Epigenetic Target Information

General Information of the Epigenetic Target (ID: EPITAR00010)

Target Name	Cyclin-dependent kinase 4 (CDK4)
Synonyms	Cell division protein kinase 4; PSK-J3 Click to Show/Hide
Gene Name	CDK4
Sequence	MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE Click to Show/Hide
Family	Protein kinase superfamily; CMGC Ser/Thr protein kinase family; CDC2/CDKX subfamily
Function	Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Click to Show/Hide
Gene ID	1019
HGNC ID	HGNC:1773
Ensembl Gene ID	ENSG00000135446
KEGG ID	hsa:1019
Chromosomal Location	12q14.1

RNA Modification Sequencing Data Associated with the Target (ID: EPITAR00010)

Cyclin-dependent kinase 4 (CDK4)

2'-O-Methylation (2'-O-Me)

In total 2 m6A sequence/site(s) in this target gene
mod ID: 2OMSITE000070		Click to Show/Hide the Full List
mod site	chr12:57749474-57749475:-		[1]
Sequence	CTGTGGAAACTCTGAAGCCGACCAGTTGGGCAAAATCTTTG
Cell/Tissue List	HeLa
Seq Type List	Nm-seq
Transcript ID List	ENST00000549606.5; ENST00000553237.5; ENST00000547281.5; ENST00000552713.5; ENST00000551888.5; ENST00000546489.5; ENST00000550419.5; ENST00000257904.11; ENST00000312990.10
External Link	RMBase: Nm_site_1394
mod ID: 2OMSITE000071		Click to Show/Hide the Full List
mod site	chr12:57752252-57752253:-		[1]
Sequence	CCAGCTGCTCCGGACCGAGCTCGGGTGTATGGGGCCGTAGG
Cell/Tissue List	HeLa
Seq Type List	Nm-seq
Transcript ID List	ENST00000312990.10; ENST00000551888.5; ENST00000552862.1; ENST00000257904.11; ENST00000546489.5; ENST00000547281.5; ENST00000549606.5; ENST00000550419.5; ENST00000551800.5; ENST00000552388.1; ENST00000553237.5; ENST00000551706.1
External Link	RMBase: Nm_site_1395

5-methylcytidine (m5C)

In total 1 m6A sequence/site(s) in this target gene
mod ID: M5CSITE000069		Click to Show/Hide the Full List
mod site	chr12:57748481-57748482:-		[2]
Sequence	AGGAAGAAAAGCTGCCATTTCCCTTCTGGACACTGAGAGGG
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000257904.11; ENST00000549606.5; ENST00000552713.5; ENST00000312990.10
External Link	RMBase: m5C_site_10551

N6-methyladenosine (m6A)

In total 37 m6A sequence/site(s) in this target gene
mod ID: M6ASITE013647		Click to Show/Hide the Full List
mod site	chr12:57748071-57748072:-		[3]
Sequence	CTGACAAAGCTTAGAAAGGAACTGAAATTGCTTCTTTGAAT
Motif Score	3.373380952
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000257904.11; ENST00000312990.10
External Link	RMBase: m6A_site_195736
mod ID: M6ASITE013648		Click to Show/Hide the Full List
mod site	chr12:57748135-57748136:-		[4]
Sequence	TTTCCTGCAAAACCTTAAAGACTGGTTAAATTACAGGGCCT
Motif Score	3.319380952
Cell/Tissue List	HEK293A-TOA
Seq Type List	m6A-seq
Transcript ID List	ENST00000312990.10; ENST00000257904.11
External Link	RMBase: m6A_site_195737
mod ID: M6ASITE013649		Click to Show/Hide the Full List
mod site	chr12:57748144-57748145:-		[5]
Sequence	AGAAGGGACTTTCCTGCAAAACCTTAAAGACTGGTTAAATT
Motif Score	2.185083333
Cell/Tissue List	HeLa; HEK293A-TOA
Seq Type List	m6A-seq
Transcript ID List	ENST00000257904.11; ENST00000312990.10
External Link	RMBase: m6A_site_195738
mod ID: M6ASITE013650		Click to Show/Hide the Full List
mod site	chr12:57748157-57748158:-		[5]
Sequence	AAAACCACTTGGAAGAAGGGACTTTCCTGCAAAACCTTAAA
Motif Score	4.065041667
Cell/Tissue List	HeLa; HEK293A-TOA
Seq Type List	m6A-seq
Transcript ID List	ENST00000257904.11; ENST00000312990.10
External Link	RMBase: m6A_site_195739
mod ID: M6ASITE013651		Click to Show/Hide the Full List
mod site	chr12:57748174-57748175:-		[5]
Sequence	CCATTGTGCGATTTGGAAAAACCACTTGGAAGAAGGGACTT
Motif Score	2.185083333
Cell/Tissue List	HeLa; HEK293A-TOA
Seq Type List	m6A-seq
Transcript ID List	ENST00000312990.10; ENST00000257904.11
External Link	RMBase: m6A_site_195740
mod ID: M6ASITE013652		Click to Show/Hide the Full List
mod site	chr12:57748251-57748252:-		[6]
Sequence	TTTTATACAGGAAAAACAAAACAAAGAAATAATGGTCTTTT
Motif Score	2.20572619
Cell/Tissue List	HEK293T; HeLa
Seq Type List	MeRIP-seq; DART-seq; m6A-seq
Transcript ID List	ENST00000312990.10; ENST00000257904.11
External Link	RMBase: m6A_site_195745
mod ID: M6ASITE013653		Click to Show/Hide the Full List
mod site	chr12:57748256-57748257:-		[7]
Sequence	TCCTTTTTTATACAGGAAAAACAAAACAAAGAAATAATGGT
Motif Score	2.20572619
Cell/Tissue List	HEK293T; hESC-HEK293T; HeLa; AML
Seq Type List	MeRIP-seq; MAZTER-seq; m6A-seq; miCLIP
Transcript ID List	ENST00000257904.11; ENST00000312990.10
External Link	RMBase: m6A_site_195746
mod ID: M6ASITE013654		Click to Show/Hide the Full List
mod site	chr12:57748265-57748266:-		[6]
Sequence	TATTTGGGGTCCTTTTTTATACAGGAAAAACAAAACAAAGA
Motif Score	2.110482143
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000312990.10; ENST00000257904.11
External Link	RMBase: m6A_site_195747
mod ID: M6ASITE013655		Click to Show/Hide the Full List
mod site	chr12:57748326-57748327:-		[6]
Sequence	TCTCCTTCCCATTTCTCTACACTAAGGGGTATGTTCCCTCT
Motif Score	2.506922619
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000257904.11; ENST00000312990.10
External Link	RMBase: m6A_site_195751
mod ID: M6ASITE013656		Click to Show/Hide the Full List
mod site	chr12:57748328-57748329:-		[6]
Sequence	CTTCTCCTTCCCATTTCTCTACACTAAGGGGTATGTTCCCT
Motif Score	2.078666667
Cell/Tissue List	HEK293T; hESC-HEK293T
Seq Type List	DART-seq; MAZTER-seq
Transcript ID List	ENST00000312990.10; ENST00000257904.11
External Link	RMBase: m6A_site_195752
mod ID: M6ASITE013657		Click to Show/Hide the Full List
mod site	chr12:57748383-57748384:-		[6]
Sequence	ATTACTTTGCTGCCTTAATGACATTCCCCTCCCACCTCTCC
Motif Score	2.859755952
Cell/Tissue List	HEK293T; hESC-HEK293T; AML
Seq Type List	DART-seq; MAZTER-seq; miCLIP
Transcript ID List	ENST00000312990.10; ENST00000257904.11
External Link	RMBase: m6A_site_195753
mod ID: M6ASITE013658		Click to Show/Hide the Full List
mod site	chr12:57748400-57748401:-		[6]
Sequence	TCCATCTTTCTACAGAGATTACTTTGCTGCCTTAATGACAT
Motif Score	2.494845238
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000257904.11; ENST00000312990.10
External Link	RMBase: m6A_site_195754
mod ID: M6ASITE013659		Click to Show/Hide the Full List
mod site	chr12:57748472-57748473:-		[5]
Sequence	AGCTGCCATTTCCCTTCTGGACACTGAGAGGGCAATCTTTG
Motif Score	3.643047619
Cell/Tissue List	HeLa; kidney; HEK293T; hESC-HEK293T; A549; AML
Seq Type List	m6A-seq; m6A-REF-seq; DART-seq; MAZTER-seq; m6A-CLIP/IP; miCLIP
Transcript ID List	ENST00000549606.5; ENST00000312990.10; ENST00000552713.5; ENST00000257904.11
External Link	RMBase: m6A_site_195756
mod ID: M6ASITE013660		Click to Show/Hide the Full List
mod site	chr12:57748551-57748552:-		[7]
Sequence	GCTCTGCAGCACTCTTATCTACATAAGGATGAAGGTAATCC
Motif Score	2.078666667
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000257904.11; ENST00000552713.5; ENST00000553237.5; ENST00000312990.10; ENST00000549606.5
External Link	RMBase: m6A_site_195757
mod ID: M6ASITE013661		Click to Show/Hide the Full List
mod site	chr12:57748596-57748597:-		[7]
Sequence	GAAATGCTGACTTTTAACCCACACAAGCGAATCTCTGCCTT
Motif Score	2.053113095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000257904.11; ENST00000312990.10; ENST00000553237.5; ENST00000549606.5; ENST00000546489.5; ENST00000552713.5
External Link	RMBase: m6A_site_195758
mod ID: M6ASITE013662		Click to Show/Hide the Full List
mod site	chr12:57748607-57748608:-		[6]
Sequence	TCTCCCCTCAGGAAATGCTGACTTTTAACCCACACAAGCGA
Motif Score	3.28175
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000312990.10; ENST00000552713.5; ENST00000549606.5; ENST00000546489.5; ENST00000553237.5; ENST00000257904.11
External Link	RMBase: m6A_site_195759
mod ID: M6ASITE013663		Click to Show/Hide the Full List
mod site	chr12:57749193-57749194:-		[8]
Sequence	GAGATGGAGGAGTCGGGAGCACAGCTGCTGCTGGTACTGGA
Motif Score	2.830589286
Cell/Tissue List	kidney
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000549606.5; ENST00000546489.5; ENST00000551888.5; ENST00000553237.5; ENST00000312990.10; ENST00000552713.5; ENST00000257904.11
External Link	RMBase: m6A_site_195762
mod ID: M6ASITE013664		Click to Show/Hide the Full List
mod site	chr12:57749290-57749291:-		[6]
Sequence	TGGGCTGCCTCCAGAGGATGACTGGCCTCGAGATGTATCCC
Motif Score	3.28175
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000312990.10; ENST00000547281.5; ENST00000550419.5; ENST00000257904.11; ENST00000546489.5; ENST00000552713.5; ENST00000549606.5; ENST00000551888.5; ENST00000553237.5
External Link	RMBase: m6A_site_195763
mod ID: M6ASITE013665		Click to Show/Hide the Full List
mod site	chr12:57750700-57750701:-		[7]
Sequence	CACATATGCAACACCTGTGGACATGTGGAGTGTTGGCTGTA
Motif Score	3.643047619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000312990.10; ENST00000547281.5; ENST00000553237.5; ENST00000257904.11; ENST00000550419.5; ENST00000549606.5; ENST00000551888.5; ENST00000552254.5; ENST00000546489.5; ENST00000551800.5
External Link	RMBase: m6A_site_195766
mod ID: M6ASITE013666		Click to Show/Hide the Full List
mod site	chr12:57750710-57750711:-		[8]
Sequence	TTCTGCAGTCCACATATGCAACACCTGTGGACATGTGGAGT
Motif Score	2.173910714
Cell/Tissue List	brain
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000553237.5; ENST00000551800.5; ENST00000257904.11; ENST00000551888.5; ENST00000547281.5; ENST00000552254.5; ENST00000549606.5; ENST00000550419.5; ENST00000546489.5; ENST00000312990.10
External Link	RMBase: m6A_site_195767
mod ID: M6ASITE013667		Click to Show/Hide the Full List
mod site	chr12:57750987-57750988:-		[8]
Sequence	TTCTGGTGACAAGTGGTGGAACAGTCAAGCTGGCTGACTTT
Motif Score	2.951386905
Cell/Tissue List	kidney; liver
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000552388.1; ENST00000551706.1; ENST00000551800.5; ENST00000553237.5; ENST00000312990.10; ENST00000552254.5; ENST00000549606.5; ENST00000257904.11; ENST00000547281.5; ENST00000551888.5; ENST00000546489.5; ENST00000550419.5
External Link	RMBase: m6A_site_195768
mod ID: M6ASITE013668		Click to Show/Hide the Full List
mod site	chr12:57750999-57751000:-		[8]
Sequence	AGCCAGAGAACATTCTGGTGACAAGTGGTGGAACAGTCAAG
Motif Score	2.859755952
Cell/Tissue List	kidney
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000257904.11; ENST00000552388.1; ENST00000550419.5; ENST00000551888.5; ENST00000549606.5; ENST00000547281.5; ENST00000551800.5; ENST00000552254.5; ENST00000551706.1; ENST00000312990.10; ENST00000553237.5; ENST00000546489.5
External Link	RMBase: m6A_site_195769
mod ID: M6ASITE013669		Click to Show/Hide the Full List
mod site	chr12:57751010-57751011:-		[8]
Sequence	CCGAGATCTGAAGCCAGAGAACATTCTGGTGACAAGTGGTG
Motif Score	2.951386905
Cell/Tissue List	brain; hESC-HEK293T
Seq Type List	m6A-REF-seq; MAZTER-seq
Transcript ID List	ENST00000549606.5; ENST00000550419.5; ENST00000552388.1; ENST00000553237.5; ENST00000552254.5; ENST00000257904.11; ENST00000551800.5; ENST00000551706.1; ENST00000546489.5; ENST00000551888.5; ENST00000547281.5; ENST00000312990.10
External Link	RMBase: m6A_site_195770
mod ID: M6ASITE013670		Click to Show/Hide the Full List
mod site	chr12:57751246-57751247:-		[7]
Sequence	GGACCTAAGGACATATCTGGACAAGGCACCCCCACCAGGCT
Motif Score	3.643047619
Cell/Tissue List	hESC-HEK293T; peripheral-blood; endometrial
Seq Type List	MAZTER-seq; m6A-seq
Transcript ID List	ENST00000553237.5; ENST00000257904.11; ENST00000551888.5; ENST00000552862.1; ENST00000552388.1; ENST00000550419.5; ENST00000547281.5; ENST00000549606.5; ENST00000552254.5; ENST00000546489.5; ENST00000551800.5; ENST00000551706.1; ENST00000312990.10
External Link	RMBase: m6A_site_195771
mod ID: M6ASITE013671		Click to Show/Hide the Full List
mod site	chr12:57751256-57751257:-		[6]
Sequence	ATGTAGACCAGGACCTAAGGACATATCTGGACAAGGCACCC
Motif Score	3.643047619
Cell/Tissue List	HEK293T; hESC-HEK293T; peripheral-blood; endometrial
Seq Type List	DART-seq; MAZTER-seq; m6A-seq
Transcript ID List	ENST00000546489.5; ENST00000312990.10; ENST00000551888.5; ENST00000551706.1; ENST00000552388.1; ENST00000549606.5; ENST00000552862.1; ENST00000547281.5; ENST00000257904.11; ENST00000550419.5; ENST00000553237.5; ENST00000551800.5; ENST00000552254.5
External Link	RMBase: m6A_site_195772
mod ID: M6ASITE013672		Click to Show/Hide the Full List
mod site	chr12:57751264-57751265:-		[9]
Sequence	GTTTGAGCATGTAGACCAGGACCTAAGGACATATCTGGACA
Motif Score	3.622404762
Cell/Tissue List	peripheral-blood; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000551800.5; ENST00000550419.5; ENST00000549606.5; ENST00000552388.1; ENST00000552862.1; ENST00000551888.5; ENST00000547281.5; ENST00000552254.5; ENST00000553237.5; ENST00000257904.11; ENST00000546489.5; ENST00000312990.10; ENST00000551706.1
External Link	RMBase: m6A_site_195773
mod ID: M6ASITE013673		Click to Show/Hide the Full List
mod site	chr12:57751270-57751271:-		[9]
Sequence	CCTGGTGTTTGAGCATGTAGACCAGGACCTAAGGACATATC
Motif Score	2.876744048
Cell/Tissue List	peripheral-blood; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000549606.5; ENST00000257904.11; ENST00000551888.5; ENST00000312990.10; ENST00000550419.5; ENST00000551800.5; ENST00000552862.1; ENST00000553237.5; ENST00000551706.1; ENST00000552388.1; ENST00000552254.5; ENST00000547281.5; ENST00000546489.5
External Link	RMBase: m6A_site_195774
mod ID: M6ASITE013674		Click to Show/Hide the Full List
mod site	chr12:57751313-57751314:-		[9]
Sequence	ACGTCTGTGCCACATCCCGAACTGACCGGGAGATCAAGGTA
Motif Score	3.373380952
Cell/Tissue List	peripheral-blood; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000551706.1; ENST00000257904.11; ENST00000550419.5; ENST00000547281.5; ENST00000551800.5; ENST00000549606.5; ENST00000551888.5; ENST00000552388.1; ENST00000546489.5; ENST00000553237.5; ENST00000552862.1; ENST00000312990.10; ENST00000552254.5
External Link	RMBase: m6A_site_195775
mod ID: M6ASITE013675		Click to Show/Hide the Full List
mod site	chr12:57751322-57751323:-		[8]
Sequence	GGCTGATGGACGTCTGTGCCACATCCCGAACTGACCGGGAG
Motif Score	2.053113095
Cell/Tissue List	brain; HEK293; kidney; hESC-HEK293T
Seq Type List	m6A-REF-seq; MAZTER-seq
Transcript ID List	ENST00000550419.5; ENST00000552862.1; ENST00000546489.5; ENST00000551706.1; ENST00000257904.11; ENST00000547281.5; ENST00000552254.5; ENST00000312990.10; ENST00000553237.5; ENST00000551800.5; ENST00000549606.5; ENST00000552388.1; ENST00000551888.5
External Link	RMBase: m6A_site_195776
mod ID: M6ASITE013676		Click to Show/Hide the Full List
mod site	chr12:57751411-57751412:-		[9]
Sequence	TGATCTGTAGAGAAGTGGGGACCCTGAGGAAATAATGAGAG
Motif Score	3.622404762
Cell/Tissue List	peripheral-blood
Seq Type List	m6A-seq
Transcript ID List	ENST00000553237.5; ENST00000257904.11; ENST00000552254.5; ENST00000546489.5; ENST00000551800.5; ENST00000551706.1; ENST00000547281.5; ENST00000550419.5; ENST00000552388.1; ENST00000549606.5; ENST00000312990.10; ENST00000552862.1; ENST00000551888.5
External Link	RMBase: m6A_site_195777
mod ID: M6ASITE013677		Click to Show/Hide the Full List
mod site	chr12:57751453-57751454:-		[9]
Sequence	GTGGGGAGTAAAGGGAAAAGACAGCCTATAGGTGGGGTGTG
Motif Score	2.897386905
Cell/Tissue List	peripheral-blood
Seq Type List	m6A-seq
Transcript ID List	ENST00000551800.5; ENST00000552862.1; ENST00000552388.1; ENST00000549606.5; ENST00000550419.5; ENST00000547281.5; ENST00000552254.5; ENST00000312990.10; ENST00000546489.5; ENST00000257904.11; ENST00000551706.1; ENST00000551888.5; ENST00000553237.5
External Link	RMBase: m6A_site_195778
mod ID: M6ASITE013678		Click to Show/Hide the Full List
mod site	chr12:57751560-57751561:-		[8]
Sequence	GAGGAGGCCTTCCCATCAGCACAGTTCGTGAGGTGGCTTTA
Motif Score	2.830589286
Cell/Tissue List	kidney
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000549606.5; ENST00000552254.5; ENST00000551706.1; ENST00000551800.5; ENST00000312990.10; ENST00000257904.11; ENST00000551888.5; ENST00000553237.5; ENST00000552862.1; ENST00000546489.5; ENST00000550419.5; ENST00000547281.5; ENST00000552388.1
External Link	RMBase: m6A_site_195779
mod ID: M6ASITE013679		Click to Show/Hide the Full List
mod site	chr12:57751655-57751656:-		[6]
Sequence	CGGTGCCTATGGGACAGTGTACAAGGCCCGTGATCCCCACA
Motif Score	2.856142857
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000550419.5; ENST00000257904.11; ENST00000549606.5; ENST00000552254.5; ENST00000547281.5; ENST00000552862.1; ENST00000551888.5; ENST00000551706.1; ENST00000552388.1; ENST00000551800.5; ENST00000546489.5; ENST00000312990.10; ENST00000553237.5
External Link	RMBase: m6A_site_195780
mod ID: M6ASITE013680		Click to Show/Hide the Full List
mod site	chr12:57751662-57751663:-		[8]
Sequence	TTGGTGTCGGTGCCTATGGGACAGTGTACAAGGCCCGTGAT
Motif Score	3.643047619
Cell/Tissue List	HEK293; HEK293T; hESC-HEK293T; HepG2; peripheral-blood; AML
Seq Type List	m6A-REF-seq; DART-seq; MAZTER-seq; m6A-seq; miCLIP
Transcript ID List	ENST00000552862.1; ENST00000257904.11; ENST00000551888.5; ENST00000550419.5; ENST00000551800.5; ENST00000552254.5; ENST00000312990.10; ENST00000553237.5; ENST00000546489.5; ENST00000547281.5; ENST00000551706.1; ENST00000549606.5; ENST00000552388.1
External Link	RMBase: m6A_site_195781
mod ID: M6ASITE013681		Click to Show/Hide the Full List
mod site	chr12:57752230-57752231:-		[5]
Sequence	GGGTGTATGGGGCCGTAGGAACCGGCTCCGGGGCCCCGATA
Motif Score	2.930744048
Cell/Tissue List	HeLa; HepG2; A549; peripheral-blood; HEK293A-TOA; iSLK; MSC; TIME
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000547281.5; ENST00000552388.1; ENST00000312990.10; ENST00000549606.5; ENST00000552862.1; ENST00000550419.5; ENST00000553237.5; ENST00000551800.5; ENST00000551706.1; ENST00000551888.5; ENST00000546489.5; ENST00000257904.11
External Link	RMBase: m6A_site_195782
mod ID: M6ASITE013682		Click to Show/Hide the Full List
mod site	chr12:57752259-57752260:-		[5]
Sequence	TCTGCGTCCAGCTGCTCCGGACCGAGCTCGGGTGTATGGGG
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; A549; peripheral-blood; HEK293A-TOA; iSLK; MSC; TIME
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000551706.1; ENST00000552388.1; ENST00000551888.5; ENST00000546489.5; ENST00000312990.10; ENST00000549606.5; ENST00000547281.5; ENST00000552862.1; ENST00000553237.5; ENST00000551800.5; ENST00000550419.5; ENST00000257904.11
External Link	RMBase: m6A_site_195783
mod ID: M6ASITE013683		Click to Show/Hide the Full List
mod site	chr12:57752342-57752343:-		[7]
Sequence	CGCCTCTTTGGCAGCTGGTCACATGGTGAGGGTGGGGGTGA
Motif Score	2.047297619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000552862.1; ENST00000551706.1; ENST00000549606.5; ENST00000551800.5; ENST00000312990.10
External Link	RMBase: m6A_site_195784

Ref 1	Nm-seq maps 2'-O-methylation sites in human mRNA with base precision. Nat Methods. 2017 Jul;14(7):695-698. doi: 10.1038/nmeth.4294. Epub 2017 May 15.
Ref 2	5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m(5)C reader. Cell Res. 2017 May;27(5):606-625. doi: 10.1038/cr.2017.55. Epub 2017 Apr 18.
Ref 3	N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection. Cell Host Microbe. 2016 Nov 9;20(5):654-665. doi: 10.1016/j.chom.2016.09.015. Epub 2016 Oct 20.
Ref 4	The U6 snRNA m(6)A Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention. Cell. 2017 May 18;169(5):824-835.e14. doi: 10.1016/j.cell.2017.05.003.
Ref 5	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 6	DART-seq: an antibody-free method for global m(6)A detection. Nat Methods. 2019 Dec;16(12):1275-1280. doi: 10.1038/s41592-019-0570-0. Epub 2019 Sep 23.
Ref 7	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 8	Single-base mapping of m(6)A by an antibody-independent method. Sci Adv. 2019 Jul 3;5(7):eaax0250. doi: 10.1126/sciadv.aax0250. eCollection 2019 Jul.
Ref 9	R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m(6)A/MYC/CEBPA Signaling. Cell. 2018 Jan 11;172(1-2):90-105.e23. doi: 10.1016/j.cell.2017.11.031. Epub 2017 Dec 14.

Epigenetic Target Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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