m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation

m6A Modification:
Crosstalk ID	M6ACROT05734			[1]
m⁶A modification miR-6858 miR-6858 METTL14 Methylation : m⁶A sites Direct Enhancement Non-coding RNA miR-6858 GSDMC lncRNA miRNA circRNA
m6A Regulator	Methyltransferase-like 14 (METTL14)		WRITER	Regulator Info
m6A Target	miR-6858			Targert Gene
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type	Non-coding RNA (ncRNA)
Epigenetic Regulator	miR-6858		microRNA	View Details
Regulated Target	Gasdermin C (GSDMC)			View Details
Crosstalk Relationship	m6A → ncRNA		Enhancement
Crosstalk Mechanism	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA
Crosstalk Summary	METTL14-upregulated miR-6858 triggers cell apoptosis in keratinocytes of oral lichen planus through decreasing Gasdermin C (GSDMC)
Responsed Disease	Lichen planus	ICD-11: EA91.4		Disease Info
Cell Process	mRNA degradation
Cell Process	Cell apoptosis

References

Ref 1	METTL14-upregulated miR-6858 triggers cell apoptosis in keratinocytes of oral lichen planus through decreasing GSDMC. Commun Biol. 2023 Sep 23;6(1):976. doi: 10.1038/s42003-023-05360-6.