m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation

m6A Modification:
Crosstalk ID	M6ACROT05150			[1], [2]
Non-coding RNA miR-103-3p METTL14 lncRNA miRNA circRNA Direct Inhibition m⁶A modification GPX4 GPX4 METTL14 Methylation : m⁶A sites
m6A Regulator	Methyltransferase-like 14 (METTL14)		WRITER	Regulator Info
m6A Target	Phospholipid hydroperoxide glutathione peroxidase GPX4 (GPX4)			Targert Gene
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type	Non-coding RNA (ncRNA)
Epigenetic Regulator	hsa-miR-103-3p		microRNA	View Details
Regulated Target	Methyltransferase-like protein 14 (METTL14)			View Details
Crosstalk Relationship	ncRNA → m6A		Inhibition
Crosstalk Mechanism	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator
Crosstalk Summary	hsa-miR-103-3p targets the m6 A methyltransferase METTL14 to inhibit osteoblastic bone formation.METTL14 represses osteoclast formation to ameliorate osteoporosis via enhancing Phospholipid hydroperoxide glutathione peroxidase GPX4 (GPX4) mRNA stability
Responsed Disease	Osteoporosis	ICD-11: FB83.1		Disease Info

References

Ref 1	MiR-103-3p targets the m(6) A methyltransferase METTL14 to inhibit osteoblastic bone formation. Aging Cell. 2021 Feb;20(2):e13298. doi: 10.1111/acel.13298. Epub 2021 Jan 13.
Ref 2	METTL14 represses osteoclast formation to ameliorate osteoporosis via enhancing GPX4 mRNA stability. Environ Toxicol. 2023 Sep;38(9):2057-2068. doi: 10.1002/tox.23829. Epub 2023 May 17.