m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT05062
|
[1] | |||
m6A modification
AK311120
AK311120
ALKBH5
Demethylation
 : m6A sites
Direct
Enhancement
Non-coding RNA
AK311120
YTHDC2
lncRNA miRNA circRNA
|
|||||
| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | RNA demethylase ALKBH5 (ALKBH5) | ERASER | |||
| m6A Target | Lnc-AK311120 | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | Non-coding RNA (ncRNA) | ||||
| Epigenetic Regulator | Lnc-AK311120 | LncRNA | View Details | ||
| Regulated Target | YTH N6-methyladenosine RNA binding protein C2 (YTHDC2) | View Details | |||
| Crosstalk Relationship | m6A → ncRNA | Enhancement | |||
| Crosstalk Mechanism | m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA | ||||
| Crosstalk Summary | Knockdown of ALKBH5 resulted in a significant increase in the m6A modification level of lnc-Lnc-AK311120, accompanied by a downregulation in the expression level of AK311120. AK311120 interacted with the RNA-binding proteins DExH-Box helicase 9 (DHX9) and YTH N6-methyladenosine RNA binding protein C2 (YTHDC2) to form a ternary complex, while mitogen-activated protein kinase kinase 7 (MAP2K7) served as the shared downstream target gene of DHX9 and YTHDC2. | ||||