiol methyltransferase 1A (TMT1A)
Synonyms	DKFZP586A0522; METTL7A; methyltransferase like 7A Click to Show/Hide
Gene Name	TMT1A
Sequence	MELTIFILRLAIYILTFPLYLLNFLGLWSWICKKWFPYFLVRFTVIYNEQMASKKRELFSNLQEFAGPSGKLSLLEVGCGTGANFKFYPPGCRVTCIDPNPNFEKFLIKSIAENRHLQFERFVVAAGENMHQVADGSVDVVVCTLVLCSVKNQERILREVCRVLRPGGAFYFMEHVAAECSTWNYFWQQVLDPAWHLLFDGCNLTRESWKALERASFSKLKLQHIQAPLSWELVRPHIYGYAVK Click to Show/Hide
Family	Methyltransferase superfamily
Function	Thiol S-methyltransferase that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to alkyl and phenolic thiol-containing acceptor substrates. Together with TMT1B accounts for most of S-thiol methylation activity in the endoplasmic reticulum of hepatocytes (PubMed:37137720). Able to methylate the N6 position of adenosine residues in long non-coding RNAs (lncRNAs) (PubMed:34980213). May facilitate lncRNAs transfer into exosomes at the tumor-stroma interface (PubMed:34980213). Promotes osteogenic and odontogenic differentiation by regulating the expression of genes involved in stem cell differentiation and survival (PubMed:34226523, PubMed:34790668). Targeted from the endoplasmic reticulum to lipid droplets, where it recruits cellular proteins to form functional organelles (PubMed:19773358). Click to Show/Hide
Gene ID	25840
HGNC ID	HGNC:24550
Ensembl Gene ID	ENSG00000185432
KEGG ID	hsa:25840
Chromosomal Location	12q13.12

RNA Modification Sequencing Data Associated with the Target (ID: EPITAR00075)

Thiol methyltransferase 1A (TMT1A)

Adenosine-to-Inosine editing (A-to-I)

In total 45 m6A sequence/site(s) in this target gene
mod ID: A2ISITE005530		Click to Show/Hide the Full List
mod site	chr12:50930297-50930298:+		[1]
Sequence	TTTTTTTTTTTTTGGCGGGAAGAAAGAGTTTTGCTCTTGTT
Transcript ID List	ENST00000548553.1; ENST00000550097.1; ENST00000547104.1; ENST00000332160.5
External Link	RMBase: RNA-editing_site_28487
mod ID: A2ISITE005531		Click to Show/Hide the Full List
mod site	chr12:50930300-50930301:+		[2]
Sequence	TTTTTTTTTTGGCGGGAAGAAAGAGTTTTGCTCTTGTTGCC
Transcript ID List	ENST00000547104.1; ENST00000550097.1; ENST00000548553.1; ENST00000332160.5
External Link	RMBase: RNA-editing_site_28488
mod ID: A2ISITE005532		Click to Show/Hide the Full List
mod site	chr12:50930301-50930302:+		[2]
Sequence	TTTTTTTTTGGCGGGAAGAAAGAGTTTTGCTCTTGTTGCCC
Transcript ID List	ENST00000550097.1; ENST00000332160.5; ENST00000547104.1; ENST00000548553.1
External Link	RMBase: RNA-editing_site_28489
mod ID: A2ISITE005533		Click to Show/Hide the Full List
mod site	chr12:50930335-50930336:+		[2]
Sequence	GTTGCCCAGGCTGGAGTGCAATGACGTGATCTCCGCTCACT
Transcript ID List	ENST00000547104.1; ENST00000332160.5; ENST00000548553.1; ENST00000550097.1
External Link	RMBase: RNA-editing_site_28490
mod ID: A2ISITE005534		Click to Show/Hide the Full List
mod site	chr12:50930338-50930339:+		[2]
Sequence	GCCCAGGCTGGAGTGCAATGACGTGATCTCCGCTCACTGCA
Transcript ID List	ENST00000332160.5; ENST00000550097.1; ENST00000547104.1; ENST00000548553.1
External Link	RMBase: RNA-editing_site_28491
mod ID: A2ISITE005535		Click to Show/Hide the Full List
mod site	chr12:50930343-50930344:+		[2]
Sequence	GGCTGGAGTGCAATGACGTGATCTCCGCTCACTGCAACCTC
Transcript ID List	ENST00000547104.1; ENST00000332160.5; ENST00000550097.1; ENST00000548553.1
External Link	RMBase: RNA-editing_site_28492
mod ID: A2ISITE005536		Click to Show/Hide the Full List
mod site	chr12:50930379-50930380:+		[2]
Sequence	ACCTCCACCTCGCGGGTTTAAGCGATTCTTCTGCCTCAGCC
Transcript ID List	ENST00000547104.1; ENST00000548553.1; ENST00000332160.5; ENST00000550097.1
External Link	RMBase: RNA-editing_site_28493
mod ID: A2ISITE005537		Click to Show/Hide the Full List
mod site	chr12:50930396-50930397:+		[3]
Sequence	TTAAGCGATTCTTCTGCCTCAGCCTCCCTAGTAGCTGGGAT
Transcript ID List	ENST00000548553.1; ENST00000550097.1; ENST00000332160.5; ENST00000547104.1
External Link	RMBase: RNA-editing_site_28494
mod ID: A2ISITE005538		Click to Show/Hide the Full List
mod site	chr12:50930408-50930409:+		[1]
Sequence	TCTGCCTCAGCCTCCCTAGTAGCTGGGATTACAGGTGCCCA
Transcript ID List	ENST00000547104.1; ENST00000548553.1; ENST00000332160.5; ENST00000550097.1
External Link	RMBase: RNA-editing_site_28495
mod ID: A2ISITE005539		Click to Show/Hide the Full List
mod site	chr12:50930418-50930419:+		[2]
Sequence	CCTCCCTAGTAGCTGGGATTACAGGTGCCCACCACCATGCC
Transcript ID List	ENST00000550097.1; ENST00000548553.1; ENST00000547104.1; ENST00000332160.5
External Link	RMBase: RNA-editing_site_28496
mod ID: A2ISITE005540		Click to Show/Hide the Full List
mod site	chr12:50930440-50930441:+		[2]
Sequence	AGGTGCCCACCACCATGCCCAGCTAATTTGTATTTTTAGTT
Transcript ID List	ENST00000332160.5; ENST00000548553.1; ENST00000550097.1; ENST00000547104.1
External Link	RMBase: RNA-editing_site_28497
mod ID: A2ISITE005541		Click to Show/Hide the Full List
mod site	chr12:50930474-50930475:+		[2]
Sequence	TTTAGTTGAGACAGGGTTTCACTACGTTGGCCAGGCTGGTC
Transcript ID List	ENST00000550097.1; ENST00000548553.1; ENST00000547104.1; ENST00000332160.5
External Link	RMBase: RNA-editing_site_28498
mod ID: A2ISITE005542		Click to Show/Hide the Full List
mod site	chr12:50930498-50930499:+		[3]
Sequence	CGTTGGCCAGGCTGGTCTTGAACTCCTGATCTCAGGCAATC
Transcript ID List	ENST00000332160.5; ENST00000550097.1; ENST00000548553.1; ENST00000547104.1
External Link	RMBase: RNA-editing_site_28499
mod ID: A2ISITE005543		Click to Show/Hide the Full List
mod site	chr12:50930524-50930525:+		[1]
Sequence	TGATCTCAGGCAATCCACCCACCTCAGCCTCCCAAAGTGCT
Transcript ID List	ENST00000548553.1; ENST00000547104.1; ENST00000332160.5; ENST00000550097.1
External Link	RMBase: RNA-editing_site_28500
mod ID: A2ISITE005544		Click to Show/Hide the Full List
mod site	chr12:50930529-50930530:+		[2]
Sequence	TCAGGCAATCCACCCACCTCAGCCTCCCAAAGTGCTGGGAT
Transcript ID List	ENST00000547104.1; ENST00000550097.1; ENST00000332160.5; ENST00000548553.1
External Link	RMBase: RNA-editing_site_28501
mod ID: A2ISITE005545		Click to Show/Hide the Full List
mod site	chr12:50930538-50930539:+		[2]
Sequence	CCACCCACCTCAGCCTCCCAAAGTGCTGGGATGACAGGCGT
Transcript ID List	ENST00000332160.5; ENST00000547104.1; ENST00000548553.1; ENST00000550097.1
External Link	RMBase: RNA-editing_site_28502
mod ID: A2ISITE005546		Click to Show/Hide the Full List
mod site	chr12:50930652-50930653:+		[2]
Sequence	GAGTGCAATGCTGTGATCTCAGCTTACCACAACCTCCACCT
Transcript ID List	ENST00000547104.1; ENST00000550097.1; ENST00000332160.5; ENST00000548553.1
External Link	RMBase: RNA-editing_site_28503
mod ID: A2ISITE005547		Click to Show/Hide the Full List
mod site	chr12:50930663-50930664:+		[4]
Sequence	TGTGATCTCAGCTTACCACAACCTCCACCTCCCGGGTTCAA
Transcript ID List	ENST00000332160.5; ENST00000550097.1; ENST00000547104.1; ENST00000548553.1
External Link	RMBase: RNA-editing_site_28504
mod ID: A2ISITE005548		Click to Show/Hide the Full List
mod site	chr12:50930683-50930684:+		[2]
Sequence	ACCTCCACCTCCCGGGTTCAAGTGATTCACCTGCCTCAGCC
Transcript ID List	ENST00000548553.1; ENST00000332160.5; ENST00000547104.1; ENST00000550097.1
External Link	RMBase: RNA-editing_site_28505
mod ID: A2ISITE005549		Click to Show/Hide the Full List
mod site	chr12:50930712-50930713:+		[2]
Sequence	CCTGCCTCAGCCTCCTGAGTAGCTGGTATTACAGGCATGCG
Transcript ID List	ENST00000547104.1; ENST00000550097.1; ENST00000548553.1; ENST00000332160.5
External Link	RMBase: RNA-editing_site_28506
mod ID: A2ISITE005550		Click to Show/Hide the Full List
mod site	chr12:50930722-50930723:+		[1]
Sequence	CCTCCTGAGTAGCTGGTATTACAGGCATGCGTCACCACGCC
Transcript ID List	ENST00000332160.5; ENST00000547104.1; ENST00000548553.1; ENST00000550097.1
External Link	RMBase: RNA-editing_site_28507
mod ID: A2ISITE005551		Click to Show/Hide the Full List
mod site	chr12:50930724-50930725:+		[2]
Sequence	TCCTGAGTAGCTGGTATTACAGGCATGCGTCACCACGCCGG
Transcript ID List	ENST00000332160.5; ENST00000550097.1; ENST00000548553.1; ENST00000547104.1
External Link	RMBase: RNA-editing_site_28508
mod ID: A2ISITE005552		Click to Show/Hide the Full List
mod site	chr12:50930761-50930762:+		[2]
Sequence	CCGGCTAATTTTGTACTTTTAGTAGAGATGGTGTTTCCCCA
Transcript ID List	ENST00000547104.1; ENST00000332160.5; ENST00000550097.1; ENST00000548553.1
External Link	RMBase: RNA-editing_site_28509
mod ID: A2ISITE005553		Click to Show/Hide the Full List
mod site	chr12:50930843-50930844:+		[4]
Sequence	TGCCTGCCTCGGCCTCCCAAAGTGCTGTGATTACAGACGTC
Transcript ID List	ENST00000332160.5; ENST00000548553.1; ENST00000547104.1; ENST00000550097.1
External Link	RMBase: RNA-editing_site_28510
mod ID: A2ISITE005554		Click to Show/Hide the Full List
mod site	chr12:50930855-50930856:+		[2]
Sequence	CCTCCCAAAGTGCTGTGATTACAGACGTCAGCCACCATGCC
Transcript ID List	ENST00000548553.1; ENST00000547104.1; ENST00000550097.1; ENST00000332160.5
External Link	RMBase: RNA-editing_site_28511
mod ID: A2ISITE005555		Click to Show/Hide the Full List
mod site	chr12:50931445-50931446:+		[2]
Sequence	GGGGCTGGGCGTGGTGGCTCACGCCTGTAATCCTAGCACTT
Transcript ID List	ENST00000550097.1; ENST00000548553.1; ENST00000547104.1; rmsk_3788206; ENST00000332160.5
External Link	RMBase: RNA-editing_site_28512
mod ID: A2ISITE005556		Click to Show/Hide the Full List
mod site	chr12:50931453-50931454:+		[2]
Sequence	GCGTGGTGGCTCACGCCTGTAATCCTAGCACTTTGGGAGGC
Transcript ID List	ENST00000547104.1; rmsk_3788206; ENST00000332160.5; ENST00000550097.1; ENST00000548553.1
External Link	RMBase: RNA-editing_site_28513
mod ID: A2ISITE005557		Click to Show/Hide the Full List
mod site	chr12:50931454-50931455:+		[1]
Sequence	CGTGGTGGCTCACGCCTGTAATCCTAGCACTTTGGGAGGCC
Transcript ID List	ENST00000550097.1; rmsk_3788206; ENST00000332160.5; ENST00000547104.1; ENST00000548553.1
External Link	RMBase: RNA-editing_site_28514
mod ID: A2ISITE005558		Click to Show/Hide the Full List
mod site	chr12:50931462-50931463:+		[1]
Sequence	CTCACGCCTGTAATCCTAGCACTTTGGGAGGCCGAGGCGGG
Transcript ID List	ENST00000548553.1; ENST00000547104.1; ENST00000550097.1; ENST00000332160.5; rmsk_3788206
External Link	RMBase: RNA-editing_site_28515
mod ID: A2ISITE005559		Click to Show/Hide the Full List
mod site	chr12:50931496-50931497:+		[2]
Sequence	AGGCGGGTGGATCACGAGGTAGGAGTTAAAGACCAGCCTGG
Transcript ID List	ENST00000548553.1; ENST00000550097.1; ENST00000332160.5; ENST00000547104.1; rmsk_3788206
External Link	RMBase: RNA-editing_site_28516
mod ID: A2ISITE005560		Click to Show/Hide the Full List
mod site	chr12:50931563-50931564:+		[2]
Sequence	TACAAAAAAAAAAAAAAATTAGCCAGGCGTGGTGGTGGGTG
Transcript ID List	ENST00000548553.1; ENST00000332160.5; ENST00000550097.1; ENST00000547104.1; rmsk_3788206
External Link	RMBase: RNA-editing_site_28517
mod ID: A2ISITE005561		Click to Show/Hide the Full List
mod site	chr12:50931567-50931568:+		[2]
Sequence	AAAAAAAAAAAAAATTAGCCAGGCGTGGTGGTGGGTGCCTG
Transcript ID List	ENST00000547104.1; ENST00000332160.5; ENST00000550097.1; ENST00000548553.1; rmsk_3788206
External Link	RMBase: RNA-editing_site_28518
mod ID: A2ISITE005562		Click to Show/Hide the Full List
mod site	chr12:50931589-50931590:+		[2]
Sequence	GCGTGGTGGTGGGTGCCTGTAATCCCAGGTACTTGGAAGGC
Transcript ID List	rmsk_3788206; ENST00000550097.1; ENST00000547104.1; ENST00000548553.1; ENST00000332160.5
External Link	RMBase: RNA-editing_site_28519
mod ID: A2ISITE005563		Click to Show/Hide the Full List
mod site	chr12:50931590-50931591:+		[2]
Sequence	CGTGGTGGTGGGTGCCTGTAATCCCAGGTACTTGGAAGGCT
Transcript ID List	ENST00000547104.1; rmsk_3788206; ENST00000550097.1; ENST00000548553.1; ENST00000332160.5
External Link	RMBase: RNA-editing_site_28520
mod ID: A2ISITE005564		Click to Show/Hide the Full List
mod site	chr12:50931605-50931606:+		[2]
Sequence	CTGTAATCCCAGGTACTTGGAAGGCTGAGGCAGGAGAATCT
Transcript ID List	ENST00000332160.5; rmsk_3788206; ENST00000547104.1; ENST00000550097.1; ENST00000548553.1
External Link	RMBase: RNA-editing_site_28521
mod ID: A2ISITE005565		Click to Show/Hide the Full List
mod site	chr12:50931606-50931607:+		[2]
Sequence	TGTAATCCCAGGTACTTGGAAGGCTGAGGCAGGAGAATCTC
Transcript ID List	ENST00000332160.5; ENST00000548553.1; rmsk_3788206; ENST00000550097.1; ENST00000547104.1
External Link	RMBase: RNA-editing_site_28522
mod ID: A2ISITE005566		Click to Show/Hide the Full List
mod site	chr12:50931635-50931636:+		[2]
Sequence	CAGGAGAATCTCTTGAACCCAGAAGGCGAAGGTTGCAGTGA
Transcript ID List	ENST00000332160.5; rmsk_3788206; ENST00000548553.1; ENST00000547104.1; ENST00000550097.1
External Link	RMBase: RNA-editing_site_28523
mod ID: A2ISITE005567		Click to Show/Hide the Full List
mod site	chr12:50931651-50931652:+		[2]
Sequence	ACCCAGAAGGCGAAGGTTGCAGTGAACCGAGATCATGCCAT
Transcript ID List	ENST00000547104.1; ENST00000548553.1; ENST00000332160.5; ENST00000550097.1; rmsk_3788206
External Link	RMBase: RNA-editing_site_28524
mod ID: A2ISITE005568		Click to Show/Hide the Full List
mod site	chr12:50931656-50931657:+		[2]
Sequence	GAAGGCGAAGGTTGCAGTGAACCGAGATCATGCCATTGTAC
Transcript ID List	ENST00000550097.1; rmsk_3788206; ENST00000547104.1; ENST00000548553.1; ENST00000332160.5
External Link	RMBase: RNA-editing_site_28525
mod ID: A2ISITE005569		Click to Show/Hide the Full List
mod site	chr12:50931665-50931666:+		[2]
Sequence	GGTTGCAGTGAACCGAGATCATGCCATTGTACTCTAGCCTG
Transcript ID List	ENST00000332160.5; ENST00000548553.1; rmsk_3788206; ENST00000547104.1; ENST00000550097.1
External Link	RMBase: RNA-editing_site_28526
mod ID: A2ISITE005570		Click to Show/Hide the Full List
mod site	chr12:50931670-50931671:+		[2]
Sequence	CAGTGAACCGAGATCATGCCATTGTACTCTAGCCTGGGTGA
Transcript ID List	ENST00000332160.5; ENST00000550097.1; ENST00000548553.1; ENST00000547104.1; rmsk_3788206
External Link	RMBase: RNA-editing_site_28527
mod ID: A2ISITE005571		Click to Show/Hide the Full List
mod site	chr12:50931680-50931681:+		[2]
Sequence	AGATCATGCCATTGTACTCTAGCCTGGGTGACAAGAGCAAG
Transcript ID List	ENST00000332160.5; ENST00000548553.1; ENST00000550097.1; rmsk_3788206; ENST00000547104.1
External Link	RMBase: RNA-editing_site_28528
mod ID: A2ISITE005572		Click to Show/Hide the Full List
mod site	chr12:50931751-50931752:+		[2]
Sequence	AAAGAAGTAGAGACAGGGAGACAGGGTCTCACTGTGTTGCC
Transcript ID List	ENST00000548553.1; ENST00000550097.1; ENST00000547104.1; ENST00000332160.5
External Link	RMBase: RNA-editing_site_28529
mod ID: A2ISITE005573		Click to Show/Hide the Full List
mod site	chr12:50931753-50931754:+		[2]
Sequence	AGAAGTAGAGACAGGGAGACAGGGTCTCACTGTGTTGCCTA
Transcript ID List	ENST00000332160.5; ENST00000548553.1; ENST00000547104.1; ENST00000550097.1
External Link	RMBase: RNA-editing_site_28530
mod ID: A2ISITE005574		Click to Show/Hide the Full List
mod site	chr12:50932080-50932081:+		[2]
Sequence	CAGTTTAGTATATCCATAAAACTATTTGAGGTGGTTAAGGT
Transcript ID List	ENST00000548553.1; ENST00000332160.5; ENST00000550097.1; ENST00000547104.1
External Link	RMBase: RNA-editing_site_28531

N6-methyladenosine (m6A)

In total 43 m6A sequence/site(s) in this target gene
mod ID: M6ASITE012399		Click to Show/Hide the Full List
mod site	chr12:50924043-50924044:+		[5]
Sequence	GTTCAGTCCAGAAAGGCAGGACAACCCGACGCGAGGCAGGG
Motif Score	3.643047619
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000550502.1; ENST00000548553.1
External Link	RMBase: m6A_site_188121
mod ID: M6ASITE012400		Click to Show/Hide the Full List
mod site	chr12:50924713-50924714:+		[5]
Sequence	AAGTACACTGCGCTTATAAAACTCTAGCAGGAAGCTAGCAG
Motif Score	2.627720238
Cell/Tissue List	HeLa; HEK293T
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000548553.1; ENST00000550502.1
External Link	RMBase: m6A_site_188122
mod ID: M6ASITE012401		Click to Show/Hide the Full List
mod site	chr12:50924744-50924745:+		[5]
Sequence	AAGCTAGCAGCTGTCTCCAAACCCAGAGAAGGGGAAACAGG
Motif Score	2.185083333
Cell/Tissue List	HeLa; HEK293T
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000548553.1; ENST00000550502.1
External Link	RMBase: m6A_site_188123
mod ID: M6ASITE012402		Click to Show/Hide the Full List
mod site	chr12:50924760-50924761:+		[5]
Sequence	CCAAACCCAGAGAAGGGGAAACAGGAATCGATTAGGAATAA
Motif Score	2.20572619
Cell/Tissue List	HeLa; HEK293T
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000548553.1; ENST00000550502.1
External Link	RMBase: m6A_site_188124
mod ID: M6ASITE012403		Click to Show/Hide the Full List
mod site	chr12:50924820-50924821:+		[5]
Sequence	CTTCTGAGGAAAAGCTGGGAACCTTCTCATTTTGCCTTATG
Motif Score	2.930744048
Cell/Tissue List	HeLa; HepG2; HEK293T; fibroblasts; Huh7; MSC; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000548553.1; ENST00000550502.1
External Link	RMBase: m6A_site_188125
mod ID: M6ASITE012404		Click to Show/Hide the Full List
mod site	chr12:50924844-50924845:+		[5]
Sequence	TCTCATTTTGCCTTATGAAAACTAAGCTGAATCGACTGCTG
Motif Score	2.627720238
Cell/Tissue List	HeLa; HepG2; HEK293T; fibroblasts; Huh7; MSC; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000548553.1; ENST00000550502.1
External Link	RMBase: m6A_site_188126
mod ID: M6ASITE012405		Click to Show/Hide the Full List
mod site	chr12:50924869-50924870:+		[5]
Sequence	GCTGAATCGACTGCTGCCAAACATCTATTAGGCAAAATTGG
Motif Score	2.20572619
Cell/Tissue List	HeLa; HepG2; HEK293T; fibroblasts; Huh7; MSC; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000548553.1; ENST00000550502.1
External Link	RMBase: m6A_site_188127
mod ID: M6ASITE012406		Click to Show/Hide the Full List
mod site	chr12:50925064-50925065:+		[5]
Sequence	CTTACCATCTTTATCCTGAGACTGGCCATTTACATCCTGAC
Motif Score	3.319380952
Cell/Tissue List	HeLa; HepG2; HEK293T; H1A; H1B; hESCs; fibroblasts; GM12878; Huh7; HEK293A-TOA; MSC; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000547104.1; ENST00000550097.1; ENST00000332160.5; ENST00000550502.1; ENST00000548553.1
External Link	RMBase: m6A_site_188128
mod ID: M6ASITE012407		Click to Show/Hide the Full List
mod site	chr12:50925083-50925084:+		[6]
Sequence	GACTGGCCATTTACATCCTGACATTTCCCTTGTACCTGCTG
Motif Score	2.859755952
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000547104.1; ENST00000550502.1; ENST00000548553.1; ENST00000332160.5; ENST00000550097.1
External Link	RMBase: m6A_site_188129
mod ID: M6ASITE012408		Click to Show/Hide the Full List
mod site	chr12:50925105-50925106:+		[5]
Sequence	ATTTCCCTTGTACCTGCTGAACTTTCTGGGCTTGTGGAGCT
Motif Score	3.373380952
Cell/Tissue List	HeLa; HepG2; HEK293T; H1A; H1B; hESCs; fibroblasts; GM12878; Huh7; MSC; TIME; TREX; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000550502.1; ENST00000332160.5; ENST00000550097.1; ENST00000548553.1; ENST00000547104.1
External Link	RMBase: m6A_site_188130
mod ID: M6ASITE012409		Click to Show/Hide the Full List
mod site	chr12:50925184-50925185:+		[5]
Sequence	TTCACTGTGATATACAACGAACAGATGGCAAGCAAGAAGCG
Motif Score	2.951386905
Cell/Tissue List	HeLa; HepG2; HEK293T; hESC-HEK293T; H1A; H1B; fibroblasts; GM12878; MM6; Huh7; MSC; TREX; endometrial
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List	ENST00000547104.1; ENST00000332160.5; ENST00000550502.1; ENST00000548553.1; ENST00000550097.1
External Link	RMBase: m6A_site_188131
mod ID: M6ASITE012410		Click to Show/Hide the Full List
mod site	chr12:50925250-50925251:+		[5]
Sequence	TTTGCGGGCCCCTCCGGGAAACTCTCCCTGCTGGAAGTGGG
Motif Score	2.627720238
Cell/Tissue List	HeLa; HEK293T; HepG2; fibroblasts; GM12878; MM6; Huh7; peripheral-blood; MSC; TREX; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000550097.1; ENST00000548553.1; ENST00000332160.5; ENST00000547104.1; ENST00000550502.1
External Link	RMBase: m6A_site_188132
mod ID: M6ASITE012411		Click to Show/Hide the Full List
mod site	chr12:50925378-50925379:+		[5]
Sequence	GATCAAGAGCATTGCAGAGAACCGACACCTGCAGTTTGAGC
Motif Score	2.930744048
Cell/Tissue List	HeLa; HEK293T; Huh7; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000550097.1; ENST00000547104.1; ENST00000548553.1; ENST00000332160.5; ENST00000550502.1
External Link	RMBase: m6A_site_188133
mod ID: M6ASITE012412		Click to Show/Hide the Full List
mod site	chr12:50925382-50925383:+		[6]
Sequence	AAGAGCATTGCAGAGAACCGACACCTGCAGTTTGAGCGCTT
Motif Score	2.865571429
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000548553.1; ENST00000550502.1; ENST00000550097.1; ENST00000332160.5; ENST00000547104.1
External Link	RMBase: m6A_site_188134
mod ID: M6ASITE012413		Click to Show/Hide the Full List
mod site	chr12:50925423-50925424:+		[5]
Sequence	TGTGGTAGCTGCCGGGGAGAACATGCACCAGGTGGCTGATG
Motif Score	2.951386905
Cell/Tissue List	HeLa; HEK293T; hESC-HEK293T; TREX
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List	ENST00000550097.1; ENST00000548553.1; ENST00000332160.5; ENST00000550502.1; ENST00000547104.1
External Link	RMBase: m6A_site_188135
mod ID: M6ASITE012414		Click to Show/Hide the Full List
mod site	chr12:50925492-50925493:+		[5]
Sequence	GGTGCTGTGCTCTGTGAAGAACCAGGAGCGGATTCTCCGCG
Motif Score	2.930744048
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000550097.1; ENST00000332160.5; ENST00000547104.1; ENST00000550502.1; ENST00000548553.1
External Link	RMBase: m6A_site_188136
mod ID: M6ASITE012415		Click to Show/Hide the Full List
mod site	chr12:50925532-50925533:+		[5]
Sequence	GAGGTGTGCAGAGTGCTGAGACCGGTGAGTGAAAGGGTGTG
Motif Score	2.876744048
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000332160.5; ENST00000548553.1; ENST00000550502.1; ENST00000550097.1; ENST00000547104.1
External Link	RMBase: m6A_site_188137
mod ID: M6ASITE012416		Click to Show/Hide the Full List
mod site	chr12:50929978-50929979:+		[6]
Sequence	ACTTGGAATTACTTCTGGCAACAAGTCCTGGATCCTGCCTG
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000332160.5; ENST00000548553.1; ENST00000547104.1; ENST00000550097.1
External Link	RMBase: m6A_site_188138
mod ID: M6ASITE012417		Click to Show/Hide the Full List
mod site	chr12:50930085-50930086:+		[7]
Sequence	CTCTAAGCTGAAGCTGCAGCACATCCAGGCCCCACTGTCCT
Motif Score	2.830589286
Cell/Tissue List	brain; kidney
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000547104.1; ENST00000550097.1; ENST00000332160.5; ENST00000548553.1
External Link	RMBase: m6A_site_188139
mod ID: M6ASITE012418		Click to Show/Hide the Full List
mod site	chr12:50930234-50930235:+		[5]
Sequence	TGCTAAGTGGGAGAAGAGAAACCTTTTTTTTGGGGGGCGGT
Motif Score	2.185083333
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000548553.1; ENST00000547104.1; ENST00000332160.5; ENST00000550097.1
External Link	RMBase: m6A_site_188140
mod ID: M6ASITE012419		Click to Show/Hide the Full List
mod site	chr12:50930551-50930552:+		[7]
Sequence	CCTCCCAAAGTGCTGGGATGACAGGCGTGAGCAACCGCACC
Motif Score	2.859755952
Cell/Tissue List	kidney; liver
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000332160.5; ENST00000550097.1; ENST00000548553.1; ENST00000547104.1
External Link	RMBase: m6A_site_188141
mod ID: M6ASITE012420		Click to Show/Hide the Full List
mod site	chr12:50930855-50930856:+		[7]
Sequence	CCTCCCAAAGTGCTGTGATTACAGACGTCAGCCACCATGCC
Motif Score	2.07285119
Cell/Tissue List	liver
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000547104.1; ENST00000548553.1; ENST00000550097.1; ENST00000332160.5
External Link	RMBase: m6A_site_188142
mod ID: M6ASITE012421		Click to Show/Hide the Full List
mod site	chr12:50930982-50930983:+		[5]
Sequence	AAAGAATTCACATCAAAAAAACAGCTTTGAACTCCCCCTTC
Motif Score	2.20572619
Cell/Tissue List	HeLa; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000547104.1; ENST00000550097.1; ENST00000332160.5; ENST00000548553.1
External Link	RMBase: m6A_site_188143
mod ID: M6ASITE012422		Click to Show/Hide the Full List
mod site	chr12:50930992-50930993:+		[5]
Sequence	CATCAAAAAAACAGCTTTGAACTCCCCCTTCAAAGGAAACA
Motif Score	3.373380952
Cell/Tissue List	HeLa; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000547104.1; ENST00000548553.1; ENST00000332160.5; ENST00000550097.1
External Link	RMBase: m6A_site_188144
mod ID: M6ASITE012423		Click to Show/Hide the Full List
mod site	chr12:50931010-50931011:+		[5]
Sequence	GAACTCCCCCTTCAAAGGAAACAGTCGACTTTCATAATTAG
Motif Score	2.20572619
Cell/Tissue List	HeLa; kidney; Huh7
Seq Type List	m6A-seq; m6A-REF-seq; MeRIP-seq
Transcript ID List	ENST00000547104.1; ENST00000550097.1; ENST00000332160.5; ENST00000548553.1
External Link	RMBase: m6A_site_188145
mod ID: M6ASITE012424		Click to Show/Hide the Full List
mod site	chr12:50931017-50931018:+		[8]
Sequence	CCCTTCAAAGGAAACAGTCGACTTTCATAATTAGCATCTAC
Motif Score	3.287565476
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000550097.1; ENST00000547104.1; ENST00000548553.1; ENST00000332160.5
External Link	RMBase: m6A_site_188146
mod ID: M6ASITE012425		Click to Show/Hide the Full List
mod site	chr12:50931287-50931288:+		[5]
Sequence	CTTAAATCACTCCAAAGAAGACTTTAAAAAGGGAGCAGTGA
Motif Score	3.319380952
Cell/Tissue List	HeLa; HEK293T
Seq Type List	m6A-seq; DART-seq
Transcript ID List	ENST00000332160.5; ENST00000548553.1; ENST00000550097.1; ENST00000547104.1
External Link	RMBase: m6A_site_188147
mod ID: M6ASITE012426		Click to Show/Hide the Full List
mod site	chr12:50931421-50931422:+		[7]
Sequence	ATTGTGTTTTAAAAAAAGAGACAGGGGGCTGGGCGTGGTGG
Motif Score	2.897386905
Cell/Tissue List	kidney
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000332160.5; ENST00000547104.1; ENST00000550097.1; ENST00000548553.1
External Link	RMBase: m6A_site_188148
mod ID: M6ASITE012427		Click to Show/Hide the Full List
mod site	chr12:50931507-50931508:+		[9]
Sequence	TCACGAGGTAGGAGTTAAAGACCAGCCTGGCCAACATGGCA
Motif Score	2.876744048
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	rmsk_3788206; ENST00000332160.5; ENST00000548553.1; ENST00000550097.1; ENST00000547104.1
External Link	RMBase: m6A_site_188149
mod ID: M6ASITE012428		Click to Show/Hide the Full List
mod site	chr12:50931530-50931531:+		[9]
Sequence	AGCCTGGCCAACATGGCAAAACCCTACTAAAGATACAAAAA
Motif Score	2.185083333
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	rmsk_3788206; ENST00000550097.1; ENST00000547104.1; ENST00000548553.1; ENST00000332160.5
External Link	RMBase: m6A_site_188150
mod ID: M6ASITE012429		Click to Show/Hide the Full List
mod site	chr12:50931631-50931632:+		[9]
Sequence	GAGGCAGGAGAATCTCTTGAACCCAGAAGGCGAAGGTTGCA
Motif Score	2.930744048
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	rmsk_3788206; ENST00000547104.1; ENST00000550097.1; ENST00000332160.5; ENST00000548553.1
External Link	RMBase: m6A_site_188151
mod ID: M6ASITE012430		Click to Show/Hide the Full List
mod site	chr12:50931656-50931657:+		[9]
Sequence	GAAGGCGAAGGTTGCAGTGAACCGAGATCATGCCATTGTAC
Motif Score	2.930744048
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000332160.5; rmsk_3788206; ENST00000547104.1; ENST00000550097.1; ENST00000548553.1
External Link	RMBase: m6A_site_188152
mod ID: M6ASITE012431		Click to Show/Hide the Full List
mod site	chr12:50931690-50931691:+		[6]
Sequence	ATTGTACTCTAGCCTGGGTGACAAGAGCAAGACTCCGTCTC
Motif Score	2.859755952
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000547104.1; ENST00000550097.1; ENST00000332160.5; ENST00000548553.1; rmsk_3788206
External Link	RMBase: m6A_site_188153
mod ID: M6ASITE012432		Click to Show/Hide the Full List
mod site	chr12:50931701-50931702:+		[9]
Sequence	GCCTGGGTGACAAGAGCAAGACTCCGTCTCAAAAAAAAAAA
Motif Score	3.319380952
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000550097.1; rmsk_3788206; ENST00000548553.1; ENST00000332160.5; ENST00000547104.1
External Link	RMBase: m6A_site_188154
mod ID: M6ASITE012433		Click to Show/Hide the Full List
mod site	chr12:50931849-50931850:+		[8]
Sequence	GTTGGGATTACAGGTGTGAGACAGTGCACCTGGCCGAAATA
Motif Score	2.897386905
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000548553.1; ENST00000550097.1; ENST00000547104.1; ENST00000332160.5
External Link	RMBase: m6A_site_188155
mod ID: M6ASITE012434		Click to Show/Hide the Full List
mod site	chr12:50931957-50931958:+		[6]
Sequence	AATTAACATACAAGGTTGCCACACCTAGTTCTGCCCAGCTT
Motif Score	2.053113095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000550097.1; ENST00000332160.5; ENST00000548553.1; ENST00000547104.1
External Link	RMBase: m6A_site_188156
mod ID: M6ASITE012435		Click to Show/Hide the Full List
mod site	chr12:50932054-50932055:+		[8]
Sequence	AGTCTTAAGATAAAGATTGTACTTGACAGTTTAGTATATCC
Motif Score	3.278136905
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000548553.1; ENST00000332160.5; ENST00000550097.1; ENST00000547104.1
External Link	RMBase: m6A_site_188157
mod ID: M6ASITE012436		Click to Show/Hide the Full List
mod site	chr12:50932059-50932060:+		[8]
Sequence	TAAGATAAAGATTGTACTTGACAGTTTAGTATATCCATAAA
Motif Score	2.859755952
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000550097.1; ENST00000332160.5; ENST00000547104.1; ENST00000548553.1
External Link	RMBase: m6A_site_188158
mod ID: M6ASITE012437		Click to Show/Hide the Full List
mod site	chr12:50932080-50932081:+		[5]
Sequence	CAGTTTAGTATATCCATAAAACTATTTGAGGTGGTTAAGGT
Motif Score	2.627720238
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000548553.1; ENST00000332160.5; ENST00000550097.1; ENST00000547104.1
External Link	RMBase: m6A_site_188159
mod ID: M6ASITE012438		Click to Show/Hide the Full List
mod site	chr12:50932178-50932179:+		[5]
Sequence	AAGTCTACTAAATTAGGAAAACCTTGAATAATTAGGTATCC
Motif Score	2.185083333
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000550097.1; ENST00000332160.5; ENST00000547104.1; ENST00000548553.1
External Link	RMBase: m6A_site_188160
mod ID: M6ASITE012439		Click to Show/Hide the Full List
mod site	chr12:50932216-50932217:+		[5]
Sequence	TCCTAGGTAAGAGCCCCTAAACATCAAGCAATCTGTGAGTC
Motif Score	2.20572619
Cell/Tissue List	HeLa; HEK293T; hESC-HEK293T
Seq Type List	m6A-seq; DART-seq; MAZTER-seq
Transcript ID List	ENST00000550097.1; ENST00000332160.5; ENST00000548553.1; ENST00000547104.1
External Link	RMBase: m6A_site_188161
mod ID: M6ASITE012440		Click to Show/Hide the Full List
mod site	chr12:50932339-50932340:+		[6]
Sequence	TGGAAGCTGTGAAAATCATCACAAGTGCCTCTGAAAGCGAG
Motif Score	2.047297619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000332160.5; ENST00000547104.1; ENST00000550097.1; ENST00000548553.1
External Link	RMBase: m6A_site_188162
mod ID: M6ASITE012441		Click to Show/Hide the Full List
mod site	chr12:50932486-50932487:+		[6]
Sequence	TCAAATCAACCAATAAATTCACATTTGTGTTAGGAACAGAA
Motif Score	2.047297619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000332160.5; ENST00000548553.1; ENST00000547104.1
External Link	RMBase: m6A_site_188163

2'-O-Methylation (2'-O-Me)

In total 2 m6A sequence/site(s) in this target gene
mod ID: 2OMSITE000048		Click to Show/Hide the Full List
mod site	chr12:50924823-50924824:+		[10]
Sequence	CTGAGGAAAAGCTGGGAACCTTCTCATTTTGCCTTATGAAA
Cell/Tissue List	HeLa
Seq Type List	Nm-seq
Transcript ID List	ENST00000548553.1; ENST00000550502.1
External Link	RMBase: Nm_site_1332
mod ID: 2OMSITE000049		Click to Show/Hide the Full List
mod site	chr12:50924824-50924825:+		[10]
Sequence	TGAGGAAAAGCTGGGAACCTTCTCATTTTGCCTTATGAAAA
Cell/Tissue List	HeLa
Seq Type List	Nm-seq
Transcript ID List	ENST00000550502.1; ENST00000548553.1
External Link	RMBase: Nm_site_1333

Ref 1	Systematic identification of abundant A-to-I editing sites in the human transcriptome. Nat Biotechnol. 2004 Aug;22(8):1001-5. doi: 10.1038/nbt996. Epub 2004 Jul 18.
Ref 2	Widespread RNA editing of embedded alu elements in the human transcriptome. Genome Res. 2004 Sep;14(9):1719-25. doi: 10.1101/gr.2855504.
Ref 3	Identification of widespread ultra-edited human RNAs. PLoS Genet. 2011 Oct;7(10):e1002317. doi: 10.1371/journal.pgen.1002317. Epub 2011 Oct 20.
Ref 4	Accurate identification of A-to-I RNA editing in human by transcriptome sequencing. Genome Res. 2012 Jan;22(1):142-50. doi: 10.1101/gr.124107.111. Epub 2011 Sep 29.
Ref 5	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 6	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 7	Single-base mapping of m(6)A by an antibody-independent method. Sci Adv. 2019 Jul 3;5(7):eaax0250. doi: 10.1126/sciadv.aax0250. eCollection 2019 Jul.
Ref 8	DART-seq: an antibody-free method for global m(6)A detection. Nat Methods. 2019 Dec;16(12):1275-1280. doi: 10.1038/s41592-019-0570-0. Epub 2019 Sep 23.
Ref 9	N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection. Cell Host Microbe. 2016 Nov 9;20(5):654-665. doi: 10.1016/j.chom.2016.09.015. Epub 2016 Oct 20.
Ref 10	Nm-seq maps 2'-O-methylation sites in human mRNA with base precision. Nat Methods. 2017 Jul;14(7):695-698. doi: 10.1038/nmeth.4294. Epub 2017 May 15.

Epigenetic Target Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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