m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation

m6A Modification:
Crosstalk ID	M6ACROT05664				[1]
m⁶A modification Circ_MOCOS Circ_MOCOS ALKBH5 Demethylation : m⁶A sites Direct Enhancement Non-coding RNA circ_0003552 Regulated Target lncRNA miRNA circRNA
m6A Regulator	RNA demethylase ALKBH5 (ALKBH5)			ERASER	Regulator Info
m6A Target	hsa_circ_0003552 (Circ_MOCOS)				Targert Gene
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type	Non-coding RNA (ncRNA)
Epigenetic Regulator	hsa_circ_0003552 (Circ_MOCOS)			circRNA	View Details
Crosstalk Relationship	m6A → ncRNA			Enhancement
Crosstalk Mechanism	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA
Crosstalk Summary	Benzo[a]pyrene-induced up-regulation of hsa_circ_0003552 (Circ_MOCOS) via ALKBH5-mediated m6A modification promotes DNA damage in human bronchial epithelial cells.
Responsed Drug	Benzo[a]pyrene				Drug Info
In-vitro Model	16HBE14o-	Normal	Homo sapiens		CVCL_0112
In-vitro Model	BEAS-2B	Normal	Homo sapiens		CVCL_0168

References

Ref 1	Benzo[a]pyrene-induced up-regulation of circ_0003552 via ALKBH5-mediated m(6)A modification promotes DNA damage in human bronchial epithelial cells. Environ Pollut. 2023 Nov 1;336:122367. doi: 10.1016/j.envpol.2023.122367. Epub 2023 Aug 11.