m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT05371
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[1] | |||
Non-coding RNA
CircFTO
METTL14
lncRNA miRNA circRNA
Indirect
Enhancement
m6A modification
SOX9
SOX9
YTHDF2
: m6A sites
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| m6A Modification: | |||||
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| m6A Regulator | YTH domain-containing family protein 2 (YTHDF2) | READER | |||
| m6A Target | Transcription factor SOX-9 (SOX9) | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | Non-coding RNA (ncRNA) | ||||
| Epigenetic Regulator | Circ_FTO | circRNA | View Details | ||
| Regulated Target | Methyltransferase-like protein 14 (METTL14) | View Details | |||
| Crosstalk Relationship | ncRNA → m6A | Enhancement | |||
| Crosstalk Mechanism | ncRNAs indirectly impacts m6A modification through downstream signaling pathways | ||||
| Crosstalk Summary | Circ_FTO facilitates the formation of methyltransferases complex to suppress Transcription factor SOX-9 (SOX9) expression with assistance from YTH domain family 2 (YTHDF2) through an m6A-dependent mechanism. Furthermore, inhibition of circFTO improved symptoms of RA in vivo.Remarkably, the biotinylated antisense of circFTO successfully captured Methyltransferase-like protein 14 (METTL14), while the METTL14 antibody also effectively captured circFTO. circFTO also was found to colocalize with METTL14 protein in chondrocytes. These findings strongly support the interaction between circFTO and the WTAP/METTL3/METTL14 complex.Collectively, our findings suggest a potential role for circFTO in facilitating the formation of WTAP/METTL3/METTL14 complex and enhancing overall m6A modification levels within chondrocytes. | ||||
| Responsed Disease | Rheumatoid arthritis | ICD-11: FA20 | |||
| In-vivo Model | For the therapeutic intervention, AAV5/sh-circFTO or AAV5/sh-NC vectors were administered on day 21, concurrently with booster vaccination. Ankle joint cavities received an injection of 5 L of AAV5 solution containing 2 × 109 viral particles per L. This injection was repeated weekly for a duration of 5 weeks, after which the mice were euthanized 2 months following the initial administration of AAV5. | ||||
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
| FA20: Rheumatoid arthritis | 434 Compound(s) Regulating the Disease | Click to Show/Hide the Full List | ||
| Sarilumab | Approved | [2] | ||
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Kevzara
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| Sulindac | Approved | [3] | ||
| Synonyms |
Aclin; Aflodac; Arthrobid; Arthrocine; Chibret; Clinoril; Copal; Copals; Kenalin; Klinoril; Mobilin; Sulindaco; Sulindacum; Sulindal; Alphapharm Brand of Sulindac; Apo Sulin; Apotex Brand of Sulindac; Cahill May Roberts Brand of Sulindac; Chemia Brand of Sulindac; Copal resin; Copal rosin varnish; Gum copal; KendrickBrand of Sulindac; Merck Brand of Sulindac; Novo Sundac; Novopharm Brand of Sulindac; Nu Pharm Brand of Sulindac; Nu Sulindac; Resin copal; Sulindac sulfoxide; MK 231; MK231; S 8139; Apo-Sulin; Clinoril (TN); MK-231; Merck Sharp & Dohme Brand of Sulindac; Novo-Sundac; Nu-Pharm Brand of Sulindac; Nu-Sulindac; Sulindaco [INN-Spanish]; Sulindacum [INN-Latin]; Sulindac (JAN/USP/INN); Sulindac [USAN:BAN:INN:JAN]; Z-5-Fluoro-2-methyl-1-[p-(methlsulfinyl)benzylidene]indene-3-acetic acid; Cis-5-Fluoro-2-methyl-1-((p-methylsulfinyl)benzylidene)indene-3-acetic acid; {5-fluoro-2-methyl-1-[4-(methylsulfinyl)benzylidene]-1h-inden-3-yl}acetic acid; Cis-5-Fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid; [(1E)-5-fluoro-2-methyl-1-{[4-(methylsulfinyl)phenyl]methylidene}-1H-inden-3-yl]acetic acid; {(1E)-5-fluoro-2-methyl-1-[4-(methylsulfinyl)benzylidene]-1H-inden-3-yl}acetic acid; {(1Z)-5-fluoro-2-methyl-1-[4-(methylsulfinyl)benzylidene]-1H-inden-3-yl}acetic acid; (E)-(1)-5-Fluoro-2-methyl-1-((4-(methylsulphinyl)phenyl)methylene)-1H-indene-3-acetic acid; (Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid; (Z)-5-Fluoro-2-methyl-1-[[4-(methyl-sulfinyl)phenyl]methylene]-1H-indene-3-acetic acid; (Z)-5-Fluoro-2-methyl-1-[p-(methylsulfinyl)benzylidene]indene-3-acetic acid; 2-[(3E)-6-fluoro-2-methyl-3-[(4-methylsulfinylphenyl)methylidene]inden-1-yl]acetic acid; 2-[(3Z)-6-fluoro-2-methyl-3-[(4-methylsulfinylphenyl)methylidene]inden-1-yl]acetic acid; 2-[6-fluoro-2-methyl-3-[(4-methylsulfinylphenyl)methylidene]inden-1-yl]acetic acid; 5-Fluoro-2-methyl-1-((4-(methylsulphinyl)phenyl)methylene)-1H-indene-3-acetic acid
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| Ofatumumab | Phase 3 | [4] | ||
| Synonyms |
Arzerra (TN)
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| Baricitinib | Approved | [5] | ||
| Synonyms |
Baricitinib (LY3009104, INCB028050); Baricitinib [USAN:INN]; C16H17N7O2S; INCB 028050; INCB-028050; INCB028050; ISP4442I3Y; J-503551; LY-3009104; LY3009104; Olumiant (TN); UNII-ISP4442I3Y; olumiant
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| Felbinac | Approved | [6] | ||
| Synonyms |
Felbinac); Felbinac, Takeda Chemical Industries Ltd; Seltouch, Takeda
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| Salsalate | Approved | [6] | ||
| Synonyms |
Diacesal; Diplosal; Disalcid; Disalicylsaeure; Disalyl; Nobacid; Salflex; Salical; Salina; Saloxium; Salsalato; Salsalatum;Salysal; Sasapirin; Sasapyrin; Sasapyrine; Sasapyrinum; Disalicylic acid; Sal Ester Sal; Salicylic Acid Salicylate; Salicyloylsalicylic acid; Salicylsalicylic acid; Disalcid (TN); O-Salicylcylsalicylsaeure; O-Salicyloylsalicylic Acid; O-Salicylsalicylic acid; Salflex (TN); Salicylic acid, bimolecular ester; Salicylic acid, salicylate; Salsalato [INN-Spanish]; Salsalatum [INN-Latin]; Salsitab (TN); Sasapyrine (JAN); Mono-Gesic (TN); Salsalate (USP/INN); Salsalate [USAN:INN:BAN]; Benzoic acid, 2-hydroxy-, 2-carboxyphenyl ester; 2-((2-Hydroxybenzoyl)oxy)benzoic acid; 2-(2-hydroxybenzoyl)oxybenzoic acid; 2-Carboxyphenyl salicylate; 2-Salicyloyloxybenzoic Acid; 2-{[(2-hydroxyphenyl)carbonyl]oxy}benzoic acid
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| Fostamatinib | Phase 3 | [7] | ||
| Synonyms |
901119-35-5; R788; Tavalisse; UNII-SQ8A3S5101; R-788 Free acid; R 788; R-788; R-935788 Free acid; SQ8A3S5101; R7935788; Fostamatinib [USAN:INN]
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| Belumosudil | Approved | [8] | ||
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| Canakinumab | Approved | [9] | ||
| Synonyms |
Ilaris (TN)
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| Methotrexate | Phase 3 | [10] | ||
| Synonyms |
Rheumatrex; Amethopterin; Metatrexan; Hdmtx; Abitrexate; Mexate; Methylaminopterinum; Methotrexatum; Antifolan; Metotrexato; Methylaminopterin; MTX; (S)-2-(4-(((2,4-Diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioic acid; Methotrexat; Amethopterine; Maxtrex; Rasuvo; L-Amethopterin; A-Methopterin; A-Methpterin; Amethopterin L-; Folex-Pfs; Methotrexat-Ebewe; N-Bismethylpteroylglutamic acid; Methotrexate, L-; Metotressato [DCIT]; Methotextrate; Mexate-Aq; [3H]methotrexate
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| IPI-145 | Phase 3 | [11] | ||
| Synonyms |
Duvelisib; 1201438-56-3; INK-1197; UNII-610V23S0JI;
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| Indomethacin | Approved | [6] | ||
| Synonyms |
Aconip; Amuno; Arthrexin; Artracin; Artrinovo; Artrivia; Bonidin; Bonidon; Catlep; Confortid; Dolcidium; Dolovin; Durametacin; Elmetacin; Hicin; IMN; Idomethine; Imbrilon; Inacid; Indacin; Indameth; Indmethacine; Indocid; Indocin; Indomecol; Indomed; Indomee; Indometacin; Indometacina; Indometacine; Indometacinum; Indometacyna; Indomethacine; Indomethacinum; Indomethancin; Indomethazine; Indomethegan; Indomethine; Indometicina; Indomo; Indomod; Indoptic; Indoptol; Indorektal; Indoxen; Inflazon; Infrocin; Lausit; Liometacen; Metacen; Metartril; Methazine; Metindol; Mezolin; Miametan; Mikametan; Mobilan; Novomethacin; Reumacide; Sadoreum; Tannex; Vonum; Bonidon Gel; DESMETHYL INDOMETHACIN; Dolcidium PL;Flexin continus; Indocid Pda; Indocid Sr; Indocin Sr; Indolar SR; Indometacyna [Polish]; Indometicina [Spanish]; Inteban sp; Rhemacin LA; Rheumacin LA; I 7378; IN1454; Indomet 140; Aconip (TN); Apo-Indomethacin; Chibro-amuno; Chrono-indicid; Chrono-indocid; Indo-Lemmon; Indo-Spray; Indo-phlogont; Indo-rectolmin; Indo-tablinen; Indocid (TN); Indocid (pharmaceutical); Indocin (TN); Indocin I.V; Indometacina [INN-Spanish]; Indometacine [INN-French]; Indometacinum [INN-Latin]; Indomethacin (USP); Indomethacin [USAN:BAN]; Novo-Methacin; Indochron E-R (TN); Indocin I.V.; Indocin-SR (TN); Indometacin (JP15/INN); Indomethacin & MAP-30; Indomethacin, Indochron E-R, Indocin-SR, Indocid, Indocin, Indomethacin
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| Inosine pranobex | Approved | [6] | ||
| Synonyms |
Imunovir (TN)
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| Secukinumab | Phase 2 | [12] | ||
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| Infliximab | Approved | [13] | ||
| Synonyms |
Remicade (TN)
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| Citrofen | Approved | [6] | ||
| Synonyms |
Citrofen (TN)
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| Meclofenamate Sodium | Approved | [6] | ||
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| Oxaprozin | Approved | [6] | ||
| Synonyms |
Actirin; Alvo; Danoprox; Daypro; Dayrun; Deflam; Oxaprozina; Oxaprozine; Oxaprozinum; Voir; Xopane; Apotex brand of oxaprozin; CSC brand of oxaprozin; Pfizer brand of oxaprozin; Rhoxalpharma brand of oxaprozin; TRB brand of oxaprozin; Lyl)propenoic acid; NCI310839; O 9637; WY 21743; Apo-Oxaprozin; Daypro (TN); Duraprox (TN); Oxaprozina [INN-Spanish]; Oxaprozine [INN-French]; Oxaprozinum [INN-Latin]; Rhoxal-oxaprozin; WY-21743; WY-21,743; Oxaprozin (JP15/USAN/INN); Oxaprozin [USAN:BAN:INN:JAN]; Beta-(4,5-Diphenyloxazol-2-yl)propionic acid; 3-(4, 5-Diphenyl-2-oxazo; 3-(4,5-Diphenyl-1,3-oxazol-2-yl)propanoic acid; 3-(4,5-Diphenyl-2-oxazolyl)propenoic acid; 4, 5-Diphenyl-2-oxazolepropionic acid; 4,5-Diphenyl-2-oxazolepropanoic acid; 4,5-Diphenyl-2-oxazolepropionic acid
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| Zinc salts | Approved | [6] | ||
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| Adalimumab | Approved | [14] | ||
| Synonyms |
Humira; Adalimumab (genetical recombination); Humira (TN); Adalimumab (USAN/INN); Adalimumab (genetical recombination) (JAN)
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| Orthokine | Approved | [6] | ||
| Synonyms |
Orthokine (TN)
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| Dexamethasone | Approved | [15] | ||
| Synonyms |
Adexone; Anaflogistico; Aphtasolon; Aphthasolone; Auxiron; Azium; Calonat; Corson; Corsone; Cortisumman; DXM; Decacort; Decacortin; Decaderm; Decadron; Decagel; Decaject; Decalix; Decameth; Decasone; Decaspray; Dectancyl; Dekacort; Deltafluorene; Dergramin; Deronil; Desadrene; Desametasone; Desamethasone; Desameton; Deseronil; Dexacort; Dexacortal; Dexacortin; Dexadeltone; Dexafarma; Dexair; Dexalona; Dexaltin; Dexametasona; Dexameth; Dexamethansone; Dexamethasonum; Dexamethazone; Dexamonozon; Dexapolcort; Dexaprol; Dexason; Dexasone; Dexinolon; Dexinoral; Dexone; Dexonium; Dexpak; Dextelan; Dezone; Dinormon; Dxms; Fluormethylprednisolone; Fluormone; Fluorocort; Fortecortin; Gammacorten; Hexadecadrol; Hexadrol; IontoDex; Loverine; Luxazone; Maxidex; Mediamethasone; Methylfluorprednisolone; Mexidex; Millicorten; Mymethasone; Oradexon; Policort; Posurdex; Prodex; Spoloven; Superprednol; Turbinaire; Visumetazone; Alcon Brand of Dexamethasone; Bisu DS; Desametasone [DCIT]; Dexa Mamallet; Dexamethasone Base; Dexamethasone Intensol; Dexamethasone alcohol; ECR Brand of Dexamethasone; Foy Brand of Dexamethasone; Hexadrol Elixir; Hexadrol Tablets; ICN Brand of Dexamethasone; Lokalison F; Merck Brand of Dexamethasone; Pet Derm III; Prednisolon F; Prednisolone F; Sunia Sol D; Dexone 4; MK 125; Merz Brand 1 of Dexamethasone; Merz Brand 2 of Dexamethasone; Aeroseb-D; Aeroseb-Dex; Azium (Veterinary); Decadron (TN); Decadron Tablets, Elixir; Decadron, Dexamethasone; Decadron-LA; Dex-ide; Dexa-Cortidelt;Dexa-Cortisyl; Dexa-Mamallet; Dexa-Scheroson; Dexa-sine; Dexacen-4; Dexametasona [INN-Spanish]; Dexamethasonum [INN-Latin]; Dexone 0.5; Dexone 0.75; Dexone 1.5; Hl-dex; Isopto-Dex; OTO-104; Ocu-trol;Pet-Derm Iii; SK-Dexamethasone; Decaject L.A.; Dexamethasone [INN:BAN:JAN]; Decaject-L.A.; Dexamethasone (JP15/USP/INN); Delta1-9alpha-Fluoro-16alpha-methylcortisol; Delta(sup 1)-9-alpha-Fluoro-16-alpha-methylcortisol; (3H)-Dexamethasone; 1-Dehydro-16.alpha.-methyl-9.alpha.-fluorohydrocortisone; 1-Dehydro-16alpha-methyl-9alpha-fluorohydrocortisone; 16-alpha-Methyl-9-alpha-fluoro-1-dehydrocortisol; 16-alpha-Methyl-9-alpha-fluoro-delta(sup 1)-hydrocortisone; 16-alpha-Methyl-9-alpha-fluoro-delta1-hydrocortisone; 16-alpha-Methyl-9-alpha-fluoroprednisolone; 16.alpha.-Methyl-9.alpha.-fluoro-1-dehydrocortisol; 16.alpha.-Methyl-9.alpha.-fluoroprednisolone; 16alpha-Methyl-9alpha-fluoro-1-dehydrocortisol; 16alpha-Methyl-9alpha-fluoro-delta(sup 1)-hydrocortisone; 16alpha-Methyl-9alpha-fluoroprednisolone; 9-alpha-Fluoro-16-alpha-methylprednisolone; 9.alpha.-Fluoro-16.alpha.-methylprednisolone; 9A-FLUORO-16BETA-METHYLPREDNISOLONE; 9alpha-Fluoro-16alpha-methylprednisolone
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| SK-1306X | Approved | [6] | ||
| Synonyms |
Cararthron; Joins
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| Tenoxicam | Approved | [16] | ||
| Synonyms |
Artriunic; Liman; Mobiflex; Reutenox; Tenoxicamum; Tilcotil; Apotex brand of tenoxicam; Novag brand of tenoxicam; Novopharm brand of tenoxicam; Roche brand of tenoxicam; Solvay brand of tenoxicam; Apo-Tenoxicam; Mobiflex (TN); Novo-Tenoxicam; Ro 12-0068; Ro-120068; Tenoxicamum [INN-Latin]; Tilcotil (TN); Ro 12-0068/000; Ro-12-0068; Tenoxicam (JAN/USAN/INN); Tenoxicam [USAN:BAN:INN:JAN]; (3E)-3-[hydroxy-(pyridin-2-ylamino)methylidene]-2-methyl-1,1-dioxothieno[2,3-e]thiazin-4-one; (3Z)-3-[hydroxy-(pyridin-2-ylamino)methylidene]-2-methyl-1,1-dioxothieno[2,3-e]thiazin-4-one; 2H-Thieno(2,3-e)-1,2-thiazine-3-carboxamide, 4-hydroxy-2-methyl-N-2-pyridinyl-, 1,1-dioxide; 3-[hydroxy-(pyridin-2-ylamino)methylidene]-2-methyl-1,1-dioxothieno[2,3-e]thiazin-4-one; 4-HYDROXY-2-METHYL-N-2-PYRIDINYL-2H-THIENO[2,3-E]-1,2-THIAZINE-3-CARBOXAMIDE 1,1-DIOXIDE; 4-Hydroxy-2-methyl-N-2-pyridinyl-2H-thieno(2,3-e)-1,2-thiazine-3-carboxamide1,1-dioxide; 4-Hydroxy-2-methyl-N-2-pyridyl-2H-thieno(2,3-e)-1,2-thiazine-3-carboxamide 1,1-dioxide; 4-hydroxy-2-methyl-N-(pyridin-2-yl)-2H-thieno[2,3-e][1,2]thiazine-3-carboxamide 1,1-dioxide
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| Etanercept | Approved | [17] | ||
| Synonyms |
Etanercept (sciatica); Etanercept (sciatica), BioAssets Development; Etanercept (sciatica), Cephalon
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| Meloxicam | Approved | [18] | ||
| Synonyms |
Meloxicam (SoluMatrix/arthritis); Meloxicam nanoformulation capsules (arthritis), iCeutica; Meloxicam (SoluMatrix/arthritis), iCeutica
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| Gold sodium thiomalate | Approved | [6] | ||
| Synonyms |
Sodium aurothiomalate
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| Vamorolone | Approved | [19] | ||
| Synonyms |
vamorolone; 13209-41-1; UNII-8XP29XMB43; VBP-15; 8XP29XMB43; CHEMBL2348780; 17,21-Dihydroxy-16alpha-methylpregna-1,4,9(11)-triene-3,20-dione; A-Methyl-9,11-dehydro Prednisolone; (8S,10S,13S,14S,16R,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,12,14,15,16-hexahydro-6H-cyclopenta[a]phenanthren-3-one; Vamorolone [USAN]; VBP-15 free alcohol; VBP 15; EINECS 236-177-8; AC1MHYKY; Vamorolone (USAN/INN); SCHEMBL143459; GTPL9247; A)-17,21-dihydroxy-16-methylpregna-1,4,9(11)-triene-3,20-dione; ZINC33650317
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| Abatacept | Approved | [20] | ||
| Synonyms |
Orencia (TN)
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| Tofacitinib | Approved | [21] | ||
| Synonyms |
Tasocitinib; 477600-75-2; 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile; CP-690550; CP 690550; racemic-tofacitinib; 1259404-17-5; tofacitinibum; CP-690,550; UNII-87LA6FU830; 3-((3R,4R)-rel-4-Methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile; 3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile; Tofacitinib (CP-690550,Tasocitinib); CHEMBL221959; CHEBI:71200; Xeljanz (TN)
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| OM-89 | Approved | [6] | ||
| Synonyms |
Subreum; UroVaxom; UroVaxon; OM-8980
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| Rimexolone | Approved | [22] | ||
| Synonyms |
Rimexolone (sustained release intra-articular steroid suspension, Plexis, arthritis)
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| Certolizumab | Approved | [23] | ||
| Synonyms |
CDP-870; Cimzia; PHA-738144; Simziya
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| Alclofenac | Approved | [6] | ||
| Synonyms |
22131-79-9; Alclophenac; Prinalgin; Medifenac; Reufenac; Allopydin; Mervan; Alclofenacum; Alclofenaco; Zumaril; Neoston; Neosten; 2-(4-(Allyloxy)-3-chlorophenyl)acetic acid; [4-(Allyloxy)-3-chlorophenyl]acetic acid; Desinflam; Marvan Forte; 3-Chloro-4-(2-propenyloxy)benzeneacetic acid; (4-Allyloxy-3-chlorphenyl)essigsaeure; MY 101; Epinal; Benzeneacetic acid, 3-chloro-4-(2-propenyloxy)-; Alclofenacum [INN-Latin]; Alclofenaco [INN-Spanish]; UNII-M9CP5H21N8; W 7320; CHEBI:31183; EINECS 244-795-4
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| Careram | Approved | [24] | ||
| Synonyms |
Iguratimod
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| Flurbiprofen | Approved | [25] | ||
| Synonyms |
Adfeed; Adofeed; Anmetarin; Ansaid; Anside; Antadys; Cebutid; FLP; Flubiprofen; Flugalin; Flurbiprofene; Flurbiprofeno; Flurbiprofenum; Fluriproben; Flurofen; Froben; Ocufen; Ocuflur; Stayban; Yakuban; Zepolas; FLURBIPROFEN SODIUM; Froben Sr; BTS 18322; F0371; FP 70; IN1332; U 27182; Ansaid (TN); Apo-Flurbiprofen; BTS-18322; Flurbiprofene [INN-French]; Flurbiprofeno [INN-Spanish]; Flurbiprofenum [INN-Latin]; Froben (TN); MKS-11; Novo-Flurprofen; Nu-Flurbiprofen; U 27,182; U-27182; L-790,330; Flurbiprofen (JP15/USP/INN); Flurbiprofen [USAN:INN:BAN:JAN]; [+/-]-2-Fluoro-alpha-methyl-4-biphenylacetic acid; (+-)-2-(2-Fluoro-4-biphenylyl)propionic acid; (+-)-2-Fluoro-alpha-methyl-4-biphenylacetic acid; (+/-)-2-Fluoro-alpha-methyl-4-biphenylacetic acid; (+/-)-2-Fluoro-alpha-methyl[1,1′ -biphenyl]-4-acetic Acid; (1)-2-Fluoro-alpha-methyl(1,1'-biphenyl)-4-acetic acid; 2-(2-Fluorobiphenyl-4-yl)propionic Acid; 2-(2-fluoro-[1,1'-biphenyl-4-yl])propanoic acid; 2-(2-fluorobiphenyl-4-yl)propanoic acid; 2-(3-fluoro-4-phenylphenyl)propanoic acid; 2-Fluoro-alpha-methyl-(1,1'-biphenyl)-4-acetic acid; 2-Fluoro-alpha-methyl-4-biphenylacetic acid; 3-Fluoro-4-phenylhydratropic acid
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| Nafcillin | Approved | [26] | ||
| Synonyms |
Nafcilina; Nafcilline; Nafcillinum; Nallpen; Naphcillin; Naphthamidopenicillin; Unipen; NAFCILLIN SODIUM; Nafcillin sodium for injection; Nallpen In Plastic Container; Nafcilin-1; Nafcilina [INN-Spanish]; Nafcillin & VRC3375; Nafcillin (INN); Nafcillin [INN:BAN]; Nafcilline [INN-French]; Nafcillinum [INN-Latin]; Nafcillin, Monosodium Salt, Anhydrous; (2-Ethoxy-1-naphthyl)penicillin; (2-ethoxy-1-naphthalenyl)penicillin; (2S,5R,6R)-6-({[2-(ethyloxy)naphthalen-1-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; (2S,5R,6R)-6-[(2-ethoxynaphthalene-1-carbonyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; (2S,5R,6R)-6-{[(2-ethoxynaphthalen-1-yl)carbonyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; 6-(2-ethoxy-1-naphthamido)penicillanic acid; 6-[(2-Ethoxy-naphthalene-1-carbonyl)-amino]-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid anion; 6beta-(2-ethoxynaphthalene-1-carboxamido)-2,2-dimethylpenam-3alpha-carboxylic acid
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| Etofenamate | Approved | [6] | ||
| Synonyms |
30544-47-9; Rheumon; Bayrogel; Rheumon gel; UNII-KZF0XM66JC; Etofenamatum [INN-Latin]; Etofenamato [INN-Spanish]; Bay d 1107; C18H18F3NO4; TVX 485; WHR 5020; EINECS 250-231-8; KZF0XM66JC; BRN 2953263; 2-(2-Hydroxyethoxy)ethyl 2-((3-(trifluoromethyl)phenyl)amino)benzoate; 2-(2-hydroxyethoxy)ethyl 2-[3-(trifluoromethyl)anilino]benzoate; WHR-5020; NCGC00016804-01; 2-(2-Hydroxyaethoxy)aethylester der flutenaminsaeure [German]; CAS-30544-47-9; 2-(2-hydroxyethoxy)ethyl 2-{[3-(trifluoromethyl)phenyl]amino}benzoate
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| Etoricoxib | Approved | [27] | ||
| Synonyms |
Algix; Arcoxia; Etoricoxibe; Nucoxia; Tauxib; L791456; MK 0663; MK 663; Algix (TN); Arcoxia (TN); L-791456; MK-0663; MK-663; Merck Sharp & Dohme brand of etoricoxib; Tauxib (TN); Etoricoxib (USAN/INN); Etoricoxib [USAN:INN:BAN]; 5-Chloro-6'-methyl-3-(p-(methylsulfonyl)phenyl)-2,3'-bipyridine; 5-chloro-2-(6-methylpyridin-3-yl)-3-(4-methylsulfonylphenyl)pyridine; 5-chloro-6'-methyl-3-[4-(methylsulfonyl)phenyl]-2,3'-bipyridine; 5CH
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| Golimumab | Approved | [28] | ||
| Synonyms |
Simponi (TN); Golimumab (USAN/INN)
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| Rilonacept | Approved | [29] | ||
| Synonyms |
Rilonacept (USAN/INN)
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| Tolmetin | Approved | [30] | ||
| Synonyms |
Tolectin; Tolmetina; Tolmetine; Tolmetino; Tolmetinum; Tolmetina [DCIT]; MCN 2559; McN-2559; Tolectin (TN); Tolmetin Sodium, Dihydrate; Tolmetine [INN-French]; Tolmetino [INN-Spanish]; Tolmetinum [INN-Latin]; Tolmetin (USAN/INN); Tolmetin [USAN:BAN:INN]; Acido 1-metil-5-(p-tolnil)-pirrol-2-acetico; Acido 1-metil-5-(p-tolnil)-pirrol-2-acetico [Spanish]; 1-Methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetic acid; 1-Methyl-5-(4-methylbenzoyl)-pyrrole-2-acetic acid; 1-Methyl-5-p-toluoylpyrrole-2-acetic acid; 2-[1-methyl-5-(4-methylbenzoyl)pyrrol-2-yl]acetic acid; 5-(p-Toluoyl)-1-methylpyrrole-2-acetic acid
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| Denosumab | Phase 2 | [31] | ||
| Synonyms |
Denosumab (USAN); Denosumab (genetical recombination); Prolia (TN); Denosumab (genetical recombination) (JAN)
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| Leflunomide | Approved | [32] | ||
| Synonyms |
Arava; Leflunomid; Leflunomida; Leflunomidum; Lefunamide; Aventis Behring Brand of Leflunomide; Aventis Brand of Leflunomide; Aventis Pharma Brand of Leflunomide; Hoechst Brand of Leflunomide; HWA 486; L 5025; SU 101; SU101; Arava (TN); Arava, Leflunomide; HWA-486; Leflunomida [INN-Spanish]; Leflunomide [USAN:INN]; Leflunomidum [INN-Latin]; Lefunomide [Inn-Spanish]; RS-34821; SU 101 (pharmaceutical); SU-101; AP-501/42475599; Leflunomide (JAN/USAN/INN); N-(4-trifluoromethyphenyl)-5-methylisoxazole-4-carboxamide; N-(4'-Trifluoromethylphenyl)-5-methylisoxazole-4-carboxamide; Alpha,alpha,alpha-Trifluoro-5-methyl-4-isoxazolecarboxy-p-toluidide; 4-Isoxazolecarboxamide, 5-methyl-N-(4-(trifluoromethyl)phenyl; 4-isoxazolecarboxamide,5-methyl-N-(4-(trifluoromethyl)phenyl); 5-Methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazolecarboxamide; 5-Methylisoxazole-4-(4-trifluoromethyl)carboxanilide; 5-Methylisoxazole-4-(4-trifluoromethylcarboxanilide); 5-Methylisoxazole-4-carboxylic acid (4-trifluoromethyl)anilide; 5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide; 5-methyl-N-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxamide; 5-methyl-N-[4-(trifluoromethyl)phenyl]isoxazole-4-carboxamide
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| Penicillamine | Approved | [33] | ||
| Synonyms |
D-Penicillamine; 52-67-5; Cuprimine; D-(-)-Penicillamine; 3-Mercapto-D-valine; Depen; Cuprenil; D-Penamine; (-)-Penicillamine; (2S)-2-Amino-3-methyl-3-sulfanylbutanoic acid; D-Mercaptovaline; Mercaptovaline; Perdolat; Penicillamin; Pendramine; Kuprenil; Depamine; Mercaptyl; Trolovol; Metalcaptase; Artamine; Cupripen; (S)-3,3-Dimethylcysteine; D-Valine, 3-mercapto-; Penicillaminum; Penicilamina; Sufirtan; beta-Thiovaline; Dimethylcysteine; D-beta,beta-Dimethylcysteine; D-3-Mercaptovaline; beta,beta-Dimethylcysteine; Penicillamina; Penicilllamine; Sufortan; Copper penicillaminate; D Penicillamine; Penicillamina [DCIT]; Reduced penicillamine; D 3 Mercaptovaline; TBB068824; Beta,beta Dimethylcysteine; Cuprimine (TN); D-Penicilamine; D-Penicyllamine; Depen (TN); P-1280; Penicilamina [INN-Spanish]; Penicillaminate, Copper; Penicillaminum [INN-Latin]; Reduced D-penicillamine; D,3-Mercaptovaline; D-beta-Mercaptovaline; Distamine (*Hydrochloride*); Metalcaptase (*Hydrochloride*); Penicillamine (JAN/USP/INN); Penicillamine [USAN:INN:BAN:JAN]; Alpha-Amino-beta-methyl-beta-mercaptobutyric acid; D-(-)-2-Amino-3-mercapto-3-methylbutanoic acid; (2S)-2-amino-3-methyl-3-sulfanyl-butanoic acid; (D)-PENICILLAMINE; (S)-Penicillamin; (S)-Penicillamine; 2-Amino-3-mercapto-3-methylbutanoic acid; 3,3-Dimethyl-D-cysteine; 3-Mercaptovaline; 3-sulfanyl-D-valine
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| Dimethyl Sulfoxide | Approved | [6] | ||
| Synonyms |
Rimso-50
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| Tocilizumab | Approved | [34] | ||
| Synonyms |
Actemra; Actemra (TN); Tocilizumab (USAN/INN); Tocilizumab (genetical recombination); Tocilizumab (genetical recombination) (JAN); humanized IgG1 monoclonal antibody
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| Benorilate | Approved | [6] | ||
| Synonyms |
5003-48-5; BENORYLATE; 4-acetamidophenyl 2-acetoxybenzoate; Benoral; Salipran; Benortan; Fenasprate; Fenasparate; Aspirin acetaminophen ester; Benorilato; Benorilato [Spanish]; p-Acetamidophenyl acetylsalicylate; Benorilatum [INN-Latin]; Benorilato [INN-Spanish]; UNII-W1QX9DV96G; p-N-Acetylaminophenylacetylsalicylate; TO 125; WIN 11450; 4'-(Acetamido)phenyl-2-acetoxybenzoate; 2-Acetoxy-4'-(acetamino)phenylbenzoate; CCRIS 1739; Benzoic acid, 2-(acetyloxy)-, 4-(acetylamino)phenyl ester; 4-Acetamidophenyl salicylate acet
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| Halopredone acetate | Approved | [6] | ||
| Synonyms |
Haloart (TN)
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| Teriflunomide | Approved | [35] | ||
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| Upadacitinib | Approved | [36] | ||
| Synonyms |
ABT-494
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| Siponimod | Phase 2 | [19] | ||
| Synonyms |
BAF312
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| Oxyphenbutazone | Approved | [6] | ||
| Synonyms |
Tandearil
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| FENBUFEN | Approved | [6] | ||
| Synonyms |
36330-85-5; Lederfen; Cinopal; Napanol; Bufemid; 4-(4-Biphenylyl)-4-oxobutyric acid; 3-(4-Phenylbenzoyl)propionic acid; 3-(4-Biphenylylcarbonyl)propionic acid; 4-(biphenyl-4-yl)-4-oxobutanoic acid; gamma-Oxo(1,1'-biphenyl)-4-butanoic acid; 3-(4-Biphenylcarbonyl)propionic acid; Cinopol; Fenbufenum [INN-Latin]; Fenbufene [INN-French]; 4-([1,1'-biphenyl]-4-yl)-4-oxobutanoic acid; CL-82204; CL 82204; 4-biphenyl-4-yl-4-oxobutanoic acid; Butyric acid 4-(4-biphenyl)-4-oxo-; UNII-9815R1WR9B; 4-oxo-4-(4-phenylphenyl)butanoic a
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| Dexchlorpheniramine Maleate | Approved | [6] | ||
| Synonyms |
Polaramine
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| Enbrel | Approved | [37] | ||
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| Fenoprofen | Approved | [38] | ||
| Synonyms |
Fenoprofene; Fenoprofeno; Fenoprofenum; Feprona; Nalfon; Nalgesic; Feneprofen calcium salt dihydrate; Fenoprofen calcium; Fenoprofen calcium hydrate; Lilly 53838; Fenoprofen Dihydrate, Calcium Salt; Fenoprofene [INN-French]; Fenoprofeno [INN-Spanish]; Fenoprofenum [INN-Latin]; Fenopron (TN); Fenoprofen (USAN/INN); Fenoprofen [USAN:BAN:INN]; Alpha-(m-phenoxyphenyl)propionic acid; Alpha-Methyl-3-phenoxybenzeneacetic acid; (+-)-2-(3-Phenoxyphenyl)propionic acid; (+-)-m-Phenoxyhydratropic acid; 2-(3-Phenoxyphenyl)propanoic acid; 2-(3-Phenoxyphenyl)propionic acid; 2-(m-phenoxyphenyl)propionic acid; 2-[3-(phenyloxy)phenyl]propanoic acid
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| Celecoxib | Approved | [39] | ||
| Synonyms |
CEL; Celebra; Celebrex; Celecox; Celecoxi; Celocoxib; Eurocox; Medicoxib; Onsenal; Solexa; Xilebao; Celecoxib [Old RN]; Celecoxib [USAN]; Pfizer brand of celecoxib; SC 58635; SC58635; YM 177; YM177; AI-525; CEP-33222; Celebra (TN); Celebrex (TN); SC-58635; TPI-336; YM-177; Celebrex, Celebra, Celecoxib; Celecoxib (SC-58635); Celecoxib (JAN/USAN/INN); SC-58553, SC-58635; P-(5-p-Tolyl-3-(trifluoromethyl)pyrazol-1-yl)benzenesulfonamide; Benzenesulfonamide,4-(5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl); 4-(5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide; 4-[5-(4-METHYLPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE; 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1Hpyrazol-1-yl] benzenesulfonamide; 4-[5-(4-methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide
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| Sodium Succinate | Approved | [6] | ||
| Synonyms |
Disodium succinate; 150-90-3; Disodium butanedioate; Butanedioic acid, disodium salt; Succinic acid disodium salt; Soduxin; Jantaran sodny [Czech]; UNII-V8ZGC8ISR3; Succinic acid, disodium salt; FEMA No. 3277; CCRIS 3700; Sodium succinate dibasic; EINECS 205-778-7; V8ZGC8ISR3; Butanedioic acid, sodium salt (1:2); Succinic acid disodium salt anhydrous; Butanedioic acid disodium salt; sodium succinate (anhydrous); Jantaran sodny; Butanedioic acid disodium hexahydrate; Succinic acid, disodium salt, 99%, anhydrous
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| Sulfasalazine | Approved | [40] | ||
| Synonyms |
599-79-1; Salicylazosulfapyridine; Salazosulfapyridine; Azulfidine; Asulfidine; Salazopyridin; Sulcolon; Azopyrin; Accucol; Colo-Pleon; Salazopiridazin; Salisulf; Reupirin; Benzosulfa; Azopyrine; Salazosulfapyridin; Sulfasalazina; w-t Sasp oral; Sulfasalazinum; Sulfasalazin; Azulfidine EN; Sulfazalazine; Azulfidine EN-tabs; Salazosulfapiridina; Sas-500; Salazosulfapyridinum; Azosulfidin; SASP; Salazo-sulfapyridinum; 5-(p-(2-Pyridylsulfamyl)phenylazo)salicylic acid; Sulfasalizine
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| Anakinra | Approved | [41] | ||
| Synonyms |
Kineret; Kineret (TN); Anakinra (USAN/INN)
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| Cyproheptadine | Approved | [6] | ||
| Synonyms |
Ciproheptadina; Ciprovit; Cypoheptadine; Cyproheptadiene; Cyproheptadinum; Dihexazin; Dronactin; Eiproheptadine; Periactin; Periactine; Periactinol; Viternum; Cyproheptadine Hcl; MK 141; Ciproheptadina [INN-Spanish]; Ciprovit (TN); Cyproheptadine (INN); Cyproheptadine [INN:BAN]; Cyproheptadinum [INN-Latin]; Dibenzosuberonone/Cyproheptadine; Periactin (TN); 1-Methyl-4-(5-dibenzo(a,e)cycloheptatrienylidene)piperidine; 1-Methyl-4-(5H-dibenzo(a,d)cycloheptenylidene)piperidine; 4-(5-Dibenzo(a,d)cyclohepten-5-ylidine)-1-methylpiperidine; 4-(5H-Dibenzo(a,d)cyclohepten-5-ylidene)-1-methylpiperidene; 4-(5H-Dibenzo(a,d)cyclohepten-5-ylidene)-1-methylpiperidine; 4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-methylpiperidine; 4-(5H-dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine; 5-(1-Methylpiperidylidene-4)-5H-dibenzo(a,d)cyclopheptene
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| Niflumic Acid | Approved | [42] | ||
| Synonyms |
Actol; Donalgin; Flunir; Forenol; Landruma; NFL; Niflactol; Niflam; Niflugel; Niflumate; Nifluril; Acide niflumique; Acide niflumique [French]; Acido niflumico; Acido niflumico [Italian]; Acidum niflumicum; Nifluminic acid; UPSA Conseil Brand of Niflumic Acid; Upsamedica Brand of Niflumic Acid; N 0630; SC 1332; UP 83; UPSA Brand 1 of Niflumic Acid; UPSA Brand 2 of Niflumic Acid; Acid, Niflumic; Acide niflumique [INN-French]; Acido niflumico [INN-Spanish]; Acidum niflumicum [INN-Latin]; Niflugel (TN); Niflumic acid (INN); Niflumic acid [INN:DCF]; Aza-2 dimethyl-2',3' (tetrazolyl-5)-6 diphenylamino; Aza-2 dimethyl-2',3' (tetrazolyl-5)-6 diphenylamino [French]; 2-(3-(Trifluoromethyl)-phenyl)aminonicotinic acid; 2-(3-(Trifluoromethyl)anilino)nicotinic acid; 2-(3-Trifluoromethyl-phenylamino)-nicotinic acid; 2-(3-Trifluoromethylanilino)nicotinic Acid; 2-(3-[Trifluoromethyl]anilino)nicotinic acid; 2-(A,A,A-Trifluoro-m-toluidino)nicotinic acid; 2-(alpha,alpha,alpha-Trifluoro-m-toluidino)nicotinic acid; 2-[(3-TRIFLUOROMETHYL)PHENYL]AMINO-3-PYRIDINE-CARBOXYLIC ACID; 2-[(3-Trifluoromethyl)phenyl]amino]-3-pyridinecarboxylic Acid; 2-[(3-Trifluoromethylphenyl)amino]nicotinic Acid; 2-[3-(Trifluoromethyl)anilino]nicotinic acid; 2-[3-(trifluoromethyl)anilino]pyridine-3-carboxylic acid; 2-[alpha,alpha,alpha-trifluoro-m-toluidino]-nicotinic acid; 2-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}NICOTINIC ACID; 2-{[3-(trifluoromethyl)phenyl]amino}pyridine-3-carboxylic acid; 39690A
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| Nipocalimab | Phase 2 | [43] | ||
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| Nipocalimab? | Phase 3 | [43] | ||
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| BI 695501 | Phase 3 | [44] | ||
| Synonyms |
BI-695501)
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| PF-06410293 | Phase 3 | [19] | ||
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| IB-MECA | Phase 3 | [19] | ||
| Synonyms |
152918-18-8; piclidenoson; CF-101; 3-IB-Meca; N(6)-Ibamu; CF 101; Cf101; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine; UNII-30679UMI0N; N(6)-(3-Iodobenzyl)adenosine-5'-N-methyluronamide; 1-Deoxy-1-(6-(((3-iodophenyl)methyl)amino)-9H-purin-9-yl)-N-methyl-beta-D-ribofuranuronamide; CHEMBL119709; CHEBI:73286; 30679UMI0N; RPR-113090; 3-iodobenzyl-5'-N-methylcarboxamidoadenosine; N(6)-(3-iodo-benzyl)adenosine-5'-N-methyluronamide
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| SA-237 | Phase 3 | [45] | ||
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Second generation IL-6 antagonist (mAb, inflammatory disease), Chugai
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| Flobufen | Phase 3 | [46] | ||
| Synonyms |
VUFB-16066; VUFB-17203
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| BI-695500 | Application submitted | [19] | ||
| Synonyms |
Rituximab biosimilar
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| GS-5745 | Phase 3 | [19] | ||
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| CG-100649 | Phase 3 | [47] | ||
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Polmacoxib; 301692-76-2; UNII-IJ34D6YPAO; CG100649; IJ34D6YPAO; 4-(3-(3-fluorophenyl)-5,5-dimethyl-4-oxo-4,5-dihydrofuran-2-yl)benzenesulfonamide; 4-[3-(3-Fluorophenyl)-5,5-Dimethyl-4-Oxidanylidene-Furan-2-Yl]benzenesulfonamide; 4-(3-(3-Fluorophenyl)-5,5-dimethyl-4-oxo-4,5-dihydrofuran-2-yl)-benzenesulfonamide; Polmacoxib [USAN:INN]; Acelex (S. Korea); CG 100649; Polmacoxib (USAN/INN); SCHEMBL3233093; CHEMBL166863; GTPL8316; EX-A601; IJWPAFMIFNSIGD-UHFFFAOYSA-N; ZINC589683; BCP15550; AKOS025149767; SB17177; DB12399
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| Resveratrol | Phase 3 | [19] | ||
| Synonyms |
Resvida; KUC104385N; R 5010; SRT 501; Cis-resveratrol; PREVENTION 8 (RESVERATROL); RM-1812; SRT-501; Trans-resveratrol; CU-01000001503-3; KSC-10-164; Resveratrol-3-sulfate; Trans-3,4',5-trihydroxystilbene; Trans-3,4′,5-Trihydroxystilbene; Trans-1,2-(3,4',5-Trihydroxydiphenyl)ethylene; (E)-5-(2-(4-hydroxyphenyl)ethenyl)-1,3-benzenediol
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| GP-2017 | Phase 3 | [19] | ||
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| RAVAX | Phase 3 | [48] | ||
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| Cartistem | Phase 3 | [49] | ||
| Synonyms |
Stem cell therapy (cartilage disease/rheumatoid arthritis), Medipost
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| IR-201 | Phase 3 | [50] | ||
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Seryl-glutaminyl-isoleucyl-valyl-asparaginyl-aspartyl-phenylalanyl-glutaminyl-lysyl-glycyl-aspartyl-isoleucyl-alanyl-glutamyl-glycyl-tyrosyl-serine
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| Esonarimod | Phase 3 | [51] | ||
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Sonatimod; KE-298; KE-749; KE-758; NE-298; (R)-KE-298; (S)-KE-298
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| CIPEMASTAT | Phase 3 | [52] | ||
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Trocade; Ro 32-3555; 190648-49-8; UNII-02HQ4TYQ60; 02HQ4TYQ60; GFUITADOEPNRML-SJORKVTESA-N; Cipemastat [USAN:INN]; Ro 32-3555/000; Trocade (TN); Cipemastat (USAN/INN); GTPL6466; CHEMBL115653; SCHEMBL7088217; CTK8F1312; BDBM30344; MolPort-023-276-601; ZINC600699; (alphaR,betaR)-beta-(Cyclopentylmethyl)-gamma-oxo-alpha-((3,4,4-piperidinebutyrohydroxamic acid; AKOS024457333; HY-19677; Ro-32-03555; Ro-323555000; RT-015421; RO32-3555; CS-0016192; D03517; J-012306
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| Methylprednisolone | Approved | [6] | ||
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| STI-002 | Phase 3 | [19] | ||
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| ABT-874 | Discontinued in Phase 2 | [23] | ||
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| MK-8808 | Phase 1 | [53] | ||
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| Sivelestat | Application submitted | [19] | ||
| Synonyms |
127373-66-4; UNII-DWI62G0P59; 2-[[2-[[4-(2,2-dimethylpropanoyloxy)phenyl]sulfonylamino]benzoyl]amino]acetic acid; Elastase Inhibitor IV; C20H22N2O7S; N-(2-(4-(2,2-Dimethylpropionyloxy)phenylsulfonylamino)benzoyl)aminoacetic acid; Sivelestat (ONO-5046); LY544349; CHEMBL76688; LY 544349; DWI62G0P59; Glycine, N-(2-(((4-(2,2-dimethyl-1-oxopropoxy)phenyl)sulfonyl)amino)benzoyl)-; N-(o-(p-Pivaloyloxybenzene)sulfonylaminobenzoyl)glycine
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| ABP 798 | Phase 3 | [19] | ||
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| TG-C | Phase 3 | [54] | ||
| Synonyms |
3-Thiaglutaryl-Coa; S-[[(2-Hydroxy-2-oxoethyl)thio]acetyl]coenzyme A; (3R,5S,9R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-10,14,19-trioxo-2,4,6-trioxa-18,21-dithia-11,15-diaza-3,5-diphosphatricosan-23-oic acid 3,5-dioxide; TGC
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| PF-06438179 | Phase 3 | [19] | ||
| External Link | ||||
| Baricitinib | Approved | [6] | ||
| External Link | ||||
| Cilengitide | Phase 3 | [55] | ||
| Synonyms |
188968-51-6; EMD-121974; Cilengitide [USAN:INN]; UNII-4EDF46E4GI; EMD121974; EMD-12192; EMD 121974; 4EDF46E4GI; CHEMBL429876; 2-[(2S,5R,8S,11S)-5-benzyl-11-[3-(diaminomethylideneamino)propyl]-7-methyl-3,6,9,12,15-pentaoxo-8-propan-2-yl-1,4,7,10,13-pentazacyclopentadec-2-yl]acetic acid; Cyclo(L-arginylglycyl-L-aspartyl-D-phenylalanyl-N-methyl-L-valyl); Cyclo(L-arginylglycyl-L-alpha-aspartyl-D-phenylalanyl-N-methyl-L-valyl); Cilengitide (TFA salt)
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| CEP-41750 | Phase 3 | [56] | ||
| External Link | ||||
| Sarilumab | Approved | [6] | ||
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| Andolast | Phase 3 | [57] | ||
| Synonyms |
Dizolast; CR-2039; Calcium-activated potassium channel opener (inhaled powder, asthma), Rottapharm
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| Vanadate | Phase 3 | [19] | ||
| Synonyms |
Ammonium metavanadate; 7803-55-6; Ammonium vanadate(V); UNII-FL85PX638G; FL85PX638G; Ammonium metavanadate, ACS reagent; Ammoniummetavanadate; Ammonium metavanadate, 99.5%, for analysis; Ammonium metavanadate, 99.996%, (trace metal basis); Ammonium meta-Vanadate; Vanadate (VO31-), ammonium (1:1); AC1LANGP; ammonium vanadiumoylolate; H4NO3V; EC 232-261-3; azanium oxido(dioxo)vanadium; KS-00000WUM; UNTBPXHCXVWYOI-UHFFFAOYSA-O; MolPort-044-723-987; MolPort-003-925-733; MFCD00011430; AKOS030228605; AMMONIUM VANADATE (META), NH4VO3
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| CPL-7075 | Phase 3 | [19] | ||
| Synonyms |
Ajulemic acid; Lenabasum; IP-751; CT-3; 137945-48-3; IP 751; UNII-OGN7X90BT8; CPL7075; JBT-101; OGN7X90BT8; Resunab; (6aR,10aR)-1-hydroxy-6,6-dimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydrobenzo[c]chromene-9-carboxylic acid; (6ar,10ar)-3-(1,1-Dimethylheptyl)-1-Hydroxy-6,6-Dimethyl-6a,7,10,10a-Tetrahydro-6h-Benzo[c]chromene-9-Carboxylic Acid; DMH-THC-11-OIC; AB-III-56; CT 3; CPL 7075; Lenabasum [USAN]; HU-239; AC1MJ0SY; SCHEMBL26441; CHEMBL456341; GTPL9772; IP751; Mixed CB agonist/sodim channel blocker (pain), Cervelo
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| Spermidine | Phase 3 | [19] | ||
| Synonyms |
Spermidin; UNII-U87FK77H25; BRN 1698591; AI3-26636; EINECS 204-689-0; CHEMBL19612; CHEBI:16610; ATHGHQPFGPMSJY-UHFFFAOYSA-N; U87FK77H25; MFCD00008229; Spermidine hydrochloride; NSC528399; 1pot; Aminopropylbutandiamine; N-(4-Aminobutyl)-1,3-diaminopropane; Spectrum_000005; Tocris-0959; ACMC-20ajn3; AC1L1AQB; Spectrum2_000874; Spectrum3_000977; Spectrum4_001101; Spectrum5_001561; Lopac-S-2501; Biomol-NT_000212; bmse000116; bmse000951; bmse000955; Spermidine 0.1 M solution; Lopac0_001047; SCHEMBL15618; BSPBio_002613; KBioGR_001542; KBioSS_000345; 4-04-00-01300 (Beilstein Handbook Reference); DivK1c_001007; SPBio_000947; Spermidine, > =99% (GC); Spermidine, analytical standard; BPBio1_001276; GTPL2390; DTXSID4036645; CTK3J1693; KBio1_001007; KBio2_000345; KBio2_002913; KBio2_005481; KBio3_001833; MolPort-001-761-230; NINDS_001007; HY-B1776; ZINC1532612; BDBM50009353; PA(34); N-(3-Aminopropyl)-4-aminobutylamine; AKOS006222987; CCG-205124; DB03566; MCULE-8096530192; RTR-003757; SDCCGMLS-0066822.P001; IDI1_001007; NCGC00015937-01; NCGC00015937-02; NCGC00015937-03; NCGC00015937-04; NCGC00015937-05; NCGC00024903-01; NCGC00024903-02; NCGC00024903-03; AJ-26792; AN-22947; LS-45643; M923; NCI60_004294; SC-69371; DB-026892; TR-003757; CS-0013804; FT-0629162; ST24048721; ST45025991; C00315; 124S209; SR0
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| Varespladib methyl | Phase 3 | [58] | ||
| Synonyms |
A-002; LY-333013; S-3013; Varespladib methyl (oral formulation, coronary artery disease); PLA2 inhibitors (inflammation), Lilly/Shionogi; Varespladib (oral formulation, coronary artery disease), Anthera; Varespladib methyl (oral formulation, coronary artery disease), Anthera
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| GP2013 | Phase 3 | [19] | ||
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| ABP 501 | Phase 3 | [59] | ||
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| ASP-015K | Phase 3 | [19] | ||
| Synonyms |
Peficitinib; ASP015K; UNII-HPH1166CKX; 944118-01-8; HPH1166CKX; 4-[[(1R,3S)-5-hydroxy-2-adamantyl]amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide; 4-[[(1S,3R)-5-oxidanyl-2-adamantyl]amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide; Peficitinib [USAN:INN]; ASP 015K; JNJ-54781532; 9T6; Peficitinib (USAN/INN); SCHEMBL1154421; SCHEMBL9990248; SCHEMBL4447032; GTPL8315; SCHEMBL9990240; SCHEMBL1154418; CHEMBL3137308; SCHEMBL17645135; BCP18465; BDBM50124208; SB16834; DB11708; SC-17960; D10653; Peficitinib pound A
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| Anakinra | Approved | [60] | ||
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| CHS-0214 | Phase 3 | [19] | ||
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| Atacicept | Phase 2 | [61] | ||
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| Tenidap | Phase 3 | [62] | ||
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| Sirukumab | Phase 3 | [63] | ||
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| Olokizumab | Phase 3 | [19] | ||
| External Link | ||||
| LY3090106 | Phase 1 | [64] | ||
| Synonyms |
Tibulizumab
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| VX-509 | Phase 2/3 | [65] | ||
| Synonyms |
Decernotinib; Adelatinib; 944842-54-0; UNII-MZK2GP0RHK; Decernotinib(VX-509); VX509; MZK2GP0RHK; VRT-831509; VX 509; (2r)-2-Methyl-2-[[2-(1h-Pyrrolo[2,3-B]pyridin-3-Yl)pyrimidin-4-Yl]amino]-N-[2,2,2-Tris(Fluoranyl)ethyl]butanamide; (R)-2-((2-(1H-Pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)-2-methyl-N-(2,2,2-trifluoroethyl)butanamide; Decernotinib [USAN:INN]; VRT 831509; Decernotinib,VX-509; Decernotinib (USAN/INN); Decernotinib (VX-509); VX-509 (Decernotinib); SCHEMBL2630387; GTPL8309; CHEMBL3039513; KS-00001CYK
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| Olokizumab | Phase 3 | [66] | ||
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| CreaVax-RA | Phase 2a | [67] | ||
| Synonyms |
Autologous DC therapy (injectable, rheumatoid arthritis), CreaGene; Autologous dendritic cell therapy (injectable, rheumatoid arthritis), CreaGene
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| RhuDex | Phase 2a | [61] | ||
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| VX-702 | Phase 2a | [68] | ||
| Synonyms |
ST51054128; I14-1965; EC-000.2363; 6-[carbamoyl-(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)pyridine-3-carboxamide
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| Cevidoplenib | Phase 2 | [69] | ||
| Synonyms |
(S)-cyclopropyl(5-(4-(4-((4-hydroxyisoxazolidin-2-yl)methyl)-3-methyl-1H-pyrazol-1-yl)pyrimidin-2-ylamino)-1-methyl-1H-indol-3-yl)methanone; 1703788-21-9; 3N3H8BX897; AKOS040748110; BDBM196772; Cevidoplenib; Cevidoplenib [INN]; Cevidoplenib [WHO-DD]; CHEMBL3921923; CS-0039259; cyclopropyl-[5-[[4-[4-[[(4S)-4-hydroxy-1,2-oxazolidin-2-yl]methyl]-3-methylpyrazol-1-yl]pyrimidin-2-yl]amino]-1-methylindol-3-yl]methanone; EX-A5914; HY-109082; Methanone, cyclopropyl(5-((4-(4-(((4S)-4-hydroxy-2-isoxazolidinyl)methyl)-3-methyl-1H-pyrazol-1-yl)-2-pyrimidinyl)amino)-1-methyl-1H-indol-3-yl)-; MS-28778; SCHEMBL16653204; UNII-3N3H8BX897; US9212178, 1; YCZUBLQESBVOSH-IBGZPJMESA-N
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| Zunsemetinib | Phase 2 | [70] | ||
| Synonyms |
(-)-3-Chloro-4-[(3,5-difluoro-2-pyridinyl)methoxy]-2'-[2-(1-hydroxy-1-methylethyl)-4-pyrimidinyl]-5',6-dimethyl[1(2H),4'-bipyridin]-2-one; (1(2H),4'-Bipyridin)-2-one, 3-chloro-4-((3,5-difluoro-2-pyridinyl)methoxy)-2'-(2-(1-hydroxy-1-methylethyl)-4-pyrimidinyl)-5',6-dimethyl-, (-)-; (2'S)-3-Chloro-4-[(3,5-difluoro-2-pyridinyl)methoxy]-2'-[2-(1-hydroxy-1-methylethyl)-4-pyrimidinyl]-5',6-dimethyl[1(2H),4'-bipyridin]-2-one; (P)-(3-chloro-4-((3,5-difluoropyridin-2-yl)methoxy)-2'-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-5',6-dimethyl-2H-[1,4'-bipyridin]-2-one); (p)-3-Chloro-4-((3,5-difluoropyridin-2-yl)methoxy)-2'-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-5',6-dimethyl-2H-(1,4'-bipyridin)-2-one; (R)-Zunsemetinib; [1(2H),4'-Bipyridin]-2-one, 3-chloro-4-[(3,5-difluoro-2-pyridinyl)methoxy]-2'-[2-(1-hydroxy-1-methylethyl)-4-pyrimidinyl]-5',6-dimethyl-, (2'S)-; 1639791-42-6; 1640282-42-3; 1640282-44-5; 3-Chloro-4-((3,5-difluoropyridin-2-yl)methoxy)-2'-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-5',6-dimethyl-2H-[1,4'-bipyridin]-2-one; 3-chloro-4-[(3,5-difluoropyridin-2-yl)methoxy]-1-[2-[2-(2-hydroxypropan-2-yl)pyrimidin-4-yl]-5-methylpyridin-4-yl]-6-methylpyridin-2-one; 3-chloro-4-[(3,5-difluoropyridin-2-yl)methoxy]-1-{2-[2-(2-hydroxypropan-2-yl)pyrimidin-4-yl]-5-methylpyridin-4-yl}-6-methylpyridin-2-one; AKOS040756965; Ati 450; ATI 450 [WHO-DD]; ATI450; ATI-450; AX2VWG0ZCR; BDBM175242; CDD450; CDD-450; CHEMBL3704901; CS-0204147; CS-0374185; EX-A6292; GTPL11681; HY-139553; HY-139553A; MS-29543; SCHEMBL16279876; UNII-AX2VWG0ZCR; US9115089, 49; WHO 11983; zunsemetinib; Zunsemetinib [INN]; Zunsemetinib [USAN:INN]; Zunsemetinib [USAN]; Zunsemetinib M-atropisomer
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| Dazodalibep | Phase 2 | [71] | ||
| Synonyms |
VIB4920
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| Natrunix | Phase 2 | [72] | ||
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| A223 | Phase 2 | [73] | ||
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| GS-5718 | Phase 2 | [74] | ||
| Synonyms |
1-BOC-3-IODO-1H-PYRAZOLO[3,4-B]PYRIDINE; 1H-PYRAZOLO[3,4-B]PYRIDINE-1-CARBOXYLIC ACID, 3-IODO-, 1,1-DIMETHYLETHYLESTER; 1H-Pyrazolo[3,4-b]pyridine-1-carboxylicacid,3-iodo-,1,1-diMethylethylester; 920036-34-6; A860172; AKOS022178093; AMY21637; CS-0048281; FT-0702852; GS-5718; MFCD13183727; OKKLWSNHFSFXEM-UHFFFAOYSA-N; PB26872; SCHEMBL3606964; tert-Butyl 3-iodo-1H-pyrazolo[3,4-b]pyridine-1-carboxylate; tert-butyl 3-iodopyrazolo[3,4-b]pyridine-1-carboxylate; tert-Butyl3-iodo-1H-pyrazolo[3,4-b]pyridine-1-carboxylate
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| Branebrutinib | Phase 2 | [75] | ||
| Synonyms |
(S)-4-(3-(2-BUTYNOYLAMINO)PIPERIDIN-1-YL)-5-FLUORO-2,3-DIMETHYL-1H-INDOLE-7-CARBOXAMIDE; (S)-4-(3-(but-2-ynamido)piperidin-1-yl)-5-fluoro-2,3-dimethyl-1H-indole-7-carboxamide; 1912445-55-6; 1H-Indole-7-carboxamide, 5-fluoro-2,3-dimethyl-4-((3S)-3-((1-oxo-2-butyn-1-yl)amino)-1-piperidinyl)-; 4-((3S)-3-(2-BUTYNOYLAMINO)-1-PIPERIDINYL)-5-FLUORO-2,3-DIMETHYL-1HINDOLE-7-CARBOXAMIDE; 4-((3S)-3-(2-Butynoylamino)-1-piperidinyl)-5-fluoro-2,3-dimethyl-1H-indole-7-carboxamide; 4-((3S)-3-(But-2-ynamido)piperidin-1-yl)-5-fluoro-2,3-dimethyl-1H-indole-7-carboxamide; 4-[(3S)-3-(but-2-ynamido)piperidin-1-yl]-5-fluoro-2,3-dimethyl-1H-indole-7-carboxamide; 4-[(3S)-3-(but-2-ynoylamino)piperidin-1-yl]-5-fluoro-2,3-dimethyl-1H-indole-7-carboxamide; 7LBRZUYSHU; AC-31535; AKOS037649047; BCP29496; BDBM164638; BDBM166759; BMS986195; BMS986195; BMS986195; BMS-986195; Branebrutinib; Branebrutinib (BMS-986195); Branebrutinib (USAN); BRANEBRUTINIB [INN]; Branebrutinib [USAN]; BRANEBRUTINIB [WHO-DD]; BS-16393; C20H23FN4O2; CHEMBL4297674; CS-0043577; D11478; DB15347; EN300-2007801; EX-A2720; Example 223 [US20160115126A1]; GTPL9869; HY-112161; MFCD31631584; NSC807627; NSC-807627; Q50825082; s8832; SCHEMBL17699728; UNII-7LBRZUYSHU; US9688629, 123; US9688629, 223; VJPPLCNBDLZIFG-ZDUSSCGKSA-N; WHO 11026
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| EQ121 | Phase 2 | [76] | ||
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| Vobarilizumab | Phase 2 | [77] | ||
| Synonyms |
ALX-0061
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| IRL201805 | Phase 2 | [78] | ||
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| KPL-404 | Phase 2 | [79] | ||
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| ABBV-154 | Phase 2 | [80] | ||
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| FK-3311 | Phase 2 | [81] | ||
| Synonyms |
116686-15-8; FK 3311; FK3311; COX-2 Inhibitor V, FK3311; N-[4-acetyl-2-(2,4-difluorophenoxy)phenyl]methanesulfonamide; N-(4-Acetyl-2-(2,4-difluorophenoxy)phenyl)methanesulfonamide; 4'-Acetyl-2'-(2,4-difluorophenoxy)methanesulfonanilide; Methanesulfonamide, N-[4-acetyl-2-(2,4-difluorophenoxy)phenyl]-; C15H13F2NO4S; Methanesulfonamide, N-(4-acetyl-2-(2,4-difluorophenoxy)phenyl)-; DIIYLGZNZGPXRR-UHFFFAOYSA-N; AC1L4U0O; AC1Q6W4K; SCHEMBL441676; ZINC3880; DIIYLGZNZGPXRR-UHFFFAOYSA-; CTK8E9207; EX-A545; DTXSID90151474
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| TAK-783 | Phase 2 | [82] | ||
| Synonyms |
Rheumatoid arthritis therapy (oral), Takeda Pharmaceutical
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| Piclamilast | Phase 2 | [83] | ||
| Synonyms |
144035-83-6; Cpodpmb; RP 73401; 3-(Cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-methoxybenzamide; UNII-WM58D7C3ZT; RP 73-401; RP-73401; RP-73-401; RPR 73401; 3-(Cyclopentyloxy)-N-(3,5-dichloro-4-pyridinyl)-4-methoxybenzamide; WM58D7C3ZT; Benzamide, 3-(cyclopentyloxy)-N-(3,5-dichloro-4-pyridinyl)-4-methoxy-; CHEMBL42126; CHEBI:47619; RRRUXBQSQLKHEL-UHFFFAOYSA-N; RPR-73401; 3-(Cyclopentyloxy)-N-(3,5-dichloro-4-pyridyl)-p-anisamide; 3-(Cyclopentyloxy)-N-(3,5-dichloro-4-pyridyl)-4-methoxybenzamide; PIL
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| ADL-5859 | Phase 2 | [84] | ||
| Synonyms |
PF-04856880
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| SBI-087 | Phase 2 | [85] | ||
| Synonyms |
PF-05230895
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| SB-705498 | Phase 2 | [86] | ||
| Synonyms |
501951-42-4; SB705498; SB 705498; UNII-T74V9O0Y2W; (R)-1-(2-bromophenyl)-3-(1-(5-(trifluoromethyl)pyridin-2-yl)pyrrolidin-3-yl)urea; T74V9O0Y2W; 1-(2-bromophenyl)-3-[(3R)-1-[5-(trifluoromethyl)pyridin-2-yl]pyrrolidin-3-yl]urea; N-(2-Bromophenyl)-N'-[(3R)-1-[5-(trifluoromethyl)-2-pyridinyl]-3-pyrrolidinyl]urea; 1-(2-Bromophenyl)-3-[(3R)-1-[5-(trifluoromethyl)-2-pyridyl]pyrrolidin-3-yl]urea; JYILLRHXRVTRSH-GFCCVEGCSA-N; MLS006011113; SCHEMBL1350298; GTPL4311; CHEMBL207433; BMCL163287 Compound 15; BDBM20504
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| BMS-817399 | Phase 2 | [87] | ||
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| PRALNACASAN | Phase 2 | [88] | ||
| Synonyms |
VX-740; UNII-N986NI319S; 192755-52-5; N986NI319S; HMR3480/VX-740; Pralnacasan [USAN:INN]; HMR 3480; VX 470; Pralnacasan (USAN/INN); AC1L4A1A; SCHEMBL142187; GTPL6467; CHEMBL437526; DTXSID60172873; HMR3480; HMR-3480; BDBM50189360; AKOS030230853; DB04875; D08978; (4S,7S)-N-[(2R,3S)-2-ethoxy-5-oxooxolan-3-yl]-7-(isoquinoline-1-carbonylamino)-6,10-dioxo-2,3,4,7,8,9-hexahydro-1H-pyridazino[1,2-a]diazepine-4-carboxamide
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| F-8-IL-10 fusion protein | Phase 2 | [19] | ||
| Synonyms |
Dekavil; F-8-IL-10; F-8-IL-10 fusion protein (rheumatoid arthritis/endometriosis); F-8-IL-10 fusion protein (rheumatoid arthritis/endometriosis), Philogen
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| GLPG-0634 | Phase 2 | [89] | ||
| Synonyms |
Small molecule, JAK1/JAK2 inhibitor (rheumatoid arthritis), Galapagos/GSK
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| CFZ533 | Phase 2 | [90] | ||
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| PD-360324 | Phase 2 | [91] | ||
| Synonyms |
PD-0360324; MCSF mAb (RA), Pfizer; Macrophage colony stimulating factor monoclonal antibody (rheumatoid arthritis), Pfizer
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| MGCD-290 | Phase 2 | [92] | ||
| Synonyms |
MG-1; MG-3290; Histone deacetylase inhibitors (cardiovascular diseases), MethylGene; Histone deacetylase inhibitors (diabetes), MethylGene; Histone deacetylase inhibitors (fungal infection), MethylGene; Histone deacetylase inhibitors (inflammation), MethylGene; HDAC inhibitors (non-oncology), MethylGene; Histone deacetylase inhibitors (non-oncology), MethylGene
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| Prednisone/ dipyridamole | Phase 2 | [93] | ||
| Synonyms |
Synavive (TN)
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| QAL964 | Phase 2 | [94] | ||
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| M2951 | Phase 2 | [19] | ||
| Synonyms |
evobrutinib; UNII-ZA45457L1K; ZA45457L1K; 1415823-73-2; 1-(4-(((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)amino)methyl)piperidin-1-yl)prop-2-en-1-one; 1-[4-[[[6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl]amino]methyl]piperidin-1-yl]prop-2-en-1-one; Evobrutinib [INN]; GTPL9752; SCHEMBL14165673; QUIWHXQETADMGN-UHFFFAOYSA-N; MSC2364447C; MSC-2364447C; ZINC205623965; AKOS032954004; CS-6303; MSC 2364447; HY-101215; A250 [WO2012170976]; N-[(1-acryloylpiperidin-4-yl)methyl]-5-(4-phenoxyphenyl)pyrimidine-4,6-diamine; 1-(4-((6-Amin
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| AK-106-001616 | Phase 2 | [95] | ||
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| ABT-122 | Phase 2 | [96] | ||
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| ETIPREDNOL DICLOACETATE | Phase 2 | [97] | ||
| Synonyms |
BNP-166; Cronaze (Ivax); Ethinase (Ivax); Etiprednol dicloacetate < USAN; Respicort (Ivax); (11beta,17alpha)-17-(2,2-Dichloroacetoxy)-11-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylic acid ethyl ester
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| Meninge ACYW | Phase 2 | [98] | ||
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| TAK-715 | Phase 2 | [99] | ||
| Synonyms |
P38 MAP kinase inhibitor (rheumatoid arthritis), Takeda
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| ALD-518 | Phase 2 | [100] | ||
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| MPC-300-IV | Phase 2 | [19] | ||
| External Link | ||||
| GSK2982772 | Phase 1 | [19] | ||
| Synonyms |
LYPAFUINURXJSG-AWEZNQCLSA-N; 1622848-92-3; UNII-T5W3M0VO9B; T5W3M0VO9B; GSK-2982772; (S)-5-benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-1H-1,2,4-triazole-3-carboxamide; GTPL9554; SCHEMBL15956219; MolPort-044-830-634; s8484; AKOS030528033; compound 5 [PMID: 28151659]; ACN-041458; CS-6899; GSK 2982772; AS-35128; AC-29894; HY-101760; J3.650.802G; 5-benzyl-N-[(3S)-5-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-1H-1,2,4-triazole-3-carboxamide; 3-Benzyl-N-[(3s)-5-Methyl-4-Oxo-2,3,4,5-Tetrahydr
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| Anti-LT alpha | Phase 2 | [101] | ||
| External Link | ||||
| NNC-0151-0000-0000 | Phase 2 | [102] | ||
| Synonyms |
Neutrazumab; Anti-C5aR monoclonal antibodies (rheumatoid arthritis/SLE), G2/Novo Nordisk
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| External Link | ||||
| BMS-945429 | Phase 2 | [103] | ||
| External Link | ||||
| ONO-4641 | Phase 2 | [104] | ||
| Synonyms |
Sphingosine-1-phosphate agonist (tablet, mutiple sclerosis), Ono
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| IMO-8400 | Phase 2 | [19] | ||
| Synonyms |
Bazlitoran; Bazlitoran [INN]; Bazlitoran [USAN]; UNII-2U46M95B5M; 2U46M95B5M
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| CNT0-1959 | Phase 2 | [105] | ||
| External Link | ||||
| Apratastat | Phase 2 | [106] | ||
| Synonyms |
TMI-005; TMI-05; UNII-C6BZ5263BJ; 287405-51-0; C6BZ5263BJ; CHEMBL206815; TMI 005; Apratastat [USAN:INN]; Apratastat (USAN/INN); MLS006010301; SCHEMBL2834310; GTPL6482; TMI005; Apratastat, > MolPort-021-805-014; BCPP000041; ZINC28571311; BDBM50181008; DB13020; API0013699; compound 5h [PMID: 16426848]; SMR004701369; 4CA-0170; D08859; 3-Thiomorpholinecarboxamide,N-hydroxy-4-[[4-[(4-hydroxy-2-butyn-1-yl)oxy]phenyl]sulfonyl]-2,2-dimethyl-,(3S)-; TMI-1; Dual TACE/MMP-13 inhibitors (inflammation), Wyeth; Dual TACE/MMP-13 inhibitors (rheumatoid arthritis), Wyeth; Dual TACE/MMP-13 inhibitors, Wyeth-Ayerst
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| FLUASTERONE | Phase 2 | [107] | ||
| Synonyms |
HE-2500; 16alpha-Fluoroandrost-5-en-17-one
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| GS-4059 | Phase 2 | [19] | ||
| Synonyms |
tirabrutinib; 1351636-18-4; UNII-LXG44NDL2T; LXG44NDL2T; Tirabrutinib [INN]; ONO-4059(Free base); SCHEMBL14798454; MolPort-044-728-902; BDBM194087; ZINC72318699; AKOS030526437; CS-5676; HY-15771; US9199997, 9; F10085; (R)-6-amino-9-(1-(but-2-ynoyl)pyrrolidin-3-yl)-7-(4-phenoxyphenyl)-7H-purin-8(9H)-one; 6-Amino-9-((3R)-1-(2-butynoyl)-3-pyrrolidinyl)-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-one; 8H-Purin-8-one,6-amino-7,9-dihydro-9-((3R)-1-(1-oxo-2-butyn-1-yl)-3-pyrrolidinyl)-7-(4-phenoxyphenyl); 6-Amino-9-[(3R)-1-(2-butyno
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| VVZ-149 | Phase 2 | [108] | ||
| Synonyms |
VVZ-000149
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| MRC-375 | Phase 2 | [109] | ||
| Synonyms |
Tetracycline (enteric-coated oral tablet, rheumatoid arthritis), Molecular Research Center Inc
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| AWD-12-281 | Phase 2 | [110] | ||
| Synonyms |
GW-842470; AWD-12-343; AWD-12-281 (COPD), elbion/GlaxoSmithKline; AWD-12-281 (allergic rhinitis), elbion/GlaxoSmithKline; AWD-12-281 (asthma), elbion/GlaxoSmithKline; AWD-12-281 (inhaled), elbion/GlaxoSmithKline; AWD-12-281 (intranasal), elbion/GlaxoSmithKline
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| APX-001 | Investigative | [111] | ||
| Synonyms |
EPI-0010; SSS-07; Anti-TNF alpha recombinant humanized monoclonal antibody (RabMab/MLG, rheumatoid arthritis), 3SBio/Apexigen; Anti-TNF alpha recombinant humanized monoclonal antibody (RabMab/MLG, rheumatoid arthritis), 3SBio/Epitomics
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| SR-31747 | Phase 2 | [112] | ||
| Synonyms |
SR-317417A
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| STA-5326 | Phase 2 | [113] | ||
| Synonyms |
Apilimod; STA 5326; STA5326; N-[(3-methylphenyl)methylideneamino]-6-morpholin-4-yl-2-(2-pyridin-2-ylethoxy)pyrimidin-4-amine
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| BI 655064 | Phase 2 | [114] | ||
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| GSK3196165 | Phase 2 | [19] | ||
| External Link | ||||
| GSK315234 | Phase 2 | [115] | ||
| Synonyms |
Oncostatin M mAb
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| GS-9876 | Phase 1 | [19] | ||
| Synonyms |
XCIGZBVOUQVIPI-UHFFFAOYSA-N; lanraplenib; UNII-A6U64OU57E; A6U64OU57E; 6-(6-aminopyrazin-2-yl)-N-[4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]imidazo[1,2-a]pyrazin-8-amine; 6-(6-Aminopyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine; Lanraplenib [INN]; GTPL9764; SCHEMBL16820581; CHEMBL3986824; example 2 [US9290505]; BDBM212271; GS9876; US9290505, Ex.-2; Ex.-2, US9290505; Imidazo(1,2-a)pyrazin-8-amine, 6-(6-amino-2-pyrazinyl)-N-(4-(4-(3-oxetanyl)-1-piperazinyl)phenyl)-; 6-(6-Aminopyr
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| TZI-41078 | Phase 2 | [116] | ||
| Synonyms |
3,5-Di-tert-butyl-4-hydroxybenzophenone oxime
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| SAN-300 | Phase 2 | [117] | ||
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| CNTO-6785 | Phase 2 | [118] | ||
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| AMG-714 | Discontinued in Phase 1 | [23] | ||
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| LX2931 | Phase 2 | [119] | ||
| External Link | ||||
| VAY736 | Phase 2 | [19] | ||
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| KB002/003 | Phase 2 | [120] | ||
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| SSR-180575 | Phase 2 | [121] | ||
| Synonyms |
2-(7-Chloro-5-methyl-4-oxo-3-phenyl-4,5-dihydro-3H-pyridazino[4,5-b]indol-1-yl)-N,N-dimethylacetamide
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| Rabeximod | Phase 2 | [122] | ||
| Synonyms |
Rob-803; B-220 analog (RA), OxyPharma; B-220 analog (rheumatoid arthritis), OxyPharma
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| BIIB 023 | Phase 2 | [123] | ||
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| Baminercept | Phase 2 | [124] | ||
| Synonyms |
BG-9924; Soluble lymphotoxin beta receptor, Biogen; Soluble lymphotoxin beta receptor, Biogen Idec
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| PF-06823859 | Phase 2 | [125] | ||
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| MK-8457 | Phase 2 | [126] | ||
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| CDP323 | Phase 2 | [23] | ||
| Synonyms |
Zaurategrast; 455264-31-0; (S)-3-(4-((2,7-Naphthyridin-1-yl)amino)phenyl)-2-((2-bromo-3-oxospiro[3.5]non-1-en-1-yl)amino)propanoic acid; UNII-06A0IC74I3; 06A0IC74I3; C26H25BrN4O3; Zaurategrast [INN]; SCHEMBL2976322; CTK8C0588; DTXSID90196547; MolPort-023-332-826; KS-00001DY0; ANW-64932; 6274AB; ZINC100041912; AKOS016005046; CS-0322; N-(2-Bromo-3-oxospiro[3.5]non-1-en-1-yl)-4-(2,7-naphthyridin-1-ylamino)-L-phenylalanine; NCGC00378753-01
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| Tofacitinib | Approved | [127] | ||
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| BMS-986142 | Phase 2 | [19] | ||
| Synonyms |
Unii-pjx9GH268R; PJX9GH268R; CHEMBL3900554; 1643368-58-4; GTPL9857; SCHEMBL16319712; BMS986142; BDBM50194720; AKOS032954006; compound 14f [PMID: 27583770]; J3.563.199B; 73T; 6-Fluoro-5-(R)-(3-(S)-(8-Fluoro-1-Methyl-2,4-Dioxo-1,2-Dihydroquinazolin-3(4h)-Yl)-2-Methylphenyl)-2-(S)-(2-Hydroxypropan-2-Yl)-2,3,4,9-Tetrahydro-1h-Carbazole-8-Carboxamide; (7S)-3-fluoro-4-[3-(8-fluoro-1-methyl-2,4-dioxoquinazolin-3-yl)-2-methylphenyl]-7-(2-hydroxypropan-2-yl)-6,7,8,9-tetrahydro-5H-carbazole-1-carboxamide
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| NN8765 | Phase 2 | [128] | ||
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| CDP-6038 | Phase 2 | [100] | ||
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| DE-098 | Phase 2 | [129] | ||
| Synonyms |
ARG-098; Anti-Fas antibody, Santen; Anti-APO-1 antibody, Santen
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| AMG0714 | Phase 2 | [130] | ||
| Synonyms |
HuMax-IL15
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| Fosbretabulin | Phase 2 | [131] | ||
| Synonyms |
Zybrestat (TN)
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| Rimacalib | Phase 2 | [132] | ||
| Synonyms |
SMP-114
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| Mavrilimumab | Phase 2 | [133] | ||
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| NN8555 | Phase 2 | [134] | ||
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| GSK2586184 | Phase 2 | [135] | ||
| Synonyms |
GSK-2586184
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| PTC299 | Phase 2 | [136] | ||
| Synonyms |
6-(4-Fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)imidazo(2,1-b)thiazole; skf-86002; 72873-74-6; Skf 86002; F 86002; F 86002-A(2); UNII-9R6QDF1UO7; 9R6QDF1UO7; CHEMBL313417; 5-(4-Pyridyl)-6-(4-fluorophenyl)-2,3-dihydroimidazo(2,1-b)-thiazole; 4-[6-(4-fluorophenyl)-2H,3H-imidazo[2,1-b][1,3]thiazol-5-yl]pyridine; 6-(4-fluorophenyl)-5-(4-pyridyl)-2,3-dihydroimidazo[2,1-b]thiazole; 6-(4-Fluorophenyl)-2,3-dihydro-5-(4-pyridyl)imidazo[2,1-b]thiazole; Imidazo(2,1-b)thiazole,; SK&F 86002
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| CCX-354 | Phase 2 | [19] | ||
| Synonyms |
CCX-354-C; GSK2941266
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| [L/D]-aminopterin | Phase 2 | [137] | ||
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| ALX-0061 | Phase 2 | [19] | ||
| Synonyms |
Nanobody therapeutic (autoimmune/inflammatory disease), Ablynx; Anti-IL-6R nanobody therapeutic (autoimmune/inflammatory disease), Ablynx
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| Ozoralizumab | Phase 2 | [138] | ||
| Synonyms |
ATN-103
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| JNJ-38518168 | Phase 2 | [139] | ||
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| Clazakizumab | Phase 2 | [19] | ||
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| UCB-35440 | Phase 2 | [140] | ||
| Synonyms |
5-[4-(N-Carbamoyl-N-hydroxyamino)-1-butynyl]-2-[2-[4-[1(R)-(4-chlorophenyl)-1-phenylmethyl]piperazin-1-yl]ethoxy]benzamide
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| Otilimab | Phase 3 | [141] | ||
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| Pegsunercept | Phase 2 | [142] | ||
| Synonyms |
STNF-R1
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| AD-452 | Phase 2 | [143] | ||
| Synonyms |
RS(+)-mefloquine; (+)-erythro-mefloquine
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| SSR-240612 | Phase 2 | [144] | ||
| Synonyms |
N2-[3(R)-(1,3-Benzodioxol-5-yl)-3-(6-methoxynaphthalen-2-ylsulfonamido)propionyl]-4-[2(R),6(S)-dimethylpiperidin-1-ylmethyl]-N1-isopropyl-N1-methyl-D-phenylalaninamide hydrochloride
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| TOK-8801 | Phase 2 | [145] | ||
| Synonyms |
105963-46-0; Imidazo[2,1-b]thiazole-2-carboxamide, 5,6-dihydro-3,6,6-trimethyl-N-(2-phenylethyl)-; N-(2-Phenylethyl)-3,6,6-trimethyl-5,6-dihydroimidazo(2,1-b)thiazole-2-carboxamide; Imidazo[2,1-b]thiazole-2-carboxamide,5,6-dihydro-3,6,6-trimethyl-N-(2-phenylethyl)-; Tok 8801; N-(2-Phenylethyl)-3,6,6-trimethyl-5,6-dihydroimidazo[2,1-b]thiazole-2-carboxamide; Imidazo(2,1-b)thiazole-2-carboxamide, 5,6-dihydro-3,6,6-trimethyl-N-(2-phenylethyl)-; AC1L3UYM; ACMC-20m9c6; SCHEMBL9774378; CTK4A4247; AKOS030604802
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| Sirukumab | Phase 3 | [146] | ||
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| PG-760564 | Phase 2 | [147] | ||
| Synonyms |
Rheumatoid arthritis therapy, Procter & Gamble
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| Peresolimab | Phase 2 | [148] | ||
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| CH-4051 | Phase 2 | [149] | ||
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| VX-745 | Phase 2 | [150] | ||
| Synonyms |
5-(2,6-Dichlorophenyl)-2-((2,4-difluorophenyl)thio)-6H-pyrimido[1,6-b]pyridazin-6-one; 209410-46-8; Neflamapimod; VX 745; VX745; VRT-031745; UNII-TYL52QM320; TYL52QM320; CHEBI:90528; 5-(2,6-dichlorophenyl)-2-(2,4-difluorophenylthio)-6H-pyrimido[1,6-b]pyridazin-6-one; 5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfanylpyrimido[1,6-b]pyridazin-6-one; Neflamapimod (USAN); Neflamapimod [USAN]; AK-44905; C19H9Cl2F2N3OS; 5-(2,6-Dichlorophenyl)-2-[(2,4-Difluorophenyl)sulfanyl]-6h-Pyrimido[1,6-B]pyridazin-6-One; VX745, VX-745; 5-(2,6-Dichlorophenyl)-2-((2,4-difluorophenyl)thio)-6H-pyrimido(1,6-b)pyridazin-6-one; Vertex 745 (VX745)
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| PF-04171327 | Phase 2 | [151] | ||
| Synonyms |
Fosdagrocorat; UNII-HPI19004QS; 1044535-58-1; HPI19004QS; 2-Phenanthrenecarboxamide, 4b,5,6,7,8,8a,9,10-octahydro-N-(2-methyl-3-pyridinyl)-4b-(phenylmethyl)-7-(phosphonooxy)-7-(trifluoromethyl)-, (4bS,7R,8aR)-;2-Phenanthrenecarboxamide, 4b,5,6,7,8,8a,9,10-octahydro-N-(2-methyl-3-pyridinyl)-4b-(phenylmethyl)-7-(phosphonooxy)-7-(trifluoromethyl)-, (4bS,7R,8aR)-; Fosdagrocorat [USAN:INN]; PF 04171327; Fosdagrocorat (USAN/INN); SCHEMBL1707427; GTPL9649; US8901310, Example 2; CHEMBL3137316; BDBM140010; SB17317
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| MANOALIDE | Phase 2 | [152] | ||
| Synonyms |
UNII-E1DK0157K9; 75088-80-1; CHEMBL463914; CHEBI:66666; E1DK0157K9; 2(5H)-Furanone, 4-(3,6-dihydro-6-hydroxy-5-(4-methyl-6-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3-hexenyl)-2H-pyran-2-yl)-5-hydroxy-; 2(5H)-Furanone, 4-((2R,6R)-3,6-dihydro-6-hydroxy-5-((3E)-4-methyl-6-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3-hexenyl)-2H-pyran-2-yl)-5-hydroxy-, (5R)-; AC1O5NJS; SCHEMBL20551728; MolPort-020-000-975
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| Cenplacel-L | Phase 2 | [153] | ||
| Synonyms |
PDA-001
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| BT-016 | Phase 2 | [154] | ||
| Synonyms |
Tregalizumab
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| Xmab 5871 | Phase 1/2 | [155] | ||
| Synonyms |
XmAb 5871 (TN)
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| Vidofludimus | Phase 2 | [156] | ||
| Synonyms |
717824-30-1; 4SC-101; UNII-8Y1PJ3VG81; SC12267; Vidofludimus(4SC-101; SC12267); CHEMBL197194; 8Y1PJ3VG81; 2-[[2-fluoro-4-(3-methoxyphenyl)phenyl]carbamoyl]cyclopentene-1-carboxylic Acid; 2-{[2-fluoro-4-(3-methoxyphenyl)phenyl]carbamoyl}cyclopent-1-ene-1-carboxylic acid; 2-[[2-fluoranyl-4-(3-methoxyphenyl)phenyl]carbamoyl]cyclopentene-1-carboxylic acid; Vidofludimus [INN]; SC 12267; SCHEMBL247888; GTPL9860; KS-00000TTT; BDBM16111; EX-A546; DTXSID50431325; MolPort-039-193-851; BCP14555; AOB87354; s7262; ZINC14960644
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| K-832 | Phase 2 | [23] | ||
| Synonyms |
10465-81-3; 1,1'-(Azodicarbonyl)-dipiperidine; AdDP; 1,1-(Azodicarbonyl)dipiperidine; 1,1'-(Azodicarbonyl)dipiperidine; diazene-1,2-diylbis(piperidin-1-ylmethanone); NSC356027; NSC 356027; (NE)-N-(piperidine-1-carbonylimino)piperidine-1-carboxamide; azodicarboxylic acid dipiperidine; (E)-diazene-1,2-diylbis(piperidin-1-ylmethanone); Azodicarboxylic acid dipiperidide; J-503690; SR-4077; (E)-diazene-1,2-diylbis(piperidin-1-yl methanone); SR 4077; PubChem19605; piperidyl (piperidylcarbonyl)diazenyl ketone; AC1Q5JWC; AC1NWBQ9
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| PRTX-100 | Phase 1/2 | [157] | ||
| Synonyms |
Staphylococcal protein A
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| Cx-611 | Phase 1/2 | [158] | ||
| Synonyms |
Allogeneic adipose-derived stem cell therapy (intravenous, rheumatoid arthritis), Cellerix; Allogeneic adipose-derived stem cell therapy (intravenous, rheumatoid arthritis), TiGenix
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| BIO-300 | Phase 1/2 | [159] | ||
| Synonyms |
Radioprotective therapy, Humanetics
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| Chondrogen | Phase 1/2 | [160] | ||
| Synonyms |
Chondrogen (TN)
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| ART621 | Phase 1/2 | [161] | ||
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| Indomethacin | Approved | [162] | ||
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| HM71224 | Phase 1 | [163] | ||
| Synonyms |
Poseltinib; 1353552-97-2; UNII-D01E4B1U35; D01E4B1U35; LY3337641; N-(3-((2-((4-(4-methylpiperazin-1-yl)phenyl)amino)furo[3,2-d]pyrimidin-4-yl)oxy)phenyl)acrylamide; Poseltinib [INN]; GTPL9862; CHEMBL4163691; SCHEMBL14915064; BDBM50369724; BS-15248; HM-71224; LY333764; Example 228 [WO2011162515A2]; HY-109010; CS-0030508; Q27275916; 2-Propenamide, N-(3-((2-((4-(4-methyl-1-piperazinyl)phenyl)amino)furo(3,2-d)pyrimidin-4-yl)oxy)phenyl)-; N-(3-((2-(4-(4-Methylpiperazin-1-yl)anilino)furo(3,2-d)pyrimidin-4-yl)oxy)phenyl)prop-2-enamide; N-[3-[2-[4-(4-methylpiperazin-1-yl)anilino]furo[3,2-d]pyrimidin-4-yl]oxyphenyl]prop-2-enamide
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| LABP-104 | Phase 1 | [164] | ||
| Synonyms |
NIM-1324
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| ORTD-1 | Phase 1 | [165] | ||
| Synonyms |
.theta.-Defensin 1; 1-[3-[benzyl-tetrakis(3-guanidinopropyl)-[(1R)-1-hydroxyethyl]-isobutyl-isopropyl-[(1S)-1-methylpropyl]-octadecaoxo-[?]yl]propyl]guanidine; 251442-64-5; BDBM50236198; CHEMBL4073105; Cyclic-(GVCRCICTRGFCRCLCRR); DTXSID60179822; oRTD-1; RTD-1; theta-Defensin 1; theta-Defensin RTD-1
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| JNJ-67484703 | Phase 1 | [166] | ||
| Synonyms |
JNJ-4703
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| IA-14069 | Phase 1 | [167] | ||
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| BX-U001 | Phase 1 | [168] | ||
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| KPE-06001 | Phase 1 | [169] | ||
| Synonyms |
Asthma/arthritis therapy, Kemin
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| PF-05230905 | Phase 1 | [170] | ||
| Synonyms |
ATN-192
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| RG6125 | Phase 1 | [19] | ||
| External Link | ||||
| TAK-020 | Phase 1 | [19] | ||
| External Link | ||||
| AXS-06 | Phase 1 | [171] | ||
| External Link | ||||
| Aminoguanidine | Discontinued in Phase 2 | [172] | ||
| Synonyms |
Pimagedine; Hydrazinecarboximidamide; Guanyl hydrazine; Monoaminoguanidine; 2-aminoguanidine; 79-17-4; Imino semicarbazide; Aminate base; 2-azanylguanidine; Pimagedine [INN]; GUANIDINE, AMINO-; 1-aminoguanidine; UNII-SCQ4EZQ113; Hydrazinecarboximidamide(9CI); CCRIS 3511; EINECS 201-183-1; Aminoguanidine, Hemisulfate; SCQ4EZQ113; CHEMBL225304; CHEBI:40618; HAMNKKUPIHEESI-UHFFFAOYSA-N; guanylhydrazine; GER-11; AGU; amino guanidine; 1-amino-guanidine; Aminoguanidine (AG); Tocris-0787; Carbonohydrazonic diamide; INCB3284
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| OPL-CCL2-LPM | Phase 1 | [173] | ||
| Synonyms |
CCR2 targeting agent (arthritis/nephritis/cardiovascular/pulmonaryl/CNS); Leukocyte population modulator (arthritis/nephritis/cardiovascular/pulmonary/CNS), Osprey
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| External Link | ||||
| AZD9567 | Phase 1 | [19] | ||
| Synonyms |
ZQFNDBISEYQVRR-LOSJGSFVSA-N; AZD-9567; GTPL9812; SCHEMBL17643955; AZD 9567; example 1 [WO2016046260A1]; compound 15 [PMID: 29424542]; B9W; 2,2-difluoro-N-[(1R,2S)-3-methyl-1-[1-(1-methyl-6-oxopyridin-3-yl)indazol-5-yl]oxy-1-phenylbutan-2-yl]propanamide; 2,2-bis(fluoranyl)-~{N}-[(1~{R},2~{S})-3-methyl-1-[1-(1-methyl-6-oxidanylidene-pyridin-3-yl)indazol-5-yl]oxy-1-phenyl-butan-2-yl]propanamide
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| External Link | ||||
| AVE1701 | Phase 1 | [23] | ||
| External Link | ||||
| AVP-13358 | Phase 1 | [174] | ||
| Synonyms |
IgE inhibitors, AVANIR; Allergy/asthma therapeutic, AVANIR
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| Cadherin-11 | Phase 1 | [175] | ||
| Synonyms |
SDP051
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| External Link | ||||
| NCX-1015 | Phase 1 | [176] | ||
| Synonyms |
Nitroprednisolone; NCX-1004; NCX-1016; NO-prednisolone
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| External Link | ||||
| ONS-3010 | Phase 1 | [19] | ||
| External Link | ||||
| BF-389 | Phase 1 | [177] | ||
| Synonyms |
Biofor 389; UNII-MGJ3XBS5KD; MGJ3XBS5KD; BF 389; 127245-22-1; 4-(3,5-Di-tert-butyl-4-hydroxybenzylidene)-2-methyl-5,6-dihydro-2H-1,2-oxazin-3(4H)-one; Dihydro-4-(3,5-di-tert-butyl-4-hydroxybenzylidene)-2-methyl-2H-1,2-oxazin-3(4H)-one; 2H-1,2-Oxazin-3(4H)-one, dihydro-4-((3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl)methylene)-2-methyl-; 2H-1,2-Oxazin-3(4H)-one, 4-((3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl)methylene)dihydro-2-methyl-; Biofor-389; AC1O5RBB; SCHEMBL8291651; LS-100029
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| HMR-1031 | Phase 1 | [178] | ||
| Synonyms |
MDL-819767; 3(S)-[2(S)-[4,4-Dimethyl-3-[4-[3-(2-methylphenyl)ureido]benzyl]-2,5-dioxoimidazolidin-1-yl]-4-methylpentanoylamino]-3-phenylpropionic acid
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| External Link | ||||
| VI7734 | Phase 1 | [125] | ||
| External Link | ||||
| BMS-986104 | Phase 1 | [19] | ||
| Synonyms |
Unii-KJ9D084FO4; KJ9D084FO4; 1622180-31-7; CHEMBL3806158; SCHEMBL15953811; BPMMYKAHRIEVDH-VOQZNFBZSA-N; J3.582.853B; ((1R,3 S)-1-amino-3-((R)-6-hexyl-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentyl)methanol; ((1R,3S)-1-amino-3-((R)-6-hexyl-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentyl)methanol; Cyclopentanemethanol, 1-amino-3-((6R)-6-hexyl-5,6,7,8-tetrahydro-2-naphthalenyl)-, (1R,3S)-
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| AMAP-102 | Phase 1 | [179] | ||
| Synonyms |
5-HT antagonist (rheumatism), AnaMar
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| External Link | ||||
| MEDI5117 | Phase 1 | [180] | ||
| External Link | ||||
| Sc Veltuzumab | Phase 1 | [181] | ||
| External Link | ||||
| MORAb-022 | Phase 1 | [19] | ||
| Synonyms |
Antibody (inflammation/autoimmune disease), Morphotek
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| External Link | ||||
| ARG301 | Phase 1 | [182] | ||
| External Link | ||||
| SCH-900117 | Phase 1 | [183] | ||
| External Link | ||||
| DWP-422 | Phase 1 | [184] | ||
| External Link | ||||
| Gerilimzumab | Phase 1 | [19] | ||
| External Link | ||||
| VEL-0230 | Phase 1 | [185] | ||
| Synonyms |
NC-2300; Osteoporosis therapy (oral), Velcura/Nippon Chemiphar
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| External Link | ||||
| Synthetic neutrophil inhibitor peptide | Phase 1 | [186] | ||
| Synonyms |
SNIP; Nalpha-Acetyl-L-arginyl-L-glutamyl-glycyl-L-seryl-L-tyrosyl-L-phenylalanyl-L-phenylalanyl-glycyl-L-aspartyl-L-asparaginyl-L-alaninamide
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| RWJ-67657 | Phase 1 | [187] | ||
| Synonyms |
215303-72-3; RWJ 67657; RWJ67657; 4-[4-(4-Fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-3-butyn-1-ol; CHEMBL190333; 4-(4-(4-fluorophenyl)-1-(3-phenylpropyl)-5-(pyridin-4-yl)-1H-imidazol-2-yl)but-3-yn-1-ol; 4-(4-Fluorophenyl)-2-(4-hydroxy-1-butynyl)-1-(3-Phenylpropyl)-5-(4-Pyridyl)imidazole; 4-[4-(4-fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridyl)imidazol-2-yl]but-3-yn-1-ol; 4-(4-(4-Fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl)-3-butyn-1-ol
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| External Link | ||||
| MEDI4920 | Phase 1 | [19] | ||
| External Link | ||||
| RPI-78M | Discontinued in Phase 1 | [188] | ||
| Synonyms |
Antiviral agent, Receptogen; Receptin (injectable), ReceptoPharm; Receptin (oral), ReceptoPharm; RPI-78M (injectable), ReceptoPharm; RPI-78M (oral), ReceptoPharm
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| External Link | ||||
| RX-10001 | Phase 1 | [189] | ||
| External Link | ||||
| ASP2408 | Phase 1 | [190] | ||
| Synonyms |
CTLA4-Ig fusion protein
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| External Link | ||||
| GSK3117391 | Phase 1 | [191] | ||
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| ABBV-257 | Phase 1 | [19] | ||
| External Link | ||||
| VGX-1027 | Phase 1 | [192] | ||
| Synonyms |
6501-72-0; GIT 27; git-27; 2-(3-phenyl-4,5-dihydroisoxazol-5-yl)acetic acid; 4,5-DIHYDRO-3-PHENYL-5-ISOXAZOLEACETIC ACID; 2-(3-phenyl-4,5-dihydro-1,2-oxazol-5-yl)acetic Acid; GIT27; SCHEMBL1404343; CHEMBL1320667; CTK5C2027; VGX-127; EX-A366; DTXSID50445023; AOB1858; MUFJHYRCIHHATF-UHFFFAOYSA-N; MolPort-022-917-316; HMS3653J11; BCP09284; VGX 1027; VGX-1027(GIT 27); MFCD08696167; s7515; 2792AH; GIT-27 (VGX-1027); AKOS022538967; AKOS000282755; CS-2737; NCGC00186000-02; NCGC00186000-01; AK175225; HY-15507; AB0279943; KB-272590
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| GSK-1827771 | Phase 1 | [193] | ||
| Synonyms |
IL-1 antagonist (antibody, rheumatoid arthritis), GSK
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| External Link | ||||
| ASP5094 | Phase 1 | [19] | ||
| External Link | ||||
| EVT 401 | Phase 1 | [194] | ||
| External Link | ||||
| SKI-O-703 | Phase 1 | [19] | ||
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| AZ-4217 | Clinical trial | [195] | ||
| Synonyms |
AZ4217; AZ 4217
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| PMID27998201-Compound-9 | Patented | [196] | ||
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| Floctafenine | Withdrawn from market | [6] | ||
| Synonyms |
23779-99-9; Idarac; Novodolan; Diralgan; Idalon; 2,3-Dihydroxypropyl 2-((8-(trifluoromethyl)quinolin-4-yl)amino)benzoate; RU 15750; R 4318; Floctafeninum [INN-Latin]; Floctafenina [INN-Spanish]; 8-Trifluoromethyl-7-deschloroglafenine; C20H17F3N2O4; EINECS 245-881-4; BRN 0457808; 2,3-Dihydroxypropyl 2-((8-(trifluoromethyl)-quinolin-4-yl)amino)benzoate; 2,3-Dihydroxypropyl N-(8-(trifluoromethyl)-4-quinolyl)anthranilate; 4-(o-(2',3'-Dihydroxypropyloxycarbonyl)phenyl)-amino-8-trifluoromethylquinoline
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| Aurothioglucose | Withdrawn from market | [6] | ||
| Synonyms |
HMS3262I11; LP00685
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| Amiprilose | Discontinued in Preregistration | [197] | ||
| Synonyms |
Therafectin; Amiprilose hydrochloride; KAP-690; SM-1213
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| Nerelimomab | Discontinued in Phase 3 | [198] | ||
| Synonyms |
BAY-X-1351
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| M-5010 | Discontinued in Phase 3 | [199] | ||
| Synonyms |
M-5011; T-3788; 2(R)-[4-(3-Methyl-2-thienyl)phenyl]propionic acid
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| BR3-Fc | Discontinued in Phase 2 | [200] | ||
| External Link | ||||
| KC706 | Discontinued in Phase 2 | [201] | ||
| External Link | ||||
| EFLETIRIZINE | Discontinued in Phase 2 | [202] | ||
| Synonyms |
Efletirizine < Rec INN; Ucb-28754; 2-[2-[4-[Bis(4-fluorophenyl)methyl]piperazin-1-yl]ethoxy]acetic acid
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| IX207-887 | Discontinued in Phase 2 | [203] | ||
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| AMG 108 | Discontinued in Phase 2 | [204] | ||
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| HR325 | Discontinued in Phase 2 | [205] | ||
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| Apricoxib | Discontinued in Phase 2 | [206] | ||
| Synonyms |
TG01
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| TA-383 | Discontinued in Phase 2 | [207] | ||
| Synonyms |
Cis-2-(4-Chlorophenyl)-4,5-diphenyl-2-imidazoline hydrochloride; Cis-2-(4-Chlorophenyl)-4,5-diphenyl-4,5-dihydro-1H-imidazole hydrochloride
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| Camobucol | Discontinued in Phase 2 | [208] | ||
| Synonyms |
AGIX-4207; AGIX-4207 IV; V-protectant (rheumatoid arthritis), AtheroGenics
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| SM-8849 | Discontinued in Phase 2 | [209] | ||
| Synonyms |
113759-19-6; 4-(1-(2-fluoro-4-biphenylyl)ethyl)-2-methylaminothiazole; 4-[1-(2-fluoro-4-biphenylyl)ethyl]-2-methylaminothiazole; ZTFDMDJGJVUYQE-UHFFFAOYSA-N; AC1L3Y3S; SCHEMBL5078854; 4-(1-(2-Fluoro-4-biphenyl)ethyl)-2-methylaminothiazole; (+)-2-methylamino-4-(1-(2-fluoro-4-biphenylyl)ethyl)thiazole; 4-[1-(3-fluoro-4-phenylphenyl)ethyl]-N-methyl-1,3-thiazol-2-amine; 2-Thiazolamine, 4-(1-(2-fluoro(1,1'-biphenyl)-4-yl)ethyl)-N-methyl-
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| Zolimomab aritox | Discontinued in Phase 2 | [210] | ||
| Synonyms |
XomaZyme-CD5 Plus; XomaZyme-H65; XomaZyme-lym; OrthoZyme-CD5+; Xmmly-h65-rta; XomaZyme-H65-rta
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| Fontolizumab | Discontinued in Phase 2 | [23] | ||
| Synonyms |
Fontolizumab (USAN/INN)
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| CP-195543 | Discontinued in Phase 2 | [211] | ||
| Synonyms |
LB4 antagonist (RA), Pfizer; LB4 antagonist (inflammation), Pfizer; Leukotriene B4 antagonist (inflammation), Pfizer; Leukotriene B4 antagonist (rheumatoid arthritis), Pfizer
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| MLN3897 | Discontinued in Phase 2 | [23] | ||
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| S-5751 | Discontinued in Phase 2 | [212] | ||
| Synonyms |
AC1NSK82; GTPL1898; S5751; (Z)-7-[(1R,2R,3R,5S)-2-[(5-hydroxy1-benzothiophene-3-carbonyl)amino]-7,7-dimethyl-3-bicyclo[3.1.1]heptanyl]hept-5-enoic acid; (Z)-7-[(1S,3R,4R,5R)-4-[(5-hydroxy-1-benzothiophene-3-carbonyl)amino]-6,6-dimethyl-3-bicyclo[3.1.1]heptanyl]hept-5-enoic acid
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| INCB47986 | Discontinued in Phase 2 | [213] | ||
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| MP-435 | Discontinued in Phase 2 | [214] | ||
| Synonyms |
C5a antagonist (rheumatoid arthritis), Mitsubishi Tanabe
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| CPA-926 | Discontinued in Phase 2 | [215] | ||
| Synonyms |
6-(2-Acetamido-2-deoxy-beta-D-glucopyranosyloxy)-7-hydroxy-2H-1-benzopyran-2-one
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| ISIS 104838 | Discontinued in Phase 2 | [216] | ||
| External Link | ||||
| SINOMENINE | Discontinued in Phase 2 | [217] | ||
| Synonyms |
Cucoline; Kukoline; (9alpha,13alpha,14alpha)-4-Hydroxy-3,7-dimethoxy-17-methyl-7,8-didehydromorphinan-6-one
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| Linetastine | Discontinued in Phase 2 | [218] | ||
| Synonyms |
Tmk688; UNII-7U248Z56LA; 110501-66-1; TMK-688; 159776-68-8; 7U248Z56LA; Linetastine [INN]; Tmk 688; Linazolast; CCRIS 6902; Linazolast (JAN); YM-257; AC1O5R98; CHEMBL314338; SCHEMBL1614484; [4-[(1E,3E)-5-[2-(4-benzhydryloxypiperidin-1-yl)ethylamino]-5-oxopenta-1,3-dienyl]-2-methoxyphenyl] ethyl carbonate; Carbonic acid, 4-(5-((2-(4-(diphenylmethoxy)-1-piperidinyl)ethyl)amino)-5-oxo-1,3-pentadienyl)-2-methoxyphenyl ethyl ester; D09850; Molecule 26
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| SC-106 | Discontinued in Phase 2 | [219] | ||
| Synonyms |
AC1LAPZA; SCHEMBL6773940; IABCGGIFHPDBCJ-JTQLQIEISA-N; (3R)-3-[[2-[(3-guanidinobenzoyl)amino]acetyl]amino]pent-4-ynoic acid; (R)-3-(2-{[1-(3-Guanidino-phenyl)-methanoyl]-amino}-ethanoylamino)-pent-4-ynoic acid; (3R)-3-[[2-[[3-(diaminomethylideneamino)benzoyl]amino]acetyl]amino]pent-4-ynoic acid
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| PRO-515 | Discontinued in Phase 2 | [220] | ||
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| GW-215864 | Discontinued in Phase 2 | [221] | ||
| Synonyms |
GR-215864; GR-215864X; GW-215864X
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| HSR-609 | Discontinued in Phase 2 | [222] | ||
| Synonyms |
FY-609; 3-[4-(8-Fluoro-5,11-dihydrobenz[b]oxepino[4,3-b]pyridin-11-ylidene)piperidin-1-yl]propionic acid dihydrate
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| AnergiX.RA | Discontinued in Phase 2 | [223] | ||
| Synonyms |
AG-4263; RA-AnergiX; Antigen specific therapy (rheumatoid arthritis, AnergiX), Corixa/ Organon
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| GLPG-0259 | Discontinued in Phase 2 | [224] | ||
| Synonyms |
G-13919, GT-146, GT-1498, GT-1704, GT-314, GT-416, GT-514, GT-562
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| CBF-BS2 | Discontinued in Phase 2 | [225] | ||
| Synonyms |
KSB-302
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| NN8209 | Discontinued in Phase 2 | [226] | ||
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| IDEC-151 | Discontinued in Phase 2 | [227] | ||
| Synonyms |
Clenoliximab
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| PAMAPIMOD | Discontinued in Phase 2 | [228] | ||
| Synonyms |
449811-01-2; RO 4402257; UNII-8S2C9V11K4; Pamapimod (R-1503, Ro4402257); CHEMBL1090089; CHEBI:90685; 8S2C9V11K4; Ro4402257; Ro-4402257; R1503; R 1503; R-1503; 6-(2,4-Difluorophenoxy)-2-{[3-Hydroxy-1-(2-Hydroxyethyl)propyl]amino}-8-Methylpyrido[2,3-D]pyrimidin-7(8h)-One; Pamapimod [USAN:INN]; 6-(2,4-Difluorophenoxy)-2-((3-hydroxy-1-(2-hydroxyethyl)propyl)amino)-8-methylpyrido(2,3-d)pyrimidin-7(8H)-one; 6-(2,4-Difluorophenoxy)-2-[[3-hydroxy-1-(2-hydroxyethyl)propyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one
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| S-2474 | Discontinued in Phase 2 | [229] | ||
| Synonyms |
158089-95-3; CTK4C9584; DTXSID20724630; PHENOL, 2,6-BIS(1,1-DIMETHYLETHYL)-4-[(E)-(2-ETHYL-1,1-DIOXIDO-5-ISOTHIAZOLIDINYLIDENE)METHYL]-
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| NPC-567 | Discontinued in Phase 2 | [230] | ||
| Synonyms |
Npc 567; Arg-3-hyp-7-phe-bradykinin; UNII-DV64B0PLEH; 109333-26-8; Bradykinin, arg-hyp(3)-phe(7)-; DV64B0PLEH; Bradykinin, arg(0)-hyp(3)-phe(7)-; CHEMBL446325; CHEBI:73294; arg(0)-hyp(3)-phe(7)-bradykinin; Bradykinin, arginyl-hydroxyprolyl(3)-phenylalanine(7)-; [D-Arg(0),Hyp(3),D-Phe(7)]bradykinin; Bradykinin, N2-D-arginyl-3-(trans-4-hydroxy-L-proline)-7-D-phenylalanine-
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| T-5224 | Discontinued in Phase 2 | [231] | ||
| Synonyms |
AKOS003047196; T5224
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| AD-121 | Discontinued in Phase 1/2 | [232] | ||
| Synonyms |
PW-9101; Rheumatoid arthritis therapeutic (oral controlled release, Syncrodose), Arakis/Penwest; Rheumatoid arthritis therapeutic (oral controlled release, TIMERx), Arakis/Penwest
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| AME-527 | Discontinued in Phase 1/2 | [233] | ||
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| AZD-7140 | Discontinued in Phase 1 | [234] | ||
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| PF-4629991 | Discontinued in Phase 1 | [235] | ||
| Synonyms |
PF-991; S1P1 receptor agonist (autoimmune disease), Pfizer
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| NN8210 | Discontinued in Phase 1 | [236] | ||
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| ARRY-614 | Discontinued in Phase 1 | [237] | ||
| Synonyms |
Pexmetinib; 945614-12-0; Pexmetinib (ARRY-614); UNII-3750D0U8B5; 3750D0U8B5; Pexmetinib [INN]; Pexmetinib;ARRY-614; Pexmetinib(ARRY-614); ARRY614; SCHEMBL379035; GTPL9917; MolPort-039-193-822; LNMRSSIMGCDUTP-UHFFFAOYSA-N; BCP28410; EX-A1421; s7799; ZINC41747181; AKOS032945154; SB16914; Urea, N-(3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl)-N'-((5-fluoro-2-((1-(2-hydroxyethyl)-1H-indazol-5-yl)oxy)phenyl)methyl)-
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| Oncolysin CD6 | Discontinued in Phase 1 | [238] | ||
| Synonyms |
Anti-CD6-bR; Anti-T12-bR
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| Eltenac | Discontinued in Phase 1 | [239] | ||
| Synonyms |
BY-820; B-788-20
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| RG-4934 | Discontinued in Phase 1 | [240] | ||
| Synonyms |
IL-17 huMAb (psoriatic arthritis), Roche
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| AC-100 | Discontinued in Phase 1 | [241] | ||
| Synonyms |
Bicyclo[4.2.0]octa-1,3,5-trien-3-ylboronic acid; BENZOCYCLOBUTANE-4-BORONIC ACID; Boronic acid, bicyclo[4.2.0]octa-1,3,5-trien-3-yl-; SCHEMBL12759201; KS-00000SRU; MolPort-005-942-889; ZINC196051840; AKOS025146995; DS-8536; BC225113; AK164312; 1,2-Dihydrobenzocyclobutene-4-ylboranic acid; CS-0043999; J3.522.588I; 4-bbcb benzocyclobutene-4-boronic acid
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| IL-18BP | Discontinued in Phase 1 | [242] | ||
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| Roquinimex | Discontinued in Phase 1 | [243] | ||
| Synonyms |
Linomide
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| D-1367 | Discontinued in Phase 1 | [244] | ||
| Synonyms |
167692-94-6; 2-(3,3-dimethylbutyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; SCHEMBL15923700; DTXSID80570615; ZINC196470483; SC-92964; 2-(3,3-dimethylbutyl)-4,4,5,5,-tetramethyl-1,3,2-d; 1,3,2-Dioxaborolane, 2-(3,3-dimethylbutyl)-4,4,5,5-tetramethyl-
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| SB-242235 | Discontinued in Phase 1 | [245] | ||
| Synonyms |
193746-75-7; SB242235; SB 242235; 4-(4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidazol-5-yl)-2-methoxypyrimidine; CHEMBL95692; 4-[5-(4-fluorophenyl)-3-piperidin-4-ylimidazol-4-yl]-2-methoxypyrimidine; 4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidazol-5-yl]-2-methoxypyrimidine; Kinome_3169; SCHEMBL2267209; BDBM15458; SYN1076; PDTYLGXVBIWRIM-UHFFFAOYSA-N; MolPort-028-720-427; HMS3244I18; HMS3244J17; HMS3244I17; EX-A1881; BCP05992; ZINC1487129; 3254AH; RS0056; AKOS027323444; CS-2097; NCGC00345831-01; NCGC00345831-03
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| AZD-2315 | Discontinued in Phase 1 | [246] | ||
| Synonyms |
ZD-2315
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| AVE-9940 | Discontinued in Phase 1 | [247] | ||
| External Link | ||||
| AZD-8309 | Discontinued in Phase 1 | [248] | ||
| External Link | ||||
| MLN0415 | Discontinued in Phase 1 | [249] | ||
| Synonyms |
SCHEMBL3805703
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| AZD8566 | Discontinued in Phase 1 | [250] | ||
| External Link | ||||
| LY-231617 | Discontinued in Phase 1 | [251] | ||
| Synonyms |
2,6-Di-tert-butyl-4-(ethylaminomethyl)phenol hydrochloride
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| External Link | ||||
| CI-972 | Discontinued in Phase 1 | [252] | ||
| External Link | ||||
| R-1487 | Discontinued in Phase 1 | [253] | ||
| Synonyms |
449811-92-1; 6-(2,4-difluorophenoxy)-8-methyl-2-((tetrahydro-2H-pyran-4-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one; UNII-IO0DCY55NQ; IO0DCY55NQ; CHEMBL1230122; 6-(2,4-difluorophenoxy)-8-methyl-2-[(tetrahydro-2H-pyran-4-yl)amino]-Pyrido[2,3-d]pyrimidin-7(8H)-one; 6-(2,4-difluorophenoxy)-8-methyl-2-(tetrahydro-2h-pyran-4-ylamino)pyrido[2,3-d]pyrimidin-7(8h)-one; Kinome_3762; SCHEMBL5120612; KKKRKRMVJRHDMG-UHFFFAOYSA-N; HMS3401C13; BDBM50341342; ZINC58633224; AKOS027420928; NCGC00262195-02; KB-80224; ACM449811921
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| R1295 | Discontinued in Phase 1 | [23] | ||
| Synonyms |
CHEMBL2146615
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| KB-2683 | Discontinued in Phase 1 | [254] | ||
| External Link | ||||
| AZD-6703 | Discontinued in Phase 1 | [255] | ||
| Synonyms |
P38 MAP kinase inhibitors (rheumatoid arthritis), AstraZeneca
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| PF-251802 | Discontinued in Phase 1 | [256] | ||
| Synonyms |
PF-00251802; Selective glucocorticoid receptor agonist (1), Pfizer
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| External Link | ||||
| SC-57666 | Discontinued in Phase 1 | [257] | ||
| Synonyms |
CHEMBL274893; AC1L9EJK; SC57666; CHEBI:8982; 1-fluoro-4-[2-(4-methylsulfonylphenyl)cyclopenten-1-yl]benzene; SureCN213008; SCHEMBL213008; ZINC18527; GJGZQTGPOKPFES-UHFFFAOYSA-N; HY-U00129; BDBM50029614; DNC003789; CS-7166; C11706; 1-[2(4-Flurophenyl)-1-cyclopentyl]4-methylsulfonylbenzene; 1-[2-(4-fluorophenyl)cyclopenten-1-yl]-4-(methylsulfonyl)benzene; 1-[2-(4-fluorophenyl) cyclopenten-1-yl]-4- (methylsulfonyl)benzene; 1-fluoro-4-[2-(4-methylsulfonylphenyl)-1-cyclopentenyl]benzene
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| C-5997 | Discontinued in Phase 1 | [258] | ||
| Synonyms |
7709-58-2; 4-(Chloromethyl)thiazole hydrochloride; 4-(chloromethyl)-1,3-thiazole Hydrochloride; 4-(chloromethyl)thiazole hcl; 4-chloromethylthiazole hydrochloride; 4-chloromethylthiazole hcl; 4-(chloromethyl)thiazolehcl; C4H4ClNS.ClH; ACMC-1BBSC; chloromethylthiazole-4 hcl; AC1Q3BH9; AC1MC82W; SCHEMBL122926; 4-(Chloromethyl)thiazole, HCl; CTK6H6834; DTXSID60376874; NVTBASMQHFMANH-UHFFFAOYSA-N; MolPort-000-139-475; 4-(chloromethyl)thiazole HCl salt; ACT02312; KS-000004ND; ANW-36949; 4-chloromethyl thiazole hydrochloride
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| PF-755616 | Discontinued in Phase 1 | [259] | ||
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| GP2015 | Application submitted | [19] | ||
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| CLIK-181 | Preclinical | [260] | ||
| Synonyms |
J3.633.044I
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| SR1555 | Preclinical | [261] | ||
| Synonyms |
CHEMBL3218917; SR-1555; 1386439-51-5; 1-(4-((4'-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-[1,1'-biphenyl]-4-yl)methyl)piperazin-1-yl)ethan-1-one; 1-[4-[[4-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]phenyl]methyl]piperazin-1-yl]ethanone; SCHEMBL13974905; GTPL10145; BDBM50044227; ZINC95537675
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| CLIK-148 | Preclinical | [260] | ||
| Synonyms |
SCHEMBL7207304
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| MCP-1 | Preclinical | [262] | ||
| External Link | ||||
| Romazarit | Preclinical | [263] | ||
| Synonyms |
ORE-5007; Metabolic modulator (obesity/hyperlipidemia), Ore Pharmaceuticals
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| NPC-17923 | Terminated | [264] | ||
| Synonyms |
147960-65-4; N-(9H-(2,7-Dichlorofluorenyl)-9-ethoxycarbonyl)-4-aminobenzoic acid; Benzoic acid, 4-((3-((2,7-dichloro-9H-fluoren-9-yl)oxy)-1-oxopropyl)amino)-
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| TM-31 | Terminated | [265] | ||
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| BCX-25 | Terminated | [266] | ||
| Synonyms |
BCX-14
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| BB-1433 | Terminated | [267] | ||
| Synonyms |
BB-2014; BB-2116; BB-2284; BB-2633; BB-3029; BB-3050; BB-3103; BB-3241
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| ZK-90695 | Terminated | [268] | ||
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| RP-54745 | Terminated | [269] | ||
| Synonyms |
RP 54745; 135330-08-4; AC1L2PX8; SCHEMBL4362761; rp54745; CS-6750; 4-Chloro-5-(3,4-dihydro-1-methyl-2(1H)-isoquinolinyl)-3H-1,2-dithiol-3-one; HY-101716; 4-chloro-5-(1-methyl-3,4-dihydro-1H-isoquinolin-2-yl)dithiol-3-one; 3H-1,2-Dithiol-3-one, 4-chloro-5-(3,4-dihydro-1-methyl-2(1H)-isoquinolinyl)-
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| FR-123826 | Terminated | [270] | ||
| Synonyms |
COX-2 inhibitor, Fujisawa
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| Seprilose | Terminated | [271] | ||
| Synonyms |
GW-80126
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| NOX-200 | Terminated | [272] | ||
| Synonyms |
2-Amino-3-(1H-indol-3-yl)-2-methylpropanoic acid; alpha-Methyl-DL-tryptophan; 153-91-3; NSC9948; 13510-08-2; alpha-Methyl-L-tryptophan; M-5098; Tryptophan, alpha-methyl-; 16709-25-4; DL-alpha-Methyltryptophan; alpha-methyl-D,L-tryptophan; NSC-9948; NSC 9948; Tryptophan,a-methyl-; ACMC-1BNRO; alpha-Methyltryptophan; AC1L3UBI; AC1Q5S1L; (S)-alpha-Methyl pryptophan; SCHEMBL343309; CHEMBL559578; GTPL4693; CTK4C8033; ZTTWHZHBPDYSQB-UHFFFAOYSA-N; MolPort-003-958-850; KS-000001AA; ANW-21478
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| SAN-18 | Terminated | [273] | ||
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| CI-986 | Terminated | [274] | ||
| Synonyms |
CI 986; 5-(3,5-Di-tert-butyl-4-hydroxyphenyl)-1,3,4-thiadiazole-2(3H)-thione; 5-(3,5-Bis(1,1-dimethylethyl)-4-(hydroxyphenyl))-1,3,4-thiadiazole-2(3H)-thione choline salt; Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, salt with 5-(3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl)-1,3,4-thiadiazole-2(3H)-thione (1:1); 130116-16-4; AC1MI25H; C16H22N2OS2.C5H14NO; LS-172752; 2,6-ditert-butyl-4-(2-sulfanylidene-3H-1,3,4-thiadiazol-5-yl)phenolate
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| SDZ-224-015 | Terminated | [275] | ||
| Synonyms |
VE-13045
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| AZD-6942 | Terminated | [276] | ||
| Synonyms |
CCR2b antagonists, AstraZeneca; CCR2b, AstraZeneca
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| 3-DEAZAADENOSINE | Terminated | [277] | ||
| Synonyms |
Cc3Ado; BW-91Y78; 3DZA; 4-Amino-1-beta-D-ribofuranosyl-1H-imidazo[4,5-c]pyridine
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| WY-28342 | Terminated | [278] | ||
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| AG-2024 | Terminated | [279] | ||
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| AZD-0902 | Terminated | [280] | ||
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| Ro-31-4724 | Terminated | [281] | ||
| Synonyms |
CHEMBL92608; [[1-[N-HYDROXY-ACETAMIDYL]-3-METHYL-BUTYL]-CARBONYL-LEUCINYL]-ALANINE ETHYL ESTER; RO4; 112105-54-1; Ro 314724; ro 31-4724; AC1NUPD6; ZINC3801503; ro-314724; BDBM50146631; DB08482; RO314724; (R)-N-(N-(2-(2-(Hydroxyamino)-2-oxoethyl)-4-methyl-1-oxopentyl)-L-leucyl)-L-alanine ethyl ester; ethyl N-{(2R)-2-[2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl}-L-leucyl-L-alaninate; ethyl (2S)-2-[[(2S)-2-[[(2R)-2-[2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]propanoate
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| RO-319790 | Terminated | [282] | ||
| Synonyms |
Ro-31-9790; CHEMBL16520; Ro 31-9790; (R)-N1-((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-N4-hydroxy-2-isobutylsuccinamide; SCHEMBL4633699; QRXOZHSEEGNRFC-ZYHUDNBSSA-N; ZINC1534591; BDBM50063920; CS-6682; HY-101703
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| S-33516 | Terminated | [283] | ||
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| VE-16084 | Terminated | [284] | ||
| Synonyms |
ICE inhibitors, Sanofi Winthrop; WIN-67694
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| D-5410 | Terminated | [285] | ||
| Synonyms |
CH-138; CH-263
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| SKF-104351 | Terminated | [286] | ||
| Synonyms |
111908-94-2; Skf 104351; F 104351; 5H-Pyrrolo[1,2-a]imidazole,2-(4-fluorophenyl)-6,7-dihydro-3-(4-pyridinyl)-; 2-(4-fluorophenyl)-3-(4-pyridyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole; F-104351; AC1L3V0R; SCHEMBL7378515; DTXSID90149775; GJFVAEMLAFFGDZ-UHFFFAOYSA-N; ZINC3815711; 5H-Pyrrolo(1,2-a)imidazole, 2-(4-fluorophenyl)-6,7-dihydro-3-(4-pyridinyl)-; KB-292516; 2-p-Fluorophenyl-3-(4-pyridyl)-6,7-dihydro[5H]-pyrrolo[1,2-a]imidazole
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| SB220025 | Terminated | [287] | ||
| Synonyms |
3erk; sb 220025; SB-220025; CHEMBL274064; 165806-53-1; CHEBI:82713; 4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidazol-5-yl]pyrimidin-2-amine; 4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(2-AMINO-4-PYRIMIDINYL)-IMIDAZOLE; SB4; 5-(2-Amino-4-pyrimidinyl)-4-(4-fluorophenyl)-1-(4-piperidinlyl)imidazole; 4-[5-(4-fluorophenyl)-3-(4-piperidyl)imidazol-4-yl]pyrimidin-2-amine; SB-220025-A; 1-(4-piperidinyl)-4-(4-fluorophenyl)-5-(2-(amino)-4-pyrimidinyl)imidazole
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| RWJ-63556 | Terminated | [288] | ||
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| YM-26734 | Terminated | [289] | ||
| Synonyms |
YM 26734; 144337-18-8; CHEMBL444450; 1-Dodecanone,1,1'-[5-[3,4-dihydro-7-hydroxy-2-(4-hydroxyphenyl)-2H-1-benzopyran-4-yl]-2,4,6-trihydroxy-1,3-phenylene]bis-; 1,1'-[5-[3,4-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-2H-1-benzopyran-4-yl]-2,4,6-trihydroxy-1,3-phenylene]bis-1-dodecanone; ACMC-20n3vr; CTK4C4039; AOB2291; SYN5086; MolPort-023-276-467; BDBM50274336; AKOS024457146; 4-(3,5-Didodecanoyl-2,4,6-trihydroxyphenyl)-7-hydroxy-2-(4-hydroxyphenyl)chroman; KB-276131; YM-26734, > J-007943; 1-Dodecanone, 1
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| AZD5672 | Terminated | [290] | ||
| Synonyms |
CHEMBL1951914; SCHEMBL2767780; GTPL7686; QOSMEMHKXNNIGG-SSEXGKCCSA-N; AZD 5672; BDBM50364743; N-[1-[(3R)-3-(3,5-difluorophenyl)-3-(1-methylsulfonylpiperidin-4-yl)propyl]piperidin-4-yl]-N-ethyl-2-(4-methylsulfonylphenyl)acetamide
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| S-16276-1 | Terminated | [291] | ||
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| FR-111142 | Terminated | [292] | ||
| Synonyms |
WF-2015A
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| BW A4C | Terminated | [293] | ||
| Synonyms |
BW4C; Bwa-4C; Bwa 4C; 106328-57-8; BW-A4C; BWA4C; CHEMBL314360; C17H17NO3; N-(E)-3-(3-Phenoxyphenyl)prop-2-enylacetohydroxamine acid; Acetamide, N-hydroxy-N-(3-(3-phenoxyphenyl)-2-propenyl)-; N-[(E)-3-(3-Phenoxyphenyl)prop-2-enyl]acetohydroxamic acid; Acetohydroxamine acid, N-(E)-3-(3-phenoxyphenyl)prop-2-enyl-; Acetamide, N-hydroxy-N-(3-(3-phenoxyphenyl)-2-propenyl)-, (E)-; BW-4AC; AC1O5PJ5; BW-A-4C; BW-A 4C; JMC515449 Compound 7; BDBM22334; ZINC5138195; MFCD00869694; N-(3-phenoxycinnamyl)-N-hydroxyacetamide
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| WY-48989 | Terminated | [294] | ||
| Synonyms |
WY 48989; 136917-40-3; 4-((2-(7-Chloro-2-phenyl-2H-pyrazolo(4,3-c)quinolin-4-yl)ethyl)amino)benzonitrile; 4-[[2-(7-chloro-2-phenyl-2h-pyrazolo[4,3-c]quinolin-4-yl)ethyl]amino]benzonitrile; WY-48,989; AC1L307T; SCHEMBL10625720; DTXSID90160006; GYVYUQVVKBZPRY-UHFFFAOYSA-N; 4[[2-(7-Chloro-2-phenyl-2H-pyrazolo[4,3-c]quinolin-4-yl)ethyl]amino]benzonitrile
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| FR-133605 | Terminated | [295] | ||
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| SR-26831 | Terminated | [296] | ||
| Synonyms |
SR 26831; AC1L30OS; ((5-(2-Chlorobenzyl-2-tert-butyloxycarbonyl))-4,5,6,7-tetrahydrothieno(3,2-c)pyridine)-N-oxide; Thieno(3,2-c)pyridinium, 5-((2-chlorophenyl)methyl)-2-(2,2-dimethyl-1-oxopropoxy)-4,5,6,7-tetrahydro-5-hydroxy-; [5-[(2-chlorophenyl)methyl]-5-hydroxy-6,7-dihydro-4H-thieno[3,2-c]pyridin-5-ium-2-yl] 2,2-dimethylpropanoate
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| GDC-0834 | Terminated | [297] | ||
| Synonyms |
1133432-49-1; UNII-FM7JG3L4SR; FM7JG3L4SR; CHEMBL2057915; N-{3-[6-({4-[(2r)-1,4-Dimethyl-3-Oxopiperazin-2-Yl]phenyl}amino)-4-Methyl-5-Oxo-4,5-Dihydropyrazin-2-Yl]-2-Methylphenyl}-4,5,6,7-Tetrahydro-1-Benzothiophene-2-Carboxamide; GDC0834; CDOOFZZILLRUQH-GDLZYMKVSA-N; 2VL; GTPL9263; SCHEMBL1205333; GDC 0834; GDC 0834;GDC0834; ZINC59185874; BDBM50388183; AKOS030526267; SB18925; CS-3123; Benzo(b)thiophene-2-carboxamide, N-(3-(6-((4-((2R)-1,4-dimethyl-3-oxo-2-piperazinyl)phenyl)amino)-4,5-dihydro-4-methyl-5-oxo-2-pyraz
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| AZD-0275 | Terminated | [298] | ||
| External Link | ||||
| RPR 200765A | Terminated | [299] | ||
| Synonyms |
CHEMBL68211; SCHEMBL5770288; SCHEMBL13819552; SCHEMBL20555598; SCHEMBL18797648
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| LY-221068 | Terminated | [300] | ||
| Synonyms |
LY 221068; 132392-39-3; AC1O5RGH; SCHEMBL2746042; ly221068; 5-((3,5-Bis(1,1,-dimethylethyl)-4-hydroxyphenyl)methylene)-3-(dimethylamino)-4-thiazolidinone; 4-Thiazolidinone, 5-((3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl)methylene)-3-(dimethylamino)-
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| DPC-333 | Terminated | [301] | ||
| Synonyms |
BMS-561392; UNII-2X066A8676; BMS 561392; CHEMBL489100; BMS561392; 2X066A8676; DPC 333; 611227-74-8; SCHEMBL6350418; GTPL6509; BDBM50247606; C476910000; (2R)-2-[(3R)-3-amino-3-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-2-oxopyrrolidin-1-yl]-N-hydroxy-4-methylpentanamide
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| PXS-2076 | Terminated | [302] | ||
| Synonyms |
PXS-2000; PXS-2030; Cannabinoid CB2 agonist (rheumatoid arthritis), Pharmaxis; TNFrelease inhibitor (rheumatoid arthritis), Pharmaxis
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| ETP-46321 | Investigative | [303] | ||
| Synonyms |
1252594-99-2; CHEMBL2087474; 5-(2-((4-(methylsulfonyl)piperazin-1-yl)methyl)-8-morpholinoimidazo[1,2-a]pyrazin-6-yl)pyrimidin-2-amine; 5-[2-[(4-methylsulfonylpiperazin-1-yl)methyl]-8-morpholin-4-ylimidazo[1,2-a]pyrazin-6-yl]pyrimidin-2-amine; SCHEMBL10100315; BCP19935; ETP46321; EX-A1284; BDBM50420714; ZINC68247289; CS-3350; ETP 46321;ETP46321; HY-12340; 5-[2-[(4-methylsulfonylpiperazin-1-yl)methyl]-8-morpholin-4-yl-imidazo[1,2-a]pyrazin-6-yl]pyrimidin-2-amine
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| ODN-1411 | Investigative | [304] | ||
| External Link | ||||
| PAC-10649 | Investigative | [305] | ||
| Synonyms |
PAC-10549; COX-2 inhibitors (pain/inflammation), Pacific Corp
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| Silicon-modified indomethacin | Investigative | [306] | ||
| Synonyms |
Silexsyn; RND-100; SiM-100; Silicon-modified indomethacin (cancer); Silicon-modified indometacin (cancer), Silamed; Silicon-modified indomethacin (cancer), Silamed
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| BFPT-16864 | Investigative | [111] | ||
| Synonyms |
BFPT-6864; BRFD-104
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| Arthromir | Investigative | [111] | ||
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| NM-2014 | Investigative | [307] | ||
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| SPX-601 | Investigative | [111] | ||
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| CIGB-814 | Investigative | [111] | ||
| Synonyms |
Hsp60 peptide (juvenile idiopathic arthritis), CIGB
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| Anti-CD40-XTEN | Investigative | [308] | ||
| Synonyms |
CD40 ligand receptor antagonist (XTEN, rheumatoid arthritis/transplant rejection), Amunix
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| TNFcept | Investigative | [309] | ||
| Synonyms |
TNFcept (rheumatoid arthritis)
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| X-071-NAB | Investigative | [111] | ||
| Synonyms |
NATHMAB (systemic lupus erythematosus/multiple myeloma/arthritis), XBiotech; Natural/true human monoclonal antibody (systemic lupus erythematosus/multiple myeloma/arthritis), XBiotech
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| TENOSAL | Investigative | [310] | ||
| Synonyms |
MR-Y134; 2-(2-Thienoyloxy)benzoic acid; 2-Thiophenecarboxylic acid salicyl ester
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| DW-908 | Investigative | [111] | ||
| Synonyms |
DW-0908
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| Recombinant human TNF receptor | Investigative | [309] | ||
| Synonyms |
Recombinant human TNF receptor (arthritis); RhTNFR (arthritis), Shanghai/Taizhou; Recombinant human TNFreceptor (arthritis), Taizhou Fudan-Zhangjiang Pharmaceutical/ Shanghai Pharmaceuticals
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| XGP-110 | Investigative | [306] | ||
| Synonyms |
Synoviocyte/tumor cell inhibitor + COX-2 inhibitor (arthritis/cancer/cancer pain), Xaragen
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| MDDR 217769 | Investigative | [111] | ||
| Synonyms |
(E)-2-(4,6-Difluoroindan-1-ylidene)acetamide
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| FKB327 | Investigative | [19] | ||
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| DMARDs | Investigative | [111] | ||
| Synonyms |
DMARDs (oral, rheumatoid arthritis); DMARDs (oral, rheumatoid arthritis), Abbott; Disease-modifying antirheumatic drugs (oral, rheumatoid arthritis), Abbott
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| TX-RAD | Investigative | [111] | ||
| Synonyms |
RA1-TX; RA1-TX (ankylosing spondylitis), TxCell; RA1-TX (rheumatoid arthritis), TxCell; RA1-TX (psoriatic arthritis,inflammatory disease), TxCell
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| UR-5269 | Investigative | [111] | ||
| Synonyms |
Rheumatoid arthritis therapy, UBE Industries
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| AVX-002 | Investigative | [111] | ||
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| XGP-125 | Investigative | [111] | ||
| Synonyms |
Synoviocyte inhibitor + glucocorticoid (arthritis), Xaragen
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| DWJ-425 | Investigative | [111] | ||
| Synonyms |
DW-Ab2; MAb (RA), Daewoong; Monoclonal antibody (rheumatoid arthritis), Daewoong
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| HL-1020 | Investigative | [111] | ||
| Synonyms |
Grape seed proanthocyanidin extract (rheumatoid arthritis), Hanlim
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| XGP-120 | Investigative | [111] | ||
| Synonyms |
Synoviocyte inhibitor + DMARD (arthritis), Xaragen
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| XGP-115 | Investigative | [111] | ||
| Synonyms |
Synoviocyte inhibitor + NSAID (arthritis), Xaragen
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| CTLA-4-XTEN | Investigative | [311] | ||
| Synonyms |
Cytotoxic T-lymphocyte protein 4 modulator (XTEN, rheumatoid arthritis/transplant rejection), Amunix
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| Nano-steroid | Investigative | [111] | ||
| Synonyms |
Steroidal anti-inflammatory (slow release nanoparticle formulation), LTT Bio-Pharma; Steroids (sustained release nanoparticles), LTT Bio-Pharma/Cipra; Steroidal anti-inflammatory (rheumatoid arthritis/collagen disease), LTT Bio-Pharma
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| TNFmab | Investigative | [309] | ||
| Synonyms |
TNFmab (rheumatoid arthritis)
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| YD-101 | Investigative | [111] | ||
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| KI-0906 | Investigative | [111] | ||
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| FHT-401 | Investigative | [111] | ||
| Synonyms |
PTD-conjugated methotrexate (transdermal, rheumatoid arthritis), ForHumanTech/Hyundai
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| TCH-013 | Investigative | [111] | ||
| Synonyms |
NF-kB inhibitors (rheumatoid arthritis); NF-kB inhibitors (rheumatoid arthritis), TCH Pharmaceuticals
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| Anti-CD97 mab | Investigative | [111] | ||
| Synonyms |
Anti-CD97 monoclonal antibody (rheumatoid arthritis); Anti-CD97 mAb (RA), Organon/AMC; Anti-CD97 monoclonal antibody (rheumatoid arthritis), Organon/AMC; Anti-CD97 mAb (RA), Schering-Plough/AMC; Anti-CD97 monoclonal antibody (rheumatoid arthritis), Merck & Co/AMC; Anti-CD97 monoclonal antibody (rheumatoid arthritis), Schering-Plough/AMC
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| CIGB-55 | Investigative | [111] | ||
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| NM-9405 | Investigative | [307] | ||
| Synonyms |
Humanized Yalciomab (rheumatoid arthritis), Novelmed Therapeutics Inc; H-Yalciomab (rheumatoid arthritis), NovelmedTherapeutics Inc
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| Dendritic cell-based immunotherapy | Investigative | [111] | ||
| Synonyms |
Dendritic cell-based immunotherapy (rheumatoid arthritis); Dendritic cell-based immunotherapy (rheumatoid arthritis), Dendright; Dendritic cell-based immunotherapy (rheumatoid arthritis, injectable formulation), Dendright
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| RT-401 | Investigative | [111] | ||
| Synonyms |
BoNTA protein (topical, rhinitis), Revance
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| VVZ-138 | Investigative | [111] | ||
| Synonyms |
VVZ-000138
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| IG-AI-025 | Investigative | [111] | ||
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| CHR-4487 | Investigative | [111] | ||
| Synonyms |
Esterase-sensitive motif compounds (inflammatory disease); Esterase-sensitive motif compounds (inflammatory disease), Chroma Therapeutics
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| Ankinara | Investigative | [262] | ||
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| ROSMARINIC ACID | Investigative | [312] | ||
| Synonyms |
20283-92-5; Rosemary acid; (R)-rosmarinic acid; UNII-MQE6XG29YI; Rosmarinate; MQE6XG29YI; CHEMBL324842; CHEBI:50371; Labiatenic acid; C18H16O8; (R)-O-(3,4-Dihydroxycinnamoyl)-3-(3,4- dihydroxyphenyl)lactic acid; 3,4-Dihydroxycinnamic acid (R)-1-carboxy-2-(3,4-dihydroxyphenyl)ethyl ester; (2R)-3-(3,4-dihydroxyphenyl)-2-[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyloxy]propanoic acid; 537-15-5; Rosemaric acid; (2R)-3-(3,4-dihydroxyphenyl)-2-[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy-propanoic acid
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| CT-340 | Investigative | [111] | ||
| Synonyms |
TrkA kinase inhibitor (polyoxyethylene conjugated, LSE, arthritis, scarring, pain), Creabilis
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| ADR58 | Investigative | [313] | ||
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| CEL-2000 | Investigative | [111] | ||
| Synonyms |
T-cell modulating vaccine (LEAPS, rheumatoid arthritis), CEL-SCI
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| FM-201 | Investigative | [111] | ||
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| BMS-345541 | Investigative | [314] | ||
| Synonyms |
445430-58-0; BMS345541; BMS-345541 free base; BMS-345541 (free base); UNII-26SU0NEF5F; N1-(1,8-dimethylimidazo[1,2-a]quinoxalin-4-yl)ethane-1,2-diamine; 26SU0NEF5F; IKK Inhibitor III, BMS-345541; C14H17N5; 4-(2& -Aminoethyl)amino-1,8-dimethylimidazo[1,2-a]quinoxaline; BMS-345541(free base); IKK Inhibitor III; Kinome_3215; SCHEMBL118886; GTPL5669; CHEMBL249697; CTK8E9618; KS-00001CRN; CHEBI:91340; BDBM25919; DTXSID60196216; PSPFQEBFYXJZEV-UHFFFAOYSA-N; MolPort-035-395-836; HMS3653F06; HMS2043P05
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| CAT-2200 | Investigative | [315] | ||
| Synonyms |
MEDI-571; Anti-IL-17 antibody (rheumatoid arthritis/systemic lupus erythematosus (SLE)), MedImmune; Anti-IL-17 antibody (rheumatoid arthritis/systemic lupus erythematosus (SLE)), Cambridge Antibody Technology (CAT)
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| OCT-SG815 | Investigative | [111] | ||
| Synonyms |
OPG secretagogues (osteoporosis/arthritis), Oscotec; Osteoprotegerin secretagogues (osteoporosis/arthritis), Oscotec; OPG secretagogues (osteoporosis/arthritis), KT&G; Osteoprotegerin secretagogues (osteoporosis/arthritis), KT&G
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References
: m6A sites