m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT05984
|
[1] | |||
Non-coding RNA
miR-141
METTL14
lncRNA miRNA circRNA
Direct
Inhibition
m6A modification
Pdx1
Pdx1
METTL14
Methylation
 : m6A sites
|
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| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | Methyltransferase-like 14 (METTL14) | WRITER | |||
| m6A Target | Pancreas/duodenum homeobox protein 1 (Pdx1) | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | Non-coding RNA (ncRNA) | ||||
| Epigenetic Regulator | hsa-miR-141 | microRNA | View Details | ||
| Regulated Target | Methyltransferase-like protein 14 (METTL14) | View Details | |||
| Crosstalk Relationship | ncRNA → m6A | Inhibition | |||
| Crosstalk Mechanism | ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator | ||||
| Crosstalk Summary | MiR-200 family (miR-200b/miR-200c) and hsa-miR-141 reduced Pancreas/duodenum homeobox protein 1 (Pdx1) via targeting METTL14, which should also be a crucial contributor to beta-cell dysfunction and apoptosis in the pancreas of BPF-exposed mice. | ||||
| Responsed Drug | 4-(4-hydroxyphenyl)sulfonylphenol | ||||