m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT05836
 [1]
m6A modification XIST XIST METTL14 Methylation : m6A sites Direct Inhibition Non-coding RNA XIST Regulated Target  lncRNA       miRNA   circRNA
m6A Modification:
m6A Regulator Methyltransferase-like 14 (METTL14) WRITER
 Regulator Info 
m6A Target X inactive specific transcript (XIST)
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type Non-coding RNA (ncRNA)
Epigenetic Regulator X inactive specific transcript (XIST) LncRNA View Details
Crosstalk Relationship m6A  →  ncRNA Inhibition
Crosstalk Mechanism m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA
Crosstalk Summary Because methylation regulates X inactive specific transcript (XIST) expression, the differences in m6A-related genes expressed between the high and low XIST expression groups were analyzed. The expression of METTL14 in the low XIST expression group was notably increased compared with that in the high XIST expression group (P = 0.03276), which indicated that METTL14 participated in XIST m6A-methylation.
Responsed Disease Diffuse large B-cell lymphomas ICD-11: 2A81
 Disease Info 
Cell Process Cell proliferation
In-vitro Model
 OCI-Ly3 Diffuse large B-cell lymphoma activated B-cell type Homo sapiens CVCL_8800
OCI-Ly10 Diffuse large B-cell lymphoma Homo sapiens CVCL_8795
SU-DHL-2 Diffuse large B-cell lymphoma activated B-cell type Homo sapiens CVCL_9550
U-2932 Diffuse large B-cell lymphoma Homo sapiens CVCL_1896
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
2A81: Diffuse large B-cell lymphomas 93 Compound(s) Regulating the Disease Click to Show/Hide the Full List
 Compound Name Glofitamab Approved [2]
Synonyms
Glofitamab
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TTD: DKF7G0
 Compound Name Epcoritamab Approved [3]
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TTD: DB4M9J
 Compound Name Loncastuximab tesirine Approved [4]
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TTD: D8L5PA
 Compound Name Pozelimab Approved [5]
Synonyms
REGN3918
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TTD: D4XBR9
 Compound Name Ocrelizumab Approved [6]
Synonyms
Ocrelizumab (USAN); Ocrelizumab (genetical recombination); Ocrelizumab (genetical recombination) (JAN)
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TTD: D0YV4F
 Compound Name Ofatumumab Phase 3 [7]
Synonyms
Arzerra (TN)
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TTD: D0Y8ZN
 Compound Name Tafasitamab Approved [8]
Synonyms
Xmab 5574/MOR208
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TTD: D0R3PY
 Compound Name Umbralisib Phase 2/3 [9]
Synonyms
RP5264; TGR-1202
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CID: 72950888
TTD: D0O8SJ
DrugBank: DB14989
 Compound Name Lisocabtagene maraleucel Approved [10]
Synonyms
JCAR017
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TTD: D0M4WU
 Compound Name Durvalumab Approved [11]
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TTD: D0LS9E
 Compound Name Blinatumomab Phase 2/3 [11]
Synonyms
AMG 103; Blincyto
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TTD: D0K4RK
 Compound Name Tisagenlecleucel Application submitted [11]
Synonyms
Tisagenlecleucel-T
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TTD: D0IM6T
 Compound Name Axicabtagene ciloleucel Approved [6]
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TTD: D0DK5R
 Compound Name Ibrutinib Phase 3 [11]
Synonyms
PCI-32765; Ibrutinib (BTK inhibitor)
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CID: 24821094
TTD: D09KTS
DrugBank: DB09053
 Compound Name Pembrolizumab Approved [11]
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TTD: D08ANZ
 Compound Name Polatuzumab vedotin Approved [12]
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TTD: D05QOL
 Compound Name Nivolumab Approved [11]
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TTD: D00GOV
 Compound Name Tazemetostat Approved [11]
Synonyms
EPZ-6438; 1403254-99-8; EPZ6438; UNII-Q40W93WPE1; N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-carboxamide; Q40W93WPE1; EPZ 6438; E7438; (1,1'-Biphenyl)-3-carboxamide, N-((1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4'-(4-morpholinylmethyl)-
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CID: 66558664
TTD: D00EQL
DrugBank: DB12887
 Compound Name ICP-022 Phase 2 [13]
Synonyms
Orelabrutinib; 1655504-04-3; UNII-WJA5UO9E10; WJA5UO9E10; 4-yl]pyridine-3-carboxamide; ICP022; 2-(4-phenoxyphenyl)-6-[1-(prop-2-enoyl)piperidin-; 6-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)nicotinamide; Orelabrutinib [INN]; orelabrutinib (proposed INN); SCHEMBL16597834; US9951056, Example 3; GTPL10629; BDBM389631; EX-A3442; NSC826039; s9600; NSC-826039; example 3 [WO2015048662A2]; DB-091042; HY-129390; CS-0105163; 2-(4-phenoxyphenyl)-6-(1-prop-2-enoylpiperidin-4-yl)pyridine-3-carboxamide; 3-Pyridinecarboxamide, 6-(1-(1-oxo-2-propen-1-yl)-4-piperidinyl)-2-(4-phenoxyphenyl)-; 6-(1-(1-Oxo-2-propen-1-yl)-4-piperidinyl)-2-(4-phenoxyphenyl)-3-pyridinecarboxamide
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CID: 91667513
TTD: DUTJ12
 Compound Name BI-695500 Application submitted [11]
Synonyms
Rituximab biosimilar
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TTD: D0X3HV
 Compound Name Abexinostat Phase 3 [11]
Synonyms
PCI-24781; 783355-60-2; PCI 24781; CRA-024781; CRA 024781; UNII-IYO470654U; 3-((dimethylamino)methyl)-N-(2-(4-(hydroxycarbamoyl)phenoxy)ethyl)benzofuran-2-carboxamide; CRA-02478; Abexinostat(PCI-24781); PCI-24781 (Abexinostat); Abexinostat (PCI-24781); IYO470654U; 3-[(Dimethylamino)methyl]-N-[2-[4-[(hydroxyamino)carbonyl]phenoxy]ethyl]-2-benzofurancarboxamide; 3-((Dimethylamino)methyl)-N-(2-(4-(hydroxycarbamoyl)-phenoxy)ethyl)benzofuran-2-carboxamide
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CID: 11749858
TTD: D0V0SL
DrugBank: DB12565
 Compound Name Pixantrone Phase 3 [14]
Synonyms
Pixuvri (TN)
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CID: 134019
TTD: D0Q4OW
DrugBank: DB06193
 Compound Name Enzastaurin Phase 3 [11]
Synonyms
LY317615; LE-0014; LY317615, Enzastaurin; 3-(1-methyl-1H-indol-3-yl)-4-{1-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1H-indol-3-yl}-1H-pyrrole-2,5-dione; 3-(1-methylindol-3-yl)-4-[1-[1-(pyridin-2-ylmethyl)piperidin-4-yl]indol-3-yl]pyrrole-2,5-dione
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CID: 176167
TTD: D0I6VU
DrugBank: DB06486
 Compound Name Adcetris Phase 3 [15]
External Link
TTD: D0F4IM
 Compound Name CC-486 Phase 3 [11]
Synonyms
AG-14361; AG14361; 328543-09-5; UNII-48N0U0K50I; AG 14361; CHEMBL65892; 48N0U0K50I; Imidazo[4,5,1-jk][1,4]benzodiazepin-7(4H)-one, 2-[4-[(dimethylamino)methyl]phenyl]-5,6-dihydro-; AG-014361; 1-(4-((dimethylamino)methyl)phenyl)-8,9-dihydro-2,7,9a-triazabenzo[cd]azulen-6(7H)-one; Imidazo(4,5,1-jk)(1,4)benzodiazepin-7(4H)-one, 2-(4-((dimethylamino)methyl)phenyl)-5,6-dihydro-; 2-[4-[(Dimethylamino)methyl]phenyl]-5,6-dihydroimidazo[4,5,1-jk][1,4]benzodiazepin-7(4H)-one; SMR000486393; MLS006011157; MLS001065917; Nucleoside analogue
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CID: 9840076
TTD: D09NTC
 Compound Name GP2013 Phase 3 [15]
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TTD: D07CPM
 Compound Name Telcyta canfosfamide Phase 3 [16]
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TTD: D06BGO
 Compound Name VR876 Phase 3 [17]
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TTD: D04EVE
 Compound Name Selinexor Phase 3 [18]
Synonyms
Xpovio; KPT 330; KPT-330; KPT-330(Selinexor); KPT330;Selinexor; 1393477-72-9; 31TZ62FO8F; CHEMBL3545185; SCHEMBL14678327; Selinexor (KPT-330); Selinexor [USAN:INN]; Tube706; UNII-31TZ62FO8F
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CID: 71481097
TTD: D00LNW
DrugBank: DB11942
 Compound Name Zilovertamab vedotin Phase 2/3 [19]
Synonyms
MK-2140
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TTD: D3YJZ7
 Compound Name MOR-208 Phase 2/3 [18]
Synonyms
XmAb CD19; XENP-5574; XENP-5603; XmAb-5574; Anti-CD19 humanized mAb (cancer/autoimmune disease), Xencor; Anti-CD19 humanized monoclonal antibody (cancer/autoimmune disease), Xencor
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TTD: D02CYL
 Compound Name MT-3724 Phase 2 [20]
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TTD: DZNH43
 Compound Name Plamotamab Phase 2 [21]
Synonyms
XmAb 13676
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TTD: DLM8G6
 Compound Name PF-07901801 Phase 2 [22]
Synonyms
maplirpacept
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TTD: D6SJ0B
 Compound Name DPX Survivac Phase 2 [23]
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TTD: D5T3OY
 Compound Name Naratuximab emtansine Phase 2 [24]
Synonyms
DEBIO 1562
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TTD: D2R0UM
 Compound Name CD20 CAR T cells Phase 2 [25]
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TTD: D0Y3HP
 Compound Name Baltaleucel-T Phase 2 [15]
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TTD: D0WK1M
 Compound Name SGN-CD19A Phase 2 [26]
Synonyms
Denintuzumab mafodotin
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CID: 86278355
TTD: D0UT5A
 Compound Name DCDS-4501A Phase 2 [27]
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TTD: D0PA1B
 Compound Name Cobomarsen Phase 1 [11]
Synonyms
MRG-106
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TTD: D0P9XM
 Compound Name CD19 CAR T cells Phase 2 [25]
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TTD: D0L5HM
 Compound Name IMO-8400 Phase 2 [18]
Synonyms
Bazlitoran; Bazlitoran [INN]; Bazlitoran [USAN]; UNII-2U46M95B5M; 2U46M95B5M
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CID: 119058029
TTD: D0I0XF
 Compound Name CTL019 Phase 2 [28]
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TTD: D0I0UM
 Compound Name CART-19 Phase 1 [29]
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TTD: D0G4IW
 Compound Name BI-836826 Phase 2 [11]
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TTD: D09WKM
 Compound Name Pidilizumab Phase 2 [30]
Synonyms
CT-011
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TTD: D09MRL
 Compound Name INCB50465 Phase 2 [11]
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TTD: D07RHP
 Compound Name PNT-2258 Phase 2 [18]
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TTD: D07ACL
 Compound Name TAK-659 Phase 2 [11]
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CID: 53252276
TTD: D06KTJ
 Compound Name DEBIO 1562 Phase 2 [11]
Synonyms
MGN529
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TTD: D04SQO
 Compound Name Denintuzumab mafodotin Phase 2 [11]
External Link
TTD: D01QMK
 Compound Name Coltuximab ravtansine Phase 2 [11]
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TTD: D00UNK
 Compound Name MGCD-0103 Phase 2 [18]
Synonyms
Mocetinostat; MG 0103; MG 4230; MG 4915; MG 5026; MG0103; MG4230; MG4915; MG5206; MGCD 0103; MGCD0103; MG-0103; MG-4230; MG-4915; MG-5026; Mocetinostat, MGCD0103; N-(2-aminophenyl)-4-[[(4-pyridin-3-ylpyrimidin-2-yl)amino]methyl]benzamide; N-(2-Aminophenyl)-4-((4-pyridin-3-ylpyrimidin-2-ylamino)methyl)benzamide
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CID: 9865515
TTD: D00FHR
DrugBank: DB11830
 Compound Name CX2029 Phase 1/2 [31]
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TTD: DZ1F3N
 Compound Name GEN3013 Phase 1/2 [32]
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TTD: D9OMQ3
 Compound Name ALLO-501A Phase 1/2 [33]
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TTD: D1HID7
 Compound Name CD19 CAR T Cells Phase 1/2 [34]
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TTD: D0Z8GD
 Compound Name Anti-CD20-CAR vector-transduced autologous T cells Phase 1/2 [35]
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TTD: D0V6VD
 Compound Name MAK683 Phase 1/2 [11]
Synonyms
XLIBABIFOBYHSV-UHFFFAOYSA-N; EED inhibitor-1; 1951408-58-4; MAK-683; N-[(5-fluoro-2,3-dihydro-1-benzofuran-4-yl)methyl]-8-(2-methylpyridin-3-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine; N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-(2-methylpyridin-3-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine; SCHEMBL17841485; EX-A1723; BCP29116; ACN-053195; CS-8054; AC-30344; HY-103663
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CID: 121412508
TTD: D0UO0C
 Compound Name JCAR014 Phase 1 [36]
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TTD: D0U0BN
 Compound Name Anti-CD20 CAR-T cells Phase 1/2 [37]
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TTD: D0MA4O
 Compound Name PCAR-019 Phase 1/2 [38]
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TTD: D0M0CO
 Compound Name Anti-CD19-CAR PBL Phase 1/2 [39]
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TTD: D0J3DN
 Compound Name KTE-C19 CAR Phase 1/2 [40]
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TTD: D0G5WV
 Compound Name SNS01-T Phase 1/2 [41]
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TTD: D0F8SW
 Compound Name CD19.CAR-T cells Phase 1/2 [42]
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TTD: D0EH1J
 Compound Name CUDC-907 Phase 1 [43]
Synonyms
1339928-25-4; Fimepinostat; CUDC 907; UNII-3S9RX35S5X; CUDC907; 3S9RX35S5X; CHEMBL3622533; N-hydroxy-2-[[2-(6-methoxypyridin-3-yl)-4-morpholin-4-ylthieno[3,2-d]pyrimidin-6-yl]methyl-methylamino]pyrimidine-5-carboxamide; Fimepinostat [USAN]; PI3K/HDAC Inhibitor centn; MLS006010994; SCHEMBL1284705; GTPL8952; KS-00000TDO; EX-A742; AOB6775; DTXSID90712307; MolPort-023-293-550; JOWXJLIFIIOYMS-UHFFFAOYSA-N; HMS3656H04; BCP06870; s2759; BDBM50188961; 2341AH; ZINC73488511; ABP001045; AKOS026750340; SB16569; CUDC-907 (PI3K/HDAC Inhibi
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CID: 54575456
TTD: D0E6UZ
DrugBank: DB11891
 Compound Name Betalutin Phase 1 [11]
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CID: 131704322
TTD: D0B9XW
DrugBank: DB12227
 Compound Name Anti-CD19/22-CAR vector-transduced T cells Phase 1/2 [44]
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TTD: D08JTI
 Compound Name JCAR017 Phase 1 [45]
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TTD: D08BPS
 Compound Name Anti-CD19 CAR-T cells Phase 1/2 [46]
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TTD: D05LIH
 Compound Name Anti-CD19-CAR vector-transduced T cells Clinical trial [47]
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TTD: D03UNT
 Compound Name AUTO3 Phase 1/2 [48]
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TTD: D02ONA
 Compound Name Vmab + Y-90 Emab Phase 1b [49]
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TTD: D0Q6IF
 Compound Name Iomab-ACT Phase 1 [50]
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TTD: DZ7OC3
 Compound Name CD19t-haNK Phase 1 [51]
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TTD: DV3ZI0
 Compound Name KITE-363 Phase 1 [52]
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TTD: DI6BK9
 Compound Name PF-06821497 Phase 1 [53]
Synonyms
UNII-S4L4MM20B6; S4L4MM20B6; CHEMBL4080228; PF06821497; 1844849-10-0; 5,8-dichloro-2-[(4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-7-[(R)-methoxy(oxetan-3-yl)methyl]-3,4-dihydroisoquinolin-1(2H)-one; SCHEMBL17330426; GTPL10516; BDBM50246967; NSC800019; DB14799; HY-101571A; NSC-800019; compound 23a [PMID: 29211475]; CS-0092626; Q29209799; 1(2H)-Isoquinolinone, 5,8-dichloro-2-((1,2-dihydro-4-methoxy-6-methyl-2-oxo-3-pyridinyl)methyl)-3,4-dihydro-7-((R)-methoxy-3-oxetanylmethyl)-; 5,8-dichloro-2-[(4-methoxy-6-methyl-2-oxo-1H-pyridin-3-yl)methyl]-7-[(R)-methoxy(oxetan-3-yl)methyl]-3,4-dihydroisoquinolin-1-one; CJD
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CID: 118572065
TTD: DI1L7M
DrugBank: DB14799
 Compound Name AMG 562 Phase 1 [54]
External Link
TTD: D2PFY3
 Compound Name Veltuzumab/epratuzumab Y-90 Phase 1 [55]
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TTD: D0V0YA
 Compound Name LIlotomab satetraxetan Phase 1 [15]
External Link
TTD: D0S9EK
 Compound Name Retroviral vector-transduced autologous T cells to express CD22-specific CARs Phase 1 [56]
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TTD: D0PO0L
 Compound Name YTB323 Phase 1 [57]
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TTD: D0MWS2
 Compound Name ASP3026 Phase 1 [58]
Synonyms
1097917-15-1; ASP-3026; ASP 3026; N2-[2-Methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-1,3,5-triazine-2,4-diamine; UNII-HP4L6MXF10; HP4L6MXF10; 2-N-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]-4-N-(2-propan-2-ylsulfonylphenyl)-1,3,5-triazine-2,4-diamine; MGGBYMDAPCCKCT-UHFFFAOYSA-N; MLS006011176; GTPL7740; SCHEMBL2827739; CHEMBL3545360; C29H40N8O3S; QCR-144; EX-A140; DTXSID90149038; AOB6601; MolPort-028-720-342; BCP06436; 2229AH; ZINC68120928; s8054
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CID: 25134326
TTD: D09GEK
DrugBank: DB12729
 Compound Name ME-401 Phase 1 [11]
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TTD: D08WLY
 Compound Name Human CD19 targeted T Cells Phase 1 [59]
External Link
TTD: D08LLB
 Compound Name CC-122 Phase 1 [11]
Synonyms
1015474-32-4; Avadomide; 3-(5-Amino-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; CC122; CC 122; 3-(5-amino-2-methyl-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione; 2,6-Piperidinedione, 3-(5-amino-2-methyl-4-oxo-3(4H)-quinazolinyl)-;2,6-Piperidinedione, 3-(5-amino-2-methyl-4-oxo-3(4H)-quinazolinyl)-; Avadomide [USAN]; Avadomide(CC-122); Avadomide (USAN/INN); SCHEMBL282749; US9694015, Compound A; CHEMBL3989934; BDBM76986; RSNPAKAFCAAMBH-UHFFFAOYSA-N; EX-A1191; BCP15938; s7892; AKOS025399378; SB18829; CS-5995
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CID: 24967599
TTD: D03QZJ
DrugBank: DB14857
 Compound Name Anti-CD19/20-CAR vector-transduced T cells Clinical trial [60]
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TTD: D0NL9N
 Compound Name DCDT-2980S Discontinued in Phase 2 [61]
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TTD: D0EI1U
 Compound Name IM0-8400 Discontinued in Phase 1/2 [62]
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TTD: D0H4XV
 Compound Name Dacetuzumab Terminated [63]
Synonyms
SMR000449312; MLS000758226; MLS001424020; CHEMBL1408911; CCG-100789
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TTD: D0PU8Z
 Compound Name WHI-P154 Investigative [64]
External Link
CID: 3795
TTD: D0E5IP
References
Ref 1 Long noncoding RNA XIST: a novel independent prognostic biomarker for patients with ABC-DLBCL receiving R-CHOP treatment. Carcinogenesis. 2024 Jul 8;45(7):500-509. doi: 10.1093/carcin/bgae017.
Ref 2 FDA Approved Drug Products from FDA Official Website. 2023. Application Number: 761309
Ref 3 ClinicalTrials.gov (NCT04628494) A Phase 3 Trial of Epcoritamab in R/R DLBCL. U.S. National Institutes of Health.
Ref 4 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2021
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Ref 6 2017 FDA drug approvals. Nat Rev Drug Discov. 2018 Feb;17(2):81-85. doi: 10.1038/nrd.2018.4. Epub 2018 Jan 19.
Ref 7 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6778).
Ref 8 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020
Ref 9 ClinicalTrials.gov (NCT02793583) Study to Assess the Efficacy and Safety of Ublituximab + Umbralisib With or Without Bendamustine and Umbralisib Alone in Patients With Previously Treated Non-Hodgkins Lymphoma (UNITY-NHL). U.S. National Institutes of Health.
Ref 10 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services.
Ref 11 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
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Ref 13 ClinicalTrials.gov (NCT04438005) A Study of ICP-022 in Patients With R/R DLBCL (DLBCL). U.S. National Institutes of Health.
Ref 14 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7544).
Ref 15 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
Ref 16 Phase 3 randomised study of canfosfamide (Telcyta, TLK286) versus pegylated liposomal doxorubicin or topotecan as third-line therapy in patients with platinum-refractory or -resistant ovarian cancer.Eur J Cancer. 2009 Sep;45(13):2324-32.
Ref 17 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800040695)
Ref 18 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
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