m6A-centered Disease Response Information

General Information of the Disease (ID: M6ADIS0064)
Name
Merkel cell carcinoma
ICD
ICD-11: 2C34
Full List of Target Gene(s) of This m6A-centered Disease Response
Eukaryotic translation initiation factor 3 subunit A (EIF3A/EIF3)
 Target Info 
In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene [1]
Response Summary Knockdown of YTHDF1 in Merkel cell carcinoma (MCC) cell lines negatively affected the translation initiation factor Eukaryotic translation initiation factor 3 subunit A (EIF3A/EIF3) and reduced proliferation and clonogenic capacity in vitro.
Responsed Disease Merkel cell carcinoma [ICD-11: 2C34]
Target Regulator YTH domain-containing family protein 1 (YTHDF1) READER
 Regulator Info 
Target Regulation Up regulation
Pathway Response mRNA surveillance pathway hsa03015
Cell Process Translation
In-vitro Model MCC13 Merkel cell carcinoma Homo sapiens CVCL_2583
MCC26 Merkel cell carcinoma Homo sapiens CVCL_2585
MKL-1 Merkel cell carcinoma Homo sapiens CVCL_2600
MKL-2 Merkel cell carcinoma Homo sapiens CVCL_D027
PeTa Merkel cell carcinoma Homo sapiens CVCL_LC73
UISO-MCC-1 Merkel cell carcinoma Homo sapiens CVCL_E996
WaGa Merkel cell carcinoma Homo sapiens CVCL_E998
References
Ref 1 Oncogenic Role of an Epigenetic Reader of m(6)A RNA Modification: YTHDF1 in Merkel Cell Carcinoma. Cancers (Basel). 2020 Jan 14;12(1):202. doi: 10.3390/cancers12010202.