m6A-centered Drug Response Information
General Information of the Drug (ID: M6ADRUG0257)
| Name |
Tadalafil
|
||||
|---|---|---|---|---|---|
| Synonyms |
ADCIRCA; Acdirca; Cialis; Tadanafil; Lilly brand of tadalafil; Tadalafil [USAN]; GF 196960; IC 351; ICOS 351; Ic351; Cialis (TN); GF-196960; IC-351; KS-1117; Tadalafil (JAN/USAN/INN); Cialis, GF 196960, IC 351, ICOS 351, Tadalafil; (6R,12aR)-2,3,6,7,12,12a-Hexahydro-2-methyl-6-(3,4-(methylenedioxy)phenyl) pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione; (6R,12aR)-2,3,6,7,12,12a-Hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione; (6R-trans)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione
Click to Show/Hide
|
||||
| Structure |
 |
||||
|
3D MOL
|
|||||
| Formula |
C22H19N3O4
|
||||
| InChI |
InChI=1S/C22H19N3O4/c1-24-10-19(26)25-16(22(24)27)9-14-13-4-2-3-5-15(13)23-20(14)21(25)12-6-7-17-18(8-12)29-11-28-17/h2-8,16,21,23H,9-11H2,1H3/t16-,21-/m1/s1
|
||||
| InChIKey |
WOXKDUGGOYFFRN-IIBYNOLFSA-N
|
||||
| PubChem CID | |||||
| TTD Drug ID | |||||
| DrugBank ID | |||||
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Drug
| In total 1 item(s) under this drug | ||
| Crosstalk ID: M6ACROT05957 | ||
| m6A Regulator | RNA demethylase ALKBH5 (ALKBH5) | |
| m6A Target | Breast cancer type 1 susceptibility protein (BRCA1) | |
| Epigenetic Regulator | Protein arginine N-methyltransferase 5 (PRMT5) | |
| Regulated Target | Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial (ALKBH7) | |
| Crosstalk relationship | Histone modification → m6A | |
| Disease | Breast cancer | |