m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT05325
 [1]
Non-coding RNA AGAP2-AS1 WTAP  lncRNA       miRNA   circRNA Direct Enhancement m6A modification STAT3 STAT3 METTL14 Methylation : m6A sites
m6A Modification:
m6A Regulator Methyltransferase-like 14 (METTL14) WRITER
 Regulator Info 
m6A Target Signal transducer and activator of transcription 3 (STAT3)
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type Non-coding RNA (ncRNA)
Epigenetic Regulator LOC10013.776 (AGAP2-AS1) LncRNA View Details
Regulated Target Pre-mRNA-splicing regulator WTAP (WTAP) View Details
Crosstalk Relationship ncRNA  →  m6A Enhancement
Crosstalk Mechanism ncRNAs directly impacts m6A modification through recruiting m6A regulator
Crosstalk Summary AGAP2-AS1 bound WT1-associated protein (Pre-mRNA-splicing regulator WTAP (WTAP)) to promote the formation of the WTAP/methyltransferase-like 3 (METTL3)/METTL14 m6A methyltransferase complex. AGAP2-AS1 stabilized signal transducer and activator of Signal transducer and activator of transcription 3 (STAT3) mRNA in an m6A-dependent manner
Responsed Disease Gastric cancer ICD-11: 2B72
 Disease Info 
In-vivo Model For tumorigenesis analysis, AGS cells (1 × 106) with stable knockdown of AGAP2-AS1 or scramble, were injected into mice.
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
Signal transducer and activator of transcription 3 (STAT3) 74 Compound(s) Regulating the Target Click to Show/Hide the Full List
 Compound Name Acitretin Approved [2]
Synonyms
Acitretina; Acitretine; Acitretinum; Etretin; Isoacitretin; Isoetretin; Neotigason; Soriatane; TMMP; Acitretina [Spanish]; Acitretine [French]; Acitretinum [Latin]; Retinoid etretin; U0279; Ro 10-1670; Ro 13-7652; Soriatane (TN); Soriatane, Acitretin; Acitretin (USAN/INN); Acitretin [USAN:INN:BAN]; All-trans-Acitretin; Ro 10-1670/000; Ro-10-1670; Ro-13-7652; Ro-10-1670/000; All-trans-3,7-Dimethyl-9-(4-methoxy-2,3,6-trimethylphenyl)-2,4,6,8-nonatetraenoic acid; (2E,4E,6E,8E)-3,7-dimethyl-9-[2,3,6-trimethyl-4-(methyloxy)phenyl]nona-2,4,6,8-tetraenoic acid; (2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid; (all-E)-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic acid; 13-cis-Acitretin; 9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic acid; 9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 5284513
TTD: D05QDC
DrugBank: DB00459
 Compound Name Napabucasin Phase 3 [3]
Synonyms
83280-65-3; UNII-Z1HHM49K7O; 2-acetylnaphtho[2,3-b]furan-4,9-dione; Z1HHM49K7O; 2-Acetylnaphtho(2,3-b)furan-4,9-dione; 2-Acetyl-4H,9H-naphtho[2,3-b]furan-4,9-dione; Napabucasin [USAN:INN]; Napabucasin (BBI608); 2-Acetylfuranonaphthoquinone; CHEMBL64130; Napabucasin (JAN/USAN/INN); SCHEMBL1883845; Napabucasin - BBI 608/ FNQ; 2-Acetylfuro-1,4-naphthoquinone; DPHUWDIXHNQOSY-UHFFFAOYSA-N; MolPort-039-101-321; EX-A1314; ZINC13306865; s7977; AKOS027470201; DB12155; CS-1747; ACN-053294; HY-13919
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MOA Inhibitor
Activity EC50 = 1900 nM
External Link
CID: 10331844
TTD: D01IGZ
DrugBank: DB12155
 Compound Name Golotimod Phase 2 [4]
Synonyms
229305-39-9; SCV-07; gamma-D-Glu-L-trp; SCV07; gamma-D-Glutamyl-L-tryptophan; SCV 07; UNII-637C487Y09; 637C487Y09; (R)-2-Amino-5-(((S)-1-carboxy-2-(1H-indol-3-yl)ethyl)amino)-5-oxopentanoic acid; Golotimod [USAN:INN]; (2R)-2-amino-5-[[(1S)-1-carboxy-2-(1H-indol-3-yl)ethyl]amino]-5-oxopentanoic acid; (2R)-2-Amino-5-(((1S)-1-carboxy-2-(1H-indol-3-yl)ethyl)amino)-5-oxopentanoic acid; Golotimod (USAN/INN); GAMMA-D-GLU-TRP-OH; H-D-Glu(L-Trp-OH)-OH; SCHEMBL727944; (gamma-glutamyl-L-tryptophan); CHEMBL2103812; Golotimod (oral); Golotimod (oral), SciClone/Verta; SCV-07 (oral, tuberculosis), SciClone/Verta
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MOA Inhibitor
External Link
CID: 6992140
TTD: D02MRN
DrugBank: DB05475
 Compound Name Atiprimod Phase 1/2 [5]
Synonyms
Atiprimod [INN]; SKF 106615; SKF-106615; N,N-Diethyl-8,8-dipropyl-2-azaspiro(4.5)decane-2-propanamine; 3-(8,8-dipropyl-3-azaspiro[4.5]decan-3-yl)-N,N-diethylpropan-1-amine
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 129869
TTD: D0D9LJ
DrugBank: DB05513
 Compound Name OPB-31121 Phase 1/2 [6]
MOA Inhibitor
External Link
TTD: D0E7IM
 Compound Name IMX-110 Phase 1/2 [3]
MOA Inhibitor
External Link
TTD: D0H7DM
 Compound Name GLG-801 Phase 1/2 [3]
MOA Inhibitor
External Link
TTD: D0P7IL
 Compound Name WP-1066 Phase 1/2 [3]
Synonyms
WP1066; 857064-38-1; (S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-(1-phenylethyl)acrylamide; WP 1066; UNII-63V8AIE65T; 63V8AIE65T; AK-99218; C17H14BrN3O; (E)-3-(6-bromopyridin-2-yl)-2-cyano-N-[(1S)-1-phenylethyl]prop-2-enamide; MLS006010178; SCHEMBL1315826; QCR-16; SCHEMBL1315831; GTPL7972; CHEMBL1923234; EX-A760; AOB1497; DTXSID50235007; MolPort-044-723-708; MolPort-023-219-149; ZINC13983221; AKOS016007983; WP1066/WP-1066; CS-2736; DB12679; 2-Propenamide, 3-(6-bromo-2-pyridinyl)-2-cyano-N-((1S)-1-phenylethyl)-, (2E)-; HY-15312
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MOA Inhibitor
External Link
CID: 11210478
TTD: D0IV4C
DrugBank: DB12679
 Compound Name NT219 Phase 1/2 [7]
Synonyms
UNII-K1WT1A1UP5; K1WT1A1UP5; 1198078-60-2; (E)-3-(2-Bromo-3,4-dihydroxyphenyl)-N-(3,4,5-trihydroxybenzyl)prop-2-enethioamide; CHEMBL3679680; SCHEMBL12659248; BDBM101913; NT-219; US8536227, 5; 2-Propenethioamide, 3-(2-bromo-3,4-dihydroxyphenyl)-N-((3,4,5-trihydroxyphenyl)methyl)-; 2-Propenethioamide, 3-(2-bromo-3,4-dihydroxyphenyl)-N-((3,4,5-trihydroxyphenyl)methyl)-, (2E)-
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 135914977
TTD: DUI59O
 Compound Name OPB-51602 Phase 1 [8]
MOA Inhibitor
External Link
TTD: D01FFC
 Compound Name TAK-114 Phase 1 [9]
MOA Modulator
External Link
TTD: D01RCM
 Compound Name WP1220 Phase 1 [10]
Synonyms
mol4239; MOL-4239; PTN9LJL6PY; UNII-PTN9LJL6PY; WP-1220; 2,4-Pentadienamide, 5-(6-bromo-2-pyridinyl)-2-cyano-N-((1S)-1-phenylethyl)-, (2E,4E)-; 1204306-34-2; SCHEMBL862248; SCHEMBL1316581; CHEMBL4594434; (2E,4E)-5-(6-Bromo-2-pyridinyl)-2-cyano-N-((1S)-1-phenylethyl)-2,4-pentadienamide; (2E,4E)-5-(6-bromopyridin-2-yl)-2-cyano-N-[(1S)-1-phenylethyl]penta-2,4-dienamide
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MOA Inhibitor
External Link
CID: 44554865
TTD: D3U8YR
 Compound Name DSP-0337 Phase 1 [11]
MOA Inhibitor
External Link
TTD: DLJN17
 Compound Name OPB-111077 Phase 1 [12]
MOA Inhibitor
External Link
TTD: DN81JB
 Compound Name Quinoline carboxamide derivative 2 Patented [13]
Synonyms
PMID26394986-Compound-29
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MOA Inhibitor
External Link
CID: 67206397
TTD: D00FUZ
 Compound Name Peptidomimetic analog 3 Patented [13]
Synonyms
PMID26394986-Compound-5
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MOA Inhibitor
External Link
CID: 24772856
TTD: D02CJU
 Compound Name PMID26394986-Compound-11 Patented [13]
MOA Inhibitor
External Link
CID: 341
TTD: D02ILH
 Compound Name Flavonoid derivative 5 Patented [13]
Synonyms
PMID26394986-Compound-49
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MOA Inhibitor
External Link
TTD: D02KDA
 Compound Name Salicylic acid derivative 6 Patented [13]
Synonyms
PMID26394986-Compound-18
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 10000 nM
External Link
CID: 72550504
TTD: D03ARS
 Compound Name Gold-complexed thiosaccharide derivative 2 Patented [13]
Synonyms
PMID26394986-Compound-67
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MOA Inhibitor
External Link
CID: 56946870
TTD: D03HEP
 Compound Name Peptidomimetic analog 1 Patented [13]
Synonyms
PMID26394986-Compound-3
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MOA Inhibitor
Activity IC50 = 125 nM
External Link
TTD: D03VMP
 Compound Name Quinoline carboxamide derivative 1 Patented [13]
Synonyms
PMID26394986-Compound-28
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MOA Inhibitor
Activity IC50 = 74000 nM
External Link
CID: 4253236
TTD: D03XAK
 Compound Name Salicylic acid derivative 4 Patented [13]
Synonyms
PMID26394986-Compound-16
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MOA Inhibitor
External Link
CID: 72545583
TTD: D04ANB
 Compound Name PMID26394986-Compound-12 Patented [13]
MOA Inhibitor
External Link
CID: 237973
TTD: D04GVY
 Compound Name PMID26394986-Compound-21 Patented [13]
MOA Inhibitor
Activity IC50 = 15000 nM
External Link
CID: 73672447
TTD: D06RBL
 Compound Name Salicylic acid derivative 5 Patented [13]
Synonyms
PMID26394986-Compound-17
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MOA Inhibitor
Activity Kd = 300 nM
External Link
CID: 72188643
TTD: D08EID
 Compound Name PMID26394986-Compound-20 Patented [13]
MOA Inhibitor
Activity IC50 = 45000 nM
External Link
CID: 76336555
TTD: D08ETA
 Compound Name PMID26394986-Compound-43 Patented [13]
MOA Inhibitor
External Link
CID: 46911017
TTD: D08SEP
 Compound Name PMID26394986-Compound-50 Patented [13]
MOA Inhibitor
External Link
CID: 9881541
TTD: D09BOL
 Compound Name PMID26394986-Compound-44 Patented [13]
MOA Inhibitor
External Link
CID: 65064
TTD: D09CKU
DrugBank: DB12116
 Compound Name PMID26394986-Compound-51 Patented [13]
MOA Inhibitor
External Link
CID: 118707758
TTD: D09SYX
 Compound Name Salicylic acid derivative 3 Patented [13]
Synonyms
PMID26394986-Compound-14a
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MOA Inhibitor
Activity IC50 = 12800 nM
External Link
CID: 73333953
TTD: D09ZCV
 Compound Name Quinoline carboxamide derivative 3 Patented [13]
Synonyms
PMID26394986-Compound-30
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MOA Inhibitor
External Link
CID: 67204713
TTD: D0D8RR
 Compound Name Pyrazole derivative 62 Patented [13]
Synonyms
PMID26394986-Compound-23
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MOA Inhibitor
External Link
CID: 72543768
TTD: D0DC3S
 Compound Name Pyrazole derivative 63 Patented [13]
Synonyms
PMID26394986-Compound-24
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MOA Inhibitor
External Link
CID: 72705159
TTD: D0ET3L
 Compound Name Flavonoid derivative 3 Patented [13]
Synonyms
PMID26394986-Compound-47
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MOA Inhibitor
External Link
CID: 5281612
TTD: D0EV5U
DrugBank: DB11259
 Compound Name Peptide analog 7 Patented [13]
Synonyms
PMID26394986-Compound-1
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MOA Inhibitor
External Link
TTD: D0EW9W
 Compound Name Salicylic acid derivative 1 Patented [13]
Synonyms
PMID26394986-Compound-13a
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MOA Inhibitor
Activity IC50 = 2800 nM
External Link
CID: 68075823
TTD: D0EX9O
 Compound Name Gold-complexed thiosaccharide derivative 1 Patented [13]
Synonyms
PMID26394986-Compound-66
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MOA Inhibitor
External Link
TTD: D0FH4G
 Compound Name Gold-complexed thiosaccharide derivative 3 Patented [13]
Synonyms
PMID26394986-Compound-68
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MOA Inhibitor
External Link
TTD: D0J1US
 Compound Name PMID26394986-Compound-22 Patented [13]
MOA Inhibitor
External Link
CID: 2662
TTD: D0KP0U
DrugBank: DB00482
 Compound Name Pyrazole derivative 65 Patented [13]
Synonyms
PMID26394986-Compound-26
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MOA Inhibitor
External Link
CID: 72705348
TTD: D0M5AR
 Compound Name Pyrazole derivative 64 Patented [13]
Synonyms
PMID26394986-Compound-25
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MOA Inhibitor
External Link
CID: 72705347
TTD: D0M8OV
 Compound Name PMID26394986-Compound-42 Patented [13]
MOA Inhibitor
External Link
CID: 9799188
TTD: D0MA8T
 Compound Name Peptidomimetic analog 2 Patented [13]
Synonyms
PMID26394986-Compound-4
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MOA Inhibitor
Activity IC50 = 17 nM
External Link
TTD: D0QR1I
 Compound Name Pyrazole derivative 66 Patented [13]
Synonyms
PMID26394986-Compound-27
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MOA Inhibitor
External Link
TTD: D0S0UL
 Compound Name PMID26394986-Compound-52 Patented [13]
MOA Inhibitor
External Link
TTD: D0T1GB
 Compound Name Salicylic acid derivative 2 Patented [13]
Synonyms
PMID26394986-Compound-14
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MOA Inhibitor
Activity IC50 = 19000 nM
External Link
CID: 53388144
TTD: D0U7LL
 Compound Name Salicylic acid derivative 7 Patented [13]
Synonyms
PMID26394986-Compound-19
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MOA Inhibitor
Activity Ki = 10000 nM
External Link
CID: 72545832
TTD: D0V3PA
 Compound Name PMID26394986-Compound-53 Patented [13]
MOA Inhibitor
External Link
CID: 25226944
TTD: D0V7HS
 Compound Name Flavonoid derivative 1 Patented [13]
Synonyms
PMID26394986-Compound-45
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MOA Inhibitor
External Link
CID: 5280445
TTD: D0V7NH
DrugBank: DB15584
 Compound Name PMID26394986-Compound-54 Patented [13]
MOA Inhibitor
External Link
CID: 25226945
TTD: D0WW1Z
 Compound Name Peptidomimetic analog 4 Patented [13]
Synonyms
PMID26394986-Compound-6
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MOA Inhibitor
External Link
TTD: D0X6QQ
 Compound Name PMID26394986-Compound-13 Patented [13]
MOA Inhibitor
Activity IC50 = 35000 nM
External Link
CID: 24767791
TTD: D0Y0OQ
 Compound Name Tri-substituted purine derivative 1 Patented [13]
Synonyms
PMID26394986-Compound-9
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MOA Inhibitor
External Link
CID: 71770709
TTD: D0Y2PO
 Compound Name Flavonoid derivative 4 Patented [13]
Synonyms
PMID26394986-Compound-48
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MOA Inhibitor
External Link
CID: 5280343
TTD: D0Y3DN
DrugBank: DB04216
 Compound Name Flavonoid derivative 2 Patented [13]
Synonyms
PMID26394986-Compound-46
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MOA Inhibitor
External Link
TTD: D0Z8BD
 Compound Name PMID26394986-Compound-Figure16 Patented [13]
MOA Inhibitor
Activity IC50 < 150 nM
External Link
TTD: D0ZQ8T
 Compound Name PMID26394986-Compound-Figure17 Patented [13]
MOA Inhibitor
External Link
TTD: D0ZS8Q
 Compound Name Oxazole derivative 1 Patented [13]
Synonyms
PMID26394986-Compound-8
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MOA Inhibitor
Activity IC50 = 79000 nM
External Link
CID: 24768190
TTD: D0EZ6V
 Compound Name Curcumin analog 2 Patented [13]
Synonyms
PMID26394986-Compound-33
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MOA Inhibitor
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CID: 68019246
TTD: D0IC8O
 Compound Name Curcumin analog 1 Patented [13]
Synonyms
PMID26394986-Compound-32
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MOA Inhibitor
Activity Kd = 172 nM
External Link
CID: 11487078
TTD: D0WD1Z
 Compound Name Peptidomimetic analog 5 Patented [13]
Synonyms
PMID26394986-Compound-7
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MOA Inhibitor
Activity IC50 = 310000 nM
External Link
CID: 9870708
TTD: D0XQ3F
 Compound Name Platinum IV complexe 1 Patented [13]
Synonyms
PMID26394986-Compound-69
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MOA Inhibitor
Activity IC50 = 1400 nM
External Link
TTD: D01BVU
 Compound Name PMID26394986-Compound-10 Patented [13]
MOA Inhibitor
Activity IC50 = 86000 nM
External Link
CID: 252682
TTD: D0TU0X
 Compound Name GNF-PF-1399 Investigative [14]
Synonyms
GNF-PF-2708; GNF-PF-4643
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MOA Inhibitor
External Link
CID: 107464
TTD: D06PZK
 Compound Name ISIS-STAT3 Phase 1/2 [15]
External Link
TTD: D0B4MK
 Compound Name C188-9 Phase 1 [15]
Synonyms
QDCJDYWGYVPBDO-UHFFFAOYSA-N; UNII-KZ3DLD11RQ; KZ3DLD11RQ; AC1LQFBK; MLS006011646; SCHEMBL16394007; CHEMBL3392776; MolPort-000-644-242; N-(1B; ZINC1154831; AKOS001673470; MCULE-7568979350; NCGC00262829-02; SMR004703404; EU-0081697; AB00117290-01; C-188-9; N-[4-hydroxy-3-(2-hydroxynaphthalen-1-yl)naphthalen-1-yl]-4-methoxybenzenesulfonamide; N-[4-hydroxy-3-(2-hydroxy-1-naphthyl)-1-naphthyl]-4-methoxy-1-benzenesulfonamide; Benzenesulfonamide, N-(1',2-dihydroxy(1,2'-binaphthalen)-4'-yl)-4-methoxy-; 432001-19-9
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External Link
CID: 1324494
TTD: D09CLC
 Compound Name ISIS 113187 Investigative [15]
External Link
TTD: D03MRO
 Compound Name ISIS 113176 Investigative [15]
External Link
TTD: D07XRC
 Compound Name ISIS 113209 Investigative [15]
External Link
TTD: D09YBP
 Compound Name ISIS 113210 Investigative [15]
External Link
TTD: D0E3ZU
 Compound Name ISIS 17148 Investigative [15]
External Link
TTD: D0O3DZ
 Compound Name ISIS 17152 Investigative [15]
External Link
TTD: D0W2FY
2B72: Gastric cancer 81 Compound(s) Regulating the Disease Click to Show/Hide the Full List
 Compound Name Leniolisib Approved [16]
Synonyms
1354690-24-6; Leniolisib free base; UNII-L22772Z9CP; (S)-1-(3-((6-(6-methoxy-5-(trifluoromethyl)pyridin-3-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)amino)pyrrolidin-1-yl)propan-1-one; L22772Z9CP; 1354690-24-6 (free base); leniolisib(CDZ 173); CDZ173; CDZ-173; 1-[(3S)-3-[[6-[6-methoxy-5-(trifluoromethyl)pyridin-3-yl]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]amino]pyrrolidin-1-yl]propan-1-one; Leniolisib [INN]; Leniolisib (CDZ173); Leniolisib (USAN/INN); CDZ173-NX; SCHEMBL323054; GTPL9424; CHEMBL3643413; BDBM118299; EX-A2854; MFCD30470232; s8752; ZB1510; CS-7524; DC22326; SB18839; Example 67 [WO2012004299]; 1-{(S)-3-[6-(6-methoxy-5-trifluoromethyl-pyridin-3-yl)-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-4-y; 1-{(S)-3-[6-(6-methoxy-5-trifluoromethyl-pyridin-3-yl)-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-4-ylamino]-pyrrolidin-1-yl}-propan-1-one; AS-56217; HY-17635; A16796; D11158; US8653092, 67; Q27282602; 1-Propanone, 1-((3S)-3-((5,6,7,8-tetrahydro-6-(6-methoxy-5-(trifluoromethyl)-3-pyridinyl)pyrido(4,3-d)pyrimidin-4-yl)amino)-1-pyrrolidinyl)-; 9NQ
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CID: 57495353
TTD: DGO2C1
 Compound Name Atezolizumab Approved [3]
External Link
TTD: D0YM2K
 Compound Name Bavencio Approved [3]
External Link
TTD: D0W8HN
 Compound Name Tebentafusp Approved [17]
External Link
TTD: D0S0BJ
 Compound Name Merimepodib Approved [18]
Synonyms
Merimebodib; Merimepodib [USAN:INN]; Tyverb/Tykerb; MMPD; 198821-22-6; 2ZL2BA06FU; C23H24N4O6; CHEMBL304087; MERIMEPODIB, VI-21497, VX-497; UNII-2ZL2BA06FU; VI-21497; VX-497; VX497; Vx 497; carbamic acid
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External Link
CID: 153241
TTD: D0F0ZE
DrugBank: DB04862
 Compound Name Taxol Approved [19]
Synonyms
C47H51NO14; weekly paclitaxel; Micellar Paclitaxel; Paclitaxel [USAN:INN:BAN]; SCHEMBL15000506; Benzenepropanoic acid, beta-(benzoylamino)-alpha-hydroxy-, 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester, (2aR-(2aalpha,4beta,4abeta,6beta,9alpha(alphaR*,betaS*),11alpha,12alpha,12aalpha,12balpha))-
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CID: 36314
TTD: D0C4RB
DrugBank: DB01229
 Compound Name Ramucirumab Approved [20]
Synonyms
LY3009806
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External Link
TTD: D09HVD
 Compound Name Tucatinib Approved [21]
Synonyms
Irbinitinib; 937263-43-9; ONT-380; UNII-234248D0HH; 234248D0HH; N6-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)-N4-(3-methyl-4-((1,2,4)triazolo(1,5-a)pyridin-7-yloxy)phenyl)quinazoline-4,6-diamine; 4,6-Quinazolinediamine, N6-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)-N4-(3-methyl-4-((1,2,4)triazolo(1,5-a)pyridin-7-yloxy)phenyl)-; ONT 380; 4,6-QuinazolinediaMine, N6-(4,5-dihydro-4,4-diMethyl-2-oxazolyl)-N4-[3-Methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]-; Tucatinib [USAN:INN]; 6-DIAMINE
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CID: 51039094
TTD: D09GRX
DrugBank: DB11652
 Compound Name Antacids Approved [22]
External Link
TTD: D06AJL
 Compound Name Trastuzumab Approved [3]
Synonyms
Herceptin; Herceptin (TN); Trastuzumab (INN); Trastuzumab (genetical recombination); Trastuzumab (genetical recombination) (JAN); Trastuzumab (ERBB2 mAb inhibitor)
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External Link
TTD: D04WFL
 Compound Name Carbamazepine Phase 3 [23]
Synonyms
Carbamazepine (iv, epilepsy); Carbamazepine (iv, epilepsy), Lundbeck; Carbamazepine (iv, epilepsy), Ovation Pharmaceuticals
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External Link
CID: 2554
TTD: D04MSM
DrugBank: DB00564
 Compound Name Margetuximab Approved [3]
External Link
TTD: D01YYP
 Compound Name Nivolumab Approved [3]
External Link
TTD: D00GOV
 Compound Name GRANITE Phase 3 [24]
Synonyms
Penoxsulam; 219714-96-2; 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy-[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide; UNII-784ELC1SCZ; 784ELC1SCZ; CHEBI:81776; 2-(2,2-difluoroethoxy)-n-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide; Penoxsulam [ISO]; PXD; DSSTox_CID_14803; DSSTox_RID_79204; DSSTox_GSID_34803; SCHEMBL116968; CHEMBL1895913; DTXSID0034803; HSDB 7887; AMY12535; BCP18718; EBD18529; Tox21_301010; MFCD07363876; ZINC13827750; AKOS025401685; NCGC00163715-01; NCGC00163715-02; NCGC00163715-03; NCGC00254912-01; AC-24494; Penoxsulam 100 microg/mL in Acetonitrile; CAS-219714-96-2; FT-0696708; Penoxsulam, PESTANAL(R), analytical standard; C18481; Q22808507; 2-(2,2-Difluoroethoxy)-6-trifluoromethyl-N-(5, 8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)benzenesulfonamide; 2-(2,2-Difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]-triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide; 2-(2,2-difluoroethoxy)-N-{5,8-dimethoxy-[1,2,4]triazolo[1,5-c]pyrimidin-2-yl}-6-(trifluoromethyl)benzene-1-sulfonamide; 2-(2,2-difluoroethyl)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide; Benzenesulfonamide, 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy(1,2,4)triazolo(1,5-c)pyrimidin-2-yl)-6-(trifluoromethyl)-
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External Link
CID: 11784975
TTD: DKF9I3
 Compound Name Zolbetuximab Phase 3 [25]
Synonyms
IMAB362
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External Link
TTD: D4HQ1F
 Compound Name Tusamitamab ravtansine Phase 3 [26]
Synonyms
SAR408701
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External Link
TTD: D2D6NJ
 Compound Name Andecaliximab Phase 3 [27]
External Link
TTD: D0Z6SP
 Compound Name ABP 980 Phase 3 [28]
External Link
TTD: D0WZ0X
 Compound Name GS-5745 Phase 3 [19]
External Link
CID: 56776542
TTD: D0WL0Q
 Compound Name S-1 Phase 3 [29]
Synonyms
Ciprofibrate-coa; Ciprofibrate-coenzyme A; Coenzyme A, ciprofibrate-; AC1L4TRG; AC1Q3T4H; 111900-25-5; s-{1-[(2r,3s,4r,5r)-5-(6-amino-9h-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3; E5,5; E5-diphosphaheptadecan-17-yl} 2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methylpropanethioate(non-preferred name); Coenzyme A, S-(2-(4-(2,2-dichlorocyclopropyl)phenoxy)-2-methylpropanoate)
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External Link
CID: 163872
TTD: D0S8LJ
 Compound Name Lonsurf Phase 3 [3]
External Link
TTD: D0PM0Y
 Compound Name GDC-0068 Phase 3 [19]
Synonyms
RG7440
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External Link
CID: 24788740
TTD: D0I4TH
DrugBank: DB11743
 Compound Name Edotecarin Phase 3 [30]
Synonyms
ED-749; Edotecarin < Prop INN; J-107088; PF-804950; 12-(beta-D-Glucopyranosyl)-2,10-dihydroxy-6-[2-hydroxy-1-(hydroxymethyl)ethylamino]-6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-dione
    Click to Show/Hide
External Link
CID: 9808998
TTD: D0I1DW
DrugBank: DB04882
 Compound Name RG3638 Phase 3 [31]
Synonyms
Onartuzumab
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External Link
TTD: D0H9PT
 Compound Name G17DT Phase 3 [32]
Synonyms
Gastrimmune; Insegia
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External Link
TTD: D0G8ZQ
 Compound Name DE-766 Phase 3 [33]
External Link
TTD: D0FJ1W
 Compound Name Tesetaxel Phase 2 [34]
Synonyms
DJ-927; 333754-36-2; UNII-UG97LO5M8Y; UG97LO5M8Y; Tesetaxel [INN]; DJ927; DJ 927; CHEMBL2107787; SCHEMBL12060837; DB12019; Z-3104; (2AS,2BR,3S,4S,6S,8AR,10R,11AS,11BR,13AR)-2A-ACETOXY-6-(((2R,3S)-3-((TERT-BUTOXYCARBONYL)AMINO)-3-(3-FLUOROPYRIDIN-2-YL)-2-HYDROXYPROPANOYL)OXY)-10-((DIMETHYLAMINO)METHYL)-4-HYDROXY-7,11B,14,14-TETRAMETHYL-2A,2B,3,4,5,6,8A,11A,11B,12,13,13A-DODECAHYDRO-2H-4,8-METHANOOXETO[3'',2'':3',4']BENZO[1',2':3,4]CYCLODECA[1,2-D][1,3]DIOXOL-3-YL BENZOATE
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External Link
CID: 6918574
TTD: D0F9VH
DrugBank: DB12019
 Compound Name Nelipepimut S Phase 3 [35]
Synonyms
E75
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External Link
CID: 9941306
TTD: D0F8UV
 Compound Name BMS-986205 Phase 3 [3]
Synonyms
KRTIYQIPSAGSBP-KLAILNCOSA-N; 1923833-60-6; BMS986205; UNII-0A7729F42K; 0A7729F42K; GTPL9707; SCHEMBL18826792; SCHEMBL17740982; SCHEMBL19105151; EX-A2606; AKOS032954040; HY-101560; CS-0021719; Q29213697; (R)-N-(4-chlorophenyl)-2-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)propanamide; (2R)-N-(4-chlorophenyl)-2-[4-(6-fluoroquinolin-4-yl)cyclohexyl]propanamide; (2R)-N-(4-Chlorophenyl)-2-(4-(6-fluoro-4-quinolyl)cyclohexyl)propanamide, cis; Cyclohexaneacetamide, N-(4-chlorophenyl)-4-(6-fluoro-4-quinolinyl)-alpha-methyl-, cis-(alphaR)-
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External Link
CID: 121328278
TTD: D0DP5I
DrugBank: DB14986
 Compound Name Rivoceranib Phase 3 [3]
External Link
TTD: D0D7BX
 Compound Name Claudiximab Phase 3 [3]
Synonyms
IMAB-362; Anti-GC182 mAbs (cancer), Ganymed; Anti-GC182 monoclonal antibodies (cancer), Ganymed; Anti-CLDN18-2 mAbs (cancer), Ganymed; Anti-CLDN18-2 monoclonal antibodies (cancer), Ganymed
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External Link
TTD: D0B3ZC
 Compound Name OS-440 Phase 3 [36]
Synonyms
CNS modulator (spasticity), Osmotica
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External Link
TTD: D09OHH
 Compound Name Oraxol Phase 3 [3]
External Link
TTD: D04UWU
 Compound Name ICI 118,551 Phase 3 [19]
Synonyms
Ici 118551; (2R,3S)-1-[(7-methyl-2,3-dihydro-1H-inden-4-yl)oxy]-3-(propan-2-ylamino)butan-2-ol; CHEMBL198059; CHEBI:73289; ICI-118551; ICI118551; erythro-DL-1-(7-Methylindan-4-yloxy)-3-isopropylaminobutan-2-ol; (2R,3S)-3-(isopropylamino)-1-[(7-methyl-2,3-dihydro-1H-inden-4-yl)oxy]butan-2-ol; 2-Butanol, 1-((2,3-dihydro-7-methyl-1H-inden-4-yl)oxy)-3-((1-methylethyl)amino)-, (2R,3S)-rel-; 2-Butanol, 1-((2,3-dihydro-7-methyl-1H-inden-4-yl)oxy)-3-((1-methylethyl)amino)-, (R*,S*)-(+-)-; ICI-118,551; Ici 111,581; AC1NUNSO
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External Link
CID: 3682
TTD: D04DJS
 Compound Name Evorpacept Phase 2/3 [37]
Synonyms
ALX148
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External Link
TTD: DRP8H0
 Compound Name BNT141 Phase 2 [38]
External Link
TTD: DFZ19J
 Compound Name Anti-LAG3 Phase 2 [28]
External Link
TTD: D0T7OI
 Compound Name GSK1292263 Phase 2 [39]
External Link
CID: 24996872
TTD: D0S4II
DrugBank: DB12627
 Compound Name MM-111 Phase 2 [40]
External Link
TTD: D0Q2KM
 Compound Name Plevitrexed Phase 2 [41]
Synonyms
ZD 9331; ZD9331; 153537-73-6; Plevitrexed [INN]; ZD-9331; NSC 696259; UNII-L9P2881C3H; CHEMBL126648; (2s)-2-[(2-fluoro-4-{[(4-hydroxy-2,7-dimethylquinazolin-6-yl)methyl](prop-2-yn-1-yl)amino}benzoyl)amino]-4-(2h-tetrazol-5-yl)butanoic acid; L9P2881C3H; Plevitrexed (INN); 172521-94-7; (2S)-2-[[4-[(2,7-dimethyl-4-oxo-1H-quinazolin-6-yl)methyl-prop-2-ynylamino]-2-fluorobenzoyl]amino]-4-(2H-tetrazol-5-yl)butanoic acid; 1H-Tetrazole-5-butanoic acid,
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External Link
CID: 135430970
TTD: D0I9GR
DrugBank: DB06163
 Compound Name DS-8201 Phase 1 [28]
Synonyms
9-Aminofluorene; 9H-Fluoren-9-amine; 525-03-1; FLUOREN-9-AMINE; Fluoren-9-ylamine; UNII-4NHO2K4K5B; CCRIS 7000; BRN 2209545; 4NHO2K4K5B; OUGMRQJTULXVDC-UHFFFAOYSA-N; fluorene-9-ylamine; 9-Amino-fluoren; 9-amino-fluorene; 9H-9-fluorenamine; 9H-fluoren-9-yl-amine; AC1L1VP5; 4-12-00-03390 (Beilstein Handbook Reference); SCHEMBL353865; AC1Q53A2; AC1Q53A1; KS-00000JGC; CTK1H0380; DTXSID90200496; MolPort-001-794-448; HMS1780P20; 9H-fluoren-9-ylamine hydrochloride; ZINC1724407; ALBB-023296; CA-733; SBB005783; AKOS000264388; MCULE-8757055914; DS-
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External Link
CID: 10671
TTD: D0E8IQ
 Compound Name XL880 Phase 2 [42]
Synonyms
GSK 089; GSK 1363089; GSK1363089; XL 880; GSK1363089, GSK089, foretinib, EXEL-2880, XL880; 88Z; MET inhibitors
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External Link
CID: 42642645
TTD: D0D1GF
DrugBank: DB12307
 Compound Name Matuzumab Phase 2 [43]
Synonyms
EMD-62000; EMD-72000; Anti-EGF receptor humanized antibody (iv, cancer), Merck KGaA/ Takeda Pharmaceuticals; Anti-EGFR humanized mAb (iv, cancer), Merck KGaA/ Takeda Pharmaceuticals; Anti-epidermal growth factor receptor humanized antibody (iv, cancer), Merck KGaA/ Takeda Pharmaceuticals
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External Link
TTD: D0BZ7V
 Compound Name BAY-57-9352 Phase 2 [19]
Synonyms
Telatinib; Bay 57-9352
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External Link
CID: 9808844
TTD: D07NOI
DrugBank: DB15393
 Compound Name Bemarituzumab Phase 2 [44]
External Link
TTD: D05ISO
 Compound Name PEGPH20 Phase 2 [3]
External Link
TTD: D05INV
 Compound Name Plevitrexed (R)-isomer Phase 2 [45]
Synonyms
YW3548
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External Link
CID: 213022
TTD: D04FYZ
 Compound Name APR-246 Phase 2 [46]
Synonyms
Eprenetapopt
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External Link
CID: 52918385
TTD: D03XTY
DrugBank: DB11684
 Compound Name CRS-207 Phase 2 [35]
External Link
TTD: D02WSB
 Compound Name Opdivo + Yervoy Phase 3 [3]
External Link
TTD: D02VYE
 Compound Name CT-041 Phase 1/2 [47]
External Link
TTD: DJ6AW5
 Compound Name BPX-601 Phase 1/2 [48]
External Link
TTD: D0TY6U
 Compound Name Anti-MUC1 CAR-T cells Phase 1/2 [49]
External Link
TTD: D0C9MJ
 Compound Name Anti-Mesothelin CAR-T cells Phase 1/2 [50]
External Link
TTD: D0BE6M
 Compound Name Anti-HER2 CAR-T Phase 1/2 [51]
External Link
TTD: D08QZH
 Compound Name CAR-T Cells targeting EpCAM Phase 1/2 [52]
External Link
TTD: D08QYW
 Compound Name PAT-SC1 Phase 1/2 [53]
Synonyms
SC-1; Adjuvant therapy (gastric cancer), University of Wurzburg; SC-1 (gastric cancer), CAT; SC-1 (gastric cancer), Debiopharm; SC-1 (gastric cancer), Patrys; SC-1 (stomach cancer), OncoMab
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TTD: D00UOQ
 Compound Name ASP2138 Phase 1 [54]
External Link
TTD: DTQL30
 Compound Name SAR443216 Phase 1 [55]
External Link
TTD: DL6F3E
 Compound Name AMG 199 Phase 1 [56]
External Link
TTD: DEP3Z8
 Compound Name AMG 910 Phase 1 [57]
External Link
TTD: DEDP81
 Compound Name Alofanib Phase 1 [58]
Synonyms
1612888-66-0; 3-(N-(4-methyl-2-nitro-5-(pyridin-3-yl)phenyl)sulfamoyl)benzoic acid; RPT-835(alofanib); UNII-LQX7RFK8MZ; RPT-835; RPT835; LQX7RFK8MZ; ES000835; Alofanib [INN]; Alofanib(RPT835); Syn007154; CHEMBL4594436; SCHEMBL18660613; AMY16650; BCP31905; EX-A2731; MFCD30533418; NSC790182; s8754; Benzoic acid, 3-(((4-methyl-2-nitro-5-(3-pyridinyl)phenyl)amino)sulfonyl)-; NSC-790182; SB19665; AC-31695; AK668992; AS-56846; HY-17601; CS-0014684; RPT 835; Q27283135; 3-{[4-methyl-2-nitro-5-(pyridin-3-yl)phenyl]sulfamoyl}benzoic acid
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External Link
CID: 86280646
TTD: D47MOS
 Compound Name HER2-specific CAR T cell Phase 1 [59]
External Link
TTD: D0YF6K
 Compound Name Anti-CEA-CAR T Phase 1 [60]
External Link
TTD: D0S1QN
 Compound Name XR-5944 Phase 1 [61]
Synonyms
MLN-944; XR-11576 analogs; XR-5000 analogs; XR-5942
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External Link
CID: 439035
TTD: D0Q5TH
DrugBank: DB06364
 Compound Name A168 Phase 1 [62]
External Link
TTD: D0L9PU
 Compound Name EGFR806-specific CAR T cell Phase 1 [63]
External Link
TTD: D0I7ZH
 Compound Name AbGn-107 Phase 1 [3]
External Link
TTD: D08GZE
 Compound Name FPA144 Phase 1 [28]
External Link
TTD: D06NND
 Compound Name Minnelide 001 Phase 1 [19]
External Link
TTD: D05UFJ
 Compound Name CAR-T cells targeting EpCAM Phase 1 [64]
External Link
TTD: D01TNK
 Compound Name Anti-CEA CAR-T cells Phase 1 [65]
External Link
TTD: D00KDQ
 Compound Name EPCAM-targeted CAR-T cells Clinical trial [66]
External Link
TTD: D0T8DD
 Compound Name PMID28460551-Compound-1 Patented [67]
External Link
CID: 25190990
TTD: D0IH3I
DrugBank: DB14866
 Compound Name Conjugated 3-(indolyl)-and 3-(azaindolyl)-4-arylmaleimide compound 1 Patented [68]
Synonyms
PMID28621580-Compound-WO2012084683c62
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External Link
TTD: D04PKQ
 Compound Name TOPIXANTRONE HYDROCHLORIDE Discontinued in Phase 2 [69]
Synonyms
SCHEMBL1418986; Topixantrone hydrochloride < Prop INNM; BBR-3409 (dimaleate); 5-[2-(Dimethylamino)ethylamino]-2-[2-(2-hydroxyethylamino)ethyl]indazolo[4,3-gh]isoquinolin-6(2H)-one dihydrochloride
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CID: 6918273
TTD: D06DWQ
 Compound Name MDL 101,731 Discontinued in Phase 2 [70]
Synonyms
Tezacitabine; Fmdc cpd; 130306-02-4; UNII-7607Y95N9S; Mdl 101731; (E)-2'-Deoxy-2'-(fluoromethylene) cytidine; MDL-101731; 2'-Deoxy-2'-(fluoromethylene)cytidine; 7607Y95N9S; Cytidine, 2'-deoxy-2'-(fluoromethylene)-, (2E)-; (E)-2'-Deoxy-2'-(fluoromethylene)cytidine; Tezacitabine [INN]; tezaciabine; Tezacitabine, anhydrous; AC1O5KIG; SCHEMBL18724; SCHEMBL18725; Tezacitabine, anhydrous [INN]; CHEMBL2105467; C10H12FN3O4; DTXSID10156446; GFFXZLZWLOBBLO-ASKVSEFXSA-N; ZINC3777826; KW-2331
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CID: 6435808
TTD: D05HZI
DrugBank: DB06433
 Compound Name BBR-3438 Discontinued in Phase 2 [71]
Synonyms
Nortopixantrone; UNII-PH2639TAB4; PH2639TAB4; Nortopixantrone [INN:BAN]; AC1MI4ZO; CHEMBL150303; SCHEMBL7804438
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CID: 3038512
TTD: D01VPR
 Compound Name IPI-493 Discontinued in Phase 1 [72]
Synonyms
[(3R,5R,6S,7R,8E,10R,11R,12Z,14E)-21-amino-6-hydroxy-5,11-dimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate; AC1NS08X; SCHEMBL16226496; SCHEMBL16225851
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External Link
CID: 9893658
TTD: D0BM6S
DrugBank: DB13023
 Compound Name Kanjinti Application submitted [3]
External Link
TTD: D0CW3U
 Compound Name Anti-CD9 mab Investigative [73]
Synonyms
ALB-6; Anti-CD9 mAb (gastric cancer); Anti-CD9 mAb (gastric cancer), Osaka University
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TTD: D09BPT
References
Ref 1 AGAP2-AS1 promotes the assembly of m6A methyltransferases and activation of the IL6/STAT3 pathway by binding with WTAP in the carcinogenesis of gastric cancer. FASEB J. 2023 Dec;37(12):e23302. doi: 10.1096/fj.202301249R.
Ref 2 [Effects of acitretin on the expression of signaling pathway-related genes in epidermal squamous-cell carcinoma cells]. Zhonghua Zhong Liu Za Zhi. 2006 Jan;28(1):21-4.
Ref 3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
Ref 4 National Cancer Institute Drug Dictionary (drug id 617379).
Ref 5 Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127. doi: 10.1517/14728210802676278.
Ref 6 OPB-31121, a novel small molecular inhibitor, disrupts the JAK2/STAT3 pathway and exhibits an antitumor activity in gastric cancer cells. Cancer Lett. 2013 Jul 10;335(1):145-52. doi: 10.1016/j.canlet.2013.02.010. Epub 2013 Feb 10.
Ref 7 Clinical pipeline report, company report or official report of Purple Biotech.
Ref 8 Phase I and biomarker study of OPB-51602, a novel signal transducer and activator of transcription (STAT) 3 inhibitor, in patients with refractory solid malignancies. Ann Oncol. 2015 May;26(5):998-1005. doi: 10.1093/annonc/mdv026. Epub 2015 Jan 21.
Ref 9 Clinical pipeline report, company report or official report of Gastroenterology.
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Ref 11 Napabucasin, a novel STAT3 inhibitor suppresses proliferation, invasion and stemness of glioblastoma cells. J Exp Clin Cancer Res. 2019 Jul 5;38(1):289. doi: 10.1186/s13046-019-1289-6.
Ref 12 Phase I Dose-Finding Study of OPB-111077, a Novel STAT3 Inhibitor, in Patients with Advanced Hepatocellular Carcinoma. Cancer Res Treat. 2019 Apr;51(2):510-518. doi: 10.4143/crt.2018.226. Epub 2018 Jun 13.
Ref 13 A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421.
Ref 14 In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6.
Ref 15 TTD: Therapeutic Target Database describing target druggability information. Nucleic Acids Res. 2024 Jan 5;52(D1):D1465-D1477. doi: 10.1093/nar/gkad751.
Ref 16 FDA Approved Drug Products from FDA Official Website. 2023. Application Number: 217759.
Ref 17 FDA Approved Drug Products from FDA Official Website. 2022. Application Number: 761228.
Ref 18 FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 022059.
Ref 19 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
Ref 20 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7390).
Ref 21 ClinicalTrials.gov (NCT04499924) Tucatinib, Trastuzumab, Ramucirumab, and Paclitaxel Versus Paclitaxel and Ramucirumab in Previously Treated HER2+ Gastroesophageal Cancer (MOUNTAINEER-02). U.S. National Institutes of Health.
Ref 22 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 23 ClinicalTrials.gov (NCT01128959) Study to Assess the Safety and Tolerability of Intravenous Carbamazepine in Adults With Epilepsy. U.S. National Institutes of Health.
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