Epigenetic Target Information

General Information of the Epigenetic Target (ID: EPITAR00024)

Target Name	Small ribosomal subunit protein mS38 (AURKAIP1)
Synonyms	28S ribosomal protein S38; mitochondrial; Aurora kinase A-interacting protein; MRP-S38; AURKA-interacting protein Click to Show/Hide
Gene Name	AURKAIP1
Sequence	MLLGRLTSQLLRAVPWAGGRPPWPVSGVLGSRVCGPLYSTSPAGPGRAASLPRKGAQLELEEMLVPRKMSVSPLESWLTARCFLPRLDTGTAGTVAPPQSYQCPPSQIGEGAEQGDEGVADAPQIQCKNVLKIRRRKMNHHKYRKLVKKTRFLRRKVQEGRLRRKQIKFEKDLRRIWLKAGLKEAPEGWQTPKIYLRGK Click to Show/Hide
Family	Mitochondrion-specific ribosomal protein mS38 family
Function	May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation. Click to Show/Hide
Gene ID	54998
HGNC ID	HGNC:24114
Ensembl Gene ID	ENSG00000175756
KEGG ID	hsa:54998
Chromosomal Location	1p36.33

RNA Modification Sequencing Data Associated with the Target (ID: EPITAR00024)

Small ribosomal subunit protein mS38 (AURKAIP1)

N4-acetylcytidine (ac4C)

In total 1 m6A sequence/site(s) in this target gene
mod ID: AC4SITE000185		Click to Show/Hide the Full List
mod site	chr1:1373861-1373862:-		[1]
Sequence	GAGGCGCATCTGGCTGAAGGCGGGGCTAAAGGAAGCCCCCG
Cell/Tissue List	H1
Seq Type List	ac4C-seq
Transcript ID List	ENST00000321751.9; ENST00000338338.9; ENST00000338370.7; ENST00000378853.3
External Link	RMBase: ac4C_site_5

N6-methyladenosine (m6A)

In total 23 m6A sequence/site(s) in this target gene
mod ID: M6ASITE006500		Click to Show/Hide the Full List
mod site	chr1:1373739-1373740:-		[2]
Sequence	TAGTAATAAATTCTCAGAGGACTCAGCCTTTCCTGCGGGTC
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; A549; LCLs; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293T; TREX; MSC; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000338370.7; ENST00000321751.9; ENST00000338338.9; ENST00000378853.3
External Link	RMBase: m6A_site_1462
mod ID: M6ASITE006512		Click to Show/Hide the Full List
mod site	chr1:1373829-1373830:-		[2]
Sequence	AAGCCCCCGAAGGCTGGCAGACCCCCAAGATCTACCTGCGG
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; A549; H1A; LCLs; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293T; TREX; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000321751.9; ENST00000338338.9; ENST00000378853.3; ENST00000338370.7
External Link	RMBase: m6A_site_1463
mod ID: M6ASITE006513		Click to Show/Hide the Full List
mod site	chr1:1373885-1373886:-		[2]
Sequence	GCAGATCAAGTTCGAGAAAGACCTGAGGCGCATCTGGCTGA
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; A549; H1A; LCLs; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293T; TREX; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000321751.9; ENST00000338338.9; ENST00000338370.7; ENST00000378853.3
External Link	RMBase: m6A_site_1464
mod ID: M6ASITE006514		Click to Show/Hide the Full List
mod site	chr1:1374075-1374076:-		[3]
Sequence	CCGGCGGAAGATGAACCACCACAAGTACCGGAAGCTGGTGA
Motif Score	2.053113095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000338370.7; ENST00000338338.9; ENST00000321751.9; ENST00000378853.3
External Link	RMBase: m6A_site_1465
mod ID: M6ASITE006515		Click to Show/Hide the Full List
mod site	chr1:1374081-1374082:-		[2]
Sequence	GATCCGCCGGCGGAAGATGAACCACCACAAGTACCGGAAGC
Motif Score	2.930744048
Cell/Tissue List	HeLa; HepG2; A549; HEK293T; H1A; LCLs; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; MSC; TREX; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000378853.3; ENST00000338370.7; ENST00000338338.9; ENST00000321751.9
External Link	RMBase: m6A_site_1466
mod ID: M6ASITE006516		Click to Show/Hide the Full List
mod site	chr1:1374217-1374218:-		[2]
Sequence	TGGATACCGGGACCGCAGGGACTGTGGCTCCACCGCAATCC
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; A549; HEK293T; H1A; H1B; fibroblasts; H1299; MM6; Huh7; Jurkat; peripheral-blood; GSC-11; HEK293A-TOA; MSC; TIME; TREX; iSLK; endometrial; HEC-1-A; NB4; AML
Seq Type List	m6A-seq; MeRIP-seq; miCLIP
Transcript ID List	ENST00000321751.9; ENST00000338338.9; ENST00000338370.7; ENST00000378853.3
External Link	RMBase: m6A_site_1467
mod ID: M6ASITE006517		Click to Show/Hide the Full List
mod site	chr1:1374226-1374227:-		[2]
Sequence	TGCCCAGACTGGATACCGGGACCGCAGGGACTGTGGCTCCA
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; A549; HEK293T; H1A; H1B; fibroblasts; H1299; MM6; Huh7; Jurkat; peripheral-blood; GSC-11; HEK293A-TOA; MSC; TIME; TREX; iSLK; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000378853.3; ENST00000338370.7; ENST00000338338.9; ENST00000321751.9
External Link	RMBase: m6A_site_1468
mod ID: M6ASITE006572		Click to Show/Hide the Full List
mod site	chr1:1374239-1374240:-		[2]
Sequence	GCCCGCTGCTTCCTGCCCAGACTGGATACCGGGACCGCAGG
Motif Score	3.319380952
Cell/Tissue List	HeLa; HepG2; A549; HEK293T; H1A; H1B; fibroblasts; H1299; MM6; Huh7; Jurkat; peripheral-blood; GSC-11; HEK293A-TOA; MSC; TIME; TREX; iSLK; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000338370.7; ENST00000378853.3; ENST00000321751.9; ENST00000338338.9
External Link	RMBase: m6A_site_1469
mod ID: M6ASITE006634		Click to Show/Hide the Full List
mod site	chr1:1374516-1374517:-		[2]
Sequence	GGGGATCCTCGCTGGGACGAACCTGCTGCTCCTCAACCCGA
Motif Score	2.930744048
Cell/Tissue List	HeLa; HepG2; A549; peripheral-blood; HEK293T; MSC; NB4; MM6
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000378853.3; ENST00000338370.7; ENST00000489799.1; ENST00000338338.9; ENST00000496905.1; ENST00000321751.9
External Link	RMBase: m6A_site_1470
mod ID: M6ASITE006635		Click to Show/Hide the Full List
mod site	chr1:1374568-1374569:-		[2]
Sequence	TTCCGATGCTCACAGAGGGAACCTCAGGGGTTCAGGCCAGG
Motif Score	2.930744048
Cell/Tissue List	HeLa; peripheral-blood; HEK293T
Seq Type List	m6A-seq
Transcript ID List	ENST00000321751.9; ENST00000378853.3; ENST00000338370.7; ENST00000496905.1; ENST00000338338.9; ENST00000489799.1
External Link	RMBase: m6A_site_1471
mod ID: M6ASITE006636		Click to Show/Hide the Full List
mod site	chr1:1374758-1374759:-		[2]
Sequence	CCTGTGGCCGCCGCCCACAGACCATGCTCCTGGGGCGCCTG
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; A549; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293T; iSLK; MSC; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000378853.3; ENST00000321751.9; ENST00000489799.1; ENST00000338338.9; ENST00000496905.1; ENST00000338370.7
External Link	RMBase: m6A_site_1472
mod ID: M6ASITE006647		Click to Show/Hide the Full List
mod site	chr1:1374779-1374780:-		[2]
Sequence	TGTGTTCCAGCTCCCCTGGGACCTGTGGCCGCCGCCCACAG
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; A549; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293T; iSLK; MSC; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000378853.3; ENST00000338338.9; ENST00000321751.9; ENST00000489799.1; ENST00000496905.1; ENST00000338370.7
External Link	RMBase: m6A_site_1473
mod ID: M6ASITE006677		Click to Show/Hide the Full List
mod site	chr1:1374867-1374868:-		[2]
Sequence	GAAGCGAGGGTCGCGGCGGGACCAGACGCCCCAGTCCCGGC
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; A549; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293T; MSC; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000496905.1; ENST00000489799.1; ENST00000338370.7; ENST00000338338.9; ENST00000378853.3; ENST00000321751.9
External Link	RMBase: m6A_site_1474
mod ID: M6ASITE006678		Click to Show/Hide the Full List
mod site	chr1:1375003-1375004:-		[2]
Sequence	GCCGGCCTCCCCGTTCTGGGACCTTTCGGTGCGTCCGAGCG
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; A549; U2OS; H1299; MM6; Jurkat; GSC-11; HEK293T; HEK293A-TOA; MSC; iSLK; TIME; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000338338.9; ENST00000489799.1; ENST00000496905.1; ENST00000338370.7; ENST00000378853.3; ENST00000321751.9
External Link	RMBase: m6A_site_1475
mod ID: M6ASITE006679		Click to Show/Hide the Full List
mod site	chr1:1375036-1375037:-		[2]
Sequence	CGCGATTCGCGCGGGGGTGAACCCGGGGAGGGGGCCGGCCT
Motif Score	2.930744048
Cell/Tissue List	HeLa; HepG2; A549; U2OS; H1299; MM6; Jurkat; GSC-11; HEK293T; HEK293A-TOA; MSC; iSLK; TIME; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000338370.7; ENST00000338338.9; ENST00000496905.1; ENST00000378853.3; ENST00000321751.9; ENST00000489799.1
External Link	RMBase: m6A_site_1476
mod ID: M6ASITE006688		Click to Show/Hide the Full List
mod site	chr1:1375204-1375205:-		[2]
Sequence	CGGGGCCGACTTGGGGACGGACCGGAAGTGCCCGAGGGCGG
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; H1A; H1B; fibroblasts; A549; H1299; Jurkat; GSC-11; HEK293T; HEK293A-TOA; MSC; TREX; iSLK; TIME; endometrial; MM6
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000338338.9
External Link	RMBase: m6A_site_1477
mod ID: M6ASITE006789		Click to Show/Hide the Full List
mod site	chr1:1375247-1375248:-		[2]
Sequence	AGCGGGCGCTGTGCGTAGGAACCGCCGGGTGGCCGCTGCCG
Motif Score	2.930744048
Cell/Tissue List	HeLa; HepG2; H1A; H1B; A549; H1299; Jurkat; GSC-11; HEK293T; HEK293A-TOA; MSC; TREX; iSLK; TIME; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000338338.9
External Link	RMBase: m6A_site_1478
mod ID: M6ASITE006890		Click to Show/Hide the Full List
mod site	chr1:1375330-1375331:-		[2]
Sequence	CGTGATTCCACTAACCGGAAACCGTCGCCTTTCGGGCCCGG
Motif Score	2.185083333
Cell/Tissue List	HeLa; A549; Jurkat; HEK293A-TOA
Seq Type List	m6A-seq
Transcript ID List	ENST00000338338.9
External Link	RMBase: m6A_site_1479
mod ID: M6ASITE006971		Click to Show/Hide the Full List
mod site	chr1:1375352-1375353:-		[2]
Sequence	GGAACCGCGCGAGGACTGGGACCGTGATTCCACTAACCGGA
Motif Score	3.622404762
Cell/Tissue List	HeLa; Jurkat; HEK293A-TOA
Seq Type List	m6A-seq
Transcript ID List	ENST00000338338.9
External Link	RMBase: m6A_site_1480
mod ID: M6ASITE007054		Click to Show/Hide the Full List
mod site	chr1:1375358-1375359:-		[2]
Sequence	AGCTGAGGAACCGCGCGAGGACTGGGACCGTGATTCCACTA
Motif Score	4.065041667
Cell/Tissue List	HeLa; Jurkat; HEK293A-TOA
Seq Type List	m6A-seq
Transcript ID List	ENST00000338338.9
External Link	RMBase: m6A_site_1481
mod ID: M6ASITE007065		Click to Show/Hide the Full List
mod site	chr1:1375369-1375370:-		[2]
Sequence	GGACCAGGCGGAGCTGAGGAACCGCGCGAGGACTGGGACCG
Motif Score	2.930744048
Cell/Tissue List	HeLa; Jurkat; HEK293A-TOA
Seq Type List	m6A-seq
Transcript ID List	ENST00000338338.9
External Link	RMBase: m6A_site_1482
mod ID: M6ASITE007076		Click to Show/Hide the Full List
mod site	chr1:1375387-1375388:-		[2]
Sequence	GTTTTTTGCCTCCGTAAGGGACCAGGCGGAGCTGAGGAACC
Motif Score	3.622404762
Cell/Tissue List	HeLa; Jurkat; HEK293A-TOA
Seq Type List	m6A-seq
Transcript ID List	ENST00000338338.9
External Link	RMBase: m6A_site_1483
mod ID: M6ASITE007087		Click to Show/Hide the Full List
mod site	chr1:1375457-1375458:-		[4]
Sequence	TGGTCCGGAAACGATTCTGGACCTGCGGGTATATCCAGGGC
Motif Score	3.622404762
Cell/Tissue List	HEK293A-TOA
Seq Type List	m6A-seq
Transcript ID List	ENST00000338338.9
External Link	RMBase: m6A_site_1484

2'-O-Methylation (2'-O-Me)

In total 1 m6A sequence/site(s) in this target gene
mod ID: 2OMSITE000313		Click to Show/Hide the Full List
mod site	chr1:1373759-1373760:-		[5]
Sequence	CCCGTTGCTGCTGTGATCCGTAGTAATAAATTCTCAGAGGA
Cell/Tissue List	HeLa
Seq Type List	Nm-seq
Transcript ID List	ENST00000321751.9; ENST00000338338.9; ENST00000378853.3; ENST00000338370.7
External Link	RMBase: Nm_site_5

Ref 1	NAT10-mediated N4-acetylcytidine mRNA modification regulates self-renewal in human embryonic stem cells. Nucleic Acids Res. 2023 Sep 8;51(16):8514-8531. doi: 10.1093/nar/gkad628.
Ref 2	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 3	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 4	The U6 snRNA m(6)A Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention. Cell. 2017 May 18;169(5):824-835.e14. doi: 10.1016/j.cell.2017.05.003.
Ref 5	Nm-seq maps 2'-O-methylation sites in human mRNA with base precision. Nat Methods. 2017 Jul;14(7):695-698. doi: 10.1038/nmeth.4294. Epub 2017 May 15.

Epigenetic Target Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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