Epigenetic Target Information

General Information of the Epigenetic Target (ID: EPITAR00043)
Target Name Glutamate ionotropic receptor AMPA type subunit 2 (GRIA2)
Synonyms
GluA2; GLURB; GluR-K2; GluR-B; GluR-2; GLUR2; glutamate receptor, ionotropic, AMPA 2
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Gene Name GRIA2
Sequence
MQKIMHISVLLSPVLWGLIFGVSSNSIQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTPHIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGTHPFVIQMRPDLKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDKKDEMYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTTTIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMKVAKNAQNINPSSSQNSQNFATYKEGYNVYGIESVKI
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Family Glutamate-gated ion channel (TC 1.A.10.1) family, GRIA2 subfamily
Function
Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system (PubMed:31300657). It plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. Through complex formation with NSG1, GRIP1 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity).
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Gene ID 2891
HGNC ID HGNC:4572
Ensembl Gene ID ENSG00000120251
KEGG ID hsa:2891
Chromosomal Location 4q32.1
RNA Modification Sequencing Data Associated with the Target (ID: EPITAR00043)
Glutamate ionotropic receptor AMPA type subunit 2 (GRIA2)
Adenosine-to-Inosine editing (A-to-I)
In total 8 m6A sequence/site(s) in this target gene
mod ID: A2ISITE000635 Click to Show/Hide the Full List
mod site chr4:157278901-157278902:+ [1]
Sequence CCACATCATATTTCCACAATAAGATACCACTACATGCTTAT
Transcript ID List ENST00000507898.5; ENST00000393815.6; ENST00000503437.1; ENST00000504801.1; ENST00000506284.5; ENST00000471736.5; ENST00000509417.5; ENST00000264426.13; ENST00000296526.12; ENST00000323661.10; rmsk_1484005; ENST00000645636.1; ENST00000505888.1
External Link RMBase: RNA-editing_site_107134
mod ID: A2ISITE000636 Click to Show/Hide the Full List
mod site chr4:157336722-157336723:+ [2]
Sequence TTCCTTGGGTGCCTTTATGCAGCAAGGATGCGATATTTCGC
Transcript ID List ENST00000471736.5; ENST00000264426.13; ENST00000323661.10; ENST00000393815.6; ENST00000507898.5; ENST00000296526.12; ENST00000645636.1
External Link RMBase: RNA-editing_site_107135
mod ID: A2ISITE000637 Click to Show/Hide the Full List
mod site chr4:157336726-157336727:+ [2]
Sequence TTGGGTGCCTTTATGCAGCAAGGATGCGATATTTCGCCAAG
Transcript ID List ENST00000507898.5; ENST00000323661.10; ENST00000645636.1; ENST00000471736.5; ENST00000264426.13; ENST00000393815.6; ENST00000296526.12
External Link RMBase: RNA-editing_site_107136
mod ID: A2ISITE000638 Click to Show/Hide the Full List
mod site chr4:157336983-157336984:+ [1]
Sequence ACACACCATGAAGAGGCTATAAAATGCATAAGGTTCCTATC
Transcript ID List ENST00000471736.5; ENST00000323661.10; ENST00000645636.1; ENST00000393815.6; ENST00000264426.13; ENST00000507898.5; ENST00000296526.12
External Link RMBase: RNA-editing_site_107137
mod ID: A2ISITE000639 Click to Show/Hide the Full List
mod site chr4:157336984-157336985:+ [1]
Sequence CACACCATGAAGAGGCTATAAAATGCATAAGGTTCCTATCA
Transcript ID List ENST00000645636.1; ENST00000471736.5; ENST00000296526.12; ENST00000393815.6; ENST00000507898.5; ENST00000264426.13; ENST00000323661.10
External Link RMBase: RNA-editing_site_107138
mod ID: A2ISITE000640 Click to Show/Hide the Full List
mod site chr4:157337090-157337091:+ [1]
Sequence GTTGATCCACAGACCTGTATATGGGAAAATGGGCAACATTA
Transcript ID List ENST00000264426.13; ENST00000323661.10; ENST00000393815.6; ENST00000296526.12; ENST00000471736.5; ENST00000645636.1; ENST00000507898.5
External Link RMBase: RNA-editing_site_107139
mod ID: A2ISITE000641 Click to Show/Hide the Full List
mod site chr4:157360141-157360142:+ [1]
Sequence CACCTAAAGGATCCTCATTAAGGTGGGTGGAATAGTATAAC
Transcript ID List ENST00000510854.1; ENST00000507898.5; ENST00000393815.6; ENST00000323661.10; ENST00000264426.13; ENST00000471736.5; ENST00000296526.12; ENST00000645636.1
External Link RMBase: RNA-editing_site_107140
mod ID: A2ISITE000642 Click to Show/Hide the Full List
mod site chr4:157361385-157361386:+ [1]
Sequence GTTACTTCCAGCGATACATTAATGCTCATTTGGCTCTGCAA
Transcript ID List ENST00000323661.10; ENST00000645636.1; ENST00000264426.13; ENST00000471736.5; ENST00000393815.6; ENST00000503980.1; ENST00000296526.12; ENST00000507898.5; ENST00000510854.1
External Link RMBase: RNA-editing_site_107141
N6-methyladenosine (m6A)
In total 27 m6A sequence/site(s) in this target gene
mod ID: M6ASITE068599 Click to Show/Hide the Full List
mod site chr4:157220768-157220769:+ [3]
Sequence AGGGTGCTGAATATTCCGAGACACTGGGACCACAGCGGCAG
Motif Score 2.897386905
Cell/Tissue List GSC-11; endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000296526.12; ENST00000471736.5; ENST00000264426.13; ENST00000512774.5; ENST00000507898.5; ENST00000509417.5; ENST00000645636.1; ENST00000504801.1; ENST00000393815.6
External Link RMBase: m6A_site_655297
mod ID: M6ASITE068600 Click to Show/Hide the Full List
mod site chr4:157220776-157220777:+ [3]
Sequence GAATATTCCGAGACACTGGGACCACAGCGGCAGCTCCGCTG
Motif Score 3.622404762
Cell/Tissue List GSC-11; endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000509417.5; ENST00000645636.1; ENST00000393815.6; ENST00000507898.5; ENST00000296526.12; ENST00000264426.13; ENST00000471736.5; ENST00000504801.1; ENST00000512774.5
External Link RMBase: m6A_site_655298
mod ID: M6ASITE068601 Click to Show/Hide the Full List
mod site chr4:157220800-157220801:+ [3]
Sequence CAGCGGCAGCTCCGCTGAAAACTGCATTCAGCCAGTCCTCC
Motif Score 2.627720238
Cell/Tissue List GSC-11; endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000504801.1; ENST00000645636.1; ENST00000393815.6; ENST00000471736.5; ENST00000264426.13; ENST00000512774.5; ENST00000296526.12; ENST00000507898.5; ENST00000509417.5
External Link RMBase: m6A_site_655299
mod ID: M6ASITE068602 Click to Show/Hide the Full List
mod site chr4:157220823-157220824:+ [3]
Sequence GCATTCAGCCAGTCCTCCGGACTTCTGGAGCGGGGACAGGG
Motif Score 4.065041667
Cell/Tissue List GSC-11; endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000512774.5; ENST00000645636.1; ENST00000509417.5; ENST00000471736.5; ENST00000506284.5; ENST00000264426.13; ENST00000507898.5; ENST00000393815.6; ENST00000504801.1; ENST00000296526.12
External Link RMBase: m6A_site_655300
mod ID: M6ASITE068603 Click to Show/Hide the Full List
mod site chr4:157220838-157220839:+ [3]
Sequence TCCGGACTTCTGGAGCGGGGACAGGGCGCAGGGCATCAGCA
Motif Score 3.643047619
Cell/Tissue List GSC-11; endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000506284.5; ENST00000296526.12; ENST00000645636.1; ENST00000504801.1; ENST00000507898.5; ENST00000264426.13; ENST00000393815.6; ENST00000509417.5; ENST00000512774.5; ENST00000471736.5
External Link RMBase: m6A_site_655301
mod ID: M6ASITE068604 Click to Show/Hide the Full List
mod site chr4:157220871-157220872:+ [3]
Sequence CATCAGCAGCCACCAGCAGGACCTGGGAAATAGGGATTCTT
Motif Score 3.622404762
Cell/Tissue List GSC-11; endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000506284.5; ENST00000296526.12; ENST00000471736.5; ENST00000645636.1; ENST00000507898.5; ENST00000512774.5; ENST00000393815.6; ENST00000509417.5; ENST00000504801.1; ENST00000264426.13
External Link RMBase: m6A_site_655302
mod ID: M6ASITE068605 Click to Show/Hide the Full List
mod site chr4:157220970-157220971:+ [4]
Sequence GATCTAATTTGCAGAGGAAAACAGCCAAAGAAGGAAGAGGA
Motif Score 2.20572619
Cell/Tissue List brain; GSC-11
Seq Type List m6A-REF-seq; m6A-seq
Transcript ID List ENST00000264426.13; ENST00000393815.6; ENST00000504801.1; ENST00000512774.5; ENST00000645636.1; ENST00000296526.12; ENST00000507898.5; ENST00000509417.5; ENST00000506284.5; ENST00000471736.5
External Link RMBase: m6A_site_655303
mod ID: M6ASITE068606 Click to Show/Hide the Full List
mod site chr4:157361564-157361565:+ [5]
Sequence GTAAATCTTGCAGTATTGAAACTCAGTGAGCAAGGCGTCTT
Motif Score 2.627720238
Cell/Tissue List hNPCs
Seq Type List m6A-seq
Transcript ID List ENST00000510854.1; ENST00000296526.12; ENST00000471736.5; ENST00000393815.6; ENST00000323661.10; ENST00000503980.1; ENST00000507898.5; ENST00000264426.13; ENST00000645636.1
External Link RMBase: m6A_site_655304
mod ID: M6ASITE068607 Click to Show/Hide the Full List
mod site chr4:157361587-157361588:+ [5]
Sequence CAGTGAGCAAGGCGTCTTAGACAAGCTGAAAAACAAATGGT
Motif Score 2.897386905
Cell/Tissue List hNPCs
Seq Type List m6A-seq
Transcript ID List ENST00000510854.1; ENST00000507898.5; ENST00000323661.10; ENST00000645636.1; ENST00000393815.6; ENST00000503980.1; ENST00000264426.13; ENST00000296526.12; ENST00000471736.5
External Link RMBase: m6A_site_655305
mod ID: M6ASITE068608 Click to Show/Hide the Full List
mod site chr4:157361599-157361600:+ [5]
Sequence CGTCTTAGACAAGCTGAAAAACAAATGGTGGTACGATAAAG
Motif Score 2.20572619
Cell/Tissue List hNPCs
Seq Type List m6A-seq
Transcript ID List ENST00000510854.1; ENST00000471736.5; ENST00000296526.12; ENST00000264426.13; ENST00000645636.1; ENST00000507898.5; ENST00000323661.10; ENST00000503980.1; ENST00000393815.6
External Link RMBase: m6A_site_655306
mod ID: M6ASITE068609 Click to Show/Hide the Full List
mod site chr4:157363459-157363460:+ [5]
Sequence CTTGAATGATGCCATGAGGAACAAGGCAAGGCTGTCAATTA
Motif Score 2.951386905
Cell/Tissue List hNPCs
Seq Type List m6A-seq
Transcript ID List ENST00000645636.1; ENST00000471736.5; ENST00000296526.12; ENST00000507898.5; ENST00000393815.6; ENST00000264426.13
External Link RMBase: m6A_site_655307
mod ID: M6ASITE068610 Click to Show/Hide the Full List
mod site chr4:157363479-157363480:+ [4]
Sequence ACAAGGCAAGGCTGTCAATTACAGGAAGTACTGGAGAAAAT
Motif Score 2.07285119
Cell/Tissue List brain
Seq Type List m6A-REF-seq
Transcript ID List ENST00000264426.13; ENST00000507898.5; ENST00000471736.5; ENST00000645636.1; ENST00000393815.6; ENST00000296526.12
External Link RMBase: m6A_site_655308
mod ID: M6ASITE068611 Click to Show/Hide the Full List
mod site chr4:157363608-157363609:+ [5]
Sequence ATCTCTCGTGATTGATAAGAACCTTTTGAGTGCCTTACACA
Motif Score 2.930744048
Cell/Tissue List hNPCs; TREX
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000296526.12; ENST00000507898.5; ENST00000393815.6; ENST00000645636.1; ENST00000471736.5; ENST00000264426.13
External Link RMBase: m6A_site_655309
mod ID: M6ASITE068612 Click to Show/Hide the Full List
mod site chr4:157363685-157363686:+ [5]
Sequence AGGCATCCAGTATCTTGAAGACTTTTCTTTCAGCCAAGAAT
Motif Score 3.319380952
Cell/Tissue List hNPCs; TREX
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000393815.6; ENST00000645636.1; ENST00000264426.13; ENST00000296526.12; ENST00000471736.5
External Link RMBase: m6A_site_655310
mod ID: M6ASITE068613 Click to Show/Hide the Full List
mod site chr4:157363755-157363756:+ [5]
Sequence GTAAGGAATGATTAATTAAAACACAACATCTTTTTCTACTC
Motif Score 2.20572619
Cell/Tissue List hNPCs; TREX
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000471736.5; ENST00000393815.6; ENST00000645636.1; ENST00000264426.13; ENST00000296526.12
External Link RMBase: m6A_site_655311
mod ID: M6ASITE068614 Click to Show/Hide the Full List
mod site chr4:157363785-157363786:+ [5]
Sequence TTTTTCTACTCGAGTTACAGACAAAGCGTGGTGGACATGCA
Motif Score 2.897386905
Cell/Tissue List hNPCs; TREX
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000296526.12; ENST00000471736.5; ENST00000645636.1; ENST00000264426.13; ENST00000393815.6
External Link RMBase: m6A_site_655312
mod ID: M6ASITE068615 Click to Show/Hide the Full List
mod site chr4:157363799-157363800:+ [5]
Sequence TTACAGACAAAGCGTGGTGGACATGCACAGCTAACATGGAA
Motif Score 3.643047619
Cell/Tissue List hNPCs; TREX
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000471736.5; ENST00000645636.1; ENST00000393815.6; ENST00000264426.13; ENST00000296526.12
External Link RMBase: m6A_site_655313
mod ID: M6ASITE068616 Click to Show/Hide the Full List
mod site chr4:157363851-157363852:+ [5]
Sequence TACCTGAAGTCTTTGTACAGACAACAAACCTGTTTCTGCAG
Motif Score 2.897386905
Cell/Tissue List hNPCs; TREX
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000471736.5; ENST00000264426.13; ENST00000296526.12; ENST00000645636.1; ENST00000393815.6
External Link RMBase: m6A_site_655314
mod ID: M6ASITE068617 Click to Show/Hide the Full List
mod site chr4:157363858-157363859:+ [5]
Sequence AGTCTTTGTACAGACAACAAACCTGTTTCTGCAGCCACTAT
Motif Score 2.185083333
Cell/Tissue List hNPCs; TREX
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000264426.13; ENST00000296526.12; ENST00000645636.1; ENST00000393815.6; ENST00000471736.5
External Link RMBase: m6A_site_655315
mod ID: M6ASITE068618 Click to Show/Hide the Full List
mod site chr4:157363966-157363967:+ [5]
Sequence TTATAAAAAAAGGAAAAAAAACATTTAAAACTAAAAAATAT
Motif Score 2.20572619
Cell/Tissue List hNPCs; Huh7; TREX
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000393815.6; ENST00000471736.5; ENST00000296526.12
External Link RMBase: m6A_site_655316
mod ID: M6ASITE068619 Click to Show/Hide the Full List
mod site chr4:157363975-157363976:+ [5]
Sequence AAGGAAAAAAAACATTTAAAACTAAAAAATATTTTTAGGTA
Motif Score 2.627720238
Cell/Tissue List hNPCs; Huh7; TREX
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000393815.6; ENST00000471736.5; ENST00000296526.12
External Link RMBase: m6A_site_655317
mod ID: M6ASITE068620 Click to Show/Hide the Full List
mod site chr4:157364005-157364006:+ [5]
Sequence ATTTTTAGGTATTTTCACAAACAAACTGGCTTTTAAATAAA
Motif Score 2.20572619
Cell/Tissue List hNPCs; TREX
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000471736.5; ENST00000296526.12; ENST00000393815.6
External Link RMBase: m6A_site_655318
mod ID: M6ASITE068621 Click to Show/Hide the Full List
mod site chr4:157364051-157364052:+ [5]
Sequence TTCCATATTGGTTGAATAAGACAAAAACAATTAAACTGAGT
Motif Score 2.897386905
Cell/Tissue List hNPCs; Huh7
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000296526.12; ENST00000471736.5; ENST00000393815.6
External Link RMBase: m6A_site_655319
mod ID: M6ASITE068622 Click to Show/Hide the Full List
mod site chr4:157364057-157364058:+ [5]
Sequence ATTGGTTGAATAAGACAAAAACAATTAAACTGAGTGGGAAG
Motif Score 2.20572619
Cell/Tissue List hNPCs; Huh7
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000471736.5; ENST00000296526.12; ENST00000393815.6
External Link RMBase: m6A_site_655320
mod ID: M6ASITE068623 Click to Show/Hide the Full List
mod site chr4:157364065-157364066:+ [5]
Sequence AATAAGACAAAAACAATTAAACTGAGTGGGAAGTGAATAAA
Motif Score 2.627720238
Cell/Tissue List hNPCs; Huh7
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000471736.5; ENST00000296526.12; ENST00000393815.6
External Link RMBase: m6A_site_655321
mod ID: M6ASITE068624 Click to Show/Hide the Full List
mod site chr4:157364150-157364151:+ [5]
Sequence GTAAATGCTAAGGAAAGTAAACAAAGAGGAGATTCCAATCT
Motif Score 2.20572619
Cell/Tissue List hNPCs
Seq Type List m6A-seq
Transcript ID List ENST00000471736.5; ENST00000393815.6; ENST00000296526.12
External Link RMBase: m6A_site_655322
mod ID: M6ASITE068625 Click to Show/Hide the Full List
mod site chr4:157365248-157365249:+ [4]
Sequence AAATTTAGCTGTCCCTAATCACAGATCCTAAGGTAATATAA
Motif Score 2.047297619
Cell/Tissue List brain
Seq Type List m6A-REF-seq
Transcript ID List ENST00000393815.6; ENST00000296526.12
External Link RMBase: m6A_site_655323