m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT05616
 [1]
m6A modification hsa-miR-320a-3p hsa-miR-320a-3p ALKBH5 Demethylation : m6A sites Direct Inhibition Non-coding RNA miR-320a-3p FOXM1  lncRNA       miRNA   circRNA
m6A Modification:
m6A Regulator RNA demethylase ALKBH5 (ALKBH5) ERASER
 Regulator Info 
m6A Target hsa-miR-320a-3p
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type Non-coding RNA (ncRNA)
Epigenetic Regulator hsa-miR-320a-3p microRNA View Details
Regulated Target Forkhead box protein M1 (FOXM1) View Details
Crosstalk Relationship m6A  →  ncRNA Inhibition
Crosstalk Mechanism m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA
Crosstalk Summary ALKBH5 promotes silica-induced lung fibrosis via the hsa-miR-320a-3p/Forkhead box protein M1 (FOXM1) axis or targeting FOXM1 directly.
Responsed Disease Pulmonary Fibrosis ICD-11: CB03.4
 Disease Info 
In-vitro Model
 MRC-5 Normal Homo sapiens CVCL_0440
NIH 3T3 Normal Mus musculus CVCL_0594
In-vivo Model For the mouse model of miR-320a-3p overexpression, a total of 24 male C57BL/6 mice were divided randomly into four groups (n = 6 in each group): saline, silica, silica plus AAV9-miR-NC, and silica plus AAV9-miR-320a-3p. The mice in the silica plus AAV9-miR-NC/AAV9-miR-320a-3p groups were anesthetized using the same method, then administered intratracheally 50 uL AAV9-miR-NC/AAV9-miR-320a-3p per mouse at a titer of 8 × 1012 v. g./ml. Three weeks later, these mice were treated in the same way using anesthesia, saline, and silica as mentioned above. Subsequently, after 4 weeks, the mice were sacrificed, and the lungs were isolated and frozen at -80 ℃ for further study.
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
Forkhead box protein M1 (FOXM1) 1 Compound(s) Regulating the Target Click to Show/Hide the Full List
 Compound Name (D-Arg)(9)-p19(ARF) 26-44 peptide Investigative [2]
MOA Inhibitor
External Link
TTD: D01FSW
References
Ref 1 ALKBH5 promotes lung fibroblast activation and silica-induced pulmonary fibrosis through miR-320a-3p and FOXM1. Cell Mol Biol Lett. 2022 Mar 12;27(1):26. doi: 10.1186/s11658-022-00329-5.
Ref 2 Foxm1b transcription factor is essential for development of hepatocellular carcinomas and is negatively regulated by the p19ARF tumor suppressor. Genes Dev. 2004 Apr 1;18(7):830-50. doi: 10.1101/gad.1200704.