m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT05280
 [1]
Non-coding RNA miR-340-3p METTL3  lncRNA       miRNA   circRNA Direct Inhibition m6A modification HMOX1 HMOX1 YTHDF2 : m6A sites
m6A Modification:
m6A Regulator YTH domain-containing family protein 2 (YTHDF2) READER
 Regulator Info 
m6A Target Heme oxygenase 1 (HMOX1)
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type Non-coding RNA (ncRNA)
Epigenetic Regulator hsa-miR-340-3p microRNA View Details
Regulated Target Methyltransferase-like protein 3 (METTL3) View Details
Crosstalk Relationship ncRNA  →  m6A Inhibition
Crosstalk Mechanism ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator
Crosstalk Summary hsa-miR-340-3p-modified bone marrow mesenchymal stem cell-derived exosomes inhibit ferroptosis through Methyltransferase-like protein 3 (METTL3)-mediated m6A modification of Heme oxygenase 1 (HMOX1) to promote recovery of injured rat uterus.YTHDF2 as a critical m6A reader protein that contributes to HMOX1 mRNA degradation. YTHDF2 facilitates HMOX1 mRNA degradation by identifying the m6A binding site in the 3'-untranslated regions of HMOX1.
Responsed Disease Diseases of the female genital system ICD-11: GA6Z
 Disease Info 
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
Heme oxygenase 1 (HMOX1) 10 Compound(s) Regulating the Target Click to Show/Hide the Full List
 Compound Name Stannsoporfin Phase 2 [2]
Synonyms
SNMPP; Stanate; Sn Mesoporphyrin; Tin mesoporphyrin; Stanate (TN); Stannsoporfin (USAN/INN)
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MOA Inhibitor
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CID: 23725028
TTD: D02JAY
 Compound Name 2-Phenylheme Investigative [3]
MOA Inhibitor
External Link
CID: 17753777
TTD: D02AVZ
DrugBank: DB03906
 Compound Name Biliverdine Ix Alpha Investigative [3]
Synonyms
biliverdine; UNII-O9MIA842K9; NSC 62793; O9MIA842K9; CHEBI:17033; Biliverdin IX; 8,12-bis(2-carboxyethyl)-2,7,13,17-tetramethyl-3,18-divinylbilin-1(19)(21H,24H)-dione; Biliverdine dihydrochloride; QBUVFDKTZJNUPP-BBROENKCSA-N; Protobiliverdin IX; EINECS 204-042-2
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MOA Inhibitor
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CID: 5280353
TTD: D06SCF
DrugBank: DB02073
 Compound Name Verdoheme Investigative [4]
MOA Inhibitor
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CID: 11963948
TTD: D06UNX
 Compound Name Tin protoporphyrin Investigative [5]
Synonyms
AC1NUFJX; 3-[(1Z,4Z,10Z,14Z)-18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,22,23,24-tetraid-2-yl]propanoic acid
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MOA Inhibitor
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CID: 24197550
TTD: D0HX0D
 Compound Name 1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone Investigative [6]
Synonyms
CHEMBL493448; SCHEMBL10247513; CHEMBL1187207; BDBM50252801; DB07342; 1(adamantan1yl) 2(1himidazol1yl) ethanone; 1-(adamantan-1-yl)-2-(imidazol-1-yl)ethanone; 1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone hydrochloride
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MOA Inhibitor
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CID: 20541332
TTD: D0K1NM
DrugBank: DB07342
 Compound Name 12-Phenylheme Investigative [3]
MOA Inhibitor
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CID: 5287448
TTD: D0S8UN
 Compound Name 2-Propanol, Isopropanol Investigative [3]
Synonyms
Isopropyl alcohol; isopropanol; 2-Propanol; Propan-2-ol; 67-63-0; 2-Hydroxypropane; Hartosol; Avantine; Alkolave; Dimethylcarbinol; sec-Propyl alcohol; Takineocol; Petrohol; Alcojel; Avantin; i-Propanol; 1-Methylethanol; 2-Propyl alcohol; Propol; Lutosol; Isohol; Alcolo; Lavacol; Alcosolve 2; Imsol A; 1-Methylethyl alcohol; Arquad DMCB; Alcosolve; Spectrar; n-Propan-2-ol; i-Propylalkohol; Combi-schutz; i-Propyl alcohol; Isopropyl alcohol, rubbing; Iso-propylalkohol; Alcool isopropilico; Visco 1152; Alcool isopropylique; Sterisol hand
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MOA Inhibitor
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CID: 3776
TTD: D0W7LK
DrugBank: DB02325
 Compound Name Formic Acid Investigative [3]
Synonyms
formate; Formic acid, ion(1-); HCO2 anion; 71-47-6; formylate; aminate; methanoate; hydrogen carboxylate; CHEMBL183491; formiate; Formate ion; a carboxyl group; Hydrogencarboxylic acid; HCOO-; AC1L18W4; GTPL4540; CTK5I5292; CHEBI:15740; DTXSID60221219; BDAGIHXWWSANSR-UHFFFAOYSA-M; BDBM50155538; STL483235
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MOA Inhibitor
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CID: 284
TTD: D06EWG
DrugBank: DB01942
 Compound Name Heme Investigative [6]
Synonyms
protoheme; Haem; ferroprotoporphyrin; UNII-42VZT0U6YR; Iron protoporphyrin ix; Protohaem; Ferroheme; Reduced hematin; Ferrous protoheme; Iron protoporphyrin; Ferrous protoheme IX; Ferroprotoporphyrin IX; 14875-96-8; 42VZT0U6YR; Iron(II) protoporphyrin IX; Protoheme IX (VAN); Ferroheme (VAN); Heme (VAN); 85758-EP2305825A1; 85758-EP2305243A1; 85758-EP2270505A1; 85758-EP2270016A1; 3-[18-(2-carboxyethyl)-7,12-bis(ethenyl)-3,8,13,17-tetramethylporphyrin-21,23-diid-2-yl]propanoic acid; iron(2+); NSC 16669; NSC 267100; AC1L9FPJ; Hemin
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MOA Inhibitor
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CID: 26945
TTD: D0UU1I
GA6Z: Diseases of the female genital system 7 Compound(s) Regulating the Disease Click to Show/Hide the Full List
 Compound Name Promegestone Approved [7]
Synonyms
Surgestone (TN)
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External Link
CID: 36709
TTD: D0F2AK
DrugBank: DB13602
 Compound Name Echovist Approved [8]
Synonyms
ZK-44012; SH-U-454
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CID: 6036
TTD: D0A7GX
 Compound Name PEN-203 Discontinued in Phase 2 [9]
Synonyms
Papirines; Papilloma therapy, Pentose
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External Link
TTD: D0S7EQ
 Compound Name SIM-916 Discontinued in Phase 1 [10]
Synonyms
Womens health therapeutics, ArQule/Wyeth; Rheumatoid arthritis therapeutics (1), ArQule/Wyeth
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TTD: D0W7ZN
 Compound Name ZO-Y49 Investigative [11]
External Link
TTD: D06VTL
 Compound Name AXP-107-16 Investigative [11]
External Link
TTD: D05VWK
 Compound Name GSK-008A Investigative [12]
Synonyms
Progesterone receptor agonists (gynecological disorder); Progesterone receptor agonists (gynecological disorder), GSK
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TTD: D02WQR
References
Ref 1 miR-340-3p-modified bone marrow mesenchymal stem cell-derived exosomes inhibit ferroptosis through METTL3-mediated m(6)A modification of HMOX1 to promote recovery of injured rat uterus. Stem Cell Res Ther. 2024 Jul 29;15(1):224. doi: 10.1186/s13287-024-03846-6.
Ref 2 Chemoprevention of severe neonatal hyperbilirubinemia. Semin Perinatol. 2004 Oct;28(5):365-8.
Ref 3 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
Ref 4 DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. doi: 10.1093/nar/gkq1126. Epub 2010 Nov 8.
Ref 5 Adenovirus-mediated heme oxygenase-1 gene delivery inhibits injury-induced vascular neointima formation. Circulation. 2001 Nov 27;104(22):2710-5.
Ref 6 The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. doi: 10.1093/nar/28.1.235.
Ref 7 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2877).
Ref 8 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 9 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009802)
Ref 10 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020925)
Ref 11 The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
Ref 12 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 627).