m6A-centered Disease Response Information

General Information of the Disease (ID: M6ADIS0165)
Name
Skin tumour
ICD
ICD-11: 2F92
Full List of Target Gene(s) of This m6A-centered Disease Response
DNA damage-binding protein 2 (DDB2)
 Target Info 
In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene [1]
Response Summary METTL14 knockdown decreases GGR and DNA damage-binding protein 2 (DDB2) abundance. Conversely, overexpression of wild-type METTL14 but not its enzymatically inactive mutant increases GGR and DDB2 abundance. METTL14 is a target for selective autophagy and acts as a critical epitranscriptomic mechanism to regulate GGR and suppress UVB-induced skin tumorigenesis.
Responsed Disease Skin tumour [ICD-11: 2F92]
Target Regulator Methyltransferase-like 14 (METTL14) WRITER
 Regulator Info 
Target Regulation Up regulation
Pathway Response Nucleotide excision repair hsa03420
Cell Process Genome repair
Cell autophagy
In-vitro Model NHEK (Normal human epithelial keratinocytes)
MEF (Mouse embryonic fibroblasts)
HaCaT Normal Homo sapiens CVCL_0038
A-431 Skin squamous cell carcinoma Homo sapiens CVCL_0037
References
Ref 1 METTL14 facilitates global genome repair and suppresses skin tumorigenesis. Proc Natl Acad Sci U S A. 2021 Aug 31;118(35):e2025948118. doi: 10.1073/pnas.2025948118.